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Aerosol Science and Technology Volume 43, 2009 - Issue 8
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Original Articles

Characterization of Submicrometer Aerosol Deposition in Extrathoracic Airways during Nasal Exhalation

Jinxiang Xi Department of Systems Engineering, University of Arkansas, Little Rock, Arkansas, USA
&
P. Worth Longest Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
Pages 808-827 | Received 21 Nov 2008, Accepted 10 Mar 2009, Published online: 19 May 2009

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H. Calmet, K. Inthavong, H. Owen, D. Dosimont, O. Lehmkuhl, G. Houzeaux & M. Vázquez. (2021) Computational modelling of nasal respiratory flow. Computer Methods in Biomechanics and Biomedical Engineering 24:4, pages 440-458.
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Wei-Chung Su, Yi Chen, Marcio Bezerra & Jun Wang. (2019) Respiratory deposition of ultrafine welding fume particles. Journal of Occupational and Environmental Hygiene 16:10, pages 694-706.
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P. Worth Longest, Karl Bass, Rabijit Dutta, Vijaya Rani, Morgan L. Thomas, Ahmad El-Achwah & Michael Hindle. (2019) Use of computational fluid dynamics deposition modeling in respiratory drug delivery. Expert Opinion on Drug Delivery 16:1, pages 7-26.
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Jinxiang Xi, Ze Zhang & Xiuhua A Si. (2015) Improving intranasal delivery of neurological nanomedicine to the olfactory region using magnetophoretic guidance of microsphere carriers. International Journal of Nanomedicine 10, pages 1211-1222.
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Jinxiang Xi, JongWon Kim, Xiuhua A. Si, Wei Chung Su & Yue Zhou. (2014) Effects of the facial interface on inhalation and deposition of micrometer particles in calm air in a child airway model. Inhalation Toxicology 26:8, pages 492-505.
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Geng Tian, Michael Hindle & P. Worth Longest. (2014) Targeted Lung Delivery of Nasally Administered Aerosols. Aerosol Science and Technology 48:4, pages 434-449.
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Jinxiang Xi, Jongwon Kim, XiuhuaA. Si & Yue Zhou. (2013) Hygroscopic aerosol deposition in the human upper respiratory tract under various thermo-humidity conditions. Journal of Environmental Science and Health, Part A 48:14, pages 1790-1805.
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Articles from other publishers (39)

Xinlei Huang, Suvash C. Saha, Goutam Saha, Isabella Francis & Zhen Luo. (2024) Transport and deposition of microplastics and nanoplastics in the human respiratory tract. Environmental Advances 16, pages 100525.
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Hasan Jubaer, Morgan Thomas, Dale Farkas, Arun V. Kolanjiyil, Mohammad A.M. Momin, Michael Hindle & Worth Longest. (2024) Development of an effective two-equation turbulence modeling approach for simulating aerosol deposition across a range of turbulence levels. Journal of Aerosol Science 175, pages 106262.
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Jinxiang Xi, Xiuhua April Si & Mauro Malvè. (2023) Nasal anatomy and sniffing in respiration and olfaction of wild and domestic animals. Frontiers in Veterinary Science 10.
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Amr Seifelnasr, Xiuhua April Si & Jinxiang Xi. (2023) Visualization and Estimation of Nasal Spray Delivery to Olfactory Mucosa in an Image-Based Transparent Nasal Model. Pharmaceutics 15:6, pages 1657.
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Mohammad S. Islam, Md. Mizanur Rahman, Puchanee Larpruenrudee, Akbar Arsalanloo, Hamidreza Mortazavy Beni, Md. Ariful Islam, YuanTong Gu & Emilie Sauret. (2023) How microplastics are transported and deposited in realistic upper airways?. Physics of Fluids 35:6.
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Yu Cheng, Haiming Yu, Sen Xie, Junwei Zhao & Yuxi Ye. (2023) Study on the coal dust deposition fraction and site in the upper respiratory tract under different particle sizes and labor intensities. Science of The Total Environment 868, pages 161617.
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Anurag Tiwari, Akshoy Ranjan Paul & Anuj Jain. 2023. Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022). Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022) 35 46 .
