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Pediatric Hematology and Oncology Volume 33, 2016 - Issue 7-8
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Leukemia and lymphoma

The role of CDKN2A/B deletions in pediatric acute lymphoblastic leukemia

P. Carrasco SalasLaboratory of Molecular Pediatric Hemato-Oncology, Institute of Medical and Molecular Genetics (INGEMM), Hospital Universitario La Paz, Madrid, SpainCorrespondence[email protected]
,
L. FernándezClinical Research Program, Cancer Research National Centre, Madrid, Spain
,
M. VelaInnate Immune Research Group, IdiPAZ, Madrid, Spain
,
D. BuenoDepartment of Pediatric Hemato-Oncology and Stem Cell Transplantation, Hospital Infantil Universitario La Paz, Madrid, Spain
,
B. GonzálezDepartment of Pediatric Hemato-Oncology and Stem Cell Transplantation, Hospital Infantil Universitario La Paz, Madrid, Spain
,
J. ValentínInnate Immune Research Group, IdiPAZ, Madrid, Spain
,
P. LapunzinaLaboratory of Molecular Pediatric Hemato-Oncology, Institute of Medical and Molecular Genetics (INGEMM), Hospital Universitario La Paz, Madrid, Spain
&
A. Pérez-MartínezLaboratory of Molecular Pediatric Hemato-Oncology, Institute of Medical and Molecular Genetics (INGEMM), Hospital Universitario La Paz, Madrid, Spain;Innate Immune Research Group, IdiPAZ, Madrid, Spain;Department of Pediatric Hemato-Oncology and Stem Cell Transplantation, Hospital Infantil Universitario La Paz, Madrid, Spain
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Pages 415-422 | Received 31 Aug 2016, Accepted 18 Oct 2016, Published online: 14 Dec 2016

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Xian Zhang, Tong Wang, Yang Zhang, Fang Wang, Jiaqi Chen, Jingbo Ni, Ruijuan Sun, Zhijie Wei, Gailing Zhang, Wenqian Li, Jingjing Li & Peihua Lu. (2023) Characteristics and therapeutic approaches for patients diagnosed with T-ALL/LBL exhibiting t(8;14)(q24;q11)/TCRA/D:MYC translocation. Leukemia & Lymphoma 0:0, pages 1-7.
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Wanhua Zhang, Pu Kuang & Ting Liu. (2019) Prognostic significance of CDKN2A/B deletions in acute lymphoblastic leukaemia: a meta-analysis. Annals of Medicine 51:1, pages 28-40.
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Articles from other publishers (21)

