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Acta Oncologica Volume 39, 2000 - Issue 5
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Research Article

Feasibility of Detecting Hypoxia in Experimental Mouse Tumours with 18F-fluorinated Tracers and Positron Emission Tomography: A Study Evaluating [18F]Fluoromisonidazole and [18F]Fluoro-2-deoxy-D-glucose

Lise Bentzen Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Build. 5, DK-8000 Aarhus C, Denmark
Pages 629-637 | Published online: 08 Jul 2009

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Michael R. Horsman. (2017) Enhancing the radiation response of tumors but not early or late responding normal tissues using a vascular disrupting agent. Acta Oncologica 56:11, pages 1634-1638.
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Lise Saksø Mortensen, Simon Buus, Marianne Nordsmark, Lise Bentzen, Ole Lajord Munk, Susanne Keiding & Jens Overgaard. (2010) Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrode. Acta Oncologica 49:7, pages 934-940.
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Kerstin Bruechner, Ralf Bergmann, Alina Santiago, Birgit Mosch, Ala Yaromina, Franziska Hessel, Frank Hofheinz, Joerg van den Hoff, Michael Baumann & Bettina Beuthien-Baumann. (2009) Comparison of [18F]FDG uptake and distribution with hypoxia and proliferation in FaDu human squamous cell carcinoma (hSCC) xenografts after single dose irradiation. International Journal of Radiation Biology 85:9, pages 772-780.
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Michael R. Horsman, Thomas R. Wittenborn, Patricia S. Nielsen & Pernille B. Elming. (2020) Tumors Resistant to Checkpoint Inhibitors Can Become Sensitive after Treatment with Vascular Disrupting Agents. International Journal of Molecular Sciences 21:13, pages 4778.
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Johannes Müller, Michael Schürer, Christian Neubert, Falk Tillner, Elke Beyreuther, Theresa Suckert, Nils Peters, Cläre von Neubeck, Armin Lühr, Mechthild Krause, Rebecca Bütof & Antje Dietrich. (2020) Multi-modality bedding platform for combined imaging and irradiation of mice. Biomedical Physics & Engineering Express 6:3, pages 037003.
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Aravind S. Ravi Kumar, W. Phillip. Law, Craig Wilson, Shankar Siva & Michael S. Hofman. 2020. Imaging and Interventional Radiology for Radiation Oncology. Imaging and Interventional Radiology for Radiation Oncology 325 360 .
Yu Lin, Ying-Na Bao, Cong-Xiu Huang, Ji-Hong Zhang, Zhi-Long Yu, Ye Tian, Xiang-Cheng Wang & Yi-Tong Cui. (2019) The Effect of Carbogen Breathing on 18 F-FDG Uptake in Non-Small-Cell Lung Cancer . BioMed Research International 2019, pages 1-6.
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Sven De Bruycker, Christel Vangestel, Steven Staelens, Tim Van den Wyngaert & Sigrid Stroobants. (2018) How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research. Contrast Media & Molecular Imaging 2018, pages 1-17.
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Sven De Bruycker, Christel Vangestel, Tim Van den Wyngaert, Leonie wyffels, An Wouters, Patrick Pauwels, Steven Staelens & Sigrid Stroobants. (2016) Baseline [18F]FMISO μPET as a Predictive Biomarker for Response to HIF-1α Inhibition Combined with 5-FU Chemotherapy in a Human Colorectal Cancer Xenograft Model. Molecular Imaging and Biology 18:4, pages 606-616.
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Eline E Verwer. (2014) Positron emission tomography to assess hypoxia and perfusion in lung cancer. World Journal of Clinical Oncology 5:5, pages 824.
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MAKOTO ADACHI & LIGY THOMAS. (2013) Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients. Molecular and Clinical Oncology 1:1, pages 12-14.
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Marian Axente, Peck-Sun Lin & Andrei Pugachev. (2012) Single-fraction simulation of relative cell survival in response to uniform versus hypoxia-targeted dose escalation. Physics in Medicine and Biology 57:9, pages 2757-2774.
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Xiao-Feng Li, Yuanyuan Ma, Xiaorong Sun, John L. Humm, C. Clifton Ling & Joseph A. O'Donoghue. (2010) High 18 F-FDG Uptake in Microscopic Peritoneal Tumors Requires Physiologic Hypoxia . Journal of Nuclear Medicine 51:4, pages 632-638.
