Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 12
Submit an article Journal homepage
337
Views
19
CrossRef citations to date
0
Altmetric
Original Article

Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies

J. R. Kenny AstraZeneca R&D Charnwood, Loughborough, UK
,
L. Chen Tissue Engineering Group, School of Pharmaceutical Sciences, University of Nottingham, Nottingham, UK
,
D. F. McGinnity AstraZeneca R&D Charnwood, Loughborough, UKCorrespondence[email protected]
,
K. Grime AstraZeneca R&D Charnwood, Loughborough, UK
,
K. M. Shakesheff Tissue Engineering Group, School of Pharmaceutical Sciences, University of Nottingham, Nottingham, UK
,
B. Thomson Tissue Engineering Group, School of Pharmaceutical Sciences, University of Nottingham, Nottingham, UK
&
R. Riley AstraZeneca R&D Charnwood, Loughborough, UK
 show all
Pages 1500-1517 | Received 23 Apr 2008, Accepted 22 Sep 2008, Published online: 21 Nov 2008

Citations (19)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Robert J Riley & Claire E Wilson. (2015) Cytochrome P450 time-dependent inhibition and induction: advances in assays, risk analysis and modelling. Expert Opinion on Drug Metabolism & Toxicology 11:4, pages 557-572.
Read now
Alan Boobis, Jean-Baptiste Watelet, Rhys Whomsley, Margherita Strolin Benedetti, Pascal Demoly & Keith Tipton. (2009) Drug interactions. Drug Metabolism Reviews 41:3, pages 486-527.
Read now

Articles from other publishers (17)

Brandy Garzel, Lei Zhang, Shiew-Mei Huang & Hongbing Wang. (2019) A Change in Bile Flow: Looking Beyond Transporter Inhibition in the Development of Drug-induced Cholestasis. Current Drug Metabolism 20:8, pages 621-632.
Crossref
Souzan B. Yanni. 2015. Translational ADMET for Drug Therapy. Translational ADMET for Drug Therapy 139 178 .
Meitong Zang, Fanping Zhu, Xinxiu Li, Aijuan Yang & Jie Xing. (2014) Auto-induction of phase I and phase II metabolism of artemisinin in healthy Chinese subjects after oral administration of a new artemisinin-piperaquine fixed combination. Malaria Journal 13:1.
Crossref
Dany Spaggiari, Laurent Geiser, Youssef Daali & Serge Rudaz. (2014) A cocktail approach for assessing the in vitro activity of human cytochrome P450s: An overview of current methodologies. Journal of Pharmaceutical and Biomedical Analysis 101, pages 221-237.
Crossref
Yasuhiro Horita & Norio Doi. (2014) Comparative Study of the Effects of Antituberculosis Drugs and Antiretroviral Drugs on Cytochrome P450 3A4 and P-Glycoprotein. Antimicrobial Agents and Chemotherapy 58:6, pages 3168-3176.
Crossref
Nan Hu, Mengyue Hu, Ru Duan, Can Liu, Haifang Guo, Mian Zhang, Yunli Yu, Xinting Wang, Li Liu & Xiaodong Liu. (2014) Increased Levels of Fatty Acids Contributed to Induction of Hepatic CYP3A4 Activity Induced by Diabetes — In Vitro Evidence From HepG2 Cell and Fa2N-4 Cell Lines. Journal of Pharmacological Sciences 124:4, pages 433-444.
Crossref
Ee Lin Lim, Tiong Chai Seah, Xue Fen Koe, Habibah Abdul Wahab, Mohd Ilham Adenan, Mohd Fadzly Amar Jamil, Mohamed Isa Abdul Majid & Mei Lan Tan. (2013) In vitro evaluation of cytochrome P450 induction and the inhibition potential of mitragynine, a stimulant alkaloid. Toxicology in Vitro 27:2, pages 812-824.
Crossref
Alexander V. LyubimovKarthik Venkatakrishnan. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 62 .
Alexander V. LyubimovHiroshi Komura & Masahiro Iwaki. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 41 .
Jie Xing, Brian J. Kirby, Dale Whittington, Yakun Wan & David R. Goodlett. (2012) Evaluation of P450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes. Drug Metabolism and Disposition 40:9, pages 1757-1764.
Crossref
David HayHumphrey Hodgson, Amy Thomas & Clare Selden. 2012. Regenerative Medicine, Stem Cells and the Liver. Regenerative Medicine, Stem Cells and the Liver 98 114 .
Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki & Thomas Ebner. (2012) Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes. Drug Metabolism and Disposition 40:1, pages 93-103.
Crossref
J. Matthew Hutzler, Jack Cook & Joseph C. Fleishaker. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development 21 56 .
Zdeněk Dvořák, Radim Vrzal, Pavel Štarha, Alena Klanicová & Zdeněk Trávníček. (2010) Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes. Toxicology in Vitro 24:2, pages 425-429.
Crossref
J. Brian Houston & Aleksandra Galetin. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 169 215 .
Amin Rostami-Hodjegan. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 317 341 .
Dermot F. McGinnity, George Zhang, Jane R. Kenny, Geraldine A. Hamilton, Sara Otmani, Karen R. Stams, Suzzette Haney, Patrick Brassil, David M. Stresser & Robert J. Riley. (2009) Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells. Drug Metabolism and Disposition 37:6, pages 1259-1268.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.