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Stress
The International Journal on the Biology of Stress
Volume 12, 2009 - Issue 4
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Original Article

Effects of enrichment predominate over those of chronic stress on fear-related behavior in male rats

Rupshi Mitra Department of Biology, Stanford University, Stanford, CA, 94305, USACorrespondence[email protected]
&
Robert M. Sapolsky Department of Biology, Stanford University, Stanford, CA, 94305, USA
Pages 305-312 | Received 04 Feb 2008, Accepted 03 Jul 2008, Published online: 23 Nov 2009

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Eslen Delanogare, Raul Marin de Souza, Giovana Karoline Rosa, Fernando Garcia Guanabara, Alex Rafacho & Eduardo Luiz Gasnhar Moreira. (2020) Enriched environment ameliorates dexamethasone effects on emotional reactivity and metabolic parameters in mice. Stress 23:4, pages 466-473.
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C. M. McCormick, D. L. Mongillo & J. J. Simone. (2013) Age and adolescent social stress effects on fear extinction in female rats. Stress 16:6, pages 678-688.
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Articles from other publishers (27)

Elif Beyza Guven, Nicole Melisa Pranic & Gunes Unal. (2022) The differential effects of brief environmental enrichment following social isolation in rats. Cognitive, Affective, & Behavioral Neuroscience 22:4, pages 818-832.
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Erin L. Macartney, Malgorzata Lagisz & Shinichi Nakagawa. (2022) The relative benefits of environmental enrichment on learning and memory are greater when stressed: A meta-analysis of interactions in rodents. Neuroscience & Biobehavioral Reviews 135, pages 104554.
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Sitendu Goswami, Shiv Kumari Patel, Riyaz Kadivar, Praveen Chandra Tyagi, Pradeep Kumar Malik & Samrat Mondol. (2021) Effects of a combined enrichment intervention on the behavioural and physiological welfare of captive Asiatic lions (Panthera leo persica). Applied Animal Behaviour Science 236, pages 105222.
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Marissa A. Smail, Brittany L. Smith, Nawshaba Nawreen & James P. Herman. (2020) Differential impact of stress and environmental enrichment on corticolimbic circuits. Pharmacology Biochemistry and Behavior 197, pages 172993.
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Bruno G. Berardino, Mariela Chertoff, Octavio Gianatiempo, Carolina D. Alberca, Rocío Priegue, Ana Fiszbein, Patrick Long, Gabriel Corfas & Eduardo T. Cánepa. (2019) Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology. Neuroscience 408, pages 115-134.
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Brendan O’Flaherty, Gretchen N. Neigh & Donald Rainnie. (2019) High-fructose diet initiated during adolescence does not affect basolateral amygdala excitability or affective-like behavior in Sprague Dawley rats. Behavioural Brain Research 365, pages 17-25.
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Catherine Pérez-Valenzuela, Gonzalo Terreros & Alexies Dagnino-Subiabre. (2019) Effects of stress on the auditory system: an approach to study a common origin for mood disorders and dementia. Reviews in the Neurosciences 30:3, pages 317-324.
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Natalie Schroyens, Crhistian Luis Bender, Joaquín Matias Alfei, Victor Alejandro Molina, Laura Luyten & Tom Beckers. (2019) Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats. Behavioural Brain Research 359, pages 172-180.
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Prabahan Chakraborty & Sumantra Chattarji. (2018) Timing is everything: differential effects of chronic stress on fear extinction. Psychopharmacology 236:1, pages 73-86.
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Stephanie E. Sillivan, Nadine F. Joseph, Sarah Jamieson, Michelle L. King, Itzamarie Chévere-Torres, Illeana Fuentes, Gleb P. Shumyatsky, Alicia F. Brantley, Gavin Rumbaugh & Courtney A. Miller. (2017) Susceptibility and Resilience to Posttraumatic Stress Disorder–like Behaviors in Inbred Mice. Biological Psychiatry 82:12, pages 924-933.
