Citations (142)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (25)
André Rogerio Pereira, Ashley Silva Campos, Maria João Matos & Edson Luis Maistro. (2024) Study of the DNA damage and cell death in human peripheral blood mononuclear and HepG2/C3A cells exposed to the synthetic 3-(3-hydroxyphenyl)-7-hydroxycoumarin. Journal of Toxicology and Environmental Health, Part A 87:1, pages 33-46.
Read now
Read now
Ezeidy Denisse Gallardo-Valle, Dayanne Carbajal-Nogueda, Ma. Elena Moreno-Godínez, Eugenia Flores-Alfaro, Isela Parra-Rojas, Gerardo Huerta-Beristain, Teresa Domínguez-Reyes & Marco Antonio Ramírez-Vargas. (2023) Evaluation of the cytotoxicity and genotoxicity of glufosinate-ammonium at technical and commercial grades in HepG2 cells. Journal of Environmental Science and Health, Part B 58:8, pages 577-582.
Read now
Read now
Qiao Wu, Zhongping Duan, Long Huang & Zhijie Li. (2022) Kuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue engineering. Pharmaceutical Biology 60:1, pages 1679-1689.
Read now
Read now
Maryam Mirahmad, Reyhaneh Sabourian, Mohammad Mahdavi, Bagher Larijani & Maliheh Safavi. (2022) In vitro cell-based models of drug-induced hepatotoxicity screening: progress and limitation. Drug Metabolism Reviews 54:2, pages 161-193.
Read now
Read now
Brian Ogushi Silva, Juliana Botinhon Orlando, Camila Lehnhardt Pires, Clélia Akiko Hiruma-Lima, Isabel de Mascarenhas Gaivão, Fábio Ferreira Perazzo & Edson Luis Maistro. (2021) Genotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model. Journal of Toxicology and Environmental Health, Part A 84:12, pages 518-528.
Read now
Read now
Ana C. S. Souza, Laís K. Silva, Thais B. Queiroz, Eduardo S. Marques, Clélia A. Hiruma-Lima, Isabel O. M. Gaivão & Edson L. Maistro. (2020) Citral presents cytotoxic and genotoxic effects in human cultured cells. Drug and Chemical Toxicology 43:4, pages 435-440.
Read now
Read now
Edson Luis Maistro, Peterson Menezes Terrazzas, Fábio Ferreira Perazzo, Isabel O’Neill De Mascarenhas Gaivão, Alexandra Christinie Helena Frankland Sawaya & Paulo Cesar Pires Rosa. (2019) Salix alba (white willow) medicinal plant presents genotoxic effects in human cultured leukocytes. Journal of Toxicology and Environmental Health, Part A 82:23-24, pages 1223-1234.
Read now
Read now
Ana Luísa Vasconcelos, Maria João Silva & Henriqueta Louro. (2019) In vitro exposure to the next-generation plasticizer diisononyl cyclohexane-1,2-dicarboxylate (DINCH): cytotoxicity and genotoxicity assessment in human cells. Journal of Toxicology and Environmental Health, Part A 82:9, pages 526-536.
Read now
Read now
Juliana Botinhon Orlando, Brian Ogushi Silva, Camila Lehnhardt Pires-Cunha, Clélia Akiko Hiruma-Lima, Isabel O’Neill de Mascarenhas Gaivão & Edson Luis Maistro. (2019) Genotoxic effects induced by beta-myrcene following metabolism by liver HepG2/C3A human cells. Journal of Toxicology and Environmental Health, Part A 82:3, pages 176-185.
Read now
Read now
Richard J. Weaver, Catherine Betts, Eric A.G. Blomme, Helga H.J. Gerets, Klaus Gjervig Jensen, Philip G. Hewitt, Satu Juhila, Gilles Labbe, Michael J. Liguori, Natalie Mesens, Monday O. Ogese, Mikael Persson, Jan Snoeys, James L. Stevens, Tracy Walker & B. Kevin Park. (2017) Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 13:7, pages 767-782.
Read now
Read now
Hwee Ying Lim, Qin Shi Ho & Kim Ping Wong. (2016) Interplay of metabolizing enzymes and transporter of xenobiotics. Xenobiotica 46:1, pages 25-33.
Read now
Read now
Xingxing She, Fei Wang, Jun Ma, Xi Chen, Difeng Ren & Jun Lu. (2016)
In vitro antioxidant and protective effects of corn peptides on ethanol-induced damage in HepG2 cells. Food and Agricultural Immunology 27:1, pages 99-110.
Read now
Read now
Alaattin Sen, Gulsum Terzioglu, Pelin Atmaca, Gurbet Celik, Ozden Ozgun & Sevki Arslan. (2015) Modulatory actions of o-coumaric acid on carcinogen-activating cytochrome P450 isozymes and the potential for drug interactions in human hepatocarcinoma cells. Pharmaceutical Biology 53:9, pages 1391-1398.
Read now
Read now
Lee A Dawson. (2013) The discovery and development of vilazodone for the treatment of depression: a novel antidepressant or simply another SSRI?. Expert Opinion on Drug Discovery 8:12, pages 1529-1539.
Read now
Read now
Saeed Alqahtani, Loqman A Mohamed & Amal Kaddoumi. (2013) Experimental models for predicting drug absorption and metabolism. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1241-1254.
Read now
Read now
Adrian Hill, Natalie Mesens, Margino Steemans, Jinghai James Xu & Michael D. Aleo. (2012) Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development. Drug Metabolism Reviews 44:1, pages 127-140.
