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Original Articles

Procyanidin Effects on Adipocyte-Related Pathologies

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Pages 543-550 | Published online: 18 Jan 2007

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Francesc Puiggròs, Maria-Josepa Salvadó, Cinta Bladé & Lluís Arola. (2014) Differential Modulation of Apoptotic Processes by Proanthocyanidins as a Dietary Strategy for Delaying Chronic Pathologies. Critical Reviews in Food Science and Nutrition