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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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VII. BIOLOGICAL STUDIES OF OLIGOMERS

Pharmacokinetic Properties of Phosphorothioate Oligonucleotides

Janet M. Leeds Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
,
Richard S. Geary Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
,
Scott P. Henry Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
,
Jo Glover Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
,
William Shanahan Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
,
Jon Fitchett Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
,
Todd Burckin Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
,
LoAnne Tmong Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
&
Arthur A. Levin Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, CA, 92008
 show all
Pages 1689-1693 | Published online: 16 Aug 2006

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Read on this site (4)

Richard S Geary. (2009) Antisense oligonucleotide pharmacokinetics and metabolism. Expert Opinion on Drug Metabolism & Toxicology 5:4, pages 381-391.
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Scott P. Henry, Arthur A. Levin, Kimber White & John H. Mennear. (2006) Assessment of the Effects of ISIS 2302, an Anti-Sense Inhibitor of Human ICAM-1, on Cellular and Humoral Immunity in Mice. Journal of Immunotoxicology 3:4, pages 199-211.
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William R Shanahan Jr. (1999) ISIS 2302, an antisense inhibitor of intercellular adhesion molecule 1. Expert Opinion on Investigational Drugs 8:9, pages 1417-1429.
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Dieter Hüsken, Andrea Deichert, Jonathan Hall & Robert Häner. (1999) Combinatorial Library of Artificial Ribonucleases. Nucleosides and Nucleotides 18:6-7, pages 1507-1511.
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Articles from other publishers (9)

Cristina R. Hofman & David R. Corey. (2023) Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges. Cell Chemical Biology.
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Michaela Kearney, Paul R. Cooper, Anthony J. Smith & Henry F. Duncan. (2018) Epigenetic Approaches to the Treatment of Dental Pulp Inflammation and Repair: Opportunities and Obstacles. Frontiers in Genetics 9.
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Gitanjali Kher, Sonia Trehan & Ambikanandan Misra. 2011. Challenges in Delivery of Therapeutic Genomics and Proteomics. Challenges in Delivery of Therapeutic Genomics and Proteomics 325 386 .
Rosie Z. Yu, Tae-Won Kim, An Hong, Tanya A. Watanabe, Hans J. Gaus & Richard S. Geary. (2007) Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100. Drug Metabolism and Disposition 35:3, pages 460-468.
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Tanya A. WatanabeRichard S. GearyArthur A. Levin. (2006) Plasma Protein Binding of an Antisense Oligonucleotide Targeting Human ICAM-1 (ISIS 2302). Oligonucleotides 16:2, pages 169-180.
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Lilit MasarjianAnn De PeysterArthur A. LevinDavid K. Monteith. (2004) Distribution and Excretion of a Phosphorothioate Oligonucleotide in Rats with Experimentally Induced Renal Injury. Oligonucleotides 14:4, pages 299-310.
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Rosie Z. Yu, Richard S. Geary, David K. Monteith, John Matson, Loanne Truong, Jon Fitchett & Arthur A. Levin. (2004) Tissue Disposition of 2′‐O‐(2‐methoxy) ethyl Modified Antisense Oligonucleotides in Monkeys. Journal of Pharmaceutical Sciences 93:1, pages 48-59.
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JANET M. LEEDS, SCOTT P. HENRY, RICHARD GEARY, TODD BURCKIN & ARTHUR A. LEVIN. (2000) Comparison of the Pharmacokinetics of Subcutaneous and Intravenous Administration of a Phosphorothioate Oligodeoxynucleotide in Cynomolgus Monkeys. Antisense and Nucleic Acid Drug Development 10:6, pages 435-441.
Crossref
Arthur A Levin. (1999) A review of issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1489:1, pages 69-84.
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