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International Journal of Hyperthermia Volume 20, 2004 - Issue 2: Radiosensitization by hyperthermia: Mechanisms and clinical Implications
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Original Article

Transfection of human tumour cells with Mre11 siRNA and the increase in radiation sensitivity and the reduction in heat-induced radiosensitization

M. Xu Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USACorrespondence[email protected]
,
R. J. Myerson Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
,
C. Hunt Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
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S. Kumar Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
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E. G. Moros Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
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W. L. Straube Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
&
J. L. Roti Roti Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
 show all
Pages 157-162 | Received 13 Jun 2003, Accepted 04 Sep 2003, Published online: 09 Jul 2009

Citations (26)

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Sumeeta Varma, Robert Myerson, Eduardo Moros, Marie Taylor, William Straube & Imran Zoberi. (2012) Simultaneous radiotherapy and superficial hyperthermia for high-risk breast carcinoma: A randomised comparison of treatment sequelae in heated versus non-heated sectors of the chest wall hyperthermia. International Journal of Hyperthermia 28:7, pages 583-590.
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Berina Eppink, Przemek M. Krawczyk, Jan Stap & Roland Kanaar. (2012) Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies. International Journal of Hyperthermia 28:6, pages 509-517.
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Anna Łękawa–Ilczuk, Halina Antosz, Beata Rymgayłło–Jankowska & Tomasz Żarnowski. (2011) Expression of double strand DNA breaks repair genes in pterygium. Ophthalmic Genetics 32:1, pages 39-47.
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José A. Peñagarícano, Eduardo Moros, Petr Novák, Yulong Yan & Peter Corry. (2008) Feasibility of concurrent treatment with the scanning ultrasound reflector linear array system (SURLAS) and the helical tomotherapy system. International Journal of Hyperthermia 24:5, pages 377-388.
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Joseph L. Roti Roti. (2008) Cellular responses to hyperthermia (40–46°C): Cell killing and molecular events. International Journal of Hyperthermia 24:1, pages 3-15.
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M. Xu, R. J. Myerson, Y. Xia, T. Whitehead, E. G. Moros, W. L. Straube & J. L. Roti Roti. (2007) The effects of 41°C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines. International Journal of Hyperthermia 23:4, pages 343-351.
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J. W. J. Bergs, N. A. P. Franken, J. Haveman, E. D. Geijsen, J. Crezee & C. van Bree. (2007) Hyperthermia, cisplatin and radiation trimodality treatment: A promising cancer treatment? A review from preclinical studies to clinical application. International Journal of Hyperthermia 23:4, pages 329-341.
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Joseph L. Roti Roti. (2007) Heat-induced alterations of nuclear protein associations and their effects on DNA repair and replication. International Journal of Hyperthermia 23:1, pages 3-15.
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Articles from other publishers (18)

Susan Kilgas, Abhay Narayan Singh, Salome Paillas, Chee-Kin Then, Ignacio Torrecilla, Judith Nicholson, Lisa Browning, Iolanda Vendrell, Rebecca Konietzny, Benedikt M. Kessler, Anne E. Kiltie & Kristijan Ramadan. (2021) p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation. Cell Reports 35:8, pages 109153.
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Juri Na, Joseph A. Newman, Chee Kin Then, Junetha Syed, Iolanda Vendrell, Ignacio Torrecilla, Sophie Ellermann, Kristijan Ramadan, Roman Fischer & Anne E. Kiltie. (2021) SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. Cell Death & Disease 12:2.
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Baofeng Ma, Xiaoming Liu & Zhaoxiao Yu. (2019) The effect of high intensity focused ultrasound on the treatment of liver cancer and patients’ immunity. Cancer Biomarkers 24:1, pages 85-90.
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G. Ratnayake, A.L. Bain, N. Fletcher, C.B. Howard, K.K. Khanna & K.J. Thurecht. (2018) RNA interference to enhance radiation therapy: Targeting the DNA damage response. Cancer Letters 439, pages 14-23.
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Sungmin Lee, Beomseok Son, Gaeul Park, Hyunwoo Kim, Hyunkoo Kang, Jaewan Jeon, HyeSook Youn & BuHyun Youn. (2018) Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy. International Journal of Molecular Sciences 19:9, pages 2795.
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Tibebe A. Teklemariam, Osvaldo D. Rivera & Scott W. Nelson. 2018. Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination. Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination 135 156 .
Lihong Chang, Jiancong Huang, Kai Wang, Jingjia Li, Ruicheng Yan, Ling Zhu, Jin Ye, Xifu Wu, Shimin Zhuang, Daqing Li & Gehua Zhang. (2016) Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy. BMC Cancer 16:1.
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J-Y Wang, S-Y Chen, C-N Sun, T Chien & Y Chern. (2015) A central role of TRAX in the ATM-mediated DNA repair. Oncogene 35:13, pages 1657-1670.
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Karin Birkenkamp-Demtröder, Stephan A. Hahn, Francisco Mansilla, Kasper Thorsen, Abdelouahid Maghnouj, Rikke Christensen, Bodil Øster & Torben Falck Ørntoft. (2013) Keratin23 (KRT23) Knockdown Decreases Proliferation and Affects the DNA Damage Response of Colon Cancer Cells. PLoS ONE 8:9, pages e73593.
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Anne-Marie M. Gannon, Aisling Frizzell, Evan Healy & Robert S. Lahue. (2012) MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells. Nucleic Acids Research 40:20, pages 10324-10333.
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永 刘. (2012) Application of Magnetic Nano-Materials in Tumor Targeted Therapy. Journal of Advances in Physical Chemistry 01:03, pages 21-26.
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Joseph R. Dynlacht, Christopher N. Batuello, Jennifer T. Lopez, Kyung Keun Kim & John J. Turchi. (2011) Identification of Mre11 as a Target for Heat Radiosensitization. Radiation Research 176:3, pages 323.
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Joseph L. Roti Roti, Robert P. VanderWaal & Andrei Laszlo. 2011. Molecular Determinants of Radiation Response. Molecular Determinants of Radiation Response 227 249 .
Mats Ljungman. (2009) Targeting the DNA Damage Response in Cancer. Chemical Reviews 109:7, pages 2929-2950.
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Petr Novák, José A Peñagarícano, Volodymyr Nahirnyak, Peter Corry & Eduardo G Moros. (2008) Influence of the SURLAS applicator on radiation dose distributions during simultaneous thermoradiotherapy with helical tomotherapy. Physics in Medicine and Biology 53:10, pages 2509-2522.
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Sibgat A. Choudhury, Paul Kauler, Slobodan Devic & Terry Y-K Chow. (2007) Silencing of endo-exonuclease expression sensitizes mouse B16F10 melanoma cells to DNA damaging agents. Investigational New Drugs 25:5, pages 399-410.
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Konjeti R. Sekhar, Vijayakumar N. Sonar, Venkatraj Muthusamy, Soumya Sasi, Andrei Laszlo, Jamil Sawani, Nobuo Horikoshi, Ryuji Higashikubo, Robert G. Bristow, Michael J. Borrelli, Peter A. Crooks, James R. Lepock, Joseph L. Roti Roti & Michael L. Freeman. (2007) Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization through a Mitotic Catastrophe Pathway. Cancer Research 67:2, pages 695-701.
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Petr Novák, Eduardo G. Moros, William L. Straube & Robert J. Myerson. (2005) SURLAS: A new clinical grade ultrasound system for sequential or concomitant thermoradiotherapy of superficial tumors: Applicator description. Medical Physics 32:1, pages 230-240.
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