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Original

Anti-cancer effect of bio-reductive drug β-lapachon is enhanced by activating NQO1 with heat shock

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Pages 161-169 | Received 31 Aug 2007, Accepted 31 Oct 2007, Published online: 09 Jul 2009

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Read on this site (2)

Takeshi Hori, Takashi Kondo, Hyemi Lee, Chang W. Song & Heon Joo Park. (2011) Hyperthermia enhances the effect of β-lapachone to cause γH2AX formations and cell death in human osteosarcoma cells. International Journal of Hyperthermia 27:1, pages 53-62.
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Guang-Zhi Dong, Hyewon Youn, Moon-Taek Park, Eun-Taex Oh, Kyung Hee Park, Chang Won Song, Eun Kyung Choi & Heon Joo Park. (2009) Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of β-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein. International Journal of Hyperthermia 25:6, pages 477-487.
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Articles from other publishers (14)

Xuewen Mu, Yun Xu, Zheng Wang & Dunyun Shi. (2022) Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review. Frontiers of Chemical Science and Engineering 17:2, pages 123-138.
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Alycen P. Lundberg, Matthew W. Boudreau, Kim A. Selting, Lindsay E. Chatkewitz, Jonathan Samuelson, Joshua M. Francis, Elizabeth I. Parkinson, Anne M. Barger, Paul J. Hergenrother & Timothy M. Fan. (2021) Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy. Neoplasia 23:8, pages 811-822.
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Jinbong Park & Seung Ho Baek. (2020) Combination Therapy with Cinnamaldehyde and Hyperthermia Induces Apoptosis of A549 Non-Small Cell Lung Carcinoma Cells via Regulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase Family. International Journal of Molecular Sciences 21:17, pages 6229.
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Danielly C. Ferraz da Costa, Luciana Pereira Rangel, Mafalda Maria Duarte da Cunha Martins-Dinis, Giulia Diniz da Silva Ferretti, Vitor F. Ferreira & Jerson L. Silva. (2020) Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues. Molecules 25:4, pages 893.
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María Julia Lamberti, Ana Belén Morales Vasconsuelo, Marianela Chiaramello, Vitor Francisco Ferreira, Milena Macedo Oliveira, Sabrina Baptista Ferreira, Viviana Alicia Rivarola & Natalia Belén Rumie Vittar. (2018) NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma. Biomedicine & Pharmacotherapy 108, pages 1553-1564.
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Eun-Taex Oh & Heon Joo Park. (2015) Implications of NQO1 in cancer therapy. BMB Reports 48:11, pages 609-617.
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Eun Jung Park & Taeg Kyu Kwon. (2014) NAD(P)H Quinone Oxidoreductase 1 (NQO1) as a Cancer Therapeutic Target. Journal of Life Science 24:1, pages 98-103.
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Sangkyu Lee, In Sook Kim, Tae Hwan Kwak & Hye Hyun Yoo. (2013) Comparative metabolism study of β-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 83, pages 286-292.
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María Julia Lamberti, Natalia Belén Rumie Vittar, Fernando de Carvalho da Silva, Vitor Francisco Ferreira & Viviana Alicia Rivarola. (2013) Synergistic enhancement of antitumor effect of β-Lapachone by photodynamic induction of quinone oxidoreductase (NQO1). Phytomedicine 20:11, pages 1007-1012.
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Ki Jung AhnHyung Sik LeeSe Kyung BaiChang Won Song. (2013) Enhancement of radiation effect using beta-lapachone and underlying mechanism. Radiation Oncology Journal 31:2, pages 57.
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Ke LIAO, Fang NIU, Hai-Ping HAO & Guang-Ji WANG. (2012) Advances on structure-activity relationship of NQO1-targeting antitumor quinones. Chinese Journal of Natural Medicines 10:3, pages 170-176.
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David Siegel, Chao Yan & David Ross. (2012) NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochemical Pharmacology 83:8, pages 1033-1040.
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Guang-Zhi DongEun-Taex OhHyemi LeeMoon-Taek ParkChang Won SongHeon Joo Park. (2010) β-Lapachone suppresses radiation-induced activation of nuclear factor-κB. Experimental and Molecular Medicine 42:5, pages 327.
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Kaoru Terai, Guang-Zhi Dong, Eun-Taex Oh, Moon-Taek Park, Yeunhwa Gu, Chang Won Song & Heon Joo Park. (2009) Cisplatin enhances the anticancer effect of β-lapachone by upregulating NQO1. Anti-Cancer Drugs 20:10, pages 901-909.
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