689
Views
53
CrossRef citations to date
0
Altmetric
Review Article

Hydroxyapatite as a biomaterial – a gift that keeps on giving

ORCID Icon, , , , , ORCID Icon, , & ORCID Icon show all
Pages 1035-1062 | Received 04 Jan 2020, Accepted 25 May 2020, Published online: 16 Jun 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Renu Kumari, Alok Kumar Das, Ananad Murmu & Kumari Kanchan. (2023) Laser cladding of HA-TiO2 composite coating on Mg-alloy: microstructural characterisation and wettability analysis. Advances in Materials and Processing Technologies 0:0, pages 1-8.
Read now
Maryam Mollaei & Jaleh Varshosaz. (2023) Preparation and characterization of hydroxyapatite nanoparticles doped with nickel, tin, and molybdate ions for their antimicrobial effects. Drug Development and Industrial Pharmacy 49:2, pages 168-178.
Read now
Himanshu Bisaria, Bharat Bhusan Patra & Smita Mohanty. (2022) Surface modification during hydroxyapatite powder mixed electric discharge machining of metallic biomaterials: a review. Surface Engineering 38:7-9, pages 680-706.
Read now
N Pradeep, C Chandrasekhara Sastry, Lc Brandão & B.S. Meennakshi. (2022) 3D Printing of Shrimp Derived Chitosan with HAp as a Bio-Composite Scaffold. Materials and Manufacturing Processes 37:11, pages 1257-1266.
Read now
Mehrnoush Mehrarya, Behnaz Gharehchelou, Samin Haghighi Poodeh, Elham Jamshidifar, Sara Karimifard, Bahareh Farasati Far, Iman Akbarzadeh & Alexander Seifalian. (2022) Niosomal formulation for antibacterial applications. Journal of Drug Targeting 30:5, pages 476-493.
Read now

Articles from other publishers (47)

Mansoureh Rezapourian & Irina Hussainova. (2023) Optimal mechanical properties of Hydroxyapatite gradient Voronoi porous scaffolds for bone applications — A numerical study. Journal of the Mechanical Behavior of Biomedical Materials 148, pages 106232.
Crossref
M. Kalaiyarasan, S. Manju Bharathi, N. Rajendran, P. Bargavi, R. Ramya, K. Saranya, B. Satheesh Kumar & R. Pratibha. (2023) Synergetic effect of Fe/Ag ions incorporated HAp on AZ31 Mg alloy to improve corrosion resistance and osteogenic activity. Journal of Alloys and Compounds 960, pages 170711.
Crossref
R.L. Siqueira, N. Maurmann, P.K.P. Gaio, D.P. Pereira, P. Pranke, L.T.A. Cintra, C.H.G. Martins, O. Peitl & E.D. Zanotto. (2023) Antibacterial effect and cell metabolic activity of Na2CaSi2O6, β-NaCaPO4, and β-NaCaPO4-SiO2 versus hydroxyapatite. Ceramics International 49:18, pages 29991-30000.
Crossref
Eric Tzyy Jiann Chong, Jun Wei Ng & Ping-Chin Lee. (2023) Classification and Medical Applications of Biomaterials‐A Mini Review. BIO Integration 4:2, pages 54-61.
Crossref
Zohaib Khurshid, Mohammed Farhan A. Alfarhan, Yasmin Bayan, Javed Mazher, Necdet Adanir, George J. Dias, Paul R. Cooper & Jithendra Ratnayake. (2023) Development, physicochemical characterization and in-vitro biocompatibility study of dromedary camel dentine derived hydroxyapatite for bone repair . PeerJ 11, pages e15711.
Crossref
Seyed Javad Mousavi, Fatemeh Ejeian, Amir Razmjou & Mohammad Hossein Nasr‐Esfahani. (2023) In vivo evaluation of bone regeneration using ZIF8‐modified polypropylene membrane in rat calvarium defects. Journal of Clinical Periodontology.
Crossref
Sujeesh Sebastian, Jintian Huang, Yang Liu, Felix Tandberg, Mattias Collin, Manoj Puthia & Deepak Bushan Raina. (2023) Hydroxyapatite: An antibiotic recruiting moiety for local treatment and prevention of bone infections. Journal of Orthopaedic Research.
Crossref
Sumit Kumar, Rakesh Kumar Gupta, Kumari Archana & Renu Kumari. (2023) Development of Ternary Hydroxyapatite-Al2O3-TiO2 Nanocomposite Coating on Mg Alloy by Electrophoretic Deposition Method. Journal of Materials Engineering and Performance.
