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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 4
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Research Article

Cytochrome P450isoenzyme activities in cultured rat and mouse liver slices

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Pages 341-356 | Published online: 22 Sep 2008

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Read on this site (9)

Wojciech Kuban & Władysława Anna Daniel. (2021) Cytochrome P450 expression and regulation in the brain. Drug Metabolism Reviews 53:1, pages 1-29.
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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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M. T. Donato, R. Klocke, J. V. Castell, K. Stenzel, D. Paul & M. J. Gómez-Lechón. (2003) Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice. Xenobiotica 33:5, pages 459-473.
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D. C. Mankowski, M. P. Lawton & S. Ekins. (2000) Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates. Xenobiotica 30:8, pages 745-754.
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A.-K. Sohlenius-Sternbeck, E. Floby, M. Svedling & A. Orzechowski. (2000) High conservation of both phase I and II drug-metabolizing activities in cryopreserved rat liver slices. Xenobiotica 30:9, pages 891-903.
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B. G. LAKE, J. M. TREDGER, A. B. RENWICK, P. T. BARTON & R. J. PRICE. (1998) 3,3′-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 28:8, pages 803-811.
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Articles from other publishers (31)

Osbourne Quaye, Precious Cramer, Mark Ofosuhene, Laud K. N. Okine & Alexander K. Nyarko. (2017) Acute and Subchronic Toxicity Studies of Aqueous Extract of Desmodium adscendens (Sw) DC . Journal of Evidence-Based Complementary & Alternative Medicine 22:4, pages 753-759.
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Alexander V. LyubimovCostas Ioannides & Brian G. Lake. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
Francis Finot, Régis Masson, Fabienne Desmots, Catherine Ribault, Nicole Bichet, Joan A. Vericat, Patricia Lafouge, Christiane Guguen-Guillouzo & Pascal Loyer. (2012) Combined Stimulation with the Tumor Necrosis Factor and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices . International Journal of Hepatology 2012, pages 1-14.
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Van T. Ly & Barry Brock. (2011) Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. Chemico-Biological Interactions 193:2, pages 109-118.
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Subrata Deb & Stelvio M. Bandiera. (2010) Characterization of a new cytochrome P450 enzyme, CYP2S1, in rats: Its regulation by aryl hydrocarbon receptor agonists. Toxicology 267:1-3, pages 91-98.
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Kristen A. Mitchell & Cornelis J. Elferink. (2009) Timing is everything: Consequences of transient and sustained AhR activity. Biochemical Pharmacology 77:6, pages 947-956.
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Yuet Mei KhongJing ZhangSibo ZhouChristine CheungKai DobersteinVictor SamperHanry Yu. (2007) Novel Intra-Tissue Perfusion System for Culturing Thick Liver Tissue. Tissue Engineering 13:9, pages 2345-2356.
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Jason R. Catania, Barbara P. McGarrigle, Kate Rittenhouse-Olson & James R. Olson. (2007) Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium. Toxicology in Vitro 21:1, pages 109-115.
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S. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth & N. P. E. Vermeulen. (2006) On-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor Modulators. Drug Metabolism and Disposition 34:9, pages 1640-1649.
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Marcella Martignoni, Ruben de Kanter, Pietro Grossi, Grazia Saturno, Elena Barbaria & Mario Monshouwer. (2006) An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR. Toxicology in Vitro 20:1, pages 125-131.
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Sirkku T. Saarikoski, Steven P. Rivera, Oliver Hankinson & Kirsti Husgafvel-Pursiainen. (2005) CYP2S1: A short review. Toxicology and Applied Pharmacology 207:2, pages 62-69.
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Satu Arpiainen, Françoise Raffalli-Mathieu, Matti A. Lang, Olavi Pelkonen & Jukka Hakkola. (2005) Regulation of the Cyp2a5 Gene Involves an Aryl Hydrocarbon Receptor-Dependent Pathway . Molecular Pharmacology 67:4, pages 1325-1333.
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Marcella Martignoni, Ruben de Kanter, Pietro Grossi, Axel Mahnke, Grazia Saturno & Mario Monshouwer. (2004) An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR. Chemico-Biological Interactions 151:1, pages 1-11.
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D.J. Stevenson, C. Morgan, E. Goldie, G. Connel & M.H. Grant. (2004) Cryopreservation of viable hepatocyte monolayers in cryoprotectant media with high serum content: metabolism of testosterone and kaempherol post-cryopreservation. Cryobiology 49:2, pages 97-113.