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Archana Ashokan, Akshaya Hegde & Rupshi Mitra. (2016) Short-term environmental enrichment is sufficient to counter stress-induced anxiety and associated structural and molecular plasticity in basolateral amygdala. Psychoneuroendocrinology 69, pages 189-196.
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Patricia Mesa-Gresa, Marta Ramos-Campos & Rosa Redolat. (2016) Corticosterone levels and behavioral changes induced by simultaneous exposure to chronic social stress and enriched environments in NMRI male mice. Physiology & Behavior 158, pages 6-17.
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A S Koe, A Ashokan & R Mitra. (2016) Short environmental enrichment in adulthood reverses anxiety and basolateral amygdala hypertrophy induced by maternal separation. Translational Psychiatry 6:2, pages e729-e729.
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Gilliard Lach, Maira Assun??o Bicca, Alexandre Ademar Hoeller, Evelyn Cristina da Silva Santos, Ana Paula Ramos Costa & Thereza Christina Monteiro de Lima. (2016) Short-term enriched environment exposure facilitates fear extinction in adult rats: The NPY-Y1 receptor modulation. Neuropeptides 55, pages 73-78.
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N. Zeeni, M. Bassil, G. Fromentin, C. Chaumontet, N. Darcel, D. Tome & C.F. Daher. (2015) Environmental enrichment and cafeteria diet attenuate the response to chronic variable stress in rats. Physiology & Behavior 139, pages 41-49.
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T. D. Goode & S. Maren. (2014) Animal Models of Fear Relapse. ILAR Journal 55:2, pages 246-258.
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Matthew R. Green & Cheryl M. McCormick. (2013) Effects of stressors in adolescence on learning and memory in rodent models. Hormones and Behavior 64:2, pages 364-379.
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L Wieczorek, D Majumdar, T A Wills, L Hu, D G Winder, D J Webb & L J Muglia. (2012) Absence of Ca2+-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory. Translational Psychiatry 2:5, pages e126-e126.
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Rupshi Mitra & Robert M. Sapolsky. (2012) Short-Term Enrichment Makes Male Rats More Attractive, More Defensive and Alters Hypothalamic Neurons. PLoS ONE 7:5, pages e36092.
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Katie M. Hutchinson, Katie J. McLaughlin, Ryan L. Wright, J. Bryce Ortiz, Danya P. Anouti, Agnieszka Mika, David M. Diamond & Cheryl D. Conrad. (2012) Environmental enrichment protects against the effects of chronic stress on cognitive and morphological measures of hippocampal integrity. Neurobiology of Learning and Memory 97:2, pages 250-260.
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Yun Ha Jeong, Joon Min Kim, Jongman Yoo, Sang Hyung Lee, Hye-Sun Kim & Yoo-Hun Suh. (2011) Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer?s disease model. Journal of Neurochemistry 119:6, pages 1282-1293.
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M. N. Hill, C. J. Hillard & B. S. McEwen. (2011) Alterations in Corticolimbic Dendritic Morphology and Emotional Behavior in Cannabinoid CB1 Receptor-Deficient Mice Parallel the Effects of Chronic Stress. Cerebral Cortex 21:9, pages 2056-2064.
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. 2011. Handbook of Laboratory Animal Science, Volume II, Third Edition. Handbook of Laboratory Animal Science, Volume II, Third Edition.
Ann N. Hoffman, Charles E. Armstrong, Jeffery J. Hanna & Cheryl D. Conrad. (2010) Chronic stress, cyclic 17β-estradiol, and daily handling influences on fear conditioning in the female rat. Neurobiology of Learning and Memory 94:3, pages 422-433.
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J. Amiel Rosenkranz, Emily R. Venheim & Mallika Padival. (2010) Chronic Stress Causes Amygdala Hyperexcitability in Rodents. Biological Psychiatry 67:12, pages 1128-1136.
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Cyril Herry, Francesco Ferraguti, Nicolas Singewald, Johannes J. Letzkus, Ingrid Ehrlich & Andreas Lüthi. (2010) Neuronal circuits of fear extinction. European Journal of Neuroscience 31:4, pages 599-612.
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Sarina M. RodriguesJoseph E. LeDouxRobert M. Sapolsky. (2009) The Influence of Stress Hormones on Fear Circuitry. Annual Review of Neuroscience 32:1, pages 289-313.
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