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Research Article

Formulation and In Vitro Evaluation of Bisphosphonate Loaded Microspheres for Implantation in Osteolysis

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Pages 473-481 | Published online: 25 Sep 2008

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Sedat Ünal & Yeşim Aktaş. (2023) Bisphosphonate-loaded PLGA microspheres for bone regeneration in dental surgery: formulation, characterization, stability, and comprehensive release kinetic studies . International Journal of Polymeric Materials and Polymeric Biomaterials 72:1, pages 89-100.
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Yusuke Hattori, Hiroe Mori, Joshua Chou & Makoto Otsuka. (2016) Mechanochemical synthesis of zinc-apatitic calcium phosphate and the controlled zinc release for bone tissue engineering. Drug Development and Industrial Pharmacy 42:4, pages 595-601.
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Ji-Ho Lim, Sung-Kyun You, Jong-Suep Baek, Chan-Ju Hwang, Young-Guk Na, Sang-Chul Shin & Cheong-Weon Cho. (2012) Preparation and evaluation of polymeric microparticulates for improving cellular uptake of gemcitabine. International Journal of Nanomedicine 7, pages 2307-2314.
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Ji-Ho Lim, Sung-Kyun You, Jong-Suep Baek, Chan-Ju Hwang, Young-Guk Na, Sang-Chul Shin & Cheong-Weon Cho. (2012) Surface-modified gemcitabine with mucoadhesive polymer for oral delivery†. Journal of Microencapsulation 29:5, pages 487-496.
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Jong-Suep Baek, Hae-Hyun Kwon, Ji-Sook Hwang, Ha-Chang Sung, Jeong-Min Lee, Sang-Chul Shin, Young Ran Kim & Cheong-Weon Cho. (2011) Alendronate-loaded microparticles for improvement of intestinal cellular absorption. Journal of Drug Targeting 19:1, pages 37-48.
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Kai Su, Xuetao Shi, Rohan R Varshney & Dong-An Wang. (2011) Transplantable delivery systems for in situ controlled release of bisphosphonate in orthopedic therapy. Expert Opinion on Drug Delivery 8:1, pages 113-126.
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Letícia Cruz, Evelise Assumpção, Sérgio Faloni Andrade, Daniela Joyce Conrado, Sílvia Stanisçuaski Guterres & Adriana Raffin Pohlmann. (2010) Microencapsulation of sodium alendronate reduces drug mucosal damage in rats. Drug Delivery 17:4, pages 231-237.
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Leena Palomo, James Liu & Nabil F Bissada. (2007) Skeletal bone diseases impact the periodontium: a review of bisphosphonate therapy. Expert Opinion on Pharmacotherapy 8:3, pages 309-315.
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Eman H. Nafea, Magda A. El-Massik, Labiba K. El-Khordagui, Mona k. Marei & Nawal M. Khalafallah. (2007) Alendronate PLGA microspheres with high loading efficiency for dental applications. Journal of Microencapsulation 24:6, pages 525-538.
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Razin Mirzekerimovich Ragimov, Chermen Tamerlanovich Zakaev, Naida Murtazalievna Abdullaeva, Ruslan Kazbekovich Esiev, Sergey Viktorovich Pushkin, Dana Magomedovna Nauruzova, Mariam Bashirovna Balaeva & Sergey Nikolaevich Povetkin. (2022) Analysis of effectiveness of the use of multifunctional biopolymers of chitosan and alginate in dentistry ‎. Journal Of Advanced Pharmacy Education And Research 12:3, pages 21-27.
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Rohith Jayaram, Patrick W. O'Donnell & David A. Puleo. (2021) Systems for local, sustained release of zoledronic acid as a potential treatment for metastatic bone disease. Materials Science and Engineering: C 118, pages 111395.
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Farzad Moradikhah, Mehdi Doosti-Telgerd, Iman Shabani, Shima Soheili, Banafsheh Dolatyar & Ehsan Seyedjafari. (2020) Microfluidic fabrication of alendronate-loaded chitosan nanoparticles for enhanced osteogenic differentiation of stem cells. Life Sciences 254, pages 117768.
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Sofia S. H. Matrali & Anita K. Ghag. (2020) Feedback-Controlled Release of Alendronate from Composite Microparticles. Journal of Functional Biomaterials 11:3, pages 46.