Read now
Read now
Smrati Bhadauria, Rajeev Mishra, Ranjana Kanchan, Chakrapani Tripathi, Anurag Srivastava, Ashutosh Tiwari & Sharad Sharma. (2010) Isoniazid-induced apoptosis in HepG2 cells: Generation of oxidative stress and Bcl-2 down-regulation. Toxicology Mechanisms and Methods 20:5, pages 242-251.
Read now
Read now
Maria A Croyle. (2009) Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1189-1211.
Read now
Read now
S. Choi, B. Sainz$suffix/text()$suffix/text(), P. Corcoran, S. Uprichard & H. Jeong. (2009) Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells. Xenobiotica 39:3, pages 205-217.
Read now
Read now
André Guillouzo & Christiane Guguen-Guillouzo. (2008) Evolving concepts in liver tissue modeling and implications for in vitro toxicology. Expert Opinion on Drug Metabolism & Toxicology 4:10, pages 1279-1294.
Read now
Read now
Gregor Tuschl, Birthe Lauer & Stefan O Mueller. (2008) Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 855-870.
Read now
Read now
N. J. Hewitt, E. L. Lecluyse & S. S. Ferguson. (2007) Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and correlations. Xenobiotica 37:10-11, pages 1196-1224.
Read now
Read now
Nicola J. Hewitt, María José Gómez Lechón, J. Brian Houston, David Hallifax, Hayley S. Brown, Patrick Maurel, J. Gerald Kenna, Lena Gustavsson, Christina Lohmann, Christian Skonberg, Andre Guillouzo, Gregor Tuschl, Albert P. Li, Edward LeCluyse, Geny M. M. Groothuis & Jan G. Hengstler. (2007) Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies. Drug Metabolism Reviews 39:1, pages 159-234.
Read now
Read now
Marc Vermeir, Pieter Annaert, Rao NVS Mamidi, Dirk Roymans, Willem Meuldermans & Geert Mannens. (2005) Cell-based models to study hepatic drug metabolism and enzyme induction in humans. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 75-90.
Read now
Read now
Shunnosuke Kaito, Jun-ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu & Kouichi Yoshinari. Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury. Xenobiotica 0:0, pages 1-30.
Read now
Read now
Articles from other publishers (117)
Wolfgang Zwickenpflug, Florian Hornung, Alexandra Hollaus, Michaela S. Oswald, Zoé Chioato, Thomas Gudermann & Christof Högg. (2024)
Biosynthesis of vitamin
B
3
and
NAD
+
: incubating
HepG2
cells with the alkaloid myosmine
. Journal of the Science of Food and Agriculture.
Crossref
Crossref
Annette Zschiesche, Martin Scheu, Detlef Thieme, Annekathrin M Keiler, Benedikt Pulver, Laura M Huppertz & Volker Auwärter. (2024) Insights into the metabolism of CH-PIATA—A novel synthetic cannabinoid featuring an acetamide linker. Journal of Analytical Toxicology.
Crossref
Crossref
Anh T. TranJames J. CrawfordDebashis MandalTezcan GuneyJamie Karmel. 2023. 2023 Medicinal Chemistry Reviews. 2023 Medicinal Chemistry Reviews
473
500
.
Christian Schulz, Natalie Herzog, Stefan Kubick, Friedrich Jung & Jan-Heiner Küpper. (2023) Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies. Cells 12:17, pages 2140.
Crossref
Crossref
Olga I. Kiseleva, Ilya Y. Kurbatov, Viktoriia A. Arzumanian, Ekaterina V. Ilgisonis, Svyatoslav V. Zakharov & Ekaterina V. Poverennaya. (2023) The Expectation and Reality of the HepG2 Core Metabolic Profile. Metabolites 13:8, pages 908.
Crossref
Crossref
Antonio Zandona, Josip Madunić, Katarina Miš, Nikola Maraković, Pierre Dubois-Geoffroy, Marco Cavaco, Petra Mišetić, Jasna Padovan, Miguel Castanho, Ludovic Jean, Pierre-Yves Renard, Sergej Pirkmajer, Vera Neves & Maja Katalinić. (2023) Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells. Toxicology 494, pages 153588.
Crossref
Crossref
Ya-Lin Huang, Cristian De Gregorio, Verónica Silva, Álvaro A. Elorza, Patricio Léniz, Víctor Aliaga-Tobar, Vinicius Maracaja-Coutinho, Mauricio Budini, Fernando Ezquer & Marcelo Ezquer. (2023) Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen. Cells 12:4, pages 636.
Crossref
Crossref
Robim M. Rodrigues, Marth Stinckens, Gamze Ates & Tamara Vanhaecke. 2023. Cell Viability Assays. Cell Viability Assays
237
245
.
Dunja Dimitrijevic, Eric Fabian, Beate Nicol, Dorothee Funk-Weyer & Robert Landsiedel. (2022)
Toward Realistic Dosimetry
In Vitro
: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an
In Silico
Mass Balance Model
. Chemical Research in Toxicology 35:11, pages 1962-1973.
Crossref
Crossref
Ruben M. F. TomásAkalabya BissoyiThomas R. CongdonMatthew I. Gibson. (2022) Assay-ready Cryopreserved Cell Monolayers Enabled by Macromolecular Cryoprotectants. Biomacromolecules 23:9, pages 3948-3959.
