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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 1
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Research Article

Metabolism and disposition of 2,2′,4,4′- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice

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Pages 103-117 | Received 13 Sep 2005, Published online: 22 Sep 2008

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Alexander Suvorov, Vladimir Naumov, Victoria Shtratnikova, Maria Logacheva, Alex Shershebnev, Haotian Wu, Evgeny Gerasimov, Anna Zheludkevich, Jonathan R Pilsner & Oleg Sergeyev. (2020) Rat Liver Epigenome Programing by Perinatal Exposure to 2,2′,4′4′-Tetrabromodiphenyl Ether. Epigenomics 12:3, pages 235-249.
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Patricia A. Fair, Hui-Chen Stavros, Meagan A.M. Mollenhauer, Jamie C. DeWitt, Natasha Henry, Kurunthachalam Kannan, Se Hun Yun, Gregory D. Bossart, Deborah E. Keil & Margie M. Peden-Adams. (2012) Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture. Journal of Immunotoxicology 9:1, pages 96-107.
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Amy Lavin Williams & John M. DeSesso. (2010) The Potential of Selected Brominated Flame Retardants to Affect Neurological Development. Journal of Toxicology and Environmental Health, Part B 13:5, pages 411-448.
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Olatunbosun Arowolo, J. Richard Pilsner, Oleg Sergeyev & Alexander Suvorov. (2022) Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers. International Journal of Molecular Sciences 23:22, pages 14229.
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June K. Dunnick, Keith R. Shockley, Daniel L. Morgan, Gregory S. Travlos, Kevin Gerrish, Thai-Vu T. Ton, Ralph Wilson, Sukhdev S. Brar, Amy E. Brix, Suramya Waidyanatha, Esra Mutlu & Arun Kumar R. Pandiri. (2019) Hepatic Transcriptomic Patterns in the Neonatal Rat After Pentabromodiphenyl Ether Exposure. Toxicologic Pathology 48:2, pages 338-349.
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Hao Xu, Chao Feng, Yiyi Cao, Ying Lu, Jing Xi, Jieyun Ji, Dasheng Lu, Xin-Yu Zhang & Yang Luan. (2019) Distribution of the parent compound and its metabolites in serum, urine, and feces of mice administered 2,2′,4,4′-tetrabromodiphenyl ether. Chemosphere 225, pages 217-225.
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Peng-Yan Liu, Yan-Na Zhang, Zhen Gao & Zhan-Sheng Li. (2019) Study on photodegradation pathway and mechanism of 2,2′,4,4′-Tetrabromodiphenyl ether. Emerging Contaminants 5, pages 45-52.
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Ahmed Khalil, Sebnem E. Cevik, Stephanie Hung, Sridurgadevi Kolla, Monika A. Roy & Alexander Suvorov. (2018) Developmental Exposure to 2,2′,4,4′-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice. Frontiers in Endocrinology 9.
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Xinyue You, Tomoko Ando, Jing Xi, Yiyi Cao, Weiying Liu, Xinyu Zhang, Masamitsu Honma, Kenichi Masumura & Yang Luan. (2018) Gene mutation and micronucleus assays in gpt delta mice treated with 2,2′,4,4′-tetrabromodiphenyl ether. Mutagenesis 33:2, pages 153-160.
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Aser Abrha & Alexander Suvorov. (2018) Transcriptomic Analysis of Gonadal Adipose Tissue in Male Mice Exposed Perinatally to 2,2′,4,4′-Tetrabromodiphenyl Ether (BDE-47). Toxics 6:2, pages 21.
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Mi-Yeon Shin, Sunmi Kim, Sunggyu Lee, Hai-Joong Kim, Jeong Jae Lee, Gyuyeon Choi, Sooran Choi, Sungjoo Kim, Su Young Kim, Jeongim Park, Hyo-Bang Moon, Kyungho Choi & Sungkyoon Kim. (2018) Prenatal contribution of 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47) to total body burden in young children. Science of The Total Environment 616-617, pages 510-516.
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Zhongyu Wang, Zhiqiang Fu, Qi Yu & Jingwen Chen. (2017) Oxidation reactivity of 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) by Compound I model of cytochrome P450s. Journal of Environmental Sciences 62, pages 11-21.
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Zhan Zhang, Yongquan Yu, Hengsen Xu, Chao Wang, Minghui Ji, Jun Gu, Lu Yang, Jiansheng Zhu, Huibin Dong & Shou-Lin Wang. (2017) High-fat diet aggravates 2,2′,4,4′-tetrabromodiphenyl ether-inhibited testosterone production via DAX-1 in Leydig cells in rats. Toxicology and Applied Pharmacology 323, pages 1-8.
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Claudio A. Erratico, Anand K. Deo & Stelvio M. Bandiera. 2015. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 131 149 .
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Ka-Lok Ho, Margaret B. Murphy, Yi Wan, Bonnie M.-W. Fong, Sidney Tam, John P. Giesy, Kelvin S.-Y. Leung & Michael H.-W. Lam. (2012) Synthesis and Characterization of Bromophenol Glucuronide and Sulfate Conjugates for Their Direct LC-MS/MS Quantification in Human Urine as Potential Exposure Markers for Polybrominated Diphenyl Ethers. Analytical Chemistry 84:22, pages 9881-9888.
