Citations (43)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (13)
Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Hiroshi Ikeda, Satoshi Maeda, Machiko Hattori, Megumi Nishiwaki, Kazuhiko Kato & Hiroshi Yamazaki. (2021) Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19. Xenobiotica 51:4, pages 479-493.
Read now
Read now
Shigeyuki Kitamura & Kazumi Sugihara. (2014) Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver. Xenobiotica 44:2, pages 123-134.
Read now
Read now
Chiaki Tanoue, Kazumi Sugihara, Naoto Uramaru, Yoshitaka Tayama, Yoko Watanabe, Toru Horie, Shigeru Ohta & Shigeyuki Kitamura. (2013) Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes. Xenobiotica 43:11, pages 956-962.
Read now
Read now
Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
Read now
Read now
Marieke M Ebbens & Joris C Verster. (2010) Clinical evaluation of zaleplon in the treatment of insomnia. Nature and Science of Sleep 2, pages 115-126.
Read now
Read now
A. Madan, A. Fisher, L. Jin, D. Chapman & H. P. Bozigian. (2007) metabolism of indiplon and an assessment of its drug interaction potential. Xenobiotica 37:7, pages 736-752.
Read now
Read now
M. D. Lee, E. Ayanoglu & L. Gong. (2006) Drug-induced changes in P450 enzyme expression at the gene expression level: A new dimension to the analysis of drug–drug interactions. Xenobiotica 36:10-11, pages 1013-1080.
Read now
Read now
Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
Read now
Read now
B. G. Lake, S. E. Ball, J. Kao, A. B. Renwick, R. J. Price & J. A. Scatina. (2002) Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. Xenobiotica 32:10, pages 835-847.
Read now
Read now
A. B. Renwick, S. E. Ball, J. M. Tredger, R. J. Price, D. G. Walters, J. Kao, J. A. Scatina & B. G. Lake. (2002) Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices. Xenobiotica 32:10, pages 849-862.
Read now
Read now
A. B. Renwick, D. F. V. Lewis, S. Fulford, D. Surry, B. Williams, P. D. Worboys, X. Cai, R. W. Wang, R. J. Price, B. G. Lake & D. C. Evans. (2001) Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4. Xenobiotica 31:4, pages 187-204.
Read now
Read now
William E Heydorn. (2000) Zaleplon - a review of a novel sedative hypnotic used in the treatment of insomnia. Expert Opinion on Investigational Drugs 9:4, pages 841-858.
Read now
Read now
A. B. Renwick, D. Surry, R. J. Price, B. G. Lake & D. C. Evans. (2000) Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms. Xenobiotica 30:10, pages 955-969.
Read now
Read now
Articles from other publishers (30)
A.W. Jones, F. Musshoff, T. Krämer, A. E. Steuer, D. Gerostamoulos, O.H. Drummer, G. Drasch, M. Balikova, J. Beyer, H. Teixeira, M. Thevis, W. Schänzer, H. Druid & G. Skopp. 2022. Handbook of Forensic Medicine. Handbook of Forensic Medicine
1167
1312
.
Alexander V. LyubimovEugene G. Hrycay & Stelvio M. Bandiera. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
36
.
Yasushi Yamazoe & Kouichi Yoshinari. (2017) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system. Drug Metabolism and Pharmacokinetics 32:5, pages 229-247.
Crossref
Crossref
Malik A. Waseem, Ali Mohd Lone, Farah Ibad, Afshan Ibad, Vijay B. Yadav, Khursheed Ansari, Bashir Ahamad Shairjogrey, Geeta Watal & I. R. Siddiqui. (2017) Double Hydroamination of Alkyne via PTC and Microwave-activated Diastereoselective Synthesis of 2,3-dihydroimidazo[1,2-a]pyridine in an Aqueous Media. Journal of Heterocyclic Chemistry 54:5, pages 2733-2739.
Crossref
Crossref
Wenwen Gong, Pingxiang Xu, Shanshan Guo, Xiaorong Li, Zengliang Jin, Yuming Zhao, Ming Fan & Ming Xue. (2017) Effect of hypoxia on the pharmacokinetics and metabolism of zaleplon as a probe of CYP3A1/2 activity. RSC Advances 7:41, pages 25414-25421.
Crossref
Crossref
Julia C. Stingl, Susanne Welker, Gunther Hartmann, Volker Damann & Ruppert Gerzer. (2015) Where Failure Is Not an Option –Personalized Medicine in Astronauts. PLOS ONE 10:10, pages e0140764.
Crossref
Crossref
Philip M. Becker & Manya Somiah. (2015) Non–Benzodiazepine Receptor Agonists for Insomnia. Sleep Medicine Clinics 10:1, pages 57-76.
Crossref
Crossref
Alan Wayne Jones, Frank Musshoff, Thomas Kraemer, Andrea E. Schwaninger, Dimitri Gerostamoulos, Olaf H. Drummer, Gustav Drasch, Marie A. Balíková, Jochen Beyer, Helena Teixeira, Mario Thevis & Wilhelm Schänzer. 2014. Handbook of Forensic Medicine. Handbook of Forensic Medicine
900
993
.
Domenic A. Ciraulo & Mark Oldham. 2014. The Effects of Drug Abuse on the Human Nervous System. The Effects of Drug Abuse on the Human Nervous System
499
532
.
