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Original Articles

Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyrostats in meat production

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Pages 974-980 | Received 13 Mar 2006, Accepted 13 May 2006, Published online: 20 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Marco H. Blokland, Frederike E. van Tricht, Maria J. Groot, Leendert A. Van Ginkel & Saskia S. Sterk. (2021) Discrimination between the exogenous and endogenous origin of thiouracil in farm animals, the final chapter?. Food Additives & Contaminants: Part A 38:12, pages 2077-2090.
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Silvia Rocchi, Fulvia Caretti, Lucia Mainero Rocca, Virginia Pérez-Fernández, Pierpaolo Tomai, Chiara Dal Bosco, Roberta Curini & Alessandra Gentili. (2018) Subcritical water extraction of thyreostats from bovine muscle followed by liquid chromatography-tandem mass spectrometry. Food Additives & Contaminants: Part A 35:8, pages 1472-1483.
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Barbara Wozniak, Iwona Matraszek-Zuchowska, Sebastian Witek, Jan Zmudzki & Andrzej Posyniak. (2018) The effect of diet enriched with rapeseed meal on endogenous thiouracil contents in urine and milk of cattle. Food Additives & Contaminants: Part A 35:5, pages 892-899.
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Alessandra Gentili, Valeria De Pratti, Fulvia Caretti, Virginia Pérez-Fernández, Pierpaolo Tomai, Roberta Curini & Lucia Mainero Rocca. (2016) Residue analysis of thyreostats in baby foods via matrix solid phase dispersion and liquid chromatography – dual-polarity electrospray – tandem mass spectrometry. Food Additives & Contaminants: Part A 33:12, pages 1793-1802.
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Francesca Lega, Lidia Contiero, Giancarlo Biancotto & Roberto Angeletti. (2013) Determination of thyreostats in muscle and thyroid tissues by QuEChERS extraction and ultra-performance liquid chromatography tandem mass spectrometry. Food Additives & Contaminants: Part A 30:6, pages 949-957.
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Bruno Le Bizec, Emmanuelle Bichon, Yoann Deceuninck, Stéphanie Prévost, Fabrice Monteau, Jean-Philippe Antignac & Gaud Dervilly-Pinel. (2011) Toward a criterion for suspect thiouracil administration in animal husbandry. Food Additives & Contaminants: Part A 28:7, pages 840-847.
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J. Vanden Bussche, L. Vanhaecke, Y. Deceuninck, K. Wille, K. Bekaert, B. Le Bizec & H.F. De Brabander. (2011) Ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry detection of naturally occurring thiouracil in urine of untreated livestock, domesticated animals and humans. Food Additives & Contaminants: Part A 28:2, pages 166-172.
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Articles from other publishers (40)

Daniela Brocca & Stefania Salvatore. (2022) Report for 2020 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 19:2.
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B. Woźniak, S. Witek, I. Matraszek-Żuchowska, B. Sell & A. Posyniak. (2021) The effect of diet enriched with rapeseed meal on endogenous thiouracil contents in urine of calves. Research in Veterinary Science 136, pages 192-197.
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. (2021) Report for 2019 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 18:3.
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Konstantinos Koutsoumanis, Ana Allende, Avelino Alvarez‐Ordóñez, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, Robert Davies, Alessandra De Cesare, Lieve Herman, Roland Lindqvist, Maarten Nauta, Luisa Peixe, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Elisabetta Suffredini, Julio Álvarez Sánchez, Bojan Blagojevic, Peter Fürst, Bruno Garin‐Bastuji, Henrik Elvang Jensen, Peter Paulsen, Katleen Baert, Federica Barrucci, Alessandro Broglia, Marios Georgiadis, Michaela Hempen & Friederike Hilbert. (2020) Evaluation of public and animal health risks in case of a delayed post‐mortem inspection in ungulates. EFSA Journal 18:12.
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. (2020) Report for 2018 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 17:3.
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. (2019) Report for 2017 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 16:5.
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Barbara Woźniak, Iwona Matraszek-Żuchowska, Katarzyna Sielska, Sebastian Witek, Andrzej Posyniak, Krzysztof Niemczuk & Jan Żmudzki. (2018) Control of residues of thyreostats in slaughter animals in Poland in 2011–2017. Journal of Veterinary Research 62:4, pages 511-517.
