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Journal of Liquid Chromatography Volume 14, 1991 - Issue 5: Capillary Zone Electrophoresis
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Original Articles

Method Development and Selectivity Control for Small Molecule Pharmaceutical Separations by Capillary Electrophoresis

Michael E. Swartz Bio/Pharmaceutical Laboratory Waters Divison of Millipore 34 Maple Street Milford, Massachusetts, 01757
Pages 923-938 | Published online: 23 Oct 2006

Citations (70)

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Read on this site (5)

Z. Zhang, X. Chen & Z. Hu. (1997) Determination of Three Water-Soluble Active Ingredients in Qiangli Yingqiao Containing Vc Tablets by Capillary Zone Electrophoresis. Journal of Liquid Chromatography & Related Technologies 20:19, pages 3245-3255.
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HaleemJ. Issaq. (1994) Comparison of Chiral Separations in Capillary Zone Electrophoresis with Other Methods∗ . Instrumentation Science & Technology 22:2, pages 119-149.
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K.D. Altria & S.D. Filbey. (1993) Quantitative Pharmaceutical Analysis by Capillary Electrophoresis. Journal of Liquid Chromatography 16:11, pages 2281-2292.
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ChristineL. Copper, TracyD. Staller & MichaelJ. Sepaniak. (1993) Characterization of Polyaromatic Hydrocarbon Mixtures by Micellar Electrokinetic Capillary Chromatography. Polycyclic Aromatic Compounds 3:2, pages 121-135.
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MichaelJ. Sepaniak, RodericO. Cole & BrianK. Clark. (1992) Use of Native and Chemically Modified Cyclodextrins for the Capillary Electrophoretic Separation of Enantiomers. Journal of Liquid Chromatography 15:6-7, pages 1023-1040.
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Articles from other publishers (65)

Himangshu S. Bose, Randy M. Whittal, Brendan Marshall, Maheshinie Rajapaksha, Ning Ping Wang, Madhuchanda Bose, Elizabeth W. Perry, Zhi-Qing Zhao & Walter L. Miller. (2021) A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart. Journal of Pharmacology and Experimental Therapeutics 377:1, pages 108-120.
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Abolghasem Jouyban & Ernst Kenndler. (2008) Impurity analysis of pharmaceuticals using capillary electromigration methods. ELECTROPHORESIS 29:17, pages 3531-3551.
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Swapna Mallampati, Jochen Pauwels, Jos Hoogmartens & Ann Van Schepdael. 2008. Capillary Electrophoresis Methods for Pharmaceutical Analysis. Capillary Electrophoresis Methods for Pharmaceutical Analysis 259 315 .
Hermann W?tzig. 2008. Capillary Electrophoresis Methods for Pharmaceutical Analysis. Capillary Electrophoresis Methods for Pharmaceutical Analysis 225 244 .
T. G. Morzunova. (2006) Capillary electrophoresis in pharmaceutical analysis (A review). Pharmaceutical Chemistry Journal 40:3, pages 158-170.
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Henrik T. Rasmussen, Weiyong Li, Dirk Redlich & M. Ilias Jimidar. 2005. Handbook of Pharmaceutical Analysis by HPLC. Handbook of Pharmaceutical Analysis by HPLC 145 190 .
Martijn J. Hilhorst, Govert W. Somsen & Gerhardus J. de Jong. (2001) Capillary electrokinetic separation techniques for profiling of drugs and related products. ELECTROPHORESIS 22:12, pages 2542-2564.
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S. S. Park, A. Cate & B. S. Chang. 2001. CE in Biotechnology: Practical Applications for Protein and Peptide Analyses. CE in Biotechnology: Practical Applications for Protein and Peptide Analyses 34 38 .
Bernhard Koppenhoefer, Andreas Jakob, Xiaofeng Zhu & Bingcheng Lin. (2000) Separation of Enantiomers of Drugs by Capillary Electrophoresis with Permethyl-gamma-Cyclodextrin as Chiral Solvating Agent. Journal of High Resolution Chromatography 23:6, pages 413-429.
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Bernhard Koppenhoefer, Xiaofeng Zhu, Andreas Jakob, Stefan Wuerthner & Bingcheng Lin. (2000) Separation of drug enantiomers by capillary electrophoresis in the presence of neutral cyclodextrins. Journal of Chromatography A 875:1-2, pages 135-161.
