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Acta Oncologica Volume 55, 2016 - Issue 12
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LETTERS TO THE EDITOR

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm

Maria SaagerDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany; ;Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; ;National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany; Correspondence[email protected]
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Christin GlowaDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany; ;Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; ;National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany;
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Peter PeschkeNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany; ;Clinical Cooperation Unit Molecular Radiooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;
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Stephan BronsNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany; ;Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany;
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Rebecca GrünDepartment of Biophysics, Helmholtz Center for Heavy Ion Research (GSI), Darmstadt, Germany
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Michael ScholzDepartment of Biophysics, Helmholtz Center for Heavy Ion Research (GSI), Darmstadt, Germany
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Peter E. HuberDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany; ;National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany; ;Clinical Cooperation Unit Molecular Radiooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;
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Jürgen DebusDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany; ;National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany;
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Christian P. KargerDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; ;National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany;
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Pages 1512-1515 | Received 16 Aug 2016, Accepted 15 Oct 2016, Published online: 09 Nov 2016

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Cai Grau, Morten Høyer, Per Rugaard Poulsen, Ludvig Paul Muren, Stine Sofia Korreman, Kari Tanderup, Jacob Christian Lindegaard, Jan Alsner & Jens Overgaard. (2017) Rethink radiotherapy – BIGART 2017. Acta Oncologica 56:11, pages 1341-1352.
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Armin Lühr, Cläre von Neubeck, Stephan Helmbrecht, Michael Baumann, Wolfgang Enghardt & Mechthild Krause. (2017) Modeling in vivo relative biological effectiveness in particle therapy for clinically relevant endpoints. Acta Oncologica 56:11, pages 1392-1398.
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Johannes Müller, Christian Neubert, Cläre von Neubeck, Michael Baumann, Mechthild Krause, Wolfgang Enghardt, Rebecca Bütof, Antje Dietrich & Armin Lühr. (2017) Proton radiography for inline treatment planning and positioning verification of small animals. Acta Oncologica 56:11, pages 1399-1405.
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Articles from other publishers (22)