Crossref
Crossref
Fernando Ezquer, Ya-Lin Huang & Marcelo Ezquer. (2022) New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury. International Journal of Molecular Sciences 23:5, pages 2669.
Crossref
Crossref
Annette Zschiesche, Zdenek Chundela, Detlef Thieme & Annekathrin M. Keiler. (2021) HepG2 as promising cell‐based model for biosynthesis of long‐term metabolites: Exemplified for metandienone. Drug Testing and Analysis 14:2, pages 298-306.
Crossref
Crossref
Gabriela de Oliveira Prado Corrêa, Danieli Camilo Marcato, Wagner Soares Ramos, Marcos Antônio Corrêa, Regina Maria Barretto Cicarelli & Vera Lucia Borges Isaac. (2022) In vitro evaluation of the cytotoxicity and eye irritation potential of preservatives widely used in cosmetics. Brazilian Journal of Pharmaceutical Sciences 58.
Crossref
Crossref
Christopher A. Schofield, Tracy M. Walker, Maxine A. Taylor, Metul Patel, Denise F. Vlachou, Justyna M. Macina, Martin P. Vidgeon-Hart, Ann Williams, Paul J. McGill, Carla F. Newman & Melanie Z. Sakatis. (2021) Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury. Chemical Research in Toxicology 34:12, pages 2485-2499.
Crossref
Crossref
James M. Armitage, Alessandro Sangion, Rohan Parmar, Alexandra B. Looky & Jon A. Arnot. (2021) Update and Evaluation of a High-Throughput In Vitro Mass Balance Distribution Model: IV-MBM EQP v2.0. Toxics 9:11, pages 315.
Crossref
Crossref
Minmin Qu, Hua Xu, Wuju Li, Jia Chen, Yajiao Zhang, Bin Xu, Zhi Li, Tao Liu, Lei Guo & Jianwei Xie. (2021) Dynamically monitoring cellular γ-H2AX reveals the potential of carcinogenicity evaluation for genotoxic compounds. Archives of Toxicology 95:11, pages 3559-3573.
Crossref
Crossref
Thi Phuong Tao, Katrin Brandmair, Silke Gerlach, Julia Przibilla, Camille Géniès, Carine Jacques‐Jamin, Andreas Schepky, Uwe Marx, Nicola J. Hewitt, Ilka Maschmeyer & Jochen Kühnl. (2021) Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model. Journal of Applied Toxicology 41:10, pages 1553-1567.
Crossref
Crossref
Thomas J. DiProspero, Erin Dalrymple & Matthew R. Lockett. (2021) Physiologically relevant oxygen tensions differentially regulate hepatotoxic responses in HepG2 cells. Toxicology in Vitro 74, pages 105156.
Crossref
Crossref
Jia-Li Xing, Yu-Xin Wang & Shun-Da Du. (2021)
Application and research progress of
in vitro
liver cancer cell culture models
. World Chinese Journal of Digestology 29:11, pages 563-570.
Crossref
Crossref
Ryan Savill, Helge Baues, Emmely Voigt, Oliver Zierau, Detlef Thieme & Annekathrin Martina Keiler. (2021) Cell culture as a toolbox to generate phase I metabolites for antidoping screening. Drug Testing and Analysis 13:6, pages 1169-1177.
Crossref
Crossref
O. Escobar-Chavarría, R. Cossío-Bayúgar, P. Ramírez-Noguera, M.G. Prado-Ochoa, A.M. Velázquez-Sánchez, M.A. Muñoz-Guzmán, E. Angeles & F. Alba-Hurtado. (2021) In vivo and in vitro apoptosis induced by new acaricidal ethyl-carbamates in Rhipicephalus microplus. Ticks and Tick-borne Diseases 12:1, pages 101603.
Crossref
Crossref
Masato Ooka, Caitlin Lynch & Menghang Xia. (2020) Application of In Vitro Metabolism Activation in High-Throughput Screening. International Journal of Molecular Sciences 21:21, pages 8182.
Crossref
Crossref
Florian Padberg, Henrik Hering, Andreas Luch & Sebastian Zellmer. (2020) Indirect co-cultivation of HepG2 with differentiated THP-1 cells induces AHR signalling and release of pro-inflammatory cytokines. Toxicology in Vitro 68, pages 104957.
Crossref
Crossref
Leonard Barasa, Hari P. Vemana, Nirupama Surubhotla, Sin S. Ha, Jing Kong, Alison Yong, John L. Croft, Vikas V. Dukhande & Sabesan Yoganathan. (2020) Synthesis and Biological Evaluation of Structurally Diverse Benzimidazole Scaffolds as Potential Chemotherapeutic Agents. Anti-Cancer Agents in Medicinal Chemistry 20:3, pages 301-314.
Crossref
Crossref
Seiichi Ishida. 2020. Organ-on-a-chip. Organ-on-a-chip
181
213
.
Casey C. Clark, Julio Aleman, Lysette Mutkus & Aleksander Skardal. (2019) A mechanically robust thixotropic collagen and hyaluronic acid bioink supplemented with gelatin nanoparticles. Bioprinting 16, pages e00058.
Crossref
Crossref
Martín I. Roma, Victoria E. Schiariti Lampropulos, Iván Ayllón-Cabrera, Ana N. Salazar Sanabria, Marcela M. López Nigro, Roxana N. Peroni & Marta A. Carballo. (2019) Modulation of hepatic ABC transporters by Eruca vesicaria intake: Potential diet-drug interactions. Food and Chemical Toxicology 133, pages 110797.