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Claire M. Koenig, Jozsef Lango, Isaac N. Pessah & Robert F. Berman. (2012) Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. Neurotoxicology and Teratology 34:6, pages 571-580.
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Charlotte Marteau, Sylvie Chevolleau, Isabelle Jouanin, Elisabeth Perdu, Georges De Sousa, Roger Rahmani, Jean‐Philippe Antignac, Bruno LeBizec, Daniel Zalko & Laurent Debrauwer. (2012) Development of a liquid chromatography/atmospheric pressure photo‐ionization high‐resolution mass spectrometry analytical method for the simultaneous determination of polybrominated diphenyl ethers and their metabolites: application to BDE‐47 metabolism in human hepatocytes. Rapid Communications in Mass Spectrometry 26:6, pages 599-610.
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Erik Pacyniak, Bruno Hagenbuch, Curtis D. Klaassen, Lois Lehman-McKeeman & Grace L. Guo. (2011) Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. Toxicology and Applied Pharmacology 257:1, pages 23-31.
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G. S. Bondy, D. Gaertner, W. Cherry, E. MacLellan, L. Coady, D. L. Arnold, J. Doucet & P. R. Rowsell. (2011) Brominated diphenyl ether (BDE) levels in liver, adipose, and milk from adult and juvenile rats exposed by gavage to the DE‐71 technical mixture. Environmental Toxicology 26:6, pages 677-690.
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Ping He, Aiguo Wang Qiang Niu, Lijuan Guo, Tao Xia & Xuemin Chen. (2010) Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats. Toxicology and Industrial Health 27:3, pages 279-288.
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Erik Pacyniak, Megan Roth, Bruno Hagenbuch & Grace L. Guo. (2010) Mechanism of Polybrominated Diphenyl Ether Uptake into the Liver: PBDE Congeners Are Substrates of Human Hepatic OATP Transporters. Toxicological Sciences 115:2, pages 344-353.
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Moira A. McKernan, Barnett A. Rattner, Jeff S. Hatfield, Robert C. Hale & Mary Ann Ottinger. (2010) Absorption and biotransformation of polybrominated diphenyl ethers DE-71 and DE-79 in chicken (Gallus gallus), mallard (Anas platyrhynchos), American kestrel (Falco sparverius) and black-crowned night-heron (Nycticorax nycticorax) eggs. Chemosphere 79:1, pages 100-109.
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Heli Routti, Robert J. Letcher, Shaogang Chu, Bert van Bavel & Geir W. Gabrielsen. (2009) Polybrominated Diphenyl Ethers and Their Hydroxylated Analogues in Ringed Seals ( Phoca hispida ) from Svalbard and the Baltic Sea . Environmental Science & Technology 43:10, pages 3494-3499.
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June K. Dunnick & Abraham Nyska. (2009) Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers. Experimental and Toxicologic Pathology 61:1, pages 1-12.
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Janice K. Huwe, Heldur Hakk & Linda S. Birnbaum. (2008) Tissue Distribution of Polybrominated Diphenyl Ethers in Male Rats and Implications for Biomonitoring. Environmental Science & Technology 42:18, pages 7018-7024.
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Si Zhang, Steve Bursian, Pamela A. Martin, Hing Man Chan & Jonathan W. Martin. (2009) Dietary accumulation, disposition, and metabolism of technical pentabrominated diphenyl ether (DE‐71) in pregnant mink ( Mustela vison ) and their offspring . Environmental Toxicology and Chemistry 27:5, pages 1184-1193.
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Janice K. Huwe, Heldur Hakk, David J. Smith, Janet J. Diliberto, Vicki Richardson, Heather M. Stapleton & Linda S. Birnbaum. (2008) Comparative Absorption and Bioaccumulation of Polybrominated Diphenyl Ethers following Ingestion via Dust and Oil in Male Rats. Environmental Science & Technology 42:7, pages 2694-2700.
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Xinghua Qiu, Minerva Mercado-Feliciano, Robert M. Bigsby & Ronald A. Hites. (2007) Measurement of Polybrominated Diphenyl Ethers and Metabolites in Mouse Plasma after Exposure to a Commercial Pentabromodiphenyl Ether Mixture. Environmental Health Perspectives 115:7, pages 1052-1058.
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Linda S. Birnbaum & Elaine A. Cohen Hubal. (2006) Polybrominated Diphenyl Ethers: A Case Study for Using Biomonitoring Data to Address Risk Assessment Questions. Environmental Health Perspectives 114:11, pages 1770-1775.
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Rocío F. Cantón, J. Thomas Sanderson, Sandra Nijmeijer, Åke Bergman, Robert J. Letcher & Martin van den Berg. (2006) In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: A novel mechanism of action?. Toxicology and Applied Pharmacology 216:2, pages 274-281.
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