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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 4
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Research Article

Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines

D. Hallifax Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PT, UK
,
A. Galetin Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PT, UK
&
J. B. Houston Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PT, UK
Pages 353-367 | Received 29 Nov 2007, Accepted 29 Nov 2007, Published online: 22 Sep 2008

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Tetsuo Yamagata, Ugo Zanelli, Dieter Gallemann, Dominique Perrin, Hugues Dolgos & Carl Petersson. (2017) Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set. Xenobiotica 47:9, pages 741-751.
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C. Desbans, C. Hilgendorf, M. Lutz, P. Bachellier, T. Zacharias, J. C. Weber, H. Dolgos, L. Richert & A.-L. Ungell. (2014) Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors. Xenobiotica 44:1, pages 17-27.
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Brigitte Gerin, Sylvie Dell’Aiera, Lysiane Richert, Steven Smith & Hugues Chanteux. (2013) Assessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy. Xenobiotica 43:4, pages 320-335.
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Anna-Karin Sohlenius-Sternbeck, Christopher Jones, Douglas Ferguson, Brian J. Middleton, Denis Projean, Eva Floby, Johan Bylund & Lovisa Afzelius. (2012) Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes. Xenobiotica 42:9, pages 841-853.
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A.-K. Sohlenius-Sternbeck, L. Afzelius, P. Prusis, J. Neelissen, J. Hoogstraate, J. Johansson, E. Floby, A. Bengtsson, O. Gissberg, J. Sternbeck & C. Petersson. (2010) Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds. Xenobiotica 40:9, pages 637-649.
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Edmund Jon Deoon Lee, Choo Bee Lean & Lie Michael George Limenta. (2009) Role of membrane transporters in the safety profile of drugs. Expert Opinion on Drug Metabolism & Toxicology 5:11, pages 1369-1383.
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E. Floby, J. Johansson, J. Hoogstraate, N. J. Hewitt, J. Hill & A.-K. Sohlenius-Sternbeck. (2009) Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes. Xenobiotica 39:9, pages 656-662.
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Articles from other publishers (20)

Tashinga E. Bapiro, Scott Martin, Stephen D. Wilkinson, Alexandra L. Orton, Niresh Hariparsad, Stephanie Harlfinger & Dermot F. McGinnity. (2023) The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities. Drug Metabolism and Disposition 51:7, pages 892-901.
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Laura Orsolini, John M. Corkery, Stefania Chiappini, Amira Guirguis, Alessandro Vento, Domenico De Berardis, Duccio Papanti & Fabrizio Schifano. (2020) ‘New/Designer Benzodiazepines’: An Analysis of the Literature and Psychonauts’ Trip Reports. Current Neuropharmacology 18:9, pages 809-837.
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Joanne X. Shen, Sonia Youhanna, Reza Zandi Shafagh, Julianna Kele & Volker M. Lauschke. (2019) Organotypic and Microphysiological Models of Liver, Gut, and Kidney for Studies of Drug Metabolism, Pharmacokinetics, and Toxicity. Chemical Research in Toxicology 33:1, pages 38-60.
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Yitian Zhou, Joanne X. Shen & Volker M. Lauschke. (2019) Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury. Frontiers in Pharmacology 10.
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Christine M. Bowman & Leslie Z. Benet. (2019) Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharmaceutical Research 36:8.
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F. L. Wood, J. B. Houston & D. Hallifax. (2017) Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology. Drug Metabolism and Disposition 45:11, pages 1178-1188.
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Swati Chitrangi, Prabha Nair & Aparna Khanna. (2017) 3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism. Toxicology in Vitro 38, pages 8-18.
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Maria Katselou, Ioannis Papoutsis, Panagiota Nikolaou, Chara Spiliopoulou & Sotiris Athanaselis. (2016) Metabolites replace the parent drug in the drug arena. The cases of fonazepam and nifoxipam. Forensic Toxicology 35:1, pages 1-10.
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Aleksandra Galetin. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 255 288 .
Alexander V. LyubimovJasminder Sahi, Cornelia Smith, LaHoma Easterwood, Susan Grepper & Edward LeCluyse. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 53 .
Alexander V. LyubimovMurali Subramanian & Timothy S. Tracy. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 27 .
Cornelia M. Smith, Christina K. Nolan, Manda A. Edwards, Jean B. Hatfield, Todd W. Stewart, Stephen S. Ferguson, Edward L. Lecluyse & Jasminder Sahi. (2012) A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes. Journal of Pharmaceutical Sciences 101:10, pages 3989-4002.
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Jialin Mao, Michael A. Mohutsky, John P. Harrelson, Steven A. Wrighton & Stephen D. Hall. (2012) Predictions of Cytochrome P450-Mediated Drug-Drug Interactions Using Cryopreserved Human Hepatocytes: Comparison of Plasma and Protein-Free Media Incubation Conditions. Drug Metabolism and Disposition 40:4, pages 706-716.
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Hans-Udo Kasper, Elisabeth Konze, Nikolina Kutinová Canová, Hans Peter Dienes & Volker Dries. (2011) Cryopreservation of precision cut tissue slices (PCTS): Investigation of morphology and reactivity. Experimental and Toxicologic Pathology 63:6, pages 575-580.
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Diansong Zhou, Tommy B. Andersson & Scott W. Grimm. (2011) In Vitro Evaluation of Potential Drug-Drug Interactions with Ticagrelor: Cytochrome P450 Reaction Phenotyping, Inhibition, Induction, and Differential Kinetics. Drug Metabolism and Disposition 39:4, pages 703-710.
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M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón & Agustin Lahoz. (2010) Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo. Drug Metabolism and Disposition 38:9, pages 1449-1455.
Crossref
J. Brian Houston & Aleksandra Galetin. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 169 215 .
Murali Subramanian & Timothy S. Tracy. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 497 515 .
R. Scott Obach, Odette A. Fahmi & Robert L. Walsky. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 473 495 .
Masato Chiba, Yasuyuki Ishii & Yuichi Sugiyama. (2009) Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development. The AAPS Journal 11:2.
Crossref

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