Crossref
Crossref
S. Steinbrecht, S. Kammerer & J.-H. Küpper. (2019) HepG2 cells with recombinant cytochrome P450 enzyme overexpression: Their use and limitation as in vitro liver model. Journal of Cellular Biotechnology 5:1, pages 55-64.
Crossref
Crossref
Celio Ferreira, Ramona Meyer & Henriette E. Meyer zu Schwabedissen. (2019) The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862:4, pages 447-456.
Crossref
Crossref
Martin Raasch, Enrico Fritsche, Andreas Kurtz, Michael Bauer & Alexander S. Mosig. (2019) Microphysiological systems meet hiPSC technology – New tools for disease modeling of liver infections in basic research and drug development. Advanced Drug Delivery Reviews 140, pages 51-67.
Crossref
Crossref
Miriam E. Mossoba, Sanah Vohra, Howard Toomer, Shelia Pugh-Bishop, Zachary Keltner, Vanessa Topping, Thomas Black, Nicholas Olejnik, Ana Depina, Kathleen Belgrave, Jessica Sprando, Thomas J. Flynn, Paddy L. Wiesenfeld & Robert L. Sprando. (2018) Diglycolic acid induces HepG2/C3A liver cell toxicity in vitro. Toxicology in Vitro 52, pages 87-93.
Crossref
Crossref
Qiao Wu, Juan Liu, Lijin Liu, Yu Chen, Jie Wang, Ling Leng, Qunfang Yu, Zhongping Duan & Yunfang Wang. (2018) Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver. ACS Biomaterials Science & Engineering 4:8, pages 3016-3026.
Crossref
Crossref
Alessandra Natale, Joost Boeckmans, Terry Desmae, Veerle De Boe, Joery De Kock, Tamara Vanhaecke, Vera Rogiers & Robim M. Rodrigues. (2018) Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone. Toxicology Letters 284, pages 184-194.
Crossref
Crossref
Zhen Ren, Si Chen, Baitang Ning & Lei Guo. 2018. Drug-Induced Liver Toxicity. Drug-Induced Liver Toxicity
151
177
.
Mathieu Porceddu, Nelly Buron, Pierre Rustin, Bernard Fromenty & Annie Borgne-Sanchez. 2018. Drug-Induced Liver Toxicity. Drug-Induced Liver Toxicity
283
300
.
A. Paini, M. Mennecozzi, T. Horvat, K. Gerloff, T. Palosaari, J.V. Sala Benito & A. Worth. (2017) Practical use of the Virtual Cell Based Assay: Simulation of repeated exposure experiments in liver cell lines. Toxicology in Vitro 45, pages 233-240.
Crossref
Crossref
Ágota Pénzes, Elhusseiny Mohamed Mahmud Abdelwahab, Judit Rapp, Zsanett A. Péteri, Judit Bovári-Biri, Csaba Fekete, György Miskei, Krisztián Kvell & Judit E. Pongrácz. (2017) Toxicology studies of primycin-sulphate using a three-dimensional (3D) in vitro human liver aggregate model. Toxicology Letters 281, pages 44-52.
Crossref
Crossref
Bo Jiang, Liyuan Meng, Feng Zhang, Xiaoling Jin & Guiliang Zhang. (2017) Enzyme-inducing effects of berberine on cytochrome P450 1A2 in vitro and in vivo. Life Sciences 189, pages 1-7.
Crossref
Crossref
Franziska Wewering, Florent Jouy, Sükran Caliskan, Stefan Kalkhof, Martin von Bergen, Andreas Luch & Sebastian Zellmer. (2017) Hepatic co-cultures in vitro reveal suitable to detect Nrf2-mediated oxidative stress responses on the bladder carcinogen o -anisidine. Toxicology in Vitro 40, pages 153-160.
Crossref
Crossref
Titpawan Nakpheng, Supreedee Songkarak, Tan Suwandecha, Rutthapol Sritharadol, Charisopon Chunhachaichana & Teerapol Srichana. (2017) Evidences for salbutamol metabolism by respiratory and liver cell lines. Drug Metabolism and Pharmacokinetics 32:2, pages 127-134.
Crossref
Crossref
Rowena L. Sison-Young, Volker M. Lauschke, Esther Johann, Eliane Alexandre, Sébastien Antherieu, Hélène Aerts, Helga H. J. Gerets, Gilles Labbe, Delphine Hoët, Martina Dorau, Christopher A. Schofield, Cerys A. Lovatt, Julie C. Holder, Simone H. Stahl, Lysiane Richert, Neil R. Kitteringham, Robert P. Jones, Mohamed Elmasry, Richard J. Weaver, Philip G. Hewitt, Magnus Ingelman-Sundberg, Chris E. Goldring & B. Kevin Park. (2016) A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. Archives of Toxicology 91:3, pages 1385-1400.
Crossref
Crossref
Simon Bucher, Pégah Jalili, Dounia Le Guillou, Karima Begriche, Karine Rondel, Sophie Martinais, Daniel Zalko, Anne Corlu, Marie-Anne Robin & Bernard Fromenty. (2017) Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure. Environmental Toxicology 32:3, pages 1024-1036.
Crossref
Crossref
Kazuo Takayama & Hiroyuki Mizuguchi. (2017) Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening. Drug Metabolism and Pharmacokinetics 32:1, pages 12-20.
