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Journal of Liquid Chromatography Volume 14, 1991 - Issue 4
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Original Articles

Direct HPLC Separation of Thalidomide Enantiomers Using Cellulose Tris-4-Methylphenyl Benzoate Chiral Stationary Phase

Hassan Y. Aboul-enein Drug Development Laboratory Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh, 11211, Saudi Arabia
&
M. Rafiqul Islam Drug Development Laboratory Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh, 11211, Saudi Arabia
Pages 667-673 | Published online: 23 Oct 2006

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Read on this site (5)

Guy Felix & Alain Berthod. (2007) Commercial Chiral Stationary Phases for the Separations of Clinical Racemic Drugs. Separation & Purification Reviews 36:4, pages 285-481.
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Richard Thompson. (2005) A Practical Guide to HPLC Enantioseparations for Pharmaceutical Compounds. Journal of Liquid Chromatography & Related Technologies 28:7-8, pages 1215-1231.
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Ahsanul Haque & JamesT. Stewart. (1998) Determination of Racemic Thalidomide in Human Plasma by use of an Avidin Column and Solid Phase Extraction. Journal of Liquid Chromatography & Related Technologies 21:14, pages 2151-2163.
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Robert Rothchild, Kerry Sanders & KunisiS. Venkatasubban. (1993) NMR Studies of Drugs. Use of Lanthanide Shift Reagents in Polar Solvent with Thalidomide. Spectroscopy Letters 26:4, pages 597-619.
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HassanY. Aboul-Enein. (1992) Applications of Cellulose-Based Chiral Stationary Phases in Resolution of Drug Racemates a Mini Review. Analytical Letters 25:2, pages 231-238.
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Articles from other publishers (20)

Jiaxin Xiao, Tingting Tang, Xiao Liang, Kunlin Liu, Yujie Tang, Jun Li & Chaoyang Li. (2021) Chirality and concentration detection of biomolecules based on spin Hall effect of light. Physics Letters A 416, pages 127692.
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Lindsay Candelaria, Liliya V. Frolova, Brian M. Kowalski, Kateryna Artyushkova, Alexey Serov & Nikolai G. Kalugin. (2018) Surface-modified three-dimensional graphene nanosheets as a stationary phase for chromatographic separation of chiral drugs. Scientific Reports 8:1.
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Zoltán-István Szabó, Foroughbakhshfasaei Mohammadhassan, Levente Szőcs, József Nagy, Balázs Komjáti, Béla Noszál & Gergő Tóth. (2016) Stereoselective interactions and liquid chromatographic enantioseparation of thalidomide on cyclodextrin-bonded stationary phases. Journal of Inclusion Phenomena and Macrocyclic Chemistry 85:3-4, pages 227-236.
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Lei-Lei Chen, Fen-Fang Li & Zhi-Jian Tan. (2015) Chiral separation of α-cyclohexylmandelic acid enantiomers using ionic liquid/salt aqueous two-phase system. Chemical Papers 69:11.
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M. Espinosa Bosch, A.J. Ruiz Sánchez, F. Sánchez Rojas & C. Bosch Ojeda. (2008) Recent advances in analytical determination of thalidomide and its metabolites. Journal of Pharmaceutical and Biomedical Analysis 46:1, pages 9-17.
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Wenjian Lao & Jay Gan. (2006) Responses of enantioselective characteristics of imidazolinone herbicides and Chiralcel OJ column to temperature variations. Journal of Chromatography A 1131:1-2, pages 74-84.
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Yuan-Ping Ruan, Bang-Guo Wei, Xiu-Qing Xu, Gang Liu, De-Sheng Yu, Liang-Xian Liu & Pei-Qiang Huang. (2005) Detailed studies on the enantioselective synthesis and HPLC enantioseparation ofN-protected 3-hydroxyglutarimides. Chirality 17:9, pages 595-599.
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Michael Meyring, Bezhan Chankvetadze & Gottfried Blaschke. (2000) Simultaneous separation and enantioseparation of thalidomide and its hydroxylated metabolites using high-performance liquid chromatography in common-size columns, capillary liquid chromatography and nonaqueous capillary electrochromatography. Journal of Chromatography A 876:1-2, pages 157-167.
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Michael Meyring, Bezhan Chankvetadze & Gottfried Blaschke. (1999) Enantioseparation of thalidomide and its hydroxylated metabolites using capillary electrophoresis with various cyclodextrins and their combinations as chiral buffer additives. Electrophoresis 20:12, pages 2425-2431.
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Tommy Eriksson, Sven Bj�rkman, Bodil Roth, �sa Fyge & Peter H�glun. (1998) Enantiomers of thalidomide: blood distribution and the influence of serum albumin on chiral inversion and hydrolysis. Chirality 10:3, pages 223-228.
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A Chimirri, S Grasso, C Molica, A-M Monforte, P Monforte, M Zappalà, G Bruno, F Nicolò, M Witvrouw, H Jonckeere, J Balzarini & E De Clercq. (2016) Structural Features and Anti-Human Immunodeficiency Virus (HIV) Activity of the Isomers of 1-(2′,6′-Difluorophenyl)-1 H ,3 H -Thiazolo[3,4- a ]Benzimidazole, a Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor . Antiviral Chemistry and Chemotherapy 8:4, pages 363-370.
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An Van Overbeke, Hassan Y. Aboul-Enein, Willy Baeyens, Guido Van der Weken & Chris Dewaele. (1997) Enantiomeric separation of some piperidine-2,6-dione drugs on tolylcellulose by liquid chromatography. Analytica Chimica Acta 346:2, pages 183-189.
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Thomas J. Wenzel, Rebecca D. Miles & Sarah E. Weinstein. (1997) Chiral nuclear magnetic resonance shift reagents: Lanthanide mixtures with 1-(1-naphthyl) ethylurea derivatives of amino acids. Chirality 9:1, pages 1-9.
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Hassan Y. Aboul-Enein & Soliman A. Bakr. (1997) Enantiomeric separation of some piperidine-2,6-dione drugs using chiralcel OJ-R column. Chirality 9:1, pages 10-12.
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Yubing Tang, John C. Reepmeyer, Larry K. Revelle & Joe A. Wilson. (1996) Enantioseparation of 3-phenylacetylamino-2,6-piperidinedione and related chiral compounds. Journal of Chromatography A 752:1-2, pages 93-99.
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Stephan Wnendt, Michael Finkam, Werner Winter, Joachim Ossig, Gerd Raabe & Kai Zwingenberger. (1996) Enantioselective inhibition of TNF-? release by thalidomide and thalidomide-analogues. Chirality 8:5, pages 390-396.
Crossref
John C. Reepmeyer. (1996) Separation of R- and S-Thalidomide by Reversed-Phase HPLC with ?-cyclodextrin in the mobile phase. Chirality 8:1, pages 11-17.
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Eiji Yashima & Yoshio Okamoto. (1995) Chiral Discrimination on Polysaccharides Derivatives. Bulletin of the Chemical Society of Japan 68:12, pages 3289-3307.
Crossref
Tommy Eriksson, Sven Bjöurkman, Bodil Roth, Årsa Fyge & Peter Höuglund. (2004) Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide. Chirality 7:1, pages 44-52.
Crossref
R. Q. Auc�lio & A. D. Campiglia. (1994) Pharmaceutical formulation analysis of thalidomide by solid surface room temperature phosphorimetry. Mikrochimica Acta 117:1-2, pages 75-85.
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