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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 10
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Research Article

N-oxidation of irsogladine by the CYP2C subfamily in the rat, dog, monkey and man

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Pages 995-1003 | Published online: 22 Sep 2008

References

  • ANDO, T., MOMOTA, K. and SUGIYAMA, M., 1989, Absorption, distribution and excretion of 2,4-Diamino-6-(2,5-dichloropheny1)- s-triazine maleate in rats, dogs and monkeys. Arzneimittel Forschung, 36, 1221–1228.
  • CASHMAN, J. R., YANG, Z., YANG, L. and WRIGHTON, S. A., 1993, Stereo- and regioselective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes. Drug Metabolism and Disposition, 21, 492–501.
  • CHIBA, K., 1995, Identification of human cytochrome P450 isoforms involved in the metabolism of therapeutics agents: significance in clinical pharmacology and drug development. Xenobiotic Metabolism and Disposition, 10, 391–402.
  • FUNAE, Y. and ImAoKA, S., 1993, Cytochrome P450 in rodents. In Handbook of Experimental Pharmacology 105 Cytochrome P450, edited by J. B. Shenkman and H. Greim (Berlin: Springer), pp. 221–238.
  • GONZALEZ, F. J., 1993, Cytochrome P-450 in humans. In Handbook of Experimental Pharmacology 105 Cytochrome P-450, edited by J. B. Shenkman and H. Greim (Berlin: Springer), pp. 239–257.
  • IMAOKA S., YAMADA, T., HIRAI, T., HAYASHI, K., S AKAI, T., YABUSUKI, Y. and FUNAE, Y., 1996, Multiple forms of human P450 expressed in S accharomyces cerevisiae : systematic characterization and comparison with those of the rat. Biochemical Pharmacology, 51, 1041–1050.
  • KOMORI, M., SHIMADA, H., MIURA, T. and KAMATAKI, T., 1989, Interspecies homology of liver microsomal cytochrome P-450. A form of dog cytochrome P-450 (P-450-D1) crossreactive with antibodies to rat P-450-male. Biochemical Pharmacology, 38, 235–240.
  • LOWRY, O. H., ROSENBROUGH, N. J., FARR, A. L. and RANDOLL, R. J., 1981, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • MANI, C., GELVOIN, H. V., PARK, S. S., PEARCE, R., PARKINSON, A. and KUPFER, D., 1993a, Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation. Drug Metabolism and Disposition, 21, 645–656.
  • MANI, C., HODSON, E. and KUPFER, D., 1993b, Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-oxidation. Drug Metabolism and Disposition, 21, 657–661.
  • MIURA, T., SHIMADA, H., Om, H., KOMORI, M., KOMADA, T. and KAMATAKI, T., 1989, Interspecies homology of cytochrome P-450: inhibition by anti-P-450-male antibodies of testosterone hydroxylases in liver microsomes from various animal species including man. Japan Journal of Pharmacology, 49, 365–374.
  • NAKASHIMA, M., UEMATSU, T., TAKAGUCHI, Y. and HAYASHI, T., 1984, Phase I study of 2,4-Diamino-6-(2,5-dichloropheny1)-s-triazine maleate, a new anti-ulcer agent. Arzneimittel Forschung, 34, 492–498.
  • NEDELCHEVA, V. and GUT, I., 1994, P450 in the rat and man: methods of investigation, substrate specificities, and relevance to cancer. Xenobiotica, 24, 1151–1175.
  • OHTA, O., KITADA, M., HASHIZUME, T., KOMORI, M., OHI, H., KITADA, M. and KAMATAKI, T., 1983, Purification of cytochrome P-450 from polychlorinated biphenyl-treated crab-eating monkeys: high homology to a form of human cytochrome P-450. Biochimica et Biophysica Acta, 996, 142–145.
  • PROUGH, R. A. and ZIEGLER, D. M., 1977, The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactions. Archives of Biochemistry and Biophysics, 180, 363–373.
  • RODRIGUES, A. D., FERRERO, J. L., AMANN, M. T., ROBERT, G. A., CEPA, S. P., SURBER, B. W., MACHINISIST, J. M., TICH, N. R., SULLIVAN, J. P., GARVEY, D. S., FITZGERALD, M. and ARENERIC S. P., 1994, The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans. Drug Metabolism and Disposition, 22, 788–798.
  • ROUER, E., LEMOINE, A., CRESTEIL, T., ROUET, P. and LEROUX, J. P., 1987, Effects of genetic or chemically induced diabetes on imipramine metabolism; respective involvement of flavin monooxygenase and cytochrome P-450-dependent monooxygenase. Drug Metabolism and Disposition, 15, 524–528.
  • SHIMADA, T., YAMAZAKI, H., MINIURA, M., INUI, Y. and GUENGERICH, F. P., 1994, Interindividual variations in human liver cytochrome 450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics, 270, 414–423.
  • SMITH, D. A., 1991, Species differences in metabolism and pharmacokinetics: are we close to an understanding? Drug Metabolism Reviews, 23, 355–373.
  • SUGIYAMA, M., ANDO, T., OKUYAMA, Y., SUGIMOTO, T. and CHOKAI S., 1989, Metabolism of 2,4-diamino-6-(2,5-dichloropheny1)-s-triazine maleate in rats, guinea pigs, dogs and monkeys. Arzneimittel Forschung, 36, 1229–1236.
  • UEDA, F., ARATANI S., MIMURA, K., NOMURA, A. and ENOMOTO, H., 1984a, Effects of 2,4-diamino-6-(2,5-dichloropheny1)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals. Arzneimittel Forschung, 34, 474–477.
  • UEDA, F., ARATANI S., MIMURA, K., NOMURA, A. and ENOMOTO, H., 1984b, Effects of 2,4-diamino-6-(2,5-dichloropheny1)-s-triazine maleate (MN-1695) on gastric mucosal damage induced by various necrotizing agents in rats. Arzneimittel Forschung, 34, 478–484.
  • UEDA, F., KYOI, T., MIMURA, K., KIMURA, K. and YAMAMOTO, M., 1991, Intercellular communication in cultured rabbit gastric epithelial cells. Japan Journal of Pharmacology, 57, 321–328.
  • UEDA, F., KAMEDA, Y., YAMAMOTO, O. and SHIBATA, Y., 1994, Beta adregenic regulation of gap-junctional intercellular communication in cultured rabbit gastric epithelial cells. Journal of Pharmacology and Experimental Therapeutics, 271, 397–402.
  • UCHIDA, T., KOMORI, M., KITADA, M. and KAMATAKI, T., 1990, Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs. Molecular Pharmacology, 38, 644–651.
  • WEAVER, R. J., THOMPSON, S., SMITH, G., ELCOMBE, C. R., MEYER, R. T. and BURKE, M. D., 1994, A Comparative study of constitutive and induced alkoxyresorufin O-dealkylation and individual cytochrome P450 forms in cynomolugus monkey (Macaca fasckularis), human, mouse, rat and hamster liver microsomes. Biochemical Pharmacology, 47, 763–773.
  • ZINS, G. R., 1965, The in vitro production of a potent, long-acting hypotensive metabolite from diallylmelamine. Journal of Pharmacology and Experimental Therapeutics, 150, 109–117.
  • ZINS, G. R., EMMERT, D. E. and WALK, R. A., 1967, Hypotensive metabolite production and sequential metabolism of N,N-diallylmelamine in rats. Journal of Pharmacology and Experimental Therapeutics, 159, 194–205.

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