Crossref
Crossref
S. Haupenthal, K. Berg, M. Gründken, S. Vallicotti, M. Hemgesberg, K. Sak, D. Schrenk & M. Esselen. (2017) In vitro genotoxicity of carcinogenic asarone isomers. Food & Function 8:3, pages 1227-1234.
Crossref
Crossref
Yasunari Yamashita, Mitsutoshi Asakura, Ryo Mitsugi, Hideaki Fujii, Kenichiro Nagai, Koichiro Atsuda, Tomoo Itoh & Ryoichi Fujiwara. (2016) MicroRNA expression in the vildagliptin-treated two- and three-dimensional HepG2 cells. Drug Metabolism and Pharmacokinetics 31:3, pages 201-209.
Crossref
Crossref
Yuuki Nishida & Akiyoshi Taniguchi. (2015) A three-dimensional collagen-sponge-based culture system coated with simplified recombinant fibronectin improves the function of a hepatocyte cell line. In Vitro Cellular & Developmental Biology - Animal 52:3, pages 271-277.
Crossref
Crossref
Claudia Luckert, Stefanie Hessel, Dido Lenze & Alfonso Lampen. (2015) Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. Toxicology in Vitro 29:7, pages 1669-1682.
Crossref
Crossref
Jong Bong Lee, Sung Hwa Son, Min Chul Park, Tae Hwan Kim, Min Gi Kim, Sun Dong Yoo & Sunghoon Kim. (2015) A novel in vitro permeability assay using three-dimensional cell culture system. Journal of Biotechnology 205, pages 93-100.
Crossref
Crossref
Jong Min Choi, Soo Jin Oh, Sang Yoon Lee, Ji Hye Im, Jung Min Oh, Chang Seon Ryu, Hui Chan Kwak, Ji-Yoon Lee, Keon Wook Kang & Sang Kyum Kim. (2014) HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics. Archives of Pharmacal Research 38:5, pages 691-704.
Crossref
Crossref
Wim F.P.M. Van den Hof, Ainhoa Ruiz-Aracama, Anke Van Summeren, Danyel G.J. Jennen, Stan Gaj, Maarten L.J. Coonen, Karen Brauers, Will K.W.H. Wodzig, Joost H.M. van Delft & Jos C.S. Kleinjans. (2015) Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicology in Vitro 29:3, pages 489-501.
Crossref
Crossref
Uta Fernekorn, Jörg Hampl, Frank Weise, Maren Klett, Annette Läffert, Karin Friedel & Andreas Schober. (2015) Microfluidic 3D HepG2 cell culture: Reproducing hepatic tumor gene and protein expression in in vitro scaffolds. Engineering in Life Sciences 15:3, pages 340-350.
Crossref
Crossref
Vincent Le Fol, Selim Aït-Aïssa, Nicolas Cabaton, Laurence Dolo, Marina Grimaldi, Patrick Balaguer, Elisabeth Perdu, Laurent Debrauwer, François Brion & Daniel Zalko. (2015) Cell-Specific Biotransformation of Benzophenone-2 and Bisphenol-S in Zebrafish and Human in Vitro Models Used for Toxicity and Estrogenicity Screening. Environmental Science & Technology 49:6, pages 3860-3868.
Crossref
Crossref
Eduardo Scandinari Manzolli, Juliana Mara Serpeloni, Denise Grotto, Jairo Kennup Bastos, Lusânia Maria Greggi Antunes, Fernando Barbosa & Gustavo Rafael Mazzaron Barcelos. (2015)
Protective Effects of the Flavonoid Chrysin against Methylmercury-Induced Genotoxicity and Alterations of Antioxidant Status,
In Vivo
. Oxidative Medicine and Cellular Longevity 2015, pages 1-7.
Crossref
Crossref
Ewa Augustin, Magdalena Niemira, Adam Hołownia & Zofia Mazerska. (2014) CYP3A4‐dependent cellular response does not relate to CYP3A4‐catalysed metabolites of C‐1748 and C‐1305 acridine antitumor agents in HepG2 cells. Cell Biology International 38:11, pages 1291-1303.
Crossref
Crossref
Natalie D. Glube & Guus Duchateau. 2014. Drug Metabolism Prediction. Drug Metabolism Prediction
413
440
.
Feng Chen, Xiao-Hui Rao, Jin-Lian Yang, Ming-Xing Pan, Yi Gao, Zhen-Lin Li, Yang Li, You-Fu Zhu & Yan Wang. (2014) Up-Regulating CYP3A4 Expression in C3A Cells by Transfection with a Novel Chimeric Regulator of hPXR-p53-AD. PLoS ONE 9:5, pages e95752.
Crossref
Crossref
Nan Hu, Mengyue Hu, Ru Duan, Can Liu, Haifang Guo, Mian Zhang, Yunli Yu, Xinting Wang, Li Liu & Xiaodong Liu. (2014) Increased Levels of Fatty Acids Contributed to Induction of Hepatic CYP3A4 Activity Induced by Diabetes — In Vitro Evidence From HepG2 Cell and Fa2N-4 Cell Lines. Journal of Pharmacological Sciences 124:4, pages 433-444.
Crossref
Crossref
Claudia Luckert, Anke Ehlers, Thorsten Buhrke, Albrecht Seidel, Alfonso Lampen & Stefanie Hessel. (2013) Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR. Toxicology Letters 222:2, pages 180-188.
