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Journal of Dispersion Science and Technology Volume 32, 2011 - Issue 6
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Original Articles

Formulation of a Poorly Water-Soluble Drug Sirolimus in Solid Dispersions to Improve Dissolution

A. C. Preetham Department of Pharmaceutics, PES College of Pharmacy, Hanumanthanagar, Bangalore, India
&
C. S. Satish Department of Pharmaceutics, PES College of Pharmacy, Hanumanthanagar, Bangalore, IndiaCorrespondence[email protected]
Pages 778-783 | Received 16 Feb 2010, Accepted 30 Mar 2010, Published online: 23 May 2011

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Ho Yub Yoon, In Ho Chang, Yoon Tae Goo, Chang Hyun Kim, Tae Hoon Kang, Soo-Yeon Kim, Sang Jin Lee, Seh Hyon Song, Young Mi Whang & Young Wook Choi. (2019) Intravesical delivery of rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel. International Journal of Nanomedicine 14, pages 6249-6268.
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Wonkyung Cho, Min-Soo Kim, Jeong-Soo Kim, Junsung Park, Hee Jun Park, Kwang-Ho Cha, Jeong-Sook Park & Sung-Joo Hwang. (2013) Optimized formulation of solid self-microemulsifying sirolimus delivery systems. International Journal of Nanomedicine 8, pages 1673-1682.
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Min-Soo Kim, Jeong-Soo Kim, Hee Jun Park, Won Kyung Cho, Kwang-Ho Cha & Sung-Joo Hwang. (2011) Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process. International Journal of Nanomedicine 6, pages 2997-3009.
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Articles from other publishers (12)

Yasir Mehmood, Hira Shahid, Muhammad Abbas, Umar Farooq, Shaukat Ali & Mohsin Kazi. (2023) Microsponge-derived mini tablets loaded with immunosuppressive agents: Pharmacokinetic investigation in human volunteers, cell viability and IVIVC correlation. Saudi Pharmaceutical Journal 31:11, pages 101799.
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Reshal Suri, Yub Raj Neupane, Nikita Mehra, Md Nematullah, Farah Khan, Ozair Alam, Ashif Iqubal, Gaurav Kumar Jain & Kanchan Kohli. (2021) Sirolimus loaded chitosan functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles for potential treatment of age-related macular degeneration. International Journal of Biological Macromolecules 191, pages 548-559.
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Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Cao Dai Phung, Beom Soo Shin, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong & Jong Oh Kim. (2017) Targeted co-delivery of polypyrrole and rapamycin by trastuzumab-conjugated liposomes for combined chemo-photothermal therapy. International Journal of Pharmaceutics 527:1-2, pages 61-71.
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Hyo-Jung Lee, Ju-Young Kim, Sung-Hoon Park, Yun-Seok Rhee, Chun-Woong Park & Eun-Seok Park. (2017) Controlled-release oral dosage forms containing nimodipine solid dispersion and hydrophilic carriers. Journal of Drug Delivery Science and Technology 37, pages 28-37.
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Taehoon Sim, Chaemin Lim, Ngoc Ha Hoang, Hyonsung Joo, Jun Won Lee, Da-won Kim, Eun Seong Lee, Yu Seok Youn, Jong Oh Kim & Kyung Taek Oh. (2016) Nanomedicines for oral administration based on diverse nanoplatform. Journal of Pharmaceutical Investigation 46:4, pages 351-362.
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Youngseok Cho, Eun-Sol Ha, In-Hwan Baek, Min-Soo Kim, Cheong-Weon Cho & Sung-Joo Hwang. (2015) Enhanced Supersaturation and Oral Absorption of Sirolimus Using an Amorphous Solid Dispersion Based on Eudragit® E. Molecules 20:6, pages 9496-9509.
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Simone R. Carvalho, Alan B. Watts, Jay I. Peters, Sha Liu, Soraya Hengsawas, Manuel S. Escotet-Espinoza & Robert O. Williams III. (2014) Characterization and pharmacokinetic analysis of crystalline versus amorphous rapamycin dry powder via pulmonary administration in rats. European Journal of Pharmaceutics and Biopharmaceutics 88:1, pages 136-147.
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Naba Elsaid, Satyanarayana Somavarapu & Timothy L. Jackson. (2014) Cholesterol-poly(ethylene) glycol nanocarriers for the transscleral delivery of sirolimus. Experimental Eye Research 121, pages 121-129.
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Ying Lu & Kinam Park. (2013) Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs. International Journal of Pharmaceutics 453:1, pages 198-214.
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Marija Petruševska, Miha Homar, Boštjan Petek, Aleksander Resman, Darko Kocjan, Uroš Urleb & Luka Peternel. (2013) Hydroxypropyl Methylcellulose Mediated Precipitation Inhibition of Sirolimus: From a Screening Campaign to a Proof-of-Concept Human Study. Molecular Pharmaceutics 10:6, pages 2299-2310.
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Min-Soo Kim, Jeong-Soo Kim, Wonkyung Cho, Kwang-Ho Cha, Hee-Jun Park, Junsung Park & Sung-Joo Hwang. (2013) Supersaturatable formulations for the enhanced oral absorption of sirolimus. International Journal of Pharmaceutics 445:1-2, pages 108-116.
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Xiongwei Hu, Chen Lin, Dingxiong Chen, Jing Zhang, Zhihong Liu, Wei Wu & Hongtao Song. (2012) Sirolimus solid self-microemulsifying pellets: Formulation development, characterization and bioavailability evaluation. International Journal of Pharmaceutics 438:1-2, pages 123-133.
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