Anna Rogojina, Laura J. Klesse, Erin Butler, Jiwoong Kim, He Zhang, Xue Xiao, Lei Guo, Qinbo Zhou, Taylor Hartshorne, Dawn Garcia, Korri Weldon, Trevor Holland, Abhik Bandyopadhyay, Luz Perez Prado, Shidan Wang, Donghan M. Yang, Anne-Marie Langevan, Yi Zou, Allison C. Grimes, Chatchawin Assanasen, Vinod Gidvani-Diaz, Siyuan Zheng, Zhao Lai, Yidong Chen, Yang Xie, Gail E. Tomlinson, Stephen X. Skapek, Raushan T. Kurmasheva, Peter J. Houghton & Lin Xu. (2023) Comprehensive characterization of patient-derived xenograft models of pediatric leukemia. iScience 26:11, pages 108171.
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Yang Ruan, Longlong Xie & Aijun Zou. (2023) Association of CDKN2A/B mutations, PD-1, and PD-L1 with the risk of acute lymphoblastic leukemia in children. Journal of Cancer Research and Clinical Oncology 149:12, pages 10841-10850.
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Elizabeth A. Raetz, David T. Teachey, Charles Minard, Xiaowei Liu, Robin E. Norris, Kristina Z. Denic, Joel Reid, Nikki A. Evensen, Lia Gore, Elizabeth Fox, Mignon L. Loh, Brenda J. Weigel & William L. Carroll. (2023) Palbociclib in combination with chemotherapy in pediatric and young adult patients with relapsed/refractory acute lymphoblastic leukemia and lymphoma: A Children's Oncology Group study (AINV18P1). Pediatric Blood & Cancer.
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Mirella Ampatzidou, Stefanos I. Papadhimitriou, Anna Paisiou, Georgios Paterakis, Marianna Tzanoudaki, Vassilios Papadakis, Lina Florentin & Sophia Polychronopoulou. (2023) The Prognostic Effect of CDKN2A/2B Gene Deletions in Pediatric Acute Lymphoblastic Leukemia (ALL): Independent Prognostic Significance in BFM-Based Protocols. Diagnostics 13:9, pages 1589.
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钰 李. (2023) Molecular Characteristics and Clinical Significance of Acute B-Cell Acute Lymphoblastic Leukemia in Children. Advances in Clinical Medicine 13:04, pages 6469-6477.
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Alessia Schirripa, Veronika Sexl & Karoline Kollmann. (2022) Cyclin-dependent kinase inhibitors in malignant hematopoiesis. Frontiers in Oncology 12.
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Monika Lejman, Aleksandra Chałupnik, Zuzanna Chilimoniuk & Maciej Dobosz. (2022) Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children. International Journal of Molecular Sciences 23:5, pages 2755.
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Cindy Martinez, Luz Karime Yunis, Edgar Cabrera, Johnny García, Gloria Uribe, Edna Quintero, Juan Jose Yunis, Adriana Linares Ballesteros & Isabel Cristina Sarmiento. (2022) Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia. Pediatric Hematology Oncology Journal 7:1, pages 1-3.
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Sunil S. Raikar, David T. Teachey & Nathan P. Gossai. 2022. Clinical Management of Acute Lymphoblastic Leukemia. Clinical Management of Acute Lymphoblastic Leukemia 329 351 .
Karen L. Bride, Hai Hu, Anastasia Tikhonova, Tori J. Fuller, Tiffaney L. Vincent, Rawan Shraim, Marilyn M. Li, William L. Carroll, Elizabeth A. Raetz, Iannis Aifantis & David T. Teachey. (2021) Rational drug combinations with CDK4/6 inhibitors in acute lymphoblastic leukemia. Haematologica 107:8, pages 1746-1757.
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Klementina Crepinsek, Gasper Marinsek, Marko Kavcic, Tomaž Prelog, Lidija Kitanovski, Janez Jazbec & Marusa Debeljak. (2021) Clinical impacts of copy number variations in B-cell differentiation and cell cycle control genes in pediatric B-cell acute lymphoblastic leukemia: a single centre experience. Radiology and Oncology 56:1, pages 92-101.
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Elena BoldrinEnrico Gaffo, Alexandra NiedermayerJudith M. BoerMartin ZimmermannDieter WeichenhanRainer Claus, Vera MünchQian SunStefanie EnzenmüllerFelix SeyfriedSalih DemirJulia ZinngrebeGunnar CarioMartin SchrappeMonique L. Den BoerChristoph PlassKlaus-Michael Debatin, Geertruij te Kronnie, Stefania Bortoluzzi & Lüder Hinrich Meyer. (2021) MicroRNA-497/195 is tumor suppressive and cooperates with CDKN2A/B in pediatric acute lymphoblastic leukemia. Blood 138:20, pages 1953-1965.
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Donát Alpár, Bálint Egyed, Csaba Bödör & Gábor T. Kovács. (2021) Single-Cell Sequencing: Biological Insight and Potential Clinical Implications in Pediatric Leukemia. Cancers 13:22, pages 5658.
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Qiuyun Fang, Yang Song, Xiaoyuan Gong, Jun Wang, Qinghua Li, Kaiqi Liu, Yahui Feng, Qishan Hao, Yan Li, Hui Wei, Guangji Zhang, Yuntao Liu, Benfa Gong, Ying Wang, Chunlin Zhou, Dong Lin, Bingcheng Liu, Shuning Wei, Runxia Gu, Yingchang Mi & Jianxiang Wang. (2021) Gene Deletions and Prognostic Values in B-Linage Acute Lymphoblastic Leukemia. Frontiers in Oncology 11.
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Gisele O.L. Rodrigues, Sarah D. Cramer, Hila Y. Winer, Julie A. Hixon, WenQing Li, José Andres Yunes & Scott K. Durum. (2021) Mutations that collaborate with IL-7Ra signaling pathways to drive ALL. Advances in Biological Regulation 80, pages 100788.
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Denise Anderson, Patrycja Skut, Anastasia M. Hughes, Emanuela Ferrari, Jennifer Tickner, Jiake Xu, Benjamin H. Mullin, Dave Tang, Sébastien Malinge, Ursula R. Kees, Rishi S. Kotecha, Timo Lassmann & Laurence C. Cheung. (2020) The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution. Scientific Reports 10:1.
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Yucel Erbilgin, Sinem Firtina, Sevcan Mercan, Ozden Hatirnaz Ng, Serap Karaman, Orcun Tasar, Zeynep Karakas, Tulin Tiraje Celkan, Emine Zengin, Nazan Sarper, Zeynep Yildiz Yildirmak, Sinem Sisko, Ugur Ozbek & Muge Sayitoglu. (2019) Prognostic gene alterations and clonal changes in childhood B-ALL. Leukemia Research 83, pages 106159.
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Miller, Park, Saxe, Lew & Raikar. (2019) Clonal Evolution of B-Cell Acute Lymphoblastic Leukemia with del(9)(p13p21) into Mixed Phenotype Acute Leukemia Presenting as an Isolated Testicular Relapse. Reports 2:3, pages 18.
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Miriam F. Ayón-Pérez, Helia J. Pimentel-Gutiérrez, Ma. de Jesús Durán-Avelar, Norberto Vibanco-Pérez, Víctor M. Pérez-Peraza, Óscar A. Pérez-González, Rehotbevely Barrientos-Ríos, Christian F. Santillán-Ávila, José F. Zambrano-Zaragoza, Juan M. Agraz-Cibrián, Jorge Gutiérrez-Franco & Alejandro Vázquez-Reyes. (2019) <b><i>IKZF1</i></b> Gene Deletion in Pediatric Patients Diagnosed with Acute Lymphoblastic Leukemia in Mexico. Cytogenetic and Genome Research 158:1, pages 10-16.
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Manisha Agarwal, Sameer Bakhshi, Sadanand N. Dwivedi, Madhulika Kabra, Rashmi Shukla & Rachna Seth. (2018) Cyclin dependent kinase inhibitor 2A/B gene deletions are markers of poor prognosis in Indian children with acute lymphoblastic leukemia . Pediatric Blood & Cancer 65:6.
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Adrián Montaño, Maribel Forero-Castro, Darnel Marchena-Mendoza, Rocío Benito & Jesús Hernández-Rivas. (2018) New Challenges in Targeting Signaling Pathways in Acute Lymphoblastic Leukemia by NGS Approaches: An Update. Cancers 10:4, pages 110.
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