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Lucas Fotsing, Marianne Fillet, Patrice Chiap, Philippe Hubert & Jacques Crommen. (1999) Elimination of adsorption effects in the analysis of water-soluble vitamins in pharmaceutical formulations by capillary electrophoresis. Journal of Chromatography A 853:1-2, pages 391-401.
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Xiaofeng Zhu, Bingcheng Lin, Andreas Jakob, Stefan Wuerthner & Bernhard Koppenhoefer. (1999) Separation of drugs by capillary electrophoresis, Part 10. Permethyl-alpha-cyclodextrin as chiral solvating agent. Electrophoresis 20:9, pages 1878-1889.
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Vahid Majidi, Johanna Qvarnström, Qiang Tu, Wolfgang Frech & Yngvar Thomassen. (1999) Improving sensitivity for CE-ICP-MS using multicapillary parallel separation. J. Anal. At. Spectrom. 14:12, pages 1933-1935.
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Hermann Wätzig, Matthias Degenhardt & Annette Kunkel. (2005) Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications. ELECTROPHORESIS 19:16-17, pages 2695-2752.
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K.D Altria, M.A Kelly & B.J Clark. (1998) Current applications in the analysis of pharmaceuticals by capillary electrophoresis. II. TrAC Trends in Analytical Chemistry 17:4, pages 214-226.
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Lin Bingcheng, Zhu Xiaofeng, Ulrich Epperlein, Marc Schwierskott, Rainer Schlunk & Bernhard Koppenhoefer. (1998) Separation of Enantiomers of Drugs by Capillary Electrophoresis, Part 6. Hydroxypropyl-β-cyclodextrin as Chiral Solvating Agent. Journal of High Resolution Chromatography 21:4, pages 215-224.
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Kevin D. AltriaKevin D. Altria. 1998. Analysis of Pharmaceuticals by Capillary Electrophoresis. Analysis of Pharmaceuticals by Capillary Electrophoresis 44 69 .
Kevin D. AltriaKevin D. Altria. 1998. Analysis of Pharmaceuticals by Capillary Electrophoresis. Analysis of Pharmaceuticals by Capillary Electrophoresis 1 20 .
A.K Lalloo & I Kanfer. (1997) Determination of erythromycin and related substances by capillary electrophoresis. Journal of Chromatography B: Biomedical Sciences and Applications 704:1-2, pages 343-350.
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Byung-Yun Cho, Richard Strong, Gwen Fate & Ira S. Krull. (1997) High-performance capillary electrophoresis of a fermentation-derived cyclic peptide analog, animal growth promoter. Journal of Chromatography B: Biomedical Sciences and Applications 697:1-2, pages 163-174.
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P.G. Muijselaar, K. Otsuka & S. Terabe. (1997) Micelles as pseudo-stationary phases in micellar electrokinetic chromatography. Journal of Chromatography A 780:1-2, pages 41-61.
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H. Nishi. (1997) Pharmaceutical applications of micelles in chromatography and electrophoresis. Journal of Chromatography A 780:1-2, pages 243-264.
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Z. K. Shihabi. 1996. Handbook of Capillary Electrophoresis Applications. Handbook of Capillary Electrophoresis Applications 386 408 .
T. J. O’shea. 1996. Handbook of Capillary Electrophoresis Applications. Handbook of Capillary Electrophoresis Applications 301 323 .
Viviana G. Rodríguez, Silvia E Lucangioll, Germán C. Fernández Otero & Clyde N. Carducci. (2005) Purity testing of drugs by capillary electrophoresis. Journal of High Resolution Chromatography 19:12, pages 703-705.
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Stephen Naylor, Linda M. Benson & Andy J. Tomlinson. (1996) Application of capillary electrophoresis and related techniques to drug metabolism studies. Journal of Chromatography A 735:1-2, pages 415-438.
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Nishi Hiroyuki & Shigeru Terabe. (1996) Micellar electrokinetic chromatography Perspectives in drug analysis. Journal of Chromatography A 735:1-2, pages 3-27.