Crossref
Md. Sahadat Hossain, Md. Aftab Ali Shaikh, Shirin Akter Jahan, Monika Mahmud, Mashrafi Bin Mobarak, Md. Saifur Rahaman, Md. Najem Uddin & Samina Ahmed. (2023) Exploring the biomedical competency of gamma-radiation aided hydroxyapatite and its composite fabricated with nano-cellulose and chitosan. RSC Advances 13:14, pages 9654-9664.
Crossref
Ahmed K. Saleh, Emad Tolba & Ahmed Salama. (2023) In situ development of bacterial cellulose/hydroxyapatite nanocomposite membrane based on two different fermentation strategies: characterization and cytotoxicity evaluation. Biomass Conversion and Biorefinery.
Crossref
Vuk Uskoković. (2023) Supplementation of Polymeric Reservoirs with Redox-Responsive Metallic Nanoparticles as a New Concept for the Smart Delivery of Insulin in Diabetes. Materials 16:2, pages 786.
Crossref
Natalia V. Bulina, Leon A. Avakyan, Svetlana V. Makarova, Igor B. Orehov & Vladimir S. Bystrov. (2023) Structural Features of Oxyapatite. Minerals 13:1, pages 102.
Crossref
Maria Apriliani Gani, Aniek Setiya Budiatin, Dewi Wara Shinta, Chrismawan Ardianto & Junaidi Khotib. (2023) Bovine hydroxyapatite-based scaffold accelerated the inflammatory phase and bone growth in rats with bone defect. Journal of Applied Biomaterials & Functional Materials 21, pages 228080002211491.
Crossref
Chunhui Ji, Bingnan He, Shiyue Yun, Xinlei Bai & Bin Lin. (2023) The fracture mechanical behavior simulation of calcium-deficient hydroxyapatite crystals by molecular dynamics and first-principles calculation. Journal of the Mechanical Behavior of Biomedical Materials 137, pages 105526.
Crossref
Chakkapat Aenglong, Nujamee Ngasakul, Maruj Limpawattana, Wanida Sukketsiri, Suwimol Chockchaisawasdee, Costas Stathopoulos, Supita Tanasawet & Wanwimol Klaypradit. (2023) Characterization of novel calcium compounds from tilapia (Oreochromis niloticus) by-products and their effects on proliferation and differentiation of MC3T3-E1 cells. Journal of Functional Foods 100, pages 105361.
Crossref
Yingzheng Zhao, Hangbo Chen, Kunjie Ran, Yingying Zhang, Hanxiao Pan, Jianxun Shangguan, Mengqi Tong, Jiaojiao Yang, Qing Yao & Helin Xu. (2023) Porous hydroxyapatite scaffold orchestrated with bioactive coatings for rapid bone repair. Biomaterials Advances 144, pages 213202.
Crossref
Ma Peifen, Li Mengyun, Hu Jinglong, Li Danqian, Tao Yan, Xu Liwei, Zhao Han, Da Jianlong, Li Lingyan, Zhao Guanghui & Wang Zhiping. (2023) New skin tissue engineering scaffold with sulfated silk fibroin/chitosan/hydroxyapatite and its application. Biochemical and Biophysical Research Communications 640, pages 117-124.
Crossref
Meng Zhang, Hongshi Ma & Chengtie Wu. 2022. Biofabrication for Orthopedics. Biofabrication for Orthopedics 25 53 .
Ashwathi Mathirat, Pandurang Appana Dalavi, Ashwini Prabhu, Yashaswini Devi G.V.Sukumaran Anil, Kalimuthu Senthilkumar, Gi Hun Seong, Sharan S. Sargod, Sham S. Bhat & Jayachandran Venkatesan. (2022) Remineralizing Potential of Natural Nano-Hydroxyapatite Obtained from Epinephelus chlorostigma in Artificially Induced Early Enamel Lesion: An In Vitro Study. Nanomaterials 12:22, pages 3993.
Crossref
Khee Chung Hui, Nagaammai Dhanapalan, Apriliana Cahya Khayrani, Teguh Imanto & Nonni Soraya Sambudi. (2022) The synthesis of amino-functionalized carbon quantum dots-decorated hydroxyapatite as drug delivery agent. Comptes Rendus. Chimie 25:G1, pages 295-306.
Crossref
Makoto Otsuka, Hanae Saito & Tetsuo Sasaki. (2022) Analytical Evaluation of Wet and Dry Mechanochemical Syntheses of Calcium-Deficient Hydroxyapatite Containing Zinc Using X-ray Diffractometry and Near-Infrared Spectroscopy. Pharmaceutics 14:10, pages 2105.
Crossref
Sergey V. Dorozhkin. (2022) Calcium Orthophosphate (CaPO4)-Based Bioceramics: Preparation, Properties, and Applications. Coatings 12:10, pages 1380.