Puchanee Larpruenrudee, Gunther Paul, Suvash C. Saha, Shahid Husain, HamidReza Mortazavy Beni, Christopher Lawrence, Xuzhen He, Yuantong Gu & Mohammad Saidul Islam. 2023. Digital Human Modeling and Medicine. Digital Human Modeling and Medicine 253 274 .
Hadrien Calmet, David Oks, Alfonso Santiago, Guillaume Houzeaux, Antoine Le Corfec, Laura Deruyver, Clement Rigaut, Pierre Lambert, Benoit Haut & Jonathan Goole. (2022) Validation and Sensitivity analysis for a nasal spray deposition computational model. International Journal of Pharmaceutics 626, pages 122118.
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Morgan L. Thomas & P. Worth Longest. (2022) Evaluation of the polyhedral mesh style for predicting aerosol deposition in representative models of the conducting airways. Journal of Aerosol Science 159, pages 105851.
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Xiuhua April Si & Jinxiang Xi. 2022. Modeling of Mass Transport Processes in Biological Media. Modeling of Mass Transport Processes in Biological Media 311 333 .
Khaled Talaat, Adam Hecht & Jinxiang Xi. (2021) A comparison of CFPD, compartment, and uniform distribution models for radiation dosimetry of radionuclides in the lung. Journal of Radiological Protection 41:4, pages 739-763.
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Xiuhua April Si & Jinxiang Xi. (2021) Deciphering Exhaled Aerosol Fingerprints for Early Diagnosis and Personalized Therapeutics of Obstructive Respiratory Diseases in Small Airways. Journal of Nanotheranostics 2:3, pages 94-117.
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Xiuhua April Si, Muhammad Sami & Jinxiang Xi. (2021) Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study. Pharmaceutics 13:6, pages 903.
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Xiuhua April Si, Mohamed Talaat & Jinxiang Xi. (2021) SARS COV-2 virus-laden droplets coughed from deep lungs: Numerical quantification in a single-path whole respiratory tract geometry. Physics of Fluids 33:2.
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Jinxiang Xi, Mohamed Talaat, Xiuhua April Si & Shekhar Chandra. (2021) The application of statistical shape modeling for lung morphology in aerosol inhalation dosimetry. Journal of Aerosol Science 151, pages 105623.
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Kendra Shrestha, Ross Walenga, Jinxiang Xi, Yidan Shang, Hana Salati, Jim Bartley & David White. 2021. Clinical and Biomedical Engineering in the Human Nose. Clinical and Biomedical Engineering in the Human Nose 255 291 .
Sima Asadi, Anthony S. Wexler, Christopher D. Cappa, Santiago Barreda, Nicole M. Bouvier & William D. Ristenpart. (2019) Aerosol emission and superemission during human speech increase with voice loudness. Scientific Reports 9:1.
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Jinxiang Xi & Weizhong Zhao. (2019) Correlating exhaled aerosol images to small airway obstructive diseases: A study with dynamic mode decomposition and machine learning. PLOS ONE 14:1, pages e0211413.
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Dale Farkas, Michael Hindle & P. Worth Longest. (2018) Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume. Pharmaceutical Research 35:10.
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Yujun Song, Daojian Cheng & Liang ZhaoClement Kleinstreuer & Zelin Xu. 2018. Microfluidics: Fundamental, Devices and Applications. Microfluidics: Fundamental, Devices and Applications 311 350 .
E.M.A. Frederix, A.K. Kuczaj, M. Nordlund, M. Bělka, F. Lizal, J. Jedelský, J. Elcner, M. Jícha & B.J. Geurts. (2018) Simulation of size-dependent aerosol deposition in a realistic model of the upper human airways. Journal of Aerosol Science 115, pages 29-45.
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Jinxiang Xi, JongWon Kim, Xiuhua A. Si, Richard A. Corley & Yue Zhou. (2016) Modeling of inertial deposition in scaled models of rat and human nasal airways: Towards in vitro regional dosimetry in small animals. Journal of Aerosol Science 99, pages 78-93.
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Jinxiang Xi, Jiayao Eddie Yuan, Yu Zhang, Dannielle Nevorski, Zhaoxuan Wang & Yue Zhou. (2016) Visualization and Quantification of Nasal and Olfactory Deposition in a Sectional Adult Nasal Airway Cast. Pharmaceutical Research 33:6, pages 1527-1541.
