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Research Article

Relevant Issues in the Monitoring and the Toxicology of Antidepressants

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Pages 25-89 | Published online: 10 Oct 2008

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Javier De Diego-Adeliño, José Manuel Crespo, Fernando Mora, Adrián Neyra, Pedro Iborra, Luis Gutiérrez-Rojas & Selman F. Salonia. (2022) Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review. Expert Opinion on Drug Safety 21:5, pages 673-690.
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Kristina Probst-Schendzielorz, Roberto Viviani & Julia C Stingl. (2015) Effect of Cytochrome P450 polymorphism on the action and metabolism of selective serotonin reuptake inhibitors. Expert Opinion on Drug Metabolism & Toxicology 11:8, pages 1219-1232.
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Seetal Dodd, Gin S. Malhi, John Tiller, Isaac Schweitzer, Ian Hickie, Jon Paul Khoo, Darryl L. Bassett, Bill Lyndon, Philip B. Mitchell, Gordon Parker, Paul B. Fitzgerald, Marc Udina, Ajeet Singh, Steven Moylan, Francesco Giorlando, Carolyn Doughty, Christopher G. Davey, Michael Theodoros & Michael Berk. (2011) A consensus statement for safety monitoring guidelines of treatments for major depressive disorder. Australian and New Zealand Journal of Psychiatry 45:9, pages 712-725.
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Mellar P Davis. (2011) Opioid tolerance and hyperalgesia: basic mechanisms and management in review. Progress in Palliative Care 19:2, pages 73-86.
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Shivakumar Kolachalam, Stefano Aringhieri & Marco Scarselli. 2020. Brain and Heart Dynamics. Brain and Heart Dynamics 753 763 .
Maike Scherf‐Clavel, Oliver Wahl, Andreas Menke & Stefan Unterecker. (2019) Determination of hydroxybupropion in human serum for routine therapeutic drug monitoring in psychiatry: A tool for dose‐individualization in treatment with bupropion. Biomedical Chromatography 33:10.
Crossref
Tim Boogaerts, Maarten Degreef, Adrian Covaci & Alexander L.N. van Nuijs. (2019) Development and validation of an analytical procedure to detect spatio-temporal differences in antidepressant use through a wastewater-based approach. Talanta 200, pages 340-349.
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Sylwia Kedracka-Krok, Bianka Swiderska, Anna M. Bielecka-Wajdman, Gabriela Prus, Bozena Skupien-Rabian, Urszula Jankowska & Ewa Obuchowicz. (2018) Impact of imipramine on proteome of rat primary glial cells. Journal of Neuroimmunology 320, pages 25-37.
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Xiaoyun Jiao, Yongsheng Xiao, Yong Li, Muwen Liang, Xilei Xie, Xu Wang & Bo Tang. (2018) Evaluating Drug-Induced Liver Injury and Its Remission via Discrimination and Imaging of HClO and H 2 S with a Two-Photon Fluorescent Probe . Analytical Chemistry 90:12, pages 7510-7516.
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Gul Ozbey, Berna Yucel, Nurdan Eren Bodur, Serap Erdogan Taycan, Tayyibe Arslan, Nazan Cerit, Nevzat Yuksel, Ismail Cuneyt Guzey & Canan Uluoglu. (2018) Serum N-Desmethylcitalopram Concentrations are Associated with the Clinical Response to Citalopram of Patients with Major Depression. Psychiatry Investigation 15:3, pages 313-319.
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Emilie Charles, Mehdi Hammadi, Philippe Kischel, Vanessa Delcroix, Nicolas Demaurex, Cyril Castelbou, Anne-Marie Vacher, Anne Devin, Thomas Ducret, Paula Nunes & Pierre Vacher. (2016) The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload. Oncotarget 8:2, pages 3181-3196.
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Malik Nassan, Wayne T. Nicholson, Michelle A. Elliott, Carolyn R. Rohrer Vitek, John L. Black & Mark A. Frye. (2016) Pharmacokinetic Pharmacogenetic Prescribing Guidelines for Antidepressants: A Template for Psychiatric Precision Medicine. Mayo Clinic Proceedings 91:7, pages 897-907.
Crossref
Cosmin Sebastian Voican, Severine Martin, Céline Verstuyft, Emmanuelle Corruble, Gabriel Perlemuter & Romain Colle. (2016) Liver Function Test Abnormalities in Depressed Patients Treated with Antidepressants: A Real-World Systematic Observational Study in Psychiatric Settings. PLOS ONE 11:5, pages e0155234.
Crossref
MARIOLA HERBET, MONIKA GAWROŃSKA-GRZYWACZ, MAGDALENA IZDEBSKA, IWONA PIĄTKOWSKA-CHMIEL & EWA JAGIEŁŁO-WÓJTOWICZ. (2016) Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats. Experimental and Therapeutic Medicine 11:4, pages 1459-1464.
