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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 10
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Research Article

N-oxidation of irsogladine by the CYP2C subfamily in the rat, dog, monkey and man

A. NAKAMURA* Research Laboratories, Nippon Shinyaku Co., Ltd, Nishioji-Hachijo, Minami-ku, Kyoto, 601 Japan OE Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome, Higashinari-ku, Osaka, 537 Japan Department of Pharmacology, Gifu University School of Medicine, 40 Tukasa-machi, Gifu, 500 Japan
,
T. HIROTA Research Laboratories, Nippon Shinyaku Co., Ltd, Nishioji-Hachijo, Minami-ku, Kyoto, 601 Japan OE Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome, Higashinari-ku, Osaka, 537 Japan Department of Pharmacology, Gifu University School of Medicine, 40 Tukasa-machi, Gifu, 500 Japan
,
A. MORINO Research Laboratories, Nippon Shinyaku Co., Ltd, Nishioji-Hachijo, Minami-ku, Kyoto, 601 Japan OE Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome, Higashinari-ku, Osaka, 537 Japan Department of Pharmacology, Gifu University School of Medicine, 40 Tukasa-machi, Gifu, 500 Japan
,
T. SHIMADA Research Laboratories, Nippon Shinyaku Co., Ltd, Nishioji-Hachijo, Minami-ku, Kyoto, 601 Japan OE Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome, Higashinari-ku, Osaka, 537 Japan Department of Pharmacology, Gifu University School of Medicine, 40 Tukasa-machi, Gifu, 500 Japan
&
T. UEMATSU Research Laboratories, Nippon Shinyaku Co., Ltd, Nishioji-Hachijo, Minami-ku, Kyoto, 601 Japan OE Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome, Higashinari-ku, Osaka, 537 Japan Department of Pharmacology, Gifu University School of Medicine, 40 Tukasa-machi, Gifu, 500 Japan
Pages 995-1003 | Published online: 22 Sep 2008

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Peter Hlavica. (2002) N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION. Drug Metabolism Reviews 34:3, pages 451-477.
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Articles from other publishers (7)

Yasushi Yamazoe, Kazumi Ito, Yoshiya Yamamura, Ryutaro Iwama & Kouichi Yoshinari. (2016) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 1. Focusing on polycyclic arenes and the related chemicals. Drug Metabolism and Pharmacokinetics 31:5, pages 363-384.
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Mohamed B. Abou-Donia. 2015. Mammalian Toxicology. Mammalian Toxicology 101 129 .
Mohamed Abou-Donia. 2014. Handbook of Toxicology, Third Edition. Handbook of Toxicology, Third Edition.
Frederique Bravin, Radu Duca, Patrick Balaguer & Marcel Delaforge. (2009) In Vitro Cytochrome P450 Formation of a Mono-Hydroxylated Metabolite of Zearalenone Exhibiting Estrogenic Activities: Possible Occurrence of This Metabolite in Vivo. International Journal of Molecular Sciences 10:4, pages 1824-1837.
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Minseok S. Kim, Wonhye Lee, Yu Chang Kim & Je‐Kyun Park. (2008) Microvalve‐assisted patterning platform for measuring cellular dynamics based on 3D cell culture. Biotechnology and Bioengineering 101:5, pages 1005-1013.
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Robert A Coleman, Wayne P Bowen, Ian A Baines, Amanda J Woodrooffe & Anthony M Brown. (2001) Use of human tissue in ADME and safety profiling of development candidates. Drug Discovery Today 6:21, pages 1116-1126.
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Mohamed Abou-Donia, Eman Elmasry & Aqel Abu-Qare. 2001. Handbook of Toxicology, Second Edition. Handbook of Toxicology, Second Edition.

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