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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 10
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Research Article

Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase

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Pages 835-847 | Published online: 22 Sep 2008

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Hinata Ueda, Katsuya Narumi, Shuho Asano, Yoshitaka Saito, Ayako Furugen & Masaki Kobayashi. (2024) Comparative study on the occurrence of adverse effects in the concomitant use of azathioprine and aldehyde oxidase inhibitors. Expert Opinion on Drug Safety 23:1, pages 89-97.
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Francesca Toselli, Melanie Golding, Johan Nicolaï, Eric Gillent & Hugues Chanteux. (2022) Drug clearance by aldehyde oxidase: can we avoid clinical failure?. Xenobiotica 52:8, pages 890-903.
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Narges Cheshmazar, Siavoush Dastmalchi, Mineko Terao, Enrico Garattini & Maryam Hamzeh-Mivehroud. (2019) Aldehyde oxidase at the crossroad of metabolism and preclinical screening. Drug Metabolism Reviews 51:4, pages 428-452.
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Samaneh Soleymani, Roodabeh Bahramsoltani, Roja Rahimi & Mohammad Abdollahi. (2017) Clinical risks of St John’s Wort (Hypericum perforatum) co-administration. Expert Opinion on Drug Metabolism & Toxicology 13:10, pages 1047-1062.
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Tomoyuki Isobe, Masayuki Ohta, Yoshio Kaneko & Hiroyuki Kawai. (2016) Species differences in metabolism of ripasudil (K-115) are attributed to aldehyde oxidase. Xenobiotica 46:7, pages 579-590.
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Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla, Kalpesh Vaghasiya, Nagarjun Rangaraj & Jawahar Lal. (2014) Novel pre-clinical methodologies for pharmacokinetic drug–drug interaction studies: spotlight on “humanized” animal models. Drug Metabolism Reviews 46:4, pages 475-493.
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Ramakrishna Nirogi, Vishwottam Kandikere, Raghava Choudary Palacharla, Gopinadh Bhyrapuneni, Vijaya Bhargava Kanamarlapudi, Ranjith Kumar Ponnamaneni & Arun Kumar Manoharan. (2014) Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions. Xenobiotica 44:3, pages 197-204.
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Chiaki Tanoue, Kazumi Sugihara, Naoto Uramaru, Yoshitaka Tayama, Yoko Watanabe, Toru Horie, Shigeru Ohta & Shigeyuki Kitamura. (2013) Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes. Xenobiotica 43:11, pages 956-962.
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Maryam Hamzeh-Mivehroud, Seifullah Rahmani, Mohammad-Reza Rashidi, Mohammad-Ali Hosseinpour Feizi & Siavoush Dastmalchi. (2013) Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids. Xenobiotica 43:8, pages 661-670.
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Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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Saeed Pirouzpanah, Jalal Hanaee, Seyed-Vali Razavieh & Mohammad-Reza Rashidi. (2009) Inhibitory effects of flavonoids on aldehyde oxidase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 24:1, pages 14-21.
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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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A. Madan, A. Fisher, L. Jin, D. Chapman & H. P. Bozigian. (2007) metabolism of indiplon and an assessment of its drug interaction potential. Xenobiotica 37:7, pages 736-752.
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Margherita Strolin Benedetti, Rhys Whomsley & Eugène Baltes. (2006) Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 895-921.
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Nagwa H. Foda, A. Abd Elbary & O. El‐Gazayerly. (2006) Reversed–Phase Liquid Chromatographic Determination of Zaleplon in Human Plasma and its Pharmacokinetic Application. Analytical Letters 39:9, pages 1891-1905.
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A. B. Renwick, S. E. Ball, J. M. Tredger, R. J. Price, D. G. Walters, J. Kao, J. A. Scatina & B. G. Lake. (2002) Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices. Xenobiotica 32:10, pages 849-862.
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