Crossref
Elizabeth JJ Berm, Eelko Hak, Maarten Postma, Marjolein Boshuisen, Laura Breuning, Jacobus RBJ Brouwers, Ton Dhondt, Paul AF Jansen, Rob M Kok, Jan G Maring, Rob van Marum, Hans Mulder, Richard C Oude Voshaar, Arne J Risselada, Harry Venema, Liesbeth Vleugel & Bob Wilffert. (2015) Effects and cost-effectiveness of pharmacogenetic screening for CYP2D6 among older adults starting therapy with nortriptyline or venlafaxine: study protocol for a pragmatic randomized controlled trial (CYSCEtrial). Trials 16:1.
Crossref
Hye Jin Park, Hee Jung Baik, Dong Yeon Kim, Guie Yong Lee, Jae Hee Woo, Zhiyi Zuo & Rack Kyung Chung. (2015) Doxepin and imipramine but not fluoxetine reduce the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes. BMC Anesthesiology 15:1.
Crossref
Anne Katrin Krieg & Günter Gauglitz. (2015) Ultrasensitive Label-Free Immunoassay for Optical Determination of Amitriptyline and Related Tricyclic Antidepressants in Human Serum. Analytical Chemistry 87:17, pages 8845-8850.
Crossref
Dean F. MacKinnon. 2015. Psychiatry. Psychiatry 902 965 .
Ahmad Yaraghi, Nastaran Eizadi-Mood, Maryam Katani, Shadi Farsaei, Mahrang Hedaiaty, Seyyed Mohammad Mahdy Mirhosseini, Elham Beheshtian & Ali Mohammad Sabzghabaee. (2015) Arterial Blood Gas Analysis and the Outcome of Treatment in Tricyclic Antidepressants Poisoned Patients with Benzodiazepine Coingestion. Anesthesiology Research and Practice 2015, pages 1-5.
Crossref
Massimo Carlo Mauri, Alessio Fiorentini, Silvia Paletta & Alfredo Carlo Altamura. (2014) Pharmacokinetics of Antidepressants in Patients with Hepatic Impairment. Clinical Pharmacokinetics 53:12, pages 1069-1081.
Crossref
Veerle Gobin, Katleen Van Steendam, Damiaan Denys & Dieter Deforce. (2014) Selective serotonin reuptake inhibitors as a novel class of immunosuppressants. International Immunopharmacology 20:1, pages 148-156.
Crossref
Gul Ozbey, Berna Yucel, Serap E. Taycan, Derya Kan, Nurdan E. Bodur, Tayyibe Arslan, Ferda Percin, Nevzat Yuksel, Cuneyt Guzey & Canan Uluoglu. (2014) ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population. Pharmacological Reports 66:2, pages 235-238.
Crossref
Ewa Obuchowicz, Anna M. Bielecka, Monika Paul-Samojedny, Anna Pudełko & Jan Kowalski. (2014) Imipramine and fluoxetine inhibit LPS-induced activation and affect morphology of microglial cells in the rat glial culture. Pharmacological Reports 66:1, pages 34-43.
Crossref
Jingjing Wu, Yunfeng Cao, Yanyan Zhang, Yong Liu, James Y. Hong, Liangliang Zhu, Guangbo Ge & Ling Yang. (2014) Deoxyschizandrin, a Naturally Occurring Lignan, Is a Specific Probe Substrate of Human Cytochrome P450 3A. Drug Metabolism and Disposition 42:1, pages 94-104.
Crossref
Kenya Iwakura, Tadashi Ogawa, Hideki Hattori, Masae Iwai, Osamu Suzuki & Takashi Nakagawa. (2013) Simultaneous and sensitive analysis of fourth-generation antidepressants in human plasma by ultra-performance liquid chromatography–tandem mass spectrometry. Forensic Toxicology 32:1, pages 30-38.
Crossref
Pierre Baumann. 2010. Encyclopedia of Psychopharmacology. Encyclopedia of Psychopharmacology 1 9 .
. (2013) Influence of combined treatment with mianserin and simvastatin on selected biochemical serum parameters of liver and kidney function in rats. Current Issues in Pharmacy and Medical Sciences 26:3, pages 263-266.
Crossref
R. J. Lewis, M. K. Angier, K. S. Williamson & R. D. Johnson. (2013) Analysis of Sertraline in Postmortem Fluids and Tissues in 11 Aviation Accident Victims. Journal of Analytical Toxicology 37:4, pages 208-216.
Crossref
Sabine Mogwitz, Judith Buse, Stefan Ehrlich & Veit Roessner. 2013. Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome. Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome 281 349 .
Lisbeth Patteet, Manuel Morrens, Kristof E. Maudens, Peter Niemegeers, Bernard Sabbe & Hugo Neels. (2012) Therapeutic Drug Monitoring of Common Antipsychotics. Therapeutic Drug Monitoring 34:6, pages 629-651.
Crossref
Hsiao-Yun Lin, Wei-Lan Yeh, Bor-Ren Huang, Chingju Lin, Chih-Ho Lai, Ho Lin & Dah-Yuu Lu. (2012) Desipramine Protects Neuronal Cell Death and Induces Heme Oxygenase-1 Expression in Mes23.5 Dopaminergic Neurons. PLoS ONE 7:11, pages e50138.
