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Journal of Biomolecular Structure and Dynamics Volume 35, 2017 - Issue 9
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Research Articles

The signaling pathway of dopamine D2 receptor (D2R) activation using normal mode analysis (NMA) and the construction of pharmacophore models for D2R ligands

Ramin Ekhteiari SalmasDepartment of Biophysics, School of Medicine, Bahcesehir University, Istanbul, TurkeyCorrespondence[email protected]
,
Matthias SteinMolecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical System, Sandtorstrasse 1, 39106Magdeburg, Germany
,
Mine YurtseverDepartment of Chemistry, Istanbul Technical University, Istanbul, Turkey
,
Philip SeemanDepartment of Pharmacology and Psychiatry, University of Toronto, 260 Heath Street West, Unit 605, M5P 3L6Toronto, Ontario, Canada
,
Ismail ErolDepartment of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey;Department of Chemistry, Gebze Technical University, Gebze, Turkey
,
Mert MestanogluDepartment of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey
&
Serdar DurdagiDepartment of Biophysics, School of Medicine, Bahcesehir University, Istanbul, TurkeyCorrespondence[email protected]
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Pages 2040-2048 | Received 18 Mar 2016, Accepted 22 Jun 2016, Published online: 27 Jul 2016

Citations (11)

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Read on this site (3)

Mohammad Wahab Khan & Ayaluru Murali. (2023) Normal mode analysis and comparative study of intrinsic dynamics of alcohol oxidase enzymes from GMC protein family. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
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Kader Sahin, Belma Zengin Kurt, Fatih Sonmez & Serdar Durdagi. (2020) Novel AChE and BChE inhibitors using combined virtual screening, text mining and in vitro binding assays. Journal of Biomolecular Structure and Dynamics 38:11, pages 3342-3358.
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David Montgomery, Alexandra Campbell, Holli-Joi Sullivan & Chun Wu. (2019) Molecular dynamics simulation of biased agonists at the dopamine D2 receptor suggests the mechanism of receptor functional selectivity. Journal of Biomolecular Structure and Dynamics 37:12, pages 3206-3225.
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Articles from other publishers (8)

Agnieszka A. Kaczor, Tomasz M. Wróbel & Damian Bartuzi. (2022) Allosteric Modulators of Dopamine D2 Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases: Overview, Pharmacology, Structural Aspects and Synthesis. Molecules 28:1, pages 178.
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Theresa Noonan, Katrin Denzinger, Valerij Talagayev, Yu Chen, Kristina Puls, Clemens Alexander Wolf, Sijie Liu, Trung Ngoc Nguyen & Gerhard Wolber. (2022) Mind the Gap—Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence. Pharmaceuticals 15:11, pages 1304.
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Hung-Jin Huang, Yu-Hsuan Lee, Chu-Lin Chou, Cai-Mei Zheng & Hui-Wen Chiu. (2022) Investigation of potential descriptors of chemical compounds on prevention of nephrotoxicity via QSAR approach. Computational and Structural Biotechnology Journal 20, pages 1876-1884.
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Patrick Appiah‐Kubi, Fisayo Andrew Olotu & Mahmoud E. S. Soliman. (2019) Probing Binding Landscapes and Molecular Recognition Mechanisms of Atypical Antipsychotic Drugs towards the Selective Targeting of D 2 Dopamine Receptor . Molecular Informatics 38:11-12, pages 1900044.
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Elumalai Pavadai, Nisha Bhattarai, Prabin Baral, Robert V. Stahelin, Prem P. Chapagain & Bernard S. Gerstman. (2019) Conformational Flexibility of the Protein–Protein Interfaces of the Ebola Virus VP40 Structural Matrix Filament. The Journal of Physical Chemistry B 123:43, pages 9045-9053.
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Agnieszka A. Kaczor, Justyna Żuk & Dariusz Matosiuk. (2018) Comparative molecular field analysis and molecular dynamics studies of the dopamine D2 receptor antagonists without a protonatable nitrogen atom. Medicinal Chemistry Research 27:4, pages 1149-1166.
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Ai Jing Li, Wei Xie, Ming Wang & Si Chuan Xu. (2017) Molecular Mechanism and Dynamics of S -Deoxyephedrine Moving through Molecular Channels within D 3 R . ACS Omega 2:12, pages 8896-8910.
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Ramin Ekhteiari Salmas, Philip Seeman, Busecan Aksoydan, Ismail Erol, Isik Kantarcioglu, Matthias Stein, Mine Yurtsever & Serdar Durdagi. (2017) Analysis of the Glutamate Agonist LY404,039 Binding to Nonstatic Dopamine Receptor D2 Dimer Structures and Consensus Docking. ACS Chemical Neuroscience 8:6, pages 1404-1415.
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