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Ádám Tölgyesi, Anupam Giri, Enikő Barta, Thomas J McDonald & Virender K Sharma. (2018) Determination of Thyreostats in Urine Using Supported Liquid Extraction and Mixed-Mode Cation-Exchange Solid-Phase Extraction: Screening and Confirmatory Methods. Journal of Chromatographic Science 56:9, pages 858-866.
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. (2018) Report for 2016 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 15:6.
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Lieven Van Meulebroek, Jella Wauters, Beata Pomian, Julie Vanden Bussche, Philippe Delahaut, Eric Fichant & Lynn Vanhaecke. (2018) Discovery of urinary biomarkers to discriminate between exogenous and semi-endogenous thiouracil in cattle: A parallel-like randomized design. PLOS ONE 13:4, pages e0195351.
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Sebastian Witek, Barbara Wozniak, Iwona Matraszek-Zuchowska & Andrzej Posyniak. (2018) Analysis of thyreostats in bovine feces using ultra high performance liquid chromatography with tandem mass spectrometry. Journal of Separation Science 41:5, pages 1083-1090.
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. (2017) Report for 2015 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 14:11.
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J. Wauters, L. Van Meulebroek, E. Fichant, P. Delahaut & L. Vanhaecke. (2017) Discrimination between Synthetically Administered and Endogenous Thiouracil Based on Monitoring of Urine, Muscle, and Thyroid Tissue: An in Vivo Study in Young and Adult Bovines. Journal of Agricultural and Food Chemistry 65:30, pages 6231-6239.
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Leendert A. van Ginkel, Toine Bovee, Marco H. Blokland, Saskia S. Sterk, Nathalie G.E. Smits, Jelka Pleadin & Ana Vuli&x. 2016. Chemical Analysis of Non&;#x02010;antimicrobial Veterinary Drug Residues in Food. Chemical Analysis of Non&;#x02010;antimicrobial Veterinary Drug Residues in Food 141 244 .
Terenzio Bertuzzi, Silvia Rastelli, Annalisa Mulazzi & Amedeo Pietri. (2016) Trace Monitoring of Goitrin and Thiouracil in Milk and Cheese. Food Analytical Methods 9:10, pages 2952-2959.
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. (2016) Report for 2014 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 13:5.
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. (2015) Report for 2013 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 12:11.
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Julie A. L. Kiebooms, Jella Wauters, Julie Vanden Bussche & Lynn Vanhaecke. (2014) Validation of a quantitative method using liquid chromatography coupled to multiple mass spectrometry for thiouracil in feedstuffs used in animal husbandry. Analytical and Bioanalytical Chemistry 407:15, pages 4373-4384.
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Jella Wauters, Julie Vanden Bussche, Bruno Le Bizec, Julie A. L. Kiebooms, Gaud Dervilly-Pinel, Stéphanie Prevost, Barbara Wozniak, Saskia S. Sterk, Dag Grønningen, D. Glenn Kennedy, Sandra Russell, Philippe Delahaut & Lynn Vanhaecke. (2015) Toward a New European Threshold to Discriminate Illegally Administered from Naturally Occurring Thiouracil in Livestock. Journal of Agricultural and Food Chemistry 63:5, pages 1339-1346.
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Julie A. L. Kiebooms, Jella Wauters, Julie Vanden Bussche, Kurt Houf, Paul De Vos, Stefanie Van Trappen, Ilse Cleenwerck & Lynn Vanhaecke. (2014) Thiouracil-Forming Bacteria Identified and Characterized upon Porcine In Vitro Digestion of Brassicaceae Feed . Applied and Environmental Microbiology 80:23, pages 7433-7442.
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Barbara Wozniak, Sebastian Witek, Iwona Matraszek-Zuchowska & Jan Zmudzki. (2014) Development and Application of LC-MS/MS Method for the Detection of Naturally Occurring Thiouracil in Milk Samples. Food Analytical Methods 7:8, pages 1588-1597.
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. (2014) Report for 2012 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 11:6.
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. (2013) Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals). EFSA Journal 11:6, pages 3266.
