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Aerosol Science and Technology Volume 45, 2011 - Issue 7
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Original Articles

Numerical Model to Characterize the Size Increase of Combination Drug and Hygroscopic Excipient Nanoparticle Aerosols

P. Worth Longest Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
&
Michael Hindle Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
Pages 884-899 | Received 02 Dec 2010, Accepted 17 Feb 2011, Published online: 31 Mar 2011

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Laurent Boudin & David Michel. (2021) Three-Dimensional Numerical Study of a Fluid-Kinetic Model for Respiratory Aerosols with Variable Size and Temperature. Journal of Computational and Theoretical Transport 50:5, pages 507-527.
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Patrick T. O’Shaughnessy, Lawrence LeBlanc, Alessandra Pratt, Ralph Altmaier, Prathish K. Rajaraman, Ross Walenga & Ching-Long Lin. (2020) Assessment and validation of a hygroscopic growth model with different water activity estimation methods. Aerosol Science and Technology 54:10, pages 1169-1182.
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Gregory Reychler & Jean-Bernard Michotte. (2019) Development challenges and opportunities in aerosol drug delivery systems in non-invasive ventilation in adults. Expert Opinion on Drug Delivery 16:2, pages 153-162.
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P. Worth Longest, Karl Bass, Rabijit Dutta, Vijaya Rani, Morgan L. Thomas, Ahmad El-Achwah & Michael Hindle. (2019) Use of computational fluid dynamics deposition modeling in respiratory drug delivery. Expert Opinion on Drug Delivery 16:1, pages 7-26.
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Geng Tian, Michael Hindle & P. Worth Longest. (2014) Targeted Lung Delivery of Nasally Administered Aerosols. Aerosol Science and Technology 48:4, pages 434-449.
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Jinxiang Xi, Jongwon Kim, XiuhuaA. Si & Yue Zhou. (2013) Hygroscopic aerosol deposition in the human upper respiratory tract under various thermo-humidity conditions. Journal of Environmental Science and Health, Part A 48:14, pages 1790-1805.
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Articles from other publishers (63)

Adam Milsom, Adam M. Squires, Christopher Brasnett, William N. Sharratt, Annela M. Seddon & Christian Pfrang. (2023) Acoustic levitation with polarising optical microscopy (AL-POM): water uptake in a nanostructured atmospheric aerosol proxy. Environmental Science: Atmospheres 3:11, pages 1642-1650.
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Ghali Aladwani, Mohammad A.M. Momin, Benjamin Spence, Dale R. Farkas, Serena Bonasera, Amr Hassan, Michael Hindle & Worth Longest. (2023) Effects of Different Mesh Nebulizer Sources on the Dispersion of Powder Formulations Produced with a New Small-Particle Spray Dryer. International Journal of Pharmaceutics, pages 123138.
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Rudra Pangeni, Amr Ali Mohamed Hassan, Dale Farkas, Hadi Sudarjat, Worth Longest, Michael Hindle & Qingguo Xu. (2023) New Air-Jet Dry Powder Insufflator for High-Efficiency Aerosol Delivery to Rats. Molecular Pharmaceutics 20:4, pages 2207-2216.
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Ning Mao, Dingkun Zhang, Yupei Li, Ying Li, Jin Li, Li Zhao, Qingqin Wang, Zhu Cheng, Yin Zhang & Enshen Long. (2022) How do temperature, humidity, and air saturation state affect the COVID-19 transmission risk?. Environmental Science and Pollution Research 30:2, pages 3644-3658.
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Benjamin M. Spence, Worth Longest, Rabijit Dutta, Mohammad A. M. Momin, Sarah Strickler & Michael Hindle. (2022) In Vitro Evaluation of Nebulized Pharmaceutical Aerosol Delivery to the Lungs Using a New Heated Dryer System (HDS). AAPS PharmSciTech 24:1.
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Yousuf Mohammed, Amy Holmes, Philip Chi Lip Kwok, Tushar Kumeria, Sarika Namjoshi, Mohammad Imran, Lana Matteucci, Masood Ali, Waiting Tai, Heather A.E. Benson & Michael S. Roberts. (2022) Advances and future perspectives in epithelial drug delivery. Advanced Drug Delivery Reviews 186, pages 114293.
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Worth Longest, Amr Hassan, Dale Farkas & Michael Hindle. (2022) Computational Fluid Dynamics (CFD) Guided Spray Drying Recommendations for Improved Aerosol Performance of a Small-Particle Antibiotic Formulation. Pharmaceutical Research 39:2, pages 295-316.
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Connor Howe, Mohammad A.M. Momin, Dale R. Farkas, Serena Bonasera, Michael Hindle & P. Worth Longest. (2021) Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates. Pharmaceutical Research 38:9, pages 1615-1632.
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Matus E. Diveky, Michael J. Gleichweit, Sandra Roy & Ruth Signorell. (2021) Shining New Light on the Kinetics of Water Uptake by Organic Aerosol Particles. The Journal of Physical Chemistry A 125:17, pages 3528-3548.
