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International Journal of Hyperthermia Volume 34, 2018 - Issue 4
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Original Articles

Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies

Nathalie van den TempelDepartment of Molecular Genetics, Cancer Genomics Centre Netherlands Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
,
Hanny OdijkDepartment of Molecular Genetics, Cancer Genomics Centre Netherlands Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
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Netteke van HoltheDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; View further author information
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Kishan NaipalDepartment of Molecular Genetics, Cancer Genomics Centre Netherlands Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
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Anja RaamsDepartment of Molecular Genetics, Cancer Genomics Centre Netherlands Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
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Berina EppinkDepartment of Molecular Genetics, Cancer Genomics Centre Netherlands Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
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Dik C. van GentDepartment of Molecular Genetics, Cancer Genomics Centre Netherlands Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
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Jose HardilloDepartment of Otolaryngology and Head and Neck Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
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Gerda M. VerduijnDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; View further author information
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Jan C. DroogerDepartment of Medical Oncology, Ikazia Hospital, Rotterdam, The Netherlands; View further author information
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Gerard C. van RhoonDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; View further author information
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Dineke (H.) P.M. SmedtsDepartment of Gynaecological Oncology, Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
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Helena C. van DoornDepartment of Gynaecological Oncology, Erasmus University Medical Centre, Rotterdam, The Netherlands; View further author information
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Joost L. BoormansDepartment of Urology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; View further author information
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Agnes JagerDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The NetherlandsView further author information
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Martine FranckenaDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; View further author information
&
Roland KanaarDepartment of Molecular Genetics, Cancer Genomics Centre Netherlands Erasmus University Medical Centre, Rotterdam, The Netherlands; Correspondence[email protected]
View further author information
 show all
Pages 407-414 | Received 10 May 2017, Accepted 09 Jul 2017, Published online: 31 Jul 2017

Citations (20)

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Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Noriko Hosoya & Kiyoshi Miyagawa. (2024) Deregulated JNK signaling enhances apoptosis during hyperthermia. International Journal of Hyperthermia 41:1.
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Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato & Kiyoshi Miyagawa. (2022) Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia. International Journal of Hyperthermia 39:1, pages 200-208.
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Daphne Schouten, Rob van Os, Anneke M. Westermann, Hans Crezee, Geertjan van Tienhoven, M. Willemijn Kolff & Adriaan D. Bins. (2022) A randomized phase-II study of reirradiation and hyperthermia versus reirradiation and hyperthermia plus chemotherapy for locally recurrent breast cancer in previously irradiated area. Acta Oncologica 61:4, pages 441-448.
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Jarosław Przybycinski, Magdalena Nalewajska, Małgorzata Marchelek-Mysliwiec, Violetta Dziedziejko & Andrzej Pawlik. (2019) Poly-ADP-ribose polymerases (PARPs) as a therapeutic target in the treatment of selected cancers. Expert Opinion on Therapeutic Targets 23:9, pages 773-785.
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G. M. Verduijn, E. M. de Wee, Z. Rijnen, P. Togni, J. A. U. Hardillo, I. ten Hove, M. Franckena, G. C. van Rhoon & M. M. Paulides. (2018) Deep hyperthermia with the HYPERcollar system combined with irradiation for advanced head and neck carcinoma – a feasibility study. International Journal of Hyperthermia 34:7, pages 994-1001.
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Yosuke Nakagawa, Atsuhisa Kajihara, Akihisa Takahashi, Akiho S. Murata, Masaya Matsubayashi, Soichiro S. Ito, Ichiro Ota, Takahiko Nakagawa, Masatoshi Hasegawa, Tadaaki Kirita, Takeo Ohnishi & Eiichiro Mori. (2018) BRCA2 protects mammalian cells from heat shock. International Journal of Hyperthermia 34:6, pages 795-801.
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Articles from other publishers (14)

Mohammed Khurshed, Elia Prades-Sagarra, Sarah Saleh, Peter Sminia, Johanna W. Wilmink, Remco J. Molenaar, Hans Crezee & Cornelis J. F. van Noorden. (2022) Hyperthermia as a Potential Cornerstone of Effective Multimodality Treatment with Radiotherapy, Cisplatin and PARP Inhibitor in IDH1-Mutated Cancer Cells. Cancers 14:24, pages 6228.
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Qianqian Wu, Mingjing Wei, Lifang Yao, Xiaodong Cheng, Weiguo Lu, Xing Xie & Xiao Li. (2022) Hyperthermia synergistically enhances antitumor efficacy of PARP inhibitor through impacting homologous recombination repair and oxidative stress in vitro. Biochemical and Biophysical Research Communications 619, pages 49-55.
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S. Braude & J. Varghese. (2022) The oncoprotective fever hypothesis: Have antibiotics, antimalarials and antipyrectics contributed to the global rise in cancer over the past century?. Medical Hypotheses 158, pages 110720.
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Andreas R. Thomsen, Michael R. Saalmann, Nils H. Nicolay, Anca-L Grosu & Peter Vaupel. 2022. Oxygen Transport to Tissue XLIII. Oxygen Transport to Tissue XLIII 255 261 .
Mariana Paes Dias, Sarah C. Moser, Shridar Ganesan & Jos Jonkers. (2021) Understanding and overcoming resistance to PARP inhibitors in cancer therapy. Nature Reviews Clinical Oncology 18:12, pages 773-791.
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Pauline Thumser-Henner, Katarzyna J. Nytko & Carla Rohrer Bley. (2020) Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy. BMC Veterinary Research 16:1.
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Meilin Shi, Fengmei Zuo, Yingkai Tao, Yawen Liu, Jiahui Lu, Shaohui Zheng, Jiao Lu, Pingfu Hou, Jingjing Li & Kai Xu. (2020) Near-infrared laser-induced phase-shifted nanoparticles for US/MRI-guided therapy for breast cancer. Colloids and Surfaces B: Biointerfaces 196, pages 111278.
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Mathias S. Weyland, Pauline Thumser-Henner, Katarzyna J. Nytko, Carla Rohrer Bley, Simone Ulzega, Alke Petri-Fink, Marco Lattuada, Rudolf M. Füchslin & Stephan Scheidegger. (2020) Holistic View on Cell Survival and DNA Damage: How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems. Computational and Mathematical Methods in Medicine 2020, pages 1-11.
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Niloy R. Datta, H. Petra Kok, Hans Crezee, Udo S. Gaipl & Stephan Bodis. (2020) Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses. Frontiers in Oncology 10.
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A.L. Oei, H.P. Kok, S.B. Oei, M.R. Horsman, L.J.A. Stalpers, N.A.P. Franken & J. Crezee. (2020) Molecular and biological rationale of hyperthermia as radio- and chemosensitizer. Advanced Drug Delivery Reviews 163-164, pages 84-97.
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Jula Veerapong & Andrew M. Lowy. 2020. Cancer Regional Therapy. Cancer Regional Therapy 83 91 .
Michiel Kroesen, H. Tim Mulder, Gerard C. van Rhoon & Martine Franckena. (2019) Commentary: The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer. Frontiers in Oncology 9.
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Ainhoa Madariaga, Stephanie Lheureux & Amit Oza. (2019) Tailoring Ovarian Cancer Treatment: Implications of BRCA1/2 Mutations. Cancers 11:3, pages 416.
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Nathalie van den Tempel, Alex Zelensky, Hanny Odijk, Charlie Laffeber, Christine Schmidt, Inger Brandsma, Jeroen Demmers, Przemek Krawczyk & Roland Kanaar. (2019) On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation. Cancers 11:1, pages 97.
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