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. (2013) Scientific Opinion on the public health hazards to be covered by inspection of meat from sheep and goats. EFSA Journal 11:6, pages 3265.
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. (2013) Report for 2011 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 10:4.
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Julie A. L. Kiebooms, Julie Vanden Bussche, Lieselot Y. Hemeryck, Veerle Fievez & Lynn Vanhaecke. (2012) Intestinal Microbiota Contribute to the Endogenous Formation of Thiouracil in Livestock. Journal of Agricultural and Food Chemistry 60:32, pages 7769-7776.
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Joe Boison. (2012) Analysis of antithyroid drug residues in food animals. Bioanalysis 4:16, pages 2067-2083.
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J. Vanden Bussche, S. S. Sterk, H. F. De Brabander, M. H. Blokland, Y. Deceuninck, B. Le Bizec & L. Vanhaecke. (2012) Thyreostatic drugs, stability in bovine and porcine urine. Analytical and Bioanalytical Chemistry 403:10, pages 2973-2982.
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. (2012) Report for 2010 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 9:3.
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Andrew Cannavan, Jack F. Kay & Bruno Le Bizec. 2011. Chemical Analysis of Antibiotic Residues in Food. Chemical Analysis of Antibiotic Residues in Food 327 345 .
Barbara Wozniak, Iwona Matraszek Zuchowska, Jan Zmudzki, Piotr Jedziniak, Beata Korycinska, Katarzyna Sielska, Sebastian Witek & Alicja Klopot. (2011) Liquid chromatography tandem mass spectrometry with ion trap and triple quadrupole analyzers for determination of thyreostatic drugs in urine and muscle tissue. Analytica Chimica Acta 700:1-2, pages 155-166.
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Julie Vanden Bussche, Julie A. L. Kiebooms, Nathalie De Clercq, Yoann Deceuninck, Bruno Le Bizec, Hubert F. De Brabander & Lynn Vanhaecke. (2011) Feed or Food Responsible for the Presence of Low-Level Thiouracil in Urine of Livestock and Humans?. Journal of Agricultural and Food Chemistry 59:10, pages 5786-5792.
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. (2011) Report for 2009 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publications 8:5.
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H. F. De Brabander, J. Vanden Bussche, K. Wille, K. Bekaert & L. Vanhaecke. (2010) The state of the art of residue analysis: the 6th VDRA symposium 2010. Drug Testing and Analysis 2:9, pages 421-423.
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J. Vanden Bussche, L. Vanhaecke, Y. Deceuninck, K. Verheyden, K. Wille, K. Bekaert, B. Le Bizec & H.F. De Brabander. (2010) Development and validation of an ultra-high performance liquid chromatography tandem mass spectrometry method for quantifying thyreostats in urine without derivatisation. Journal of Chromatography A 1217:26, pages 4285-4293.
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Len Levy, Matthew Sharman, James Scarth, Ed Houghton, Christine Akre, James D MacNeil, Bruno Le Bizec, Leen van Ginkel, Phil Teale & Emmanuelle BichonJack F. Kay & James D. MacNeil. 2009. Analyses for Hormonal Substances in Food-producing Animals. Analyses for Hormonal Substances in Food-producing Animals 97 128 .
Bruno Le Bizec, Gaud Pinel & Jean-Philippe Antignac. (2009) Options for veterinary drug analysis using mass spectrometry. Journal of Chromatography A 1216:46, pages 8016-8034.
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Madis Lõhmus, Kalle Kallaste & Bruno Le Bizec. (2009) Determination of thyreostats in urine and thyroid gland by ultra high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography A 1216:46, pages 8080-8089.
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H.F. De Brabander, H. Noppe, K. Verheyden, J. Vanden Bussche, K. Wille, L. Okerman, L. Vanhaecke, W. Reybroeck, S. Ooghe & S. Croubels. (2009) Residue analysis: Future trends from a historical perspective. Journal of Chromatography A 1216:46, pages 7964-7976.
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J. Vanden Bussche, H. Noppe, K. Verheyden, K. Wille, G. Pinel, B. Le Bizec & H.F. De Brabander. (2009) Analysis of thyreostats: A history of 35 years. Analytica Chimica Acta 637:1-2, pages 2-12.
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