Chiaki Tanoue, Kazumi Sugihara, Naoto Uramaru, Yoko Watanabe, Yoshitaka Tayama, Shigeru Ohta & Shigeyuki Kitamura. (2013) Strain Difference of Oxidative Metabolism of the Sedative-hypnotic Zaleplon by Aldehyde Oxidase and Cytochrome P450 In Vivo and In Vitro in Rats. Drug Metabolism and Pharmacokinetics 28:3, pages 269-273.
Crossref
Crossref
Pierre Baumann & Christoph Hiemke. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics
301
329
.
Takafumi Akabane, Nicolas Gerst, Yoichi Naritomi, Jeffrey N. Masters & Kouichi Tamura. (2012) A Practical and Direct Comparison of Intrinsic Metabolic Clearance of Several Non-CYP Enzyme Substrates in Freshly Isolated and Cryopreserved Hepatocytes. Drug Metabolism and Pharmacokinetics 27:2, pages 181-191.
Crossref
Crossref
Fraser F. Fleming, Lihua Yao, P. C. Ravikumar, Lee Funk & Brian C. Shook. (2010) Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore. Journal of Medicinal Chemistry 53:22, pages 7902-7917.
Crossref
Crossref
Shayne Cox GadEugene G. Hrycay & Stelvio M. Bandiera. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Sepuri Asha & Maravajhala Vidyavathi. (2009) Role of Human Liver Microsomes in In Vitro Metabolism of Drugs—A Review. Applied Biochemistry and Biotechnology 160:6, pages 1699-1722.
Crossref
Crossref
A.L. Morera, P. Abreu-Gonzalez & M. Henry. (2009) Zaleplon increases nocturnal melatonin secretion in humans. Progress in Neuro-Psychopharmacology and Biological Psychiatry 33:6, pages 1013-1016.
Crossref
Crossref
Ajam C. Shaikh & Chinpiao Chen. (2008)
Synthesis of deuterium‐labeled zaleplon‐
d
5
as an internal standard
. Journal of Labelled Compounds and Radiopharmaceuticals 51:1, pages 72-76.
Crossref
Crossref
Manoli Vourvahis & Angela D. M. Kashuba. (2012) Mechanisms of Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Ritonavir‐Enhanced Tipranavir. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 27:6, pages 888-909.
Crossref
Crossref
Beibei Zhang, Zunjian Zhang, Yuan Tian, Fengguo Xu & Yun Chen. (2006) High-performance liquid chromatography–atmospheric pressure chemical ionisation-mass spectrometry determination of zaleplon in human plasma. Journal of Pharmaceutical and Biomedical Analysis 40:3, pages 707-714.
Crossref
Crossref
David R Drover. (2004) Comparative Pharmacokinetics and Pharmacodynamics of Short-Acting Hypnosedatives. Clinical Pharmacokinetics 43:4, pages 227-238.
Crossref
Crossref
Christian Horstkötter, Dirk Schepmann & Gottfried Blaschke. (2003) Separation and identification of zaleplon metabolites in human urine using capillary electrophoresis with laser-induced fluorescence detection and liquid chromatography–mass spectrometry. Journal of Chromatography A 1014:1-2, pages 71-81.
Crossref
Crossref
Leah M Hesse, Lisa L von Moltke & David J Greenblatt. (2003) Clinically Important Drug Interactions with Zopiclone, Zolpidem and Zaleplon. CNS Drugs 17:7, pages 513-532.
Crossref
Crossref
M. Teresa Donato & Jos?? V. Castell. (2003) Strategies and Molecular Probes to Investigate the Role of Cytochrome P450 in Drug Metabolism. Clinical Pharmacokinetics 42:2, pages 153-178.
Crossref
Crossref
Andrew Glenn Israel & Jeffrey A Kramer. (2016) Safety of Zaleplon in the Treatment of Insomnia. Annals of Pharmacotherapy 36:5, pages 852-859.
Crossref
Crossref
Kristin Wiisanen Weitzel, Julie M. Wickman, Sara Grimsley Augustin & J.Grady Strom. (2000) Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia. Clinical Therapeutics 22:11, pages 1254-1267.
Crossref
Crossref
Dennis J. CadaDanial E. BakerTerri Levien. (2017) Zaleplon. Hospital Pharmacy 35:1, pages 77-86.
Crossref
Crossref
Yi Wang & Jashvant D. Unadkat. (1999) Enzymes in addition to CYP3A4 and 3A5 mediateN-demethylation of dextromethorphan in human liver microsomes. Biopharmaceutics & Drug Disposition 20:7, pages 341-346.
Crossref
Crossref
Cynthia K. Kirkwood. (1999) Management of Insomnia. Journal of the American Pharmaceutical Association (1996) 39:5, pages 688-696.
Crossref
Crossref
Amy S. Rosen, Philippe Fournié, Mona Darwish, Philippe Danjou & Steven M. Troy. (1999) Zaleplon pharmacokinetics and absolute bioavailability. Biopharmaceutics & Drug Disposition 20:3, pages 171-175.
Crossref
Crossref
David J. Greenblatt, Jerold S. Harmatz, Lisa L. von Moltke, Bruce L. Ehrenberg, Lisa Harrel, Kate Corbett, Molly Counihan, Jennifer A. Graf, Mona Darwish, Polyxane Mertzanis, Patrick T. Martin, William H. Cevallos & Richard I. Shader. (1998) Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo*. Clinical Pharmacology & Therapeutics 64:5, pages 553-561.
Crossref
Crossref