Crossref
Crossref
Carolina Garcia-Canton, Emmanuel Minet, Arturo Anadon & Clive Meredith. (2013) Metabolic characterization of cell systems used in in vitro toxicology testing: Lung cell system BEAS-2B as a working example. Toxicology in Vitro 27:6, pages 1719-1727.
Crossref
Crossref
Walter M.A. Westerink, Joe C.R. Stevenson, G. Jean Horbach, Femke M. van de Water, Beppy van de Waart & Willem G.E.J. Schoonen. 2013. High‐Throughput Screening Methods in Toxicity Testing. High‐Throughput Screening Methods in Toxicity Testing
233
269
.
Vasilis P. Androutsopoulos & Demetrios A. Spandidos. (2013) The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation. The Journal of Nutritional Biochemistry 24:2, pages 496-504.
Crossref
Crossref
Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Keisuke Kishimoto, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Katsuhiro Kanda, Takao Hayakawa, Miho Kusuda Furue & Hiroyuki Mizuguchi. (2013) 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials 34:7, pages 1781-1789.
Crossref
Crossref
Ewa Augustin, Monika Pawłowska, Joanna Polewska, Agnieszka Potega & Zofia Mazerska. (2013) Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the anti‐tumour imidazoacridinone C‐1311 in human hepatoma cells. Cell Biology International 37:2, pages 109-120.
Crossref
Crossref
Alexander V. LyubimovJasminder Sahi, Cornelia Smith, LaHoma Easterwood, Susan Grepper & Edward LeCluyse. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
53
.
Sevki Arslan & Ozden Ozgun. (2012) Cyclamen Trochopteranthum: Cytotoxic activity and possible adverse interactions including drugs and carcinogens. Chinese Journal of Integrative Medicine.
Crossref
Crossref
Jennifer E. May, H. Ruth Morse, Jinsheng Xu & Craig Donaldson. (2012) Development of a novel, physiologically relevant cytotoxicity model: Application to the study of chemotherapeutic damage to mesenchymal stromal cells. Toxicology and Applied Pharmacology 263:3, pages 374-389.
Crossref
Crossref
Fang LIU, Hai-Ping HAO & Guang-Ji WANG. (2012) NQO1-mediated biotransformation determines the cytotoxicity of tanshinone IIA. Chinese Journal of Natural Medicines 10:5, pages 353-357.
Crossref
Crossref
Saura C. Sahu, Michael W. O'DonnellJrJr & Robert L. Sprando. (2012) Interactive toxicity of usnic acid and lipopolysaccharides in human liver HepG2 cells. Journal of Applied Toxicology 32:9, pages 739-749.
Crossref
Crossref
Saura C. Sahu, Margaret Amankwa‐Sakyi, Michael W. O'DonnellJrJr & Robert L. Sprando. (2011) Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture. Journal of Applied Toxicology 32:9, pages 722-730.
Crossref
Crossref
Tsai-Shin Chiang, Kai-Chiang Yang, Shu-Kai Zheng, Ling-Ling Chiou, Wen-Ming Hsu, Feng-Huei Lin, Guan-Tarn Huang & Hsuan-Shu Lee. (2012) The prediction of drug metabolism using scaffold-mediated enhancement of the induced cytochrome P450 activities in fibroblasts by hepatic transcriptional regulators. Biomaterials 33:21, pages 5187-5197.
Crossref
Crossref
Andreas Benesic, Nora L Rahm, Samuel Ernst & Alexander L Gerbes. (2012) Human monocyte-derived cells with individual hepatocyte characteristics: a novel tool for personalized in vitro studies. Laboratory Investigation 92:6, pages 926-936.
Crossref
Crossref
Laia Tolosa, Sandra Pinto, M. Teresa Donato, Agustín Lahoz, José V. Castell, J. Enrique O’Connor & M. José Gómez-Lechón. (2012) Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs. Toxicological Sciences 127:1, pages 187-198.
Crossref
Crossref
H. H. J. Gerets, K. Tilmant, B. Gerin, H. Chanteux, B. O. Depelchin, S. Dhalluin & F. A. Atienzar. (2012) Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biology and Toxicology 28:2, pages 69-87.
Crossref
Crossref
Brigitte Altmann, Ralf Ahrens, Alexander Welle, Heinz Dinglreiter, Marc Schneider & Andreas Schober. (2011) Microstructuring of multiwell plates for three-dimensional cell culture applications by ultrasonic embossing. Biomedical Microdevices 14:2, pages 291-301.
Crossref
Crossref
Bo Jiang, Fei Cai, Shouhong Gao, Liyuan Meng, Fengying Liang, Xiao Dai, Wen Xu & Wansheng Chen. (2012) Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components. Chemico-Biological Interactions 195:2, pages 105-113.
Crossref
Crossref
Joanne Bronson, Murali Dhar, William Ewing & Nils Lonberg. 2012. Annual Reports in Medicinal Chemistry Volume 47. Annual Reports in Medicinal Chemistry Volume 47
499
569
.
Thomas Efferth & Henry Johannes Greten. 2012. Recent Trends in Medicinal Plants Research. Recent Trends in Medicinal Plants Research
343
363
.
Anke Van Summeren, Johan Renes, Edwin C. M. Mariman, Jos C. S. Kleinjans & Joost H. M. van Delft. (2011) Response to Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells. Toxicological Sciences 121:2, pages 431-433.
