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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 12
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Original Article

Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies

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Pages 1500-1517 | Received 23 Apr 2008, Accepted 22 Sep 2008, Published online: 21 Nov 2008

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Robert J Riley & Claire E Wilson. (2015) Cytochrome P450 time-dependent inhibition and induction: advances in assays, risk analysis and modelling. Expert Opinion on Drug Metabolism & Toxicology 11:4, pages 557-572.
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Dermot F. McGinnity, George Zhang, Jane R. Kenny, Geraldine A. Hamilton, Sara Otmani, Karen R. Stams, Suzzette Haney, Patrick Brassil, David M. Stresser & Robert J. Riley. (2009) Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells. Drug Metabolism and Disposition 37:6, pages 1259-1268.
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