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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 6
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Research Article

Metabolism and disposition of 2,2′,4,4′,5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice

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Pages 515-534 | Received 03 Feb 2006, Accepted 04 Mar 2006, Published online: 22 Sep 2008

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. (2011) Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food. EFSA Journal 9:5.
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Crossref
Heli Routti, Robert J. Letcher, Shaogang Chu, Bert van Bavel & Geir W. Gabrielsen. (2009) Polybrominated Diphenyl Ethers and Their Hydroxylated Analogues in Ringed Seals ( Phoca hispida ) from Svalbard and the Baltic Sea . Environmental Science & Technology 43:10, pages 3494-3499.
Crossref
Heather M. Stapleton, Shannon M. Kelly, Ruoting Pei, Robert J. Letcher & Claudia Gunsch. (2009) Metabolism of Polybrominated Diphenyl Ethers (PBDEs) by Human Hepatocytes in Vitro . Environmental Health Perspectives 117:2, pages 197-202.
Crossref
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Crossref
Janice K. Huwe, Heldur Hakk & Linda S. Birnbaum. (2008) Tissue Distribution of Polybrominated Diphenyl Ethers in Male Rats and Implications for Biomonitoring. Environmental Science & Technology 42:18, pages 7018-7024.
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Si Zhang, Steve Bursian, Pamela A. Martin, Hing Man Chan & Jonathan W. Martin. (2009) Dietary accumulation, disposition, and metabolism of technical pentabrominated diphenyl ether (DE‐71) in pregnant mink ( Mustela vison ) and their offspring . Environmental Toxicology and Chemistry 27:5, pages 1184-1193.
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Crossref
Maria Athanasiadou, Steven N. Cuadra, Göran Marsh, Åke Bergman & Kristina Jakobsson. (2008) Polybrominated Diphenyl Ethers (PBDEs) and Bioaccumulative Hydroxylated PBDE Metabolites in Young Humans from Managua, Nicaragua. Environmental Health Perspectives 116:3, pages 400-408.
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Crossref
Xinghua Qiu, Minerva Mercado-Feliciano, Robert M. Bigsby & Ronald A. Hites. (2007) Measurement of Polybrominated Diphenyl Ethers and Metabolites in Mouse Plasma after Exposure to a Commercial Pentabromodiphenyl Ether Mixture. Environmental Health Perspectives 115:7, pages 1052-1058.
Crossref
Linda S. Birnbaum & Elaine A. Cohen Hubal. (2006) Polybrominated Diphenyl Ethers: A Case Study for Using Biomonitoring Data to Address Risk Assessment Questions. Environmental Health Perspectives 114:11, pages 1770-1775.
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