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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 9
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Clinical Pharmacokinetics and Metabolism

Clinical evaluation of P-glycoprotein inhibition by venetoclax: a drug interaction study with digoxin

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Pages 904-910 | Received 30 Jul 2017, Accepted 15 Sep 2017, Published online: 13 Oct 2017

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Meihong Zheng, Xuan Zhou, Qien Wang, Xin Chen, Bei Cao & Juan Li. (2021) Metabolomic approach to characterize the metabolic phenotypes and varied response to ouabain of diffuse large B-cell lymphoma cells. Leukemia & Lymphoma 62:7, pages 1597-1608.
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Laura Giuseppina Di Pasqua, Murwan Mahmoud Abdallah, Fausto Feletti, Mariapia Vairetti & Andrea Ferrigno. (2024) Venetoclax-Related Neutropenia in Leukemic Patients: A Comprehensive Review of the Underlying Causes, Risk Factors, and Management. Pharmaceuticals 17:4, pages 484.
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Weibin Fan, Jun Guo, Yue Zhang, Runcong Zhang & Bin Lin. (2024) Venetoclax dose adjustment due to drug-drug interactions: a case report and literature review. Anti-Cancer Drugs 35:1, pages 70-75.
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Claudia Cerella, Sruthi Reddy Gajulapalli, Anne Lorant, Deborah Gerard, Florian Muller, Yejin Lee, Kyung Rok Kim, Byung Woo Han, Christo Christov, Christian Récher, Jean-Emmanuel Sarry, Mario Dicato & Marc Diederich. (2023) ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides. Leukemia 38:1, pages 67-81.
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Andaleeb Sajid, Hadiar Rahman & Suresh V. Ambudkar. (2023) Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters. Nature Reviews Cancer 23:11, pages 762-779.
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Melanie A. Felmlee, Michael Ng & Annie Lee. 2023. Oral Bioavailability and Drug Delivery. Oral Bioavailability and Drug Delivery 339 360 .
Benoit Cox, Johan Nicolaï & Beth Williamson. (2022) The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discovery. Biopharmaceutics & Drug Disposition 44:1, pages 113-126.
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Arpita Gandhi, Benjamin Andrick, Julianne Darling, Tuyet Truong & Jessie Signorelli. (2022) Oral Antineoplastics in Acute Myeloid Leukemia: A Comprehensive Review. Clinical Lymphoma Myeloma and Leukemia 22:12, pages e1033-e1049.
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Athar Husain, Vishal Makadia, Guru R. Valicherla, Mohammed Riyazuddin & Jiaur R. Gayen. (2022) Approaches to minimize the effects of P‐glycoprotein in drug transport: A review. Drug Development Research 83:4, pages 825-841.
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Deanna Brackman, Doerthe Eckert, Rajeev Menon, Ahmed Hamed Salem, Jalaja Potluri, B. Douglas Smith, Andrew H. Wei, John Hayslip, Dale Miles, Sven Mensing, Sathej Gopalakrishnan & Jiuhong Zha. (2022) Venetoclax exposure‐efficacy and exposure‐safety relationships in patients with treatment‐naïve acute myeloid leukemia who are ineligible for intensive chemotherapy. Hematological Oncology 40:2, pages 269-279.
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Eliza R. McColl, Vessela Vassileva & Micheline Piquette-Miller. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 608 626 .
May Levin, Michal Stark, Yishai Ofran & Yehuda G. Assaraf. (2021) Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance. Cancer Cell International 21:1.
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Chong Chyn Chua, Andrew W. Roberts, John Reynolds, Chun Yew Fong, Stephen B. Ting, Jessica M. Salmon, Sarah MacRaild, Adam Ivey, Ing Soo Tiong, Shaun Fleming, Fiona C. Brown, Sun Loo, Ian J. Majewski, Stefan K. Bohlander & Andrew H. Wei. (2020) Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy. Journal of Clinical Oncology 38:30, pages 3506-3517.
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Juan Eduardo Megías-Vericat, Antonio Solana-Altabella, Octavio Ballesta-López, David Martínez-Cuadrón & Pau Montesinos. (2020) Drug-drug interactions of newly approved small molecule inhibitors for acute myeloid leukemia. Annals of Hematology 99:9, pages 1989-2007.
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Ali A. Alhadab, Ahmed Hamed Salem & Kevin J. Freise. (2020) Semimechanistic Modeling to Guide Venetoclax Coadministration with Ritonavir and Digoxin. Clinical and Translational Science 13:3, pages 555-562.
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Nikki Blosser, Jennifer Jupp, Patrick Yau & Douglas Stewart. (2019) Clinical Pharmacokinetic and Pharmacodynamic Considerations in Treating Non-Hodgkin Lymphoma. Clinical Pharmacokinetics 59:1, pages 7-23.
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Nimita Dave, Sathej Gopalakrishnan, Sven Mensing & Ahmed Hamed Salem. (2019) Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis. Clinical and Translational Science 12:6, pages 625-632.
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Ahmed Hamed Salem, Nimita Dave, Thomas Marbury, Beibei Hu, Dale Miles, Suresh K. Agarwal, Orlando F. Bueno & Rajeev M. Menon. (2019) Pharmacokinetics of the BCL-2 Inhibitor Venetoclax in Subjects with Hepatic Impairment. Clinical Pharmacokinetics 58:8, pages 1091-1100.
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Suresh K. Agarwal, Bo Tong, Orlando F. Bueno, Rajeev M. Menon & Ahmed Hamed Salem. (2018) Effect of Azithromycin on Venetoclax Pharmacokinetics in Healthy Volunteers: Implications for Dosing Venetoclax with P-gp Inhibitors. Advances in Therapy 35:11, pages 2015-2023.
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Takashi Matsumoto, Noriko Kaifuchi, Yasuharu Mizuhara, Eiji Warabi & Junko Watanabe. (2018) Use of a Caco-2 permeability assay to evaluate the effects of several Kampo medicines on the drug transporter P-glycoprotein. Journal of Natural Medicines 72:4, pages 897-904.
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Kevin J. Freise, Beibei Hu & Ahmed Hamed Salem. (2018) Impact of ritonavir dose and schedule on CYP3A inhibition and venetoclax clinical pharmacokinetics. European Journal of Clinical Pharmacology 74:4, pages 413-421.
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