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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 3
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General Xenobiochemistry

Genetic polymorphisms of human hepatic OATPs: functional consequences and effect on drug pharmacokinetics

Yingmin NieDepartment of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaView further author information
,
Jingjie YangDepartment of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaView further author information
,
Shuai LiuDepartment of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaView further author information
,
Ruiqi SunDepartment of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaView further author information
,
Huihui ChenDepartment of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaView further author information
,
Nan LongDepartment of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaView further author information
,
Rui JiangDepartment of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaView further author information
&
Chunshan GuiDepartment of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaCorrespondence[email protected]
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Pages 297-317 | Received 28 Apr 2019, Accepted 04 Jun 2019, Published online: 24 Jun 2019

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Nadeen Anabtawi, Thomas Drabison, Shuiying Hu, Alex Sparreboom & Zahra Talebi. (2022) The role of OATP1B1 and OATP1B3 transporter polymorphisms in drug disposition and response to anticancer drugs: a review of the recent literature. Expert Opinion on Drug Metabolism & Toxicology 18:7-8, pages 459-468.
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Articles from other publishers (15)

Ying Li, Han Liu, Ting Liang, Wanjun Han, Zheyue Bo, Tian Qiu, Jiawei Li, Mingming Xu, Weipeng Wang, Shuang Yang & Chunshan Gui. (2023) Importance of N-Glycosylation for the Expression and Function of Human Organic Anion Transporting Polypeptide 2B1. ACS Pharmacology & Translational Science.
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Taotao Peng, Shuai Liu, Ying Li, Hongjian Zhang, Bruno Hagenbuch & Chunshan Gui. (2023) Investigating the interactions of flavonoids with human OATP2B1: inhibition assay, IC 50 determination, and structure–activity relationship analysis . RSC Medicinal Chemistry 14:5, pages 890-898.
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Chunshan Gui, Ying Li & Taotao Peng. (2023) Development of predictive QSAR models for the substrates/inhibitors of OATP1B1 by deep neural networks. Toxicology Letters 376, pages 20-25.
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Manon C. Bouwmeester, Yu Tao, Susana Proença, Frank G. van Steenbeek, Roos-Anne Samsom, Sandra M. Nijmeijer, Theo Sinnige, Luc J. W. van der Laan, Juliette Legler, Kerstin Schneeberger, Nynke I. Kramer & Bart Spee. (2023) Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing. Molecules 28:2, pages 621.
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Zhongmin Wang, Ying Li, Cecilia E. Villanueva, Taotao Peng, Wanjun Han, Zheyue Bo, Hongjian Zhang, Bruno Hagenbuch & Chunshan Gui. (2022) The Importance of Val386 in Transmembrane Domain 8 for the Activation of OATP1B3 by Epigallocatechin Gallate. Journal of Agricultural and Food Chemistry 70:21, pages 6552-6560.
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Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu & Su Zeng. (2022) Feature, Function, and Information of Drug Transporter–Related Databases. Drug Metabolism and Disposition 50:1, pages 76-85.
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Zhongmin Wang, Ying Li, Taotao Peng, Ying Su, Xiaoting Luo, Wanjun Han, Hongjian Zhang, Jianqing Ruan & Chunshan Gui. (2021) Human Organic Anion Transporting Polypeptides 1B1, 1B3, and 2B1 Are Involved in the Hepatic Uptake of Phenolsulfonphthalein. ACS Omega 6:51, pages 35844-35851.
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Nada Božina, Lana Ganoci, Livija Simičević, Katarina Gvozdanović, Iva Klarica Domjanović, Margareta Fistrek Prlić, Tena Križ, Ana Borić Bilušić, Mario Laganović & Tamara Božina. (2021) Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review. Archives of Industrial Hygiene and Toxicology 72:2, pages 114-128.
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Shuai Liu, Taotao Peng, Zhongmin Wang, Ying Li, Hongjian Zhang & Chunshan Gui. (2021) Effect of rare coding variants of charged amino acid residues on the function of human organic anion transporting polypeptide 1B3 (SLCO1B3). Biochemical and Biophysical Research Communications 557, pages 1-7.
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Jingjie Yang, Zhongmin Wang, Shuai Liu, Weipeng Wang, Hongjian Zhang & Chunshan Gui. (2020) Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 ( SLCO 2 B 1) . Molecular Pharmaceutics 17:10, pages 3966-3978.
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Supratim Choudhuri & Curtis D. Klaassen. (2020) Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms. Toxicology and Applied Pharmacology 399, pages 115039.
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Yiqun Xiang, Shuai Liu, Jingjie Yang, Zhongmin Wang, Hongjian Zhang & Chunshan Gui. (2020) Investigation of the interactions between flavonoids and human organic anion transporting polypeptide 1B1 using fluorescent substrate and 3D-QSAR analysis. Biochimica et Biophysica Acta (BBA) - Biomembranes 1862:5, pages 183210.
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Saki Izumi, Yoshitane Nozaki, Hiroyuki Kusuhara, Koichiro Hotta, Toshiki Mochizuki, Takafumi Komori, Kazuya Maeda & Yuichi Sugiyama. (2020) Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes. Molecular Pharmaceutics.
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Jim Kaput. (2020) Lessons from application of data science strategies in nutritional research. The American Journal of Clinical Nutrition 111:1, pages 4-5.
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Danyi Lu, Menglin Chen, Yi Wang, Min Chen & Baojian Wu. 2020. Circadian Pharmacokinetics. Circadian Pharmacokinetics 131 158 .

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