Crossref
Amitava Dasgupta. 2012. Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring. Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring 385 409 .
Jong-Suep Baek, Ji-Ho Lim, Jae-Woo So, Jae-Il Kim, Tae-Wan Lee, Sung-Joo Hwang, Sang-Chul Shin, Soo-Jin Kim & Cheong-Weon Cho. (2012) The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity. Journal of Pharmaceutical Investigation 42:3, pages 109-114.
Crossref
Pierre Baumann & Christoph Hiemke. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 301 329 .
Monica M. Marcus, Kent Jardemark, Anna Malmerfelt, Jens Gertow, Åsa Konradsson-Geuken & Torgny H. Svensson. (2012) Augmentation by escitalopram, but not citalopram or R-citalopram, of the effects of low-dose risperidone: Behavioral, biochemical, and electrophysiological evidence. Synapse 66:4, pages 277-290.
Crossref
Christine L. H. Snozek, Loralie J. Langman & Amitava Dasgupta. 2012. Pharmacogenomics in Clinical Therapeutics. Pharmacogenomics in Clinical Therapeutics 15 25 .
María del Mar Ramírez Fernández, Sarah M R Wille & Nele Samyn. (2012) Quantitative Method Validation for the Analysis of 27 Antidepressants and Metabolites in Plasma With Ultraperformance Liquid Chromatography–Tandem Mass Spectrometry. Therapeutic Drug Monitoring 34:1, pages 11-24.
Crossref
Christine L.H. Snozek, Gwendolyn A. McMillin & Thomas P. Moyer. 2012. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 1057 1108 .
Uttam Garg & Angela Ferguson. 2012. Therapeutic Drug Monitoring. Therapeutic Drug Monitoring 269 289 .
Zühre Şentürk, Cafer Saka & İbrahim Teğin. (2011) Analytical methods for determination of selective serotonin reuptake inhibitor antidepressants. Reviews in Analytical Chemistry 30:2.
Crossref
Marwa A Aboukhatwa & Ashiwel S Undieh. (2010) Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition. BMC Neuroscience 11:1.
Crossref
Woosung Cho, Michael Brenner, Noel Peters & Albee Messing. (2010) Drug screening to identify suppressors of GFAP expression. Human Molecular Genetics 19:16, pages 3169-3178.
Crossref
Shiquen Zhang, Baoman Li, Ditte Lovatt, Junnan Xu, Dan Song, Steven A. Goldman, Maiken Nedergaard, Leif Hertz & Liang Peng. (2010) 5-HT 2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional ‘serotonin-specific reuptake inhibitors’ . Neuron Glia Biology 6:2, pages 113-125.
Crossref
Frank Barile. 2010. Clinical Toxicology. Clinical Toxicology 203 218 .
Tao Jiang, Zhengxing Rong, Liang Peng, Bing Chen, Yifan Xie, Congying Chen, Jing Sun, Yiping Xu, Yang Lu & Hongzhuan Chen. (2010) Simultaneous determination of citalopram and its metabolite in human plasma by LC–MS/MS applied to pharmacokinetic study. Journal of Chromatography B 878:5-6, pages 615-619.
Crossref
Kristof Demeestere, Mira Petrović, Meritxell Gros, Jo Dewulf, Herman Van Langenhove & Damià Barceló. (2009) Trace analysis of antidepressants in environmental waters by molecularly imprinted polymer-based solid-phase extraction followed by ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry. Analytical and Bioanalytical Chemistry 396:2, pages 825-837.
Crossref
Laura Mercolini, Roberto Mandrioli, Giulia Finizio, Giancarlo Boncompagni & Maria Augusta Raggi. (2010) Simultaneous HPLC determination of 14 tricyclic antidepressants and metabolites in human plasma. Journal of Separation Science 33:1, pages 23-30.
Crossref
Qiong Liu, Bing Li, Hai-Yan Zhu, Yan-Qing Wang, Jin Yu & Gen-Cheng Wu. (2009) Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression. European Neuropsychopharmacology 19:11, pages 796-805.
Crossref
Sarah M. R. Wille, Els A. De Letter, Michel H. A. Piette, Lien K. Van Overschelde, Carlos H. Van Peteghem & Willy E. Lambert. (2008) Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography–mass spectrometry. International Journal of Legal Medicine 123:6, pages 451-458.
Crossref
Stanley I. Rapoport, Mireille Basselin, Hyung-Wook Kim & Jagadeesh S. Rao. (2009) Bipolar disorder and mechanisms of action of mood stabilizers. Brain Research Reviews 61:2, pages 185-209.
Crossref
Jaegyu Hwang, Long Tai Zheng, Jiyeon Ock, Maan Gee Lee, Sang-Hyun Kim, Ho-Won Lee, Won-Ha Lee, Hae-Chul Park & Kyoungho Suk. (2008) Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants. Neuropharmacology 55:5, pages 826-834.
Crossref

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