Weiwei Wang, Ping Li, Kambiz Shahnazi, Xiaodong Wu & Jingfang Zhao. (2022) Calculating dose‐averaged linear energy transfer in an analytical treatment planning system for carbon‐ion radiotherapy. Journal of Applied Clinical Medical Physics 24:2.
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Wioletta S Kozłowska, Mario P Carante, Giulia Aricò, Alessia Embriaco, Alfredo Ferrari, Giuseppe Magro, Andrea Mairani, Ricardo Ramos, Paola Sala, Dietmar Georg & Francesca Ballarini. (2022) First application of the BIANCA biophysical model to carbon-ion patient cases. Physics in Medicine & Biology 67:11, pages 115013.
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P. Fossati, S. Tubin & E.B. Hug. 2022. Principles and Practice of Particle Therapy. Principles and Practice of Particle Therapy 27 46 .
Lisa Hintz, Christin Glowa, Maria Saager, Rosemarie Euler-Lange, Peter Peschke, Stephan Brons, Rebecca Grün, Michael Scholz, Stewart Mein, Andrea Mairani, Jürgen Debus & Christian P. Karger. (2022) Relative biological effectiveness of single and split helium ion doses in the rat spinal cord increases strongly with linear energy transfer. Radiotherapy and Oncology 170, pages 224-230.
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Tabea Pfuhl, Thomas Friedrich & Michael Scholz. (2021) Comprehensive comparison of local effect model IV predictions with the particle irradiation data ensemble. Medical Physics 49:1, pages 714-726.
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Christian P. Karger, Christin Glowa, Peter Peschke & Wilma Kraft-Weyrather. (2021) The RBE in ion beam radiotherapy: In vivo studies and clinical application. Zeitschrift für Medizinische Physik 31:2, pages 105-121.
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Maria Saager, Christin Glowa, Peter Peschke, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus & Christian P. Karger. (2020) Fractionated carbon ion irradiations of the rat spinal cord: comparison of the relative biological effectiveness with predictions of the local effect model. Radiation Oncology 15:1.
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Stewart Mein, Carmen Klein, Benedikt Kopp, Giuseppe Magro, Semi Harrabi, Christian P. Karger, Thomas Haberer, Jürgen Debus, Amir Abdollahi, Ivana Dokic & Andrea Mairani. (2020) Assessment of RBE-Weighted Dose Models for Carbon Ion Therapy Toward Modernization of Clinical Practice at HIT: In Vitro, in Vivo, and in Patients. International Journal of Radiation Oncology*Biology*Physics 108:3, pages 779-791.
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Walter Tinganelli & Marco Durante. (2020) Carbon Ion Radiobiology. Cancers 12:10, pages 3022.
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Mario P. Carante, Giulia Aricò, Alfredo Ferrari, Christian P. Karger, Wioletta Kozlowska, Andrea Mairani, Paola Sala & Francesca Ballarini. (2020) In Vivo Validation of the BIANCA Biophysical Model: Benchmarking against Rat Spinal Cord RBE Data. International Journal of Molecular Sciences 21:11, pages 3973.
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Michael Scholz. (2020) State-of-the-Art and Future Prospects of Ion Beam Therapy: Physical and Radiobiological Aspects. IEEE Transactions on Radiation and Plasma Medical Sciences 4:2, pages 147-160.
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Clarissa Gillmann, Oliver Jäkel & Christian P. Karger. (2019) RBE-weighted doses in target volumes of chordoma and chondrosarcoma patients treated with carbon ion radiotherapy: Comparison of local effect models I and IV. Radiotherapy and Oncology 141, pages 234-238.
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Akihisa Takahashi, Yukari Yoshida & Koichi Ando. (2019) 8.2.3　Relative Biological Effectiveness in Carbon-Ion Therapy8.2.3　炭素線治療における生物学的効果比. RADIOISOTOPES 68:10, pages 701-707.
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Marco Durante, Alexander Golubev, Woo-Yoon Park & Christina Trautmann. (2019) Applied nuclear physics at the new high-energy particle accelerator facilities. Physics Reports 800, pages 1-37.
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Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus & Christian P. Karger. (2018) Late normal tissue response in the rat spinal cord after carbon ion irradiation. Radiation Oncology 13:1.
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Robert D. Stewart, David J. Carlson, Michael P. Butkus, Roland Hawkins, Thomas Friedrich & Michael Scholz. (2018) A comparison of mechanism‐inspired models for particle relative biological effectiveness (RBE). Medical Physics 45:11.
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Piero Fossati, Naruhiro Matsufuji, Tadashi Kamada & Christian P. Karger. (2018) Radiobiological issues in prospective carbon ion therapy trials. Medical Physics 45:11.
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Maria Saager, Peter Peschke, Stephan Brons, Jürgen Debus & Christian P. Karger. (2018) Determination of the proton RBE in the rat spinal cord: Is there an increase towards the end of the spread-out Bragg peak?. Radiotherapy and Oncology 128:1, pages 115-120.
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Clarissa Gillmann, Antony J. Lomax, Damien C. Weber, Oliver Jäkel & Christian P. Karger. (2018) Dose–response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect?. Radiotherapy and Oncology 128:1, pages 109-114.
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Marco Durante & Jürgen Debus. (2018) Heavy Charged Particles: Does Improved Precision and Higher Biological Effectiveness Translate to Better Outcome in Patients?. Seminars in Radiation Oncology 28:2, pages 160-167.
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Christian P Karger & Peter Peschke. (2017) RBE and related modeling in carbon-ion therapy. Physics in Medicine & Biology 63:1, pages 01TR02.
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Yoonsun ChungSang Hee AhnChanghoon ChoiSohee Park. (2017) Development of Program for Relative Biological Effectiveness (RBE) Analysis of Particle Beam Therapy. Progress in Medical Physics 28:1, pages 11.
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