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Annals of Medicine Volume 41, 2009 - Issue 6
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Review Article

Tempering the wrath of RAGE: An emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation

Shi Fang Yan Division of Surgical Science, Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, New York, 10032, USA
,
Shi Du Yan Division of Surgical Science, Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, New York, 10032, USA; Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York, 10032, USA
,
Ravichandran Ramasamy Division of Surgical Science, Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, New York, 10032, USA
&
Ann Marie Schmidt Division of Surgical Science, Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, New York, 10032, USACorrespondence[email protected]
Pages 408-422 | Received 12 Sep 2008, Published online: 01 Sep 2009

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Nataliia Petriv, Lavinia Neubert, Myroslava Vatashchuk, Kai Timrott, Huizhen Suo, Inga Hochnadel, René Huber, Christina Petzold, Anastasiia Hrushchenko, Andriy S. Yatsenko, Halyna R. Shcherbata, Heiner Wedemeyer, Ralf Lichtinghagen, Halina Falfushynska, Volodymyr Lushchak, Michael P. Manns, Heike Bantel, Halyna Semchyshyn & Tetyana Yevsa. (2021) Increase of α-dicarbonyls in liver and receptor for advanced glycation end products on immune cells are linked to nonalcoholic fatty liver disease and liver cancer. OncoImmunology 10:1.
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Yingjia Chen & Tai L. Guo. (2021) Dietary advanced glycation end-products elicit toxicological effects by disrupting gut microbiome and immune homeostasis. Journal of Immunotoxicology 18:1, pages 93-104.
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Seitaro Omoto, Takehito Taniura, Tohru Nishizawa, Takeshi Tamaki, Akira Shouzu & Shosaku Nomura. (2015) Anti-atherosclerotic effects of sitagliptin in patients with type 2 diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity 8, pages 339-345.
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Ahmed M. Abu El-Asrar, Ghulam Mohammad, Mohammad Imtiaz Nawaz & Mohammad Mairaj Siddiquei. (2015) High-Mobility Group Box-1 Modulates the Expression of Inflammatory and Angiogenic Signaling Pathways in Diabetic Retina. Current Eye Research 40:11, pages 1141-1152.
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Francesco Giannessi, Maria C. Scavuzzo, Maria A. Giambelluca, Francesco Fornai, Girolamo Morelli & Riccardo Ruffoli. (2015) Chronic alcohol administration causes expression of calprotectin and RAGE altering the distribution of zinc ions in mouse testis. Systems Biology in Reproductive Medicine 61:1, pages 18-25.
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Crossref
Katrin Kierdorf & Günter Fritz. (2013) RAGE regulation and signaling in inflammation and beyond. Journal of Leukocyte Biology 94:1, pages 55-68.
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Paladd Asavarut, Hailin Zhao, Jianteng Gu & Daqing Ma. (2013) The role of HMGB1 in inflammation-mediated organ injury. Acta Anaesthesiologica Taiwanica 51:1, pages 28-33.
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Lindsi McCoard Roundy, Wanjian Jia, Jianxing Zhang, Xiangyang Ye, Glenn D. Prestwich & Siam OottamasathienQ. (2013) LL-37 induced cystitis and the receptor for advanced glycation end-products (RAGE) pathway. Advances in Bioscience and Biotechnology 04:08, pages 1-8.
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Crossref
J. Škrha, J. Šoupal, G. Loni Ekali, M. Prázný, M. Kalousová, J. Kvasnička, L. Landová, T. Zima & J. Škrha. (2013) Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus. Journal of Diabetes Research 2013, pages 1-7.
Crossref
Josephine M. Forbes & Mark E. Cooper. (2013) Mechanisms of Diabetic Complications. Physiological Reviews 93:1, pages 137-188.
Crossref
Guglielmo Sorci, Francesca Riuzzi, Ileana Giambanco & Rosario Donato. (2013) RAGE in tissue homeostasis, repair and regeneration. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:1, pages 101-109.
Crossref
Li Li Zhou, Wei Cao, Chao Xie, Jianwei Tian, Zhanmei Zhou, Qiugen Zhou, Ping Zhu, Aiqing Li, Youhua Liu, Toshio Miyata, Fan Fan Hou & Jing Nie. (2012) The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis. Kidney International 82:7, pages 759-770.
Crossref
Ping Fang, Melitta Schachner & Yan-Qin Shen. (2012) HMGB1 in Development and Diseases of the Central Nervous System. Molecular Neurobiology 45:3, pages 499-506.
Crossref
G. Joseph Broussard, Jennifer Mytar, Rung-chi Li & Gloria J. Klapstein. (2012) The role of inflammatory processes in Alzheimer’s disease. Inflammopharmacology 20:3, pages 109-126.
Crossref
Cristina M. Sena, Paulo Matafome, Joana Cris?stomo, Lisa Rodrigues, Rosa Fernandes, Paulo Pereira & Raquel M. Sei?a. (2012) Methylglyoxal promotes oxidative stress and endothelial dysfunction. Pharmacological Research 65:5, pages 497-506.
Crossref
Marcela Claudino, Gabriela Gennaro, Tania Mary Cestari, C?sar Tadeu Spadella, Gustavo Pompermaier Garlet & Gerson Francisco Assis. (2012) Spontaneous Periodontitis Development in Diabetic Rats Involves an Unrestricted Expression of Inflammatory Cytokines and Tissue Destructive Factors in the Absence of Major Changes in Commensal Oral Microbiota. Experimental Diabetes Research 2012, pages 1-10.
Crossref
Maria João Saraiva & Isabel Santos Cardoso. 2012. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases 407 432 .
Tao-Sheng Li, Satoshi Ikeda, Masayuki Kubo, Mako Ohshima, Hiroshi Kurazumi, Yoshihiro Takemoto, Kazuhiro Ueda & Kimikazu Hamano. (2011) Diabetic Impairment of C-Kit+ Bone Marrow Stem Cells Involves the Disorders of Inflammatory Factors, Cell Adhesion and Extracellular Matrix Molecules. PLoS ONE 6:10, pages e25543.
Crossref
Pamela Maher, Richard Dargusch, Jennifer L. Ehren, Shinichi Okada, Kumar Sharma & David Schubert. (2011) Fisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes. PLoS ONE 6:6, pages e21226.
Crossref
Vivette D'Agati & Ann Marie Schmidt. (2010) RAGE and the pathogenesis of chronic kidney disease. Nature Reviews Nephrology 6:6, pages 352-360.
Crossref
Geetha Srikrishna, Jonamani Nayak, Bernd Weigle, Achim Temme, Dirk Foell, Larnele Hazelwood, Anna Olsson, Niels Volkmann, Dorit Hanein & Hudson H. Freeze. (2010) Carboxylated N-glycans on RAGE promote S100A12 binding and signaling. Journal of Cellular Biochemistry 110:3, pages 645-659.
Crossref
Li Meng, Jehyun Park, Qiangjun Cai, Linda Lanting, Marpadga A. Reddy & Rama Natarajan. (2010) Diabetic conditions promote binding of monocytes to vascular smooth muscle cells and their subsequent differentiation. American Journal of Physiology-Heart and Circulatory Physiology 298:3, pages H736-H745.
Crossref
A. Bierhaus & P. P. Nawroth. (2009) Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications. Diabetologia 52:11, pages 2251-2263.
Crossref

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