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Review

Ophthalmic timolol: Plasma concentration and systemic cardiopulmonary effects

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Pages 237-245 | Received 26 Jun 2006, Accepted 26 Jun 2006, Published online: 08 Jul 2009

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Maryam Sadat Hosseini, Mojdeh Mohseni, Masood Naseripour, Mehdi Mirzaei, Kowsar Bagherzadeh, Sayyed Amirpooya Alemezadeh & Bita Mehravi. (2023) Synthesis and evaluation of modified lens using plasma treatment containing timolol-maleate loaded lauric acid-decorated chitosan-alginate nanoparticles for glaucoma. Journal of Biomaterials Science, Polymer Edition 34:13, pages 1793-1812.
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Anna Bollinger, Chiara Jeiziner, Henriette E Meyer zu Schwabedissen, Kurt E Hersberger, Samuel S Allemann & Céline K Stäuble. (2023) Severe systemic Adverse Reactions to Ophthalmic Timolol in a CYP2D6 Homozygous *4 Allele Carrier: A Case Report. Pharmacogenomics 24:14, pages 739-746.
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Philippe Denis. (2011) Travoprost/timolol fixed combination in the management of open-angle glaucoma: a clinical review. Expert Opinion on Pharmacotherapy 12:3, pages 463-471.
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M Reza Razeghinejad & Mohammad Hosein Nowroozzadeh. (2010) Anti‐glaucoma medication exposure in pregnancy: an observational study and literature review. Clinical and Experimental Optometry 93:6, pages 458-465.
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Crossref
Gerald Liew & Jie Jin Wang. (2011) Manifestaciones vasculares retinianas: ¿reflejan el estado del corazón?. Revista Española de Cardiología 64:6, pages 515-521.
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Crossref
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Berrin Gunaydin & Oya Yalcin Cok. (2011) Hazards of topical ophthalmic drug administration. Trends in Anaesthesia and Critical Care 1:1, pages 31-34.
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Aysegul Cort, Nihal Ozturk, Deniz Akpinar, Mustafa Unal, Gultekin Yucel, Akif Ciftcioglu, Piraye Yargicoglu & Mutay Aslan. (2010) Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure. Regulatory Toxicology and Pharmacology 58:1, pages 121-130.
Crossref
KK Lau, HW Ng & ML Tse. (2010) Timolol Eye Drops Induced Bradycardia. Hong Kong Journal of Emergency Medicine 17:1, pages 71-74.
Crossref
Paul N. Schacknow & John R. Samples. 2010. The Glaucoma Book. The Glaucoma Book 583 628 .
Shu-Feng Zhou. (2009) Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance. Clinical Pharmacokinetics 48:11, pages 689-723.
Crossref
Satish R. RajC. Michael SteinPablo J. SaavedraDan M. Roden. (2009) Cardiovascular Effects of Noncardiovascular Drugs. Circulation 120:12, pages 1123-1132.
Crossref
Yangfan YangKaili WuHongzhi YuanMinbin Yu. (2009) Cytochrome Oxidase 2D6 Gene Polymorphism in Primary Open-Angle Glaucoma With Various Effects to Ophthalmic Timolol. Journal of Ocular Pharmacology and Therapeutics 25:2, pages 163-172.
Crossref
Isaac SchweitzerKay MaguireChee H Ng. (2008) A case of melancholic depression induced by β‐blocker antiglaucoma agents. Medical Journal of Australia 189:7, pages 406-407.
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