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R. Carabias Martínez, E. Rodríguez Gonzalo, A.I. Muñoz Domínguez, J. Domínguez Alvarez & J. Hernández Méndez. (1996) Determination of triazine herbicides in water by micellar electrokinetic capillary chromatography. Journal of Chromatography A 733:1-2, pages 349-360.
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Michael E. Swartz, Jeffrey R. Mazzeo, Edward R. Grover & Phyllis R. Brown. (1996) Validation of enantiomeric separations by micellar electrokinetic capillary chromatography using synthetic chiral surfactants. Journal of Chromatography A 735:1-2, pages 303-310.
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K.D. Altria. (1996) Determination of drug-related impurities by capillary electrophoresis. Journal of Chromatography A 735:1-2, pages 43-56.
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Michael E. Swartz, Jeffrey R. Mazzeo, Edward R. Grover, Phyllis R. Brown & Hassan Y. Aboul-Enein. (1996) Separation of piperidine-2,6-dione drug enantiomers by micellar electrokinetic capillary chromatography using synthetic chiral surfactants. Journal of Chromatography A 724:1-2, pages 307-316.
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Joseph P. Foley & Eric S. Ahuja. 1996. Pharmaceutical and Biomedical Applications of Capillary Electrophoresis. Pharmaceutical and Biomedical Applications of Capillary Electrophoresis 81 178 .
Johan Lindeberg. (1996) Capillary electrophoresis in food analysis. Food Chemistry 55:1, pages 73-94.
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Michael E. Swartz & Phyllis R. Brown. (1996) Use of mathematically enhanced spectral analysis and spectral contrast techniques for the liquid chromatographic and capillary electrophoretic detection and identification of pharmaceutical compounds. Chirality 8:1, pages 67-76.
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Anthony Aumatell & András Guttman. (1995) Ultra-fast chiral separation of basic drugs by capillary electrophoresis. Journal of Chromatography A 717:1-2, pages 229-234.
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K. D. Altria & D. R. Rudd. (2014) An overview of method validation and system suitability aspects in capillary electrophoresis. Chromatographia 41:5-6, pages 325-331.
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O. Stålberg, D. Westerlund, U. -B. Rodby & S. Schmidt. (2014) Determination of impurities in remoxipride by capillary electrophoresis using UV-detection and LIF-detection; principles to handle sample overloading effects. Chromatographia 41:5-6, pages 287-294.
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Wolfgang Lindner, Barbara Bo¨hs & Volker Seidel. (1995) Enantioselective capillary electrophoresis of amino acid derivatives on cyclodextrin evaluation of structure-resolution relationships. Journal of Chromatography A 697:1-2, pages 549-560.
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Hiroyuki Nishi & Shigeru Terabe. (1995) Optical resolution of drugs by capillary electrophoretic techniques. Journal of Chromatography A 694:1, pages 245-276.
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Thomas SchmittThomas Schmitt. 1995. Beiträge zur Enantiomerentrennung in der Kapillarelektrophorese. Beiträge zur Enantiomerentrennung in der Kapillarelektrophorese 234 240 .
Anthony Aumatell, Robert J. Wells & Danny K.Y. Wong. (1994) Enantiomeric differentiation of a wide range of pharmacologically active substances by capillary electrophoresis using modified β-cyclodextrins. Journal of Chromatography A 686:2, pages 293-307.
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Jeffrey R. Mazzeo, Edward R. Grover, Michael E. Swartz & John S. Petersen. (1994) Novel chiral surfactant for the separation of enantiomers by micellar electrokinetic capillary chromatography. Journal of Chromatography A 680:1, pages 125-135.
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K. D. Altria, N. G. Clayton, M. Hart, R. C. Harden, J. Hevizi, J. V. Makwana & M. J. Portsmouth. (1994) An inter-company cross-validation exercise on capillary electrophoresis testing of dose uniformity of paracetamol content in formulations. Chromatographia 39:3-4, pages 180-184.
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Cheryl L. Flurer & Karen A. Wolnik. (1994) Chemical profiling of pharmaceuticals by capillary electrophoresis in the determination of drug origin. Journal of Chromatography A 674:1-2, pages 153-163.
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S. Boonkerd, M.R. Detaevernier & Y. Michotte. (1994) Use of capillary electrophoresis for the determination of vitamins of the B group in pharmaceutical preparations. Journal of Chromatography A 670:1-2, pages 209-214.