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Susan Boc, Mohammad A. M. Momin, Dale R. Farkas, Worth Longest & Michael Hindle. (2021) Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations. AAPS PharmSciTech 22:4.
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Susan Boc, Mohammad A. M. Momin, Dale R. Farkas, Worth Longest & Michael Hindle. (2021) Development and Characterization of Excipient Enhanced Growth (EEG) Surfactant Powder Formulations for Treating Neonatal Respiratory Distress Syndrome. AAPS PharmSciTech 22:4.
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Karl Bass, Dale Farkas, Amr Hassan, Serena Bonasera, Michael Hindle & P. Worth Longest. (2021) High-efficiency dry powder aerosol delivery to children: Review and application of new technologies. Journal of Aerosol Science 153, pages 105692.
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Connor HoweMichael HindleSerena BonaseraVijaya RaniP. Worth Longest. (2021) Initial Development of an Air-Jet Dry Powder Inhaler for Rapid Delivery of Pharmaceutical Aerosols to Infants. Journal of Aerosol Medicine and Pulmonary Drug Delivery 34:1, pages 57-70.
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Franck J. Kamga GninzekoMichael S. ValentineCindy K. ThoSahil R. ChindalSusan BocSneha DhapareMohammad Abdul Motalib MominAmr HassanMichael HindleDale R. FarkasP. Worth LongestRebecca L. Heise. (2020) Excipient Enhanced Growth Aerosol Surfactant Replacement Therapy in an In Vivo Rat Lung Injury Model . Journal of Aerosol Medicine and Pulmonary Drug Delivery 33:6, pages 314-322.
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Amr Hassan, Dale Farkas, Worth Longest & Michael Hindle. (2020) Characterization of excipient enhanced growth (EEG) tobramycin dry powder aerosol formulations. International Journal of Pharmaceutics 591, pages 120027.
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Guihong Chai, Amr Hassan, Tuo Meng, Lihua Lou, Jonathan Ma, Russell Simmers, Lei Zhou, Bruce K. Rubin, Qi (Tony) Zhou, P. Worth Longest, Michael Hindle & Qingguo Xu. (2020) Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery. Nanomedicine: Nanotechnology, Biology and Medicine 29, pages 102262.
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Rabijit Dutta, Benjamin Spence, Xiangyin Wei, Sneha Dhapare, Michael Hindle & P. Worth Longest. (2020) CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery. Pharmaceutical Research 37:10.
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Prathish K. Rajaraman, Jiwoong Choi, Eric A. Hoffman, Patrick T. O'Shaughnessy, Sanghun Choi, Renishkumar Delvadia, Andrew Babiskin, Ross Walenga & Ching-Long Lin. (2020) Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing. Journal of Aerosol Science 146, pages 105581.
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Hiroyuki Yoshida, Akiko Usui, Yasuhiro Abe, Yukihiro Goda & Ken-ichi Izutsu. (2020) Relationship Between Geometric and Aerodynamic Particle Size Distributions in the Formulation of Solution and Suspension Metered-Dose Inhalers. AAPS PharmSciTech 21:5.
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Laurent Boudin, David Michel & Ayman Moussa. (2020) Global existence of weak solutions to the incompressible Vlasov–Navier–Stokes system coupled to convection–diffusion equations. Mathematical Models and Methods in Applied Sciences 30:08, pages 1485-1515.
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Dale FarkasMichael HindleSerena BonaseraKarl BassWorth Longest. (2020) Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children. Journal of Aerosol Medicine and Pulmonary Drug Delivery 33:2, pages 83-98.
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Alexander Ishmatov. (2020) Influence of weather and seasonal variations in temperature and humidity on supersaturation and enhanced deposition of submicron aerosols in the human respiratory tract. Atmospheric Environment 223, pages 117226.
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Sandra Roy, Matus E. Diveky & Ruth Signorell. (2019) Mass Accommodation Coefficients of Water on Organics from Complementary Photoacoustic and Light Scattering Measurements on Laser-Trapped Droplets. The Journal of Physical Chemistry C 124:4, pages 2481-2489.
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Pran Kishore Deb, Sara Nidal Abed, Hussam Maher, Amal Al-Aboudi, Anant Paradkar, Shantanu Bandopadhyay & Rakesh K. Tekade. 2020. Drug Delivery Systems. Drug Delivery Systems 521 577 .
Benjamin M. SpenceWorth LongestXiangyin WeiSneha DhapareMichael Hindle. (2019) Development of a High-Flow Nasal Cannula and Pharmaceutical Aerosol Combination Device. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:4, pages 224-241.
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Xiaole Chen, Rui Ma, Wenqi Zhong, Baobin Sun & Xianguang Zhou. (2019) Numerical study of the effects of temperature and humidity on the transport and deposition of hygroscopic aerosols in a G3-G6 airway. International Journal of Heat and Mass Transfer 138, pages 545-552.
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Karl BassSusan BocMichael HindleKelley DodsonWorth Longest. (2019) High-Efficiency Nose-to-Lung Aerosol Delivery in an Infant: Development of a Validated Computational Fluid Dynamics Method. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:3, pages 132-148.