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Holger P Behrsing, Alison E.M Vickers & Charles A Tyson. (2003) Extended rat liver slice survival and stability monitored using clinical biomarkers. Biochemical and Biophysical Research Communications 312:1, pages 209-213.
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I.A.M de Graaf & H.J Koster. (2003) Cryopreservation of precision-cut tissue slices for application in drug metabolism research. Toxicology in Vitro 17:1, pages 1-17.
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Reinhild Glöckner, Juliane Wagener, Angelika Lieder & Dieter Müller. (2003) In vitro induction of cytochrome P4503A1-mRNA and testosterone hydroxylation in precision-cut liver slices from male and female rats. Experimental and Toxicologic Pathology 54:5-6, pages 411-415.
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Rainer Klocke, M José Gómez-Lechón, Anja Ehrhardt, Tomas Mendoza-Figueroa, M Teresa Donato, Rubén López-Revilla, José V Castell & Dieter Paul. (2002) Establishment and characterization of immortal hepatocytes derived from various transgenic mouse lines. Biochemical and Biophysical Research Communications 294:4, pages 864-871.
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E Evdokimova, H Taper & P Buc Calderon. (2002) Effects of bacterial endotoxin (lipopolysaccharides) on survival and metabolism of cultured precision-cut rat liver slices. Toxicology in Vitro 16:1, pages 47-54.
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Walter Pfaller, Michael Balls, Richard Clothier, Sandra Coecke, Paul Dierickx, Björn Ekwall, Bryan A. Hanley, Thomas Hartung, Pilar Prieto, Michael P. Ryan, Gabriele Schmuck, Dariusz Šladowski, Joan-Albert Vericat, Albrecht Wendel, Armin Wolf & Jens Zimmer. (2019) Novel Advanced In Vitro Methods for Long-term Toxicity Testing . Alternatives to Laboratory Animals 29:4, pages 393-426.
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Holger Rosenbrock, Christoph E. Hagemeyer, Margarethe Ditter, Rolf Knoth & Benedict Volk. (2001) Identification, induction and localization of cytochrome P450s of the 3A-subfamily in mouse brain. Neurotoxicity Research 3:4, pages 339-349.
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A Lupp, M Danz & D Müller. (2001) Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices. Toxicology 161:1-2, pages 53-66.
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Trevor N Johnson, M.Stuart Tanner & Geoffrey T Tucker. (2000) A comparison of the ontogeny of enterocytic and hepatic cytochromes P450 3A in the rat. Biochemical Pharmacology 60:11, pages 1601-1610.
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Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
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P. Schmieder, M. Tapper, A. Linnum, J. Denny, R. Kolanczyk & R. Johnson. (2000) Optimization of a precision-cut trout liver tissue slice assay as a screen for vitellogenin induction: comparison of slice incubation techniques. Aquatic Toxicology 49:4, pages 251-268.
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Jinqiang Chen, Mamata Gokhale, Brian Schofield, Shelly Odwin & James D. Yager. (2000) Inhibition of TGF-β-induced apoptosis by ethinyl estradiol in cultured, precision cut rat liver slices and hepatocytes. Carcinogenesis 21:6, pages 1205-1211.
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R De Kanter, P Olinga, M.H De Jager, M.T Merema, D.K.F Meijer & G.M.M Groothius. (1999) Organ Slices as an In Vitro Test System for Drug Metabolism in Human Liver, Lung and Kidney. Toxicology in Vitro 13:4-5, pages 737-744.
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A.B. Renwick, H. Mistry, P.T. Barton, F. Mallet, R.J. Price, J.A. Beamand & B.G. Lake. (1999) Effect of some Indole Derivatives on Xenobiotic Metabolism and Xenobiotic-induced Toxicity in Cultured Rat Liver Slices. Food and Chemical Toxicology 37:6, pages 609-618.
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Adam T. Drahushuk, Barbara P. McGarrigle, Brian P. Slezak, John J. Stegeman & James R. Olson. (1999) Time- and Concentration-Dependent Induction of CYP1A1 and CYP1A2 in Precision-Cut Rat Liver Slices Incubated in Dynamic Organ Culture in the Presence of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Toxicology and Applied Pharmacology 155:2, pages 127-138.
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Olivier Oudar, Alain Moreau, Gérard Feldmann & Jean-Yves Scoazec. (1998) Expression and regulation of intercellular adhesion molecule-1 (ICAM-1) in organotypic cultures of rat liver tissue. Journal of Hepatology 29:6, pages 901-909.
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D. Müller, R. Glöckner, M. Rost & P. Steinmetzer. (1998) Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slices. Experimental and Toxicologic Pathology 50:4-6, pages 507-513.
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