Crossref
Baoshuai Bai, Junxiang Hao, Mengjie Hou, Tao Wang, Xiaodi Wu, Yanhan Liu, Yiyang Wang, Chengxiang Dai, Yujie Hua, Guangyu Ji & Guangdong Zhou. (2022) Repair of Large-Scale Rib Defects Based on Steel-Reinforced Concrete-Designed Biomimetic 3D-Printed Scaffolds with Bone-Mineralized Microenvironments. ACS Applied Materials & Interfaces 14:37, pages 42388-42401.
Crossref
Oratai Jongprateep, Nonthaporn Jitanukul, Khotamy Saphongxay, Benjamon Petchareanmongkol, Ampika Bansiddhi, Apirat Laobuthee, Amornrat Lertworasirikul & Ratchatee Techapiesancharoenkij. (2022) Hydroxyapatite coating on an aluminum/bioplastic scaffold for bone tissue engineering. RSC Advances 12:41, pages 26789-26799.
Crossref
Margarita A. Goldberg, Alexander S. Fomin, Fadis F. Murzakhanov, Olga N. Makshakova, Nadezhda O. Donskaya, Olga S. Antonova, Oleg I. Gnezdilov, Ivan V. Mikheev, Alexander V. Knotko, Egor A. Kudryavtsev, Suraya A. Akhmedova, Irina K. Sviridova, Natalia S. Sergeeva, Georgy V. Mamin, Sergey M. Barinov, Marat R. Gafurov & Vladimir S. Komlev. (2022) The improved textural properties, thermal stability, and cytocompatibility of mesoporous hydroxyapatite by Mg2+ doping. Materials Chemistry and Physics 289, pages 126461.
Crossref
Vuk Uskoković & Victoria M. Wu. (2022) When Nothing Turns Itself Inside out and Becomes Something: Coating Poly(Lactic-Co-Glycolic Acid) Spheres with Hydroxyapatite Nanoparticles vs. the Other Way Around. Journal of Functional Biomaterials 13:3, pages 102.
Crossref
Ingrid E.P. Souza, Luciana V. Cambraia, Viviane S. Gomide & Eduardo H.M. Nunes. (2022) Short review on the use of graphene as a biomaterial –prospects, and challenges in Brazil. Journal of Materials Research and Technology 19, pages 2410-2430.
Crossref
Sabine van RijtKlaas de GrootSander C.G. Leeuwenburgh. (2022) Calcium Phosphate and Silicate-Based Nanoparticles: History and Emerging Trends. Tissue Engineering Part A 28:11-12, pages 461-477.
Crossref
Valeria Ambrogi, Giulia Quaglia, Donatella Pietrella, Morena Nocchetti, Alessandro Di Michele, Eleonora Bolli, Saulius Kaciulis, Alessio Mezzi, Giuseppina Padeletti & Loredana Latterini. (2022) Silver@Hydroxyapatite functionalized calcium carbonate composites: characterization, antibacterial and antibiofilm activities and cytotoxicity. Applied Surface Science 586, pages 152760.
Crossref
Ahmed Aziz, Yahya Sefidbakht, Shokouh Rezaei, Hasan Kouchakzadeh & Vuk Uskoković. (2022) Doxorubicin-loaded, pH-sensitive Albumin Nanoparticles for Lung Cancer Cell Targeting. Journal of Pharmaceutical Sciences 111:4, pages 1187-1196.
Crossref
Reka  BALINT, Gertrud Alexandra PALTINEAN, Diana Alexandra  FLOREA, Gheorghe TOMOAIA, Aurora MOCANU & Maria  TOMOAIA-COTISEL. (2022) Biomimetic and Antibacterial Composite for Orthopedic Implants. Annals of the Academy of Romanian Scientists Series on Biological Sciences 11:1, pages 120-145.
Crossref
Yinpo Qiao. (2021) Tunable luminescence and cytotoxicity of Samarium-doped calcium–strontium–hydroxyapatite for cell imaging. Functional Materials Letters 15:01.
Crossref
Yu-Qiao Chen, Ying-Jie Zhu, Zhong-Yi Wang, Han-Ping Yu & Zhi-Chao Xiong. (2022) A scalable, low-cost and green strategy for the synthesis of ultralong hydroxyapatite nanowires using peanut oil. CrystEngComm.
Crossref
Natália Morelli Possolli, Daiara Floriano da Silva, Jaqueline Vieira, Natasha Maurmann, Patricia Pranke, Ketner Bendo Demétrio, Elidio Angioletto, Oscar Rubem Klegues Montedo & Sabrina Arcaro. (2021) Dissolution, bioactivity behavior, and cytotoxicity of 19. 58Li 2 O ·11. 10ZrO 2 ·69. 32SiO 2 glass–ceramic . Journal of Biomedical Materials Research Part B: Applied Biomaterials 110:1, pages 67-78.