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Ross L. Walenga, Andrew H. Babiskin & Liang Zhao. (2019) In Silico Methods for Development of Generic Drug–Device Combination Orally Inhaled Drug Products . CPT: Pharmacometrics & Systems Pharmacology 8:6, pages 359-370.
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Chaeho Moon, Hugh D. C. Smyth, Alan B. Watts & Robert O. WilliamsIIIIII. (2019) Delivery Technologies for Orally Inhaled Products: an Update. AAPS PharmSciTech 20:3.
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Mohammad A.M. Momin, Ian G. Tucker & Shyamal C. Das. (2018) High dose dry powder inhalers to overcome the challenges of tuberculosis treatment. International Journal of Pharmaceutics 550:1-2, pages 398-417.
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Dale Farkas, Michael Hindle & P. Worth Longest. (2018) Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume. Pharmaceutical Research 35:10.
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Dale FarkasMichael HindleP. Worth Longest. (2018) Development of an Inline Dry Powder Inhaler That Requires Low Air Volume. Journal of Aerosol Medicine and Pulmonary Drug Delivery 31:4, pages 255-265.
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Dale Farkas, Michael Hindle & P. Worth Longest. (2018) Application of an inline dry powder inhaler to deliver high dose pharmaceutical aerosols during low flow nasal cannula therapy. International Journal of Pharmaceutics 546:1-2, pages 1-9.
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Ross L. WalengaP. Worth LongestAnubhav KaviratnaMichael Hindle. (2017) Aerosol Drug Delivery During Noninvasive Positive Pressure Ventilation: Effects of Intersubject Variability and Excipient Enhanced Growth. Journal of Aerosol Medicine and Pulmonary Drug Delivery 30:3, pages 190-205.
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Xiaole Chen, Yu Feng, Wenqi Zhong & Clement Kleinstreuer. (2017) Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model. Journal of Aerosol Science 105, pages 108-127.
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Niels Grasmeijer, Henderik W. Frijlink & Wouter L.J. Hinrichs. (2016) An adaptable model for growth and/or shrinkage of droplets in the respiratory tract during inhalation of aqueous particles. Journal of Aerosol Science 93, pages 21-34.
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Laurent Boudin, Céline Grandmont, Alexander Lorz & Ayman Moussa. (2015) Modelling and Numerics for Respiratory Aerosols. Communications in Computational Physics 18:3, pages 723-756.
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Laleh Golshahi, P. Worth Longest, Landon Holbrook, Jessica Snead & Michael Hindle. (2015) Production of Highly Charged Pharmaceutical Aerosols Using a New Aerosol Induction Charger. Pharmaceutical Research 32:9, pages 3007-3017.
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Jinxiang Xi, Xiuhua A. Si & Jong Won Kim. 2015. Heat Transfer and Fluid Flow in Biological Processes. Heat Transfer and Fluid Flow in Biological Processes 125 155 .
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Ross L. Walenga, Geng Tian, Michael Hindle, Joshua Yelverton, Kelley Dodson & P. Worth Longest. (2014) Variability in nose-to-lung aerosol delivery. Journal of Aerosol Science 78, pages 11-29.
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Paul B. Myrdal, Poonam Sheth & Stephen W. Stein. (2014) Advances in Metered Dose Inhaler Technology: Formulation Development. AAPS PharmSciTech 15:2, pages 434-455.
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Srinivas R.B. Behara, P. Worth Longest, Dale R. Farkas & Michael Hindle. (2014) Development of high efficiency ventilation bag actuated dry powder inhalers. International Journal of Pharmaceutics 465:1-2, pages 52-62.
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Srinivas R. B. Behara, Dale R. Farkas, Michael Hindle & P. Worth Longest. (2013) Development of a High Efficiency Dry Powder Inhaler: Effects of Capsule Chamber Design and Inhaler Surface Modifications. Pharmaceutical Research 31:2, pages 360-372.
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Srinivas R.B. Behara, P. Worth Longest, Dale R. Farkas & Michael Hindle. (2014) Development and Comparison of New High-Efficiency Dry Powder Inhalers for Carrier-Free Formulations. Journal of Pharmaceutical Sciences 103:2, pages 465-477.
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Clement Kleinstreuer. (2014) Drug-targeting methodologies with applications: A review. World Journal of Clinical Cases 2:12, pages 742.
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Emadeddin Javaheri & Warren H. Finlay. (2013) Size manipulation of hygroscopic saline droplets: Application to respiratory drug delivery. International Journal of Heat and Mass Transfer 67, pages 690-695.
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Laleh Golshahi, Geng Tian, Mandana Azimi, Yoen-Ju Son, Ross Walenga, P. Worth Longest & Michael Hindle. (2013) The Use of Condensational Growth Methods for Efficient Drug Delivery to the Lungs during Noninvasive Ventilation High Flow Therapy. Pharmaceutical Research 30:11, pages 2917-2930.
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