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Shigeru Terabe, Koji Otsuka & Hiroyuki Nishi. (1994) Separation of enantiomers by capillary electrophoretic techniques. Journal of Chromatography A 666:1-2, pages 295-319.
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R. C. Williams, J. F. Edwards & C. R. Ainsworth. (1994) Analysis of diastereoisomer impurities in chiral pharmaceutical compounds by capillary electrophoresis. Chromatographia 38:7-8, pages 441-446.
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Reinhard Kuhn, Joseph Wagner, Yvonne Walbroehl & Thomas Bereuter. (2005) Potential and limitations of an optically active crown ether for chiral separation in capillary zone electrophoresis. ELECTROPHORESIS 15:1, pages 828-834.
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Radim Vespalec & Petr Boček. (2005) Chiral separations by capillary electrophoresis: Present state of the art. ELECTROPHORESIS 15:1, pages 755-762.
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Andy J. Tomlinson, Linda M. Benson, Kenneth L. Johnson & Stephen Naylor. (2005) Investigation of drug metabolism using capillary electrophoresis with photodiode array detection and online mass spectrometry equipped with an array detector. ELECTROPHORESIS 15:1, pages 62-71.
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M. Idei, I. Mező, Zs. Vadász, A. Horváth, I. Teplán & Gy. Kéri. (1993) Comparison of high-performance liquid chromatography and capillary electrophoresis in the analysis of somatostatin analogue peptides. Journal of Chromatography A 648:1, pages 251-256.
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K.D. Altria & Y.L. Chanter. (1993) Validation of a capillary electrophoresis method for the determination of a quinolone antibiotic and its related impurities. Journal of Chromatography A 652:2, pages 459-463.
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K.D. Altria. (1993) Quantitative aspects of the application of capillary electrophoresis to the analysis of pharmaceuticals and drug related impurities. Journal of Chromatography A 646:2, pages 245-257.
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K.D. Altria, R.C. Harden, M. Hart, J. Hevizi, P.A. Hailey, J.V. Makwana & M.J. Portsmouth. (1993) Inter-company cross-validation exercise on capillary electrophoresis. Journal of Chromatography A 641:1, pages 147-153.
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Michael E. Swartz. (1993) Capillary electrophoretic determination of inorganic ions in a prenatal vitamin formulation. Journal of Chromatography A 640:1-2, pages 441-444.
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K. D. Altria. (1993) High and low injection volumes in CE for improved quantitative determination of drug related impurities. Chromatographia 35:9-12, pages 493-496.
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K.D. Altria & D.C.M. Luscombe. (1993) Application of capillary electrophoresis as a quantitative identity test for pharmaceuticals employing automated on-column standard addition. Journal of Pharmaceutical and Biomedical Analysis 11:4-5, pages 415-420.
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K.D. Altria. (1993) High-speed determination of drug related impurities by capillary electrophoresis employing commercial instrumentation. Journal of Chromatography A 636:1, pages 125-132.
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Michael E. Swartz & Michael Merion. (1993) On-line sample preconcentration on a packed-inlet capillary for improving the sensitivity of capillary electrophoretic analysis of pharmaceuticals. Journal of Chromatography A 632:1-2, pages 209-213.
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K. D. Altria. (1993) Essential peak area normalisation for quantitative impurity content determination by capillary electrophoresis. Chromatographia 35:3-4, pages 177-182.
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Robert Weinberger. 1993. Practical Capillary Electrophoresis. Practical Capillary Electrophoresis 267 285 .
Eric W. Tsai, Manohar M. Singh, Hannah H. Lu, Dominic P. Ip & Marvin A. Brooks. (1992) Application of capillary electrophoresis to pharmaceutical analysis. Journal of Chromatography A 626:2, pages 245-250.
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Jirˇi´ Snopek, Ivan Jeli´nek & Eva Smolkova´-Keulemansova´. (1992) Chiral separation by analytical electromigration methods. Journal of Chromatography A 609:1-2, pages 1-17.
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Ira S. Lurie. (1992) Micellar electrokinetic capillary chromatography of the enantiomers of amphetamine, methamphetamine and their hydroxyphenethylamine precursors. Journal of Chromatography A 605:2, pages 269-275.
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