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Xiao-Feng Li, Xiaorong Sun, Yuanyuan Ma, Makiko Suehiro, Mutian Zhang, James Russell, John L. Humm, C. Clifton Ling & Joseph A. O’Donoghue. (2009) Detection of hypoxia in microscopic tumors using 131I-labeled iodo-azomycin galactopyranoside (131I-IAZGP) digital autoradiography. European Journal of Nuclear Medicine and Molecular Imaging 37:2, pages 339-348.
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A. Huchet, P. Fernandez, M. Allard, Y. Belkacémi, J.-P. Maire, R. Trouette, S. Eimer, T. Tourdias & H. Loiseau. (2009) Imagerie moléculaire de l’hypoxie tumorale. Cancer/Radiothérapie 13:8, pages 747-757.
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Gilles Mees, Rudi Dierckx, Christel Vangestel & Christophe Van de Wiele. (2009) Molecular imaging of hypoxia with radiolabelled agents. European Journal of Nuclear Medicine and Molecular Imaging 36:10, pages 1674-1686.
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Ernst J. Postema, Alexander J. B. McEwan, Terence A. Riauka, Piyush Kumar, Dacia A. Richmond, Douglas N. Abrams & Leonard I. Wiebe. (2009) Initial results of hypoxia imaging using 1-α-d-(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole (18F-FAZA). European Journal of Nuclear Medicine and Molecular Imaging 36:10, pages 1565-1573.
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Morten Busk, Michael R. Horsman, Steen Jakobsen, Johan Bussink, Albert van der Kogel & Jens Overgaard. (2008) Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage. European Journal of Nuclear Medicine and Molecular Imaging 35:12, pages 2294-2303.
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Bi-Fang Lee, Nan-Tsing Chiu, Chien-Chung Hsia & Lie-Hang Shen. (2008) Accumulation of Tc-99m HL91 in Tumor Hypoxia: In Vitro Cell Culture and In Vivo Tumor Model. The Kaohsiung Journal of Medical Sciences 24:9, pages 461-472.
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Morten Busk, Michael R. Horsman, Paul E.G. Kristjansen, Albert J. van der Kogel, Johan Bussink & Jens Overgaard. (2008) Aerobic glycolysis in cancers: Implications for the usability of oxygen‐responsive genes and fluorodeoxyglucose‐PET as markers of tissue hypoxia. International Journal of Cancer 122:12, pages 2726-2734.
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C Champion & C Le Loirec. (2007) Positron follow-up in liquid water: II. Spatial and energetic study for the most important radioisotopes used in PET. Physics in Medicine and Biology 52:22, pages 6605-6625.
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Yazid Belkacémi, Pelagia Tsoutsou, Nicolas Magné, Pierre Castadot & David Azria. (2007) Metabolic functional imaging for tumor radiosensitivity monitoring. Critical Reviews in Oncology/Hematology 62:3, pages 227-239.
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Linda W Chan, Sebastien Hapdey, Sean English, Jurgen Seidel, Joann Carson, Anastasia L Sowers, Murali C Krishna, Michael V Green, James B Mitchell & Stephen L Bacharach. (2006) The influence of tumor oxygenation on 18F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET). Radiation Oncology 1:1.
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Esther G.C. Troost, Peter Laverman, Johannes H.A.M. Kaanders, Mariëlle Philippens, Jasper Lok, Wim J.G. Oyen, Albert J. van der Kogel, Otto C. Boerman & Johan Bussink. (2006) Imaging hypoxia after oxygenation-modification: Comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors. Radiotherapy and Oncology 80:2, pages 157-164.
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Lioe-Fee de Geus-Oei, Johannes H.A.M. Kaanders, Luc A.M. Pop, Frans H.M. Corstens & Wim J.G. Oyen. (2006) Effects of hyperoxygenation on FDG-uptake in head-and-neck cancer. Radiotherapy and Oncology 80:1, pages 51-56.
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J.G. Rajendran, K.R.G. Hendrickson, A.M. Spence, M. Muzi, K.A. Krohn & D.A. Mankoff. (2006) Hypoxia imaging-directed radiation treatment planning. European Journal of Nuclear Medicine and Molecular Imaging 33:S1, pages 44-53.
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