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Christina Koulouktsi, Stavroula Nanaki, Panagiotis Barmpalexis, Margaritis Kostoglou & Dimitrios Bikiaris. (2019) Preparation and characterization of Alendronate depot microspheres based on novel poly(-ε-caprolactone)/Vitamin E TPGS copolymers. International Journal of Pharmaceutics: X 1, pages 100014.
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Lawrence P. Fernando, Jamal S. Lewis, Brian C. Evans, Craig L. Duvall & Benjamin G. Keselowsky. (2018) Formulation and characterization of poly(propylacrylic acid)/poly(lactic-co-glycolic acid) blend microparticles for pH-dependent membrane disruption and cytosolic delivery. Journal of Biomedical Materials Research Part A 106:4, pages 1022-1033.
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Balasankar Meera Priyadarshini & Nileshkumar Dubey. 2017. Oral Healthcare and Technologies. Oral Healthcare and Technologies 221 247 .
Balasankar Meera Priyadarshini & Nileshkumar Dubey. 2017. Advancing Medicine through Nanotechnology and Nanomechanics Applications. Advancing Medicine through Nanotechnology and Nanomechanics Applications 44 77 .
P. Díaz-Rodríguez & M. Landin. 2016. Advanced Materials Interfaces. Advanced Materials Interfaces 325 378 .
Ewa Chmielewska & Paweł Kafarski. (2016) Physiologic Activity of Bisphosphonates – Recent Advances. Open Pharmaceutical Sciences Journal 3:1, pages 56-78.
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Maria Justina Roxana Virlan, Daniela Miricescu, Alexandra Totan, Maria Greabu, Cristiana Tanase, Cristina M. Sabliov, Constantin Caruntu & Bogdan Calenic. (2015) Current Uses of Poly(lactic-co-glycolic acid) in the Dental Field: A Comprehensive Review. Journal of Chemistry 2015, pages 1-12.
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Ralf Smeets, Henning Hanken, Ole Jung & Max Heiland. 2015. Medication-Related Osteonecrosis of the Jaws. Medication-Related Osteonecrosis of the Jaws 207 215 .
Hongwei Wu, Yan Xu, Gengyan Liu, Jianghong Ling, Biraja C. Dash, Jianming Ruan & Chaoyue Zhang. (2014) Emulsion cross-linked chitosan/nanohydroxyapatite microspheres for controlled release of alendronate. Journal of Materials Science: Materials in Medicine 25:12, pages 2649-2658.
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Elisabeth V. Giger, Bastien Castagner & Jean-Christophe Leroux. (2013) Biomedical applications of bisphosphonates. Journal of Controlled Release 167:2, pages 175-188.
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K. Miladi, S. Sfar, H. Fessi & A. Elaissari. (2013) Drug carriers in osteoporosis: Preparation, drug encapsulation and applications. International Journal of Pharmaceutics 445:1-2, pages 181-195.
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Maha Nasr, Gehanne A.S. Awad, Samar Mansour, Ismail Taha, Abdelhamid Al Shamy & Nahed D. Mortada. (2011) Different modalities of NaCl osmogen in biodegradable microspheres for bone deposition of risedronate sodium by alveolar targeting. European Journal of Pharmaceutics and Biopharmaceutics 79:3, pages 601-611.
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Asteria Luzardo Álvarez, Francisco Otero Espinar & José Blanco Méndez. (2011) The Application of Microencapsulation Techniques in the Treatment of Endodontic and Periodontal Diseases. Pharmaceutics 3:3, pages 538-571.
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Dario Puppi, Anna Maria Piras, Federica Chiellini, Emo Chiellini, Albino Martins, Isabel B. Leonor, Nuno Neves & Rui Reis. (2011) Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite. Journal of Tissue Engineering and Regenerative Medicine 5:4, pages 253-263.
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Maha Nasr, Gehanne A.S. Awad, Samar Mansour, Abdelhamid Al Shamy & Nahed D. Mortada. (2011) A Reliable Predictive Factorial Model for Entrapment Optimization of a Sodium Bisphosphonate into Biodegradable Microspheres. Journal of Pharmaceutical Sciences 100:2, pages 612-621.
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Montserrat Colilla, Isabel Izquierdo-Barba & María Vallet-Regí. (2010) Phosphorus-containing SBA-15 materials as bisphosphonate carriers for osteoporosis treatment. Microporous and Mesoporous Materials 135:1-3, pages 51-59.
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