Crossref
Crossref
Atsushi Iwamura, Tatsuki Fukami, Hiroko Hosomi, Miki Nakajima & Tsuyoshi Yokoi. (2011) CYP2C9-Mediated Metabolic Activation of Losartan Detected by a Highly Sensitive Cell-Based Screening Assay. Drug Metabolism and Disposition 39:5, pages 838-846.
Crossref
Crossref
M.G.L. Elferink, P. Olinga, E.M. van Leeuwen, S. Bauerschmidt, J. Polman, W.G. Schoonen, S.H. Heisterkamp & G.M.M. Groothuis. (2011) Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicology and Applied Pharmacology 253:1, pages 57-69.
Crossref
Crossref
K. Schroeder, K.D. Bremm, N. Alépée, J.G.M. Bessems, B. Blaauboer, S.N. Boehn, C. Burek, S. Coecke, L. Gombau, N.J. Hewitt, J. Heylings, J. Huwyler, M. Jaeger, M. Jagelavicius, N. Jarrett, H. Ketelslegers, I. Kocina, J. Koester, J. Kreysa, R. Note, A. Poth, M. Radtke, V. Rogiers, J. Scheel, T. Schulz, H. Steinkellner, M. Toeroek, M. Whelan, P. Winkler & W. Diembeck. (2011) Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors. Toxicology in Vitro 25:3, pages 589-604.
Crossref
Crossref
Jean-Matthieu Prot, Orianne Videau, Céline Brochot, Cécile Legallais, Henri Bénech & Eric Leclerc. (2011) A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. International Journal of Pharmaceutics 408:1-2, pages 67-75.
Crossref
Crossref
Anke Van Summeren, Johan Renes, Freek G. Bouwman, Jean-Paul Noben, Joost H. M. van Delft, Jos C. S. Kleinjans & Edwin C. M. Mariman. (2011) Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells. Toxicological Sciences 120:1, pages 109-122.
Crossref
Crossref
Kathleen Boehme, Yasmin Dietz, Philip Hewitt & Stefan O. Mueller. (2010) Activation of P53 in HepG2 cells as surrogate to detect mutagens and promutagens in vitro. Toxicology Letters 198:2, pages 272-281.
Crossref
Crossref
Barbara Bonamassa & Dexi Liu. (2010) Nonviral gene transfer as a tool for studying transcription regulation of xenobiotic metabolizing enzymes. Advanced Drug Delivery Reviews 62:13, pages 1250-1256.
Crossref
Crossref
Stefan Pfuhler, Annette Kirst, Marilyn Aardema, Norbert Banduhn, Carsten Goebel, Daisuke Araki, Margit Costabel-Farkas, Eric Dufour, Rolf Fautz, James Harvey, Nicola J. Hewitt, Jalila Hibatallah, Paul Carmichael, Martin Macfarlane, Kerstin Reisinger, Joanna Rowland, Florian Schellauf, Andreas Schepky & Julia Scheel. (2010) A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Genotoxicity. A COLIPA analysis. Regulatory Toxicology and Pharmacology 57:2-3, pages 315-324.
Crossref
Crossref
Melissa A. Baxter, Cliff Rowe, Jane Alder, Sean Harrison, Karen Piper Hanley, B. Kevin Park, Neil R. Kitteringham, Chris E. Goldring & Neil A. Hanley. (2010) Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Stem Cell Research 5:1, pages 4-22.
Crossref
Crossref
Jenni Küblbeck, Mika Reinisalo, Riitta Mustonen & Paavo Honkakoski. (2010) Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors. European Journal of Pharmaceutical Sciences 40:4, pages 263-272.
Crossref
Crossref
Shih-Feng Lan, Barbara Safiejko-Mroczka & Binil Starly. (2010) Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism. Toxicology in Vitro 24:4, pages 1314-1323.
Crossref
Crossref
Despina Bazou. (2009) Biochemical properties of encapsulated high-density 3-D HepG2 aggregates formed in an ultrasound trap for application in hepatotoxicity studies. Cell Biology and Toxicology 26:2, pages 127-141.
Crossref
Crossref
Michael Sinz, Sean Kim, Stephen Ferguson & Edward LeCluyse. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
31
.
Christiane Guguen-Guillouzo & Andre Guillouzo. 2010. Hepatocytes. Hepatocytes
1
40
.
Ragini Vuppugalla, Sean Kim, Tatyana Zvyaga, Yong-hae Han, Praveen Balimane, Punit Marathe & A. David Rodrigues. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions
585
624
.
Jens Niklas, Fozia Noor & Elmar Heinzle. (2009) Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicology and Applied Pharmacology 240:3, pages 327-336.
Crossref
Crossref
Gretchen J. Mahler, Mandy B. Esch, Raymond P. Glahn & Michael L. Shuler. (2009) Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity. Biotechnology and Bioengineering 104:1, pages 193-205.
Crossref
Crossref
M. Ohno, K. Motojima, T. Okano & A. Taniguchi. (2009) Maturation of the Extracellular Matrix and Cell Adhesion Molecules in Layered Co-cultures of HepG2 and Endothelial Cells. Journal of Biochemistry 145:5, pages 591-597.
Crossref
Crossref
Michael Sinz, Sean Kim, Stephen Ferguson & Edward Lecluyse. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook
359
389
.
