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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 2
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Molecular Toxicology

Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats

Corinne HainesConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; View further author information
,
Lynsey R. ChathamConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; View further author information
,
Audrey VardyConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; Correspondence[email protected]
View further author information
,
Clifford R. ElcombeConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; View further author information
,
John R. FosterRegulatory Science Associates, Renfreshire, UK; View further author information
&
Brian G. LakeConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; ;Centre for Toxicology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UKView further author information
Pages 227-238 | Received 22 Nov 2017, Accepted 01 Feb 2018, Published online: 26 Mar 2018

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Tomoya Yamada, Samuel M. Cohen & Brian G. Lake. (2021) Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Critical Reviews in Toxicology 51:5, pages 373-394.
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David Du Pasquier, Benoît Salinier, Katherine K. Coady, Alan Jones, Oliver Körner, Jessica LaRocca, Gregory Lemkine, Barbara Robin-Duchesne, Lennart Weltje, James R. Wheeler & Laurent Lagadic. (2024) How the Xenopus eleutheroembryonic thyroid assay compares to the amphibian metamorphosis assay for detecting thyroid active chemicals. Regulatory Toxicology and Pharmacology 149, pages 105619.
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Audrey Baze, Lucille Wiss, Liliia Horbal, Klaus Biemel, Laure Asselin & Lysiane Richert. (2024) Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures. Toxicology in Vitro 96, pages 105763.
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Kenta Minami, Akira Sato, Naruto Tomiyama, Keiko Ogata, Tadashi Kosaka, Hitoshi Hojo, Naofumi Takahashi, Hidenori Suto, Hiroaki Aoyama & Tomoya Yamada. (2024) Prenatal test cohort of a modified rat comparative thyroid assay adding brain thyroid hormone measurements and histology but lowering group size appears able to detect disruption by sodium phenobarbital. Current Research in Toxicology 6, pages 100168.
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Ann-Cathrin Haigis, Lucia Vergauwen, Carlie A LaLone, Daniel L Villeneuve, Jason M O’Brien & Dries Knapen. (2023) Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption. Toxicological Sciences 195:1, pages 1-27.
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Kenta Minami, Hidenori Suto, Akira Sato, Keiko Ogata, Tadashi Kosaka, Hitoshi Hojo, Naofumi Takahashi, Naruto Tomiyama, Takako Fukuda, Katsumasa Iwashita, Hiroaki Aoyama & Tomoya Yamada. (2023) Feasibility study for a downsized comparative thyroid assay with measurement of brain thyroid hormones and histopathology in rats: Case study with 6-propylthiouracil and sodium phenobarbital at high dose. Regulatory Toxicology and Pharmacology 137, pages 105283.
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Hirotoshi Akane, Takeshi Toyoda, Yasuko Mizuta, Young‐Man Cho, Tetsuya Ide, Tadashi Kosaka, Hitoshi Tajima, Hiroaki Aoyama & Kumiko Ogawa. (2022) Histopathological and immunohistochemical evaluation for detecting changes in blood hormone levels caused by endocrine disruptors in a 28‐day repeated‐dose study in rats. Journal of Applied Toxicology 42:10, pages 1603-1617.
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Nichole R. Vansell. (2022) Mechanisms by Which Inducers of Drug Metabolizing Enzymes Alter Thyroid Hormones in Rats. Drug Metabolism and Disposition 50:4, pages 508-517.
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Céline Parmentier, Audrey Baze, Meiggie Untrau, Andreas Kampkoetter, Dominique Lasserre & Lysiane Richert. (2022) Evaluation of human relevance of Nicofluprole-induced rat thyroid disruption. Toxicology and Applied Pharmacology 435, pages 115831.
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John R. Foster, Helen Tinwell & Stephanie Melching-Kollmuss. (2021) A review of species differences in the control of, and response to, chemical-induced thyroid hormone perturbations leading to thyroid cancer. Archives of Toxicology 95:3, pages 807-836.
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Claire Terry, Zhongyu Yan, Marco Corvaro & Sean C. Gehen. (2021) A retrospective study on EU harmonised classifications for carcinogenicity to guide future research. Regulatory Toxicology and Pharmacology 119, pages 104800.
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Jenni Küblbeck, Jonna Niskanen & Paavo Honkakoski. (2020) Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR. Cells 9:10, pages 2306.
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Brian G. Lake, Roger J. Price, Mary P. Scott, Lynsey R. Chatham, Audrey Vardy & Thomas G. Osimitz. (2020) Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance. Toxicology 439, pages 152465.
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Takafumi Yamaguchi, Minoru MaedaKeiko OgataJun AbeToru UtsumiKoji Kimura. (2019) The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats. The Journal of Toxicological Sciences 44:7, pages 459-469.
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Brian G. Lake. (2018) Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators. Toxicology Research 7:4, pages 697-717.
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