Crossref
Erick Insuasti‐Cruz, Victoria Suárez‐Jaramillo, Kevin Andres Mena Urresta, Kevin O. Pila‐Varela, Xiomira Fiallos‐Ayala, Si Amar Dahoumane & Frank Alexis. (2021) Natural Biomaterials from Biodiversity for Healthcare Applications. Advanced Healthcare Materials 11:1.
Crossref
Gehan T. El-Bassyouni, Gamal M. Turky, Sayed H. Kenawy, Abeer A. Abd El-Aty & Esmat M.A. Hamzawy. (2021) Effect of Yttrium Oxide in Hydroxyapatite Biocomposite Materials: Electrical and Antimicrobial Evaluation. ECS Journal of Solid State Science and Technology 10:12, pages 123014.
Crossref
Ekaterina Chudinova, Andrey Koptyug, Yulia Mukhortova, Artyom Pryadko, Anastasiya Volkova, Alexey Ivanov, Evgenii Plotnikov, Yelena Khan, Matthias Epple, Viktoriya Sokolova, Oleg Prymak, Timothy Douglas, Roman Surmenev & Maria Surmeneva. (2021) Functionalization of additive-manufactured Ti6Al4V scaffolds with poly(allylamine hydrochloride)/poly(styrene sulfonate) bilayer microcapsule system containing dexamethasone. Materials Chemistry and Physics 273, pages 125099.
Crossref
Henrique Borba Modolon, Jordana Inocente, Adriano Michael Bernardin, Oscar Rubem Klegues Montedo & Sabrina Arcaro. (2021) Nanostructured biological hydroxyapatite from Tilapia bone: A pathway to control crystallite size and crystallinity. Ceramics International 47:19, pages 27685-27693.
Crossref
R. Askarnia, S. Roueini Fardi, M. Sobhani & H. Staji. (2021) Ternary hydroxyapatite/chitosan/graphene oxide composite coating on AZ91D magnesium alloy by electrophoretic deposition. Ceramics International 47:19, pages 27071-27081.
Crossref
Satheesh kumar Balu, Swetha Andra, Jaison Jeevanandam, Manisha Vidyavathy S & Sampath V. (2021) Emerging marine derived nanohydroxyapatite and their composites for implant and biomedical applications. Journal of the Mechanical Behavior of Biomedical Materials 119, pages 104523.
Crossref
Zheng Wu, Jun Shi, Pingan Song, Jingguo Li & Shaokui Cao. (2021) Chitosan/hyaluronic acid based hollow microcapsules equipped with MXene/gold nanorods for synergistically enhanced near infrared responsive drug delivery. International Journal of Biological Macromolecules 183, pages 870-879.
Crossref
Silvia Balhuc, Radu Campian, Anca Labunet, Marius Negucioiu, Smaranda Buduru & Andreea Kui. (2021) Dental Applications of Systems Based on Hydroxyapatite Nanoparticles—An Evidence-Based Update. Crystals 11:6, pages 674.
Crossref
Jianghong Huang, Zhiwang Huang, Yujie Liang, Weihao Yuan, Liming Bian, Li Duan, Zhibin Rong, Jianyi Xiong, Daping Wang & Jiang Xia. (2021) 3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair. Biomaterials Science 9:7, pages 2620-2630.
Crossref
Ashraf F. Ali, Ziyad A. Alrowaili, Emad M. El-Giar, Manar M. Ahmed & Abeer M. El-Kady. (2021) Novel green synthesis of hydroxyapatite uniform nanorods via microwave-hydrothermal route using licorice root extract as template. Ceramics International 47:3, pages 3928-3937.
Crossref
Victoria M Wu, Eric Huynh, Sean Tang & Vuk Uskoković. (2020) Calcium phosphate nanoparticles as intrinsic inorganic antimicrobials: mechanism of action. Biomedical Materials 16:1, pages 015018.
Crossref
Vuk Uskoković. (2020) Blowup of Accidental Images as a Passageway to Discovery: Insights into the Interaction between Hydroxyapatite Nanoparticles and Human Mesenchymal Stem Cells. Applied Sciences 10:22, pages 8204.
Crossref
Konstantin A. Prosolov, Vladimir V. Lastovka, Olga A. Belyavskaya, Dmitry V. Lychagin, Juergen Schmidt & Yurii P. Sharkeev. (2020) Tailoring the Surface Morphology and the Crystallinity State of Cu- and Zn-Substituted Hydroxyapatites on Ti and Mg-Based Alloys. Materials 13:19, pages 4449.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.