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Jinxiang Xi, JongWon Kim & Xiuhua April Si. (2016) Effects of nostril orientation on airflow dynamics, heat exchange, and particle depositions in human noses. European Journal of Mechanics - B/Fluids 55, pages 215-228.
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P. Worth LongestLaleh GolshahiSrinivas R.B. BeharaGeng TianDale R. FarkasMichael Hindle. (2015) Efficient Nose-to-Lung (N2L) Aerosol Delivery with a Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:3, pages 189-201.
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Jinxiang Xi, Xiuhua A. Si & Jong Won Kim. 2015. Heat Transfer and Fluid Flow in Biological Processes. Heat Transfer and Fluid Flow in Biological Processes 125 155 .
Jinxiang Xi, Xiuhua A. Si, JongWon Kim, Edward Mckee & En-Bing Lin. (2014) Exhaled Aerosol Pattern Discloses Lung Structural Abnormality: A Sensitivity Study Using Computational Modeling and Fractal Analysis. PLoS ONE 9:8, pages e104682.
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Jinxiang Xi, Xiuhua Si, JongWon Kim, Guoguang Su & Haibo Dong. (2014) Modeling the pharyngeal anatomical effects on breathing resistance and aerodynamically generated sound. Medical & Biological Engineering & Computing 52:7, pages 567-577.
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Jinxiang Xi, Xiuhua A. Si & Rachel Gaide. (2014) Electrophoretic Particle Guidance Significantly Enhances Olfactory Drug Delivery: A Feasibility Study. PLoS ONE 9:1, pages e86593.
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Jinxiang Xi, JongWon Kim, Xiuhua A. Si & Yue Zhou. (2013) Diagnosing obstructive respiratory diseases using exhaled aerosol fingerprints: A feasibility study. Journal of Aerosol Science 64, pages 24-36.
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Xiuhua A. Si, Jinxiang Xi, JongWon Kim, Yue Zhou & Hualiang Zhong. (2013) Modeling of release position and ventilation effects on olfactory aerosol drug delivery. Respiratory Physiology & Neurobiology 186:1, pages 22-32.
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Xiuhua Si, Jinxiang Xi & Jongwon Kim. (2013) Effect of Laryngopharyngeal Anatomy on Expiratory Airflow and Submicrometer Particle Deposition in Human Extrathoracic Airways. Open Journal of Fluid Dynamics 03:04, pages 286-301.
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Jong Won KimJinxiang XiXiuhua A. Si. (2012) Dynamic growth and deposition of hygroscopic aerosols in the nasal airway of a 5‐year‐old child. International Journal for Numerical Methods in Biomedical Engineering 29:1, pages 17-39.
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Jinxiang Xi, Ariel Berlinski, Yue Zhou, Bruce Greenberg & Xiawei Ou. (2012) Breathing Resistance and Ultrafine Particle Deposition in Nasal–Laryngeal Airways of a Newborn, an Infant, a Child, and an Adult. Annals of Biomedical Engineering 40:12, pages 2579-2595.
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Pyeko MenachHerbert O. OburraAsmeeta Patel. (2012) Cigarette Smoking and Alcohol Ingestion as Risk Factors for Laryngeal Squamous Cell Carcinoma at Kenyatta National Hospital, Kenya. Clinical Medicine Insights: Ear, Nose and Throat 5, pages CMENT.S8610.
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P. Worth LongestGeng TianMichael Hindle. (2011) Improving the Lung Delivery of Nasally Administered Aerosols During Noninvasive Ventilation—An Application of Enhanced Condensational Growth (ECG). Journal of Aerosol Medicine and Pulmonary Drug Delivery 24:2, pages 103-118.
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Jinxiang Xi, Xiuhua Si, Jong Won Kim & Ariel Berlinski. (2011) Simulation of airflow and aerosol deposition in the nasal cavity of a 5-year-old child. Journal of Aerosol Science 42:3, pages 156-173.
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Geng Tian & P. Worth Longest. (2010) Development of a CFD Boundary Condition to Model Transient Vapor Absorption in the Respiratory Airways. Journal of Biomechanical Engineering 132:5.
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