Katsuhiko Mizuno, Miki Katoh, Hirotoshi Okumura, Nao Nakagawa, Toru Negishi, Takanori Hashizume, Miki Nakajima & Tsuyoshi Yokoi. (2009) Metabolic Activation of Benzodiazepines by CYP3A4. Drug Metabolism and Disposition 37:2, pages 345-351.
Crossref
Crossref
Kazunobu Aoyama, Kouichi Yoshinari, Hye-Ji Kim, Kiyoshi Nagata & Yasushi Yamazoe. (2009) Simultaneous Expression of Plural Forms of Human Cytochrome P450 at Desired Ratios in HepG2 Cells: Adenovirus-mediated Tool for Cytochrome P450 Reconstitution. Drug Metabolism and Pharmacokinetics 24:3, pages 209-217.
Crossref
Crossref
Maki Ohno, Kiyoto Motojima, Teruo Okano & Akiyoshi Taniguchi. (2009) Induction of Drug-Metabolizing Enzymes by Phenobarbital in Layered Co-culture of a Human Liver Cell Line and Endothelial Cells. Biological and Pharmaceutical Bulletin 32:5, pages 813-817.
Crossref
Crossref
Willem G. E. J. Schoonen, Walter M. A. Westerink & G. Jean Horbach. 2009. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology
401
452
.
Heike K. Winter, Veronika A. Ehrlich, Michael Grusch, Andreas Lackner, Rolf Schulte-Hermann, Bettina Grasl-Kraupp, Wolfgang Mikulits & Siegfried Knasmüller. (2008) Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 657:2, pages 133-139.
Crossref
Crossref
Maki OhnoKiyoto MotojimaTeruo OkanoAkiyoshi Taniguchi. (2008) Up-Regulation of Drug-Metabolizing Enzyme Genes in Layered Co-Culture of a Human Liver Cell Line and Endothelial Cells. Tissue Engineering Part A 14:11, pages 1861-1869.
Crossref
Crossref
Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Paavo Honkakoski, Janne Hukkanen & Hannu Raunio. (2008) Inhibition and induction of human cytochrome P450 enzymes: current status. Archives of Toxicology 82:10, pages 667-715.
Crossref
Crossref
J. Bursztyka, E. Perdu, K. Pettersson, I. Pongratz, M. Fernández-Cabrera, N. Olea, L. Debrauwer, D. Zalko & J.P. Cravedi. (2008) Biotransformation of genistein and bisphenol A in cell lines used for screening endocrine disruptors. Toxicology in Vitro 22:6, pages 1595-1604.
Crossref
Crossref
Thomas J. Flynn & Martine S. Ferguson. (2008) Multiendpoint mechanistic profiling of hepatotoxicants in HepG2/C3A human hepatoma cells and novel statistical approaches for development of a prediction model for acute hepatotoxicity. Toxicology in Vitro 22:6, pages 1618-1631.
Crossref
Crossref
Elin Swedenborg, Joëlle Rüegg, Anne Hillenweck, Stefan Rehnmark, Malin Hedengran Faulds, Daniel Zalko, Ingemar Pongratz & Katarina Pettersson. (2008) 3-Methylcholanthrene Displays Dual Effects on Estrogen Receptor (ER) α and ERβ Signaling in a Cell-Type Specific Fashion. Molecular Pharmacology 73:2, pages 575-586.
Crossref
Crossref
Young Jin Moon & Marilyn E. Morris. (2007) Pharmacokinetics and Bioavailability of the Bioflavonoid Biochanin A: Effects of Quercetin and EGCG on Biochanin A Disposition in Rats. Molecular Pharmaceutics 4:6, pages 865-872.
Crossref
Crossref
Walter M.A. Westerink & Willem G.E.J. Schoonen. (2007) Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicology in Vitro 21:8, pages 1592-1602.
Crossref
Crossref
Walter M.A. Westerink & Willem G.E.J. Schoonen. (2007) Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicology in Vitro 21:8, pages 1581-1591.
Crossref
Crossref
Therese Söderdahl, Barbara Küppers-Munther, Nico Heins, Josefina Edsbagge, Petter Björquist, Ian Cotgreave & Bengt Jernström. (2007) Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells. Toxicology in Vitro 21:5, pages 929-937.
Crossref
Crossref
Sonia R. Miranda & Sharon A. Meyer. (2007) Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food and Chemical Toxicology 45:5, pages 871-877.
Crossref
Crossref
Masataka Maruyama, Tamihide Matsunaga, Eri Harada & Shigeru Ohmori. (2007) Comparison of Basal Gene Expression and Induction of CYP3As in HepG2 and Human Fetal Liver Cells. Biological and Pharmaceutical Bulletin 30:11, pages 2091-2097.
Crossref
Crossref
James P. Camp & Adam T. Capitano. (2008) Induction of Zone‐Like Liver Function Gradients in HepG2 Cells by Varying Culture Medium Height. Biotechnology Progress 23:6, pages 1485-1491.
Crossref
Crossref
Y. Parmentier, M.-J. Bossant, M. Bertrand & B. Walther. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
231
257
.
Hai Wu, Ping Cai, Dahn L. Clemens, Thomas R. Jerrells, G.A. Shakeel Ansari & Bhupendra S. Kaphalia. (2006) Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism. Toxicology and Applied Pharmacology 216:2, pages 238-247.
Crossref
Crossref
Moo-Yeal Lee, Chan Beum Park, Jonathan S. Dordick & Douglas S. Clark. (2005) Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses. Proceedings of the National Academy of Sciences 102:4, pages 983-987.
Crossref
Crossref