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Journal of Psychoactive Drugs Volume 49, 2017 - Issue 1
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Articles

Loperamide, the “Poor Man’s Methadone”: Brief Review

Cornel N. StanciuResident Physician, Department of Psychiatric Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USACorrespondence[email protected]
, M.D. &
Samantha A. GnanasegaramResident Physician, Department of Psychiatric Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA
, M.D.
Pages 18-21 | Received 23 Jun 2016, Accepted 21 Oct 2016, Published online: 05 Dec 2016

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Jennifer Jones, Anthony Lembo, Joel Heidelbaugh, Louis Kuritzky & Brian Lacy. (2021) Management of irritable bowel syndrome with diarrhea: focus on eluxadoline. Current Medical Research and Opinion 37:4, pages 567-578.
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Amr Salama, Yana Levin, Pramod Jha & Richard Alweis. (2017) Ventricular fibrillation due to overdose of loperamide, the “poor man’s methadone”. Journal of Community Hospital Internal Medicine Perspectives 7:4, pages 222-226.
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Articles from other publishers (16)

Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman & David J. Gallacher. (2023) The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. Biomolecules 13:9, pages 1355.
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Vishwajit Hegde, Tarun Dalia, Taher Tayeb, Elizabeth Cotter & Andrija Vidic. (2023) Loperamide-induced cardiogenic syncope: a case report of a life-threatening presentation of an over-the-counter drug. European Heart Journal - Case Reports 7:2.
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K Aaron Geno, Adina Badea, Kara L Lynch, Paul Jannetto, Jacqueline A Hubbard, Robert D Nerenz & Mark A Cervinski. (2022) An Opioid Hiding in Plain Sight: Loperamide-Induced False-Positive Fentanyl and Buprenorphine Immunoassay Results. The Journal of Applied Laboratory Medicine 7:6, pages 1318-1328.
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Vincent Guinchat, Nicolas Ansermot, Kuntheavy Ing Lorenzini, Dimitri Politis, Youssef Daali, Chin B. Eap & Séverine Crettol. (2022) Case Report: Opioid Use Disorder Associated With Low/Moderate Dose of Loperamide in an Intellectual Disability Patient With CYP3A and P-Glycoprotein Reduced Activity. Frontiers in Psychiatry 13.
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Mohamed Al GarhySona MohanAisha Al Dhufairi. (2021) Loperamide and P‐glycoprotein modulator in opioid detoxification. Progress in Neurology and Psychiatry 25:3, pages 25-28.
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Łukasz Sobczak & Krzysztof Goryński. (2020) Pharmacological Aspects of Over-the-Counter Opioid Drugs Misuse. Molecules 25:17, pages 3905.
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Anderson Wang, Michael Nguyen, Jesus Diaz & Travis Smith. (2020) Loperamide toxicity mimicking peripartum cardiomyopathy. The American Journal of Emergency Medicine 38:3, pages 693.e5-693.e6.
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C. James Watson, James D. Whitledge, Alexander F. Barbuto, Katherine L. Boyle & Michael Ganetsky. (2020) Toxicity of agents used for opioid withdrawal: a case-based approach. International Anesthesiology Clinics 58:2, pages 19-27.
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N E Webb, D M Wood, J C Black, E Amioka, R C Dart & P I Dargan. (2020) Non-medical use of loperamide in the UK and the USA. QJM: An International Journal of Medicine 113:1, pages 25-30.
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Yukuang Guo, Hyunwoo Lee & Hyunyoung Jeong. 2020. The Microbiome in Health and Disease. The Microbiome in Health and Disease 61 93 .
Pavan Kumar Nukala, Siddhant Palekar, Manali Patki, Yige Fu & Ketan Patel. (2019) Multi-dose oral abuse deterrent formulation of loperamide using hot melt extrusion. International Journal of Pharmaceutics 569, pages 118629.
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Gema Vera, Rocío Girón, María Isabel Martín‐Fontelles & Raquel Abalo. (2019) Radiographic dose‐dependency study of loperamide effects on gastrointestinal motor function in the rat. Temporal relationship with nausea‐like behavior. Neurogastroenterology & Motility 31:8.
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George Sam Wang & Christopher Hoyte. (2019) Novel Drugs of Abuse. Pediatrics In Review 40:2, pages 71-78.
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David V. Gauvin, Zachary J. Zimmermann & Theodore J. Baird. (2019) In further defense of nonclinical abuse liability testing of biologics. Regulatory Toxicology and Pharmacology 101, pages 103-120.
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Fabrizio Schifano, Stefania Chiappini, John Corkery & Amira Guirguis. (2018) Abuse of Prescription Drugs in the Context of Novel Psychoactive Substances (NPS): A Systematic Review. Brain Sciences 8:4, pages 73.
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Tamer Akel & Soad Bekheit. (2018) Loperamide cardiotoxicity: “A Brief Review”. Annals of Noninvasive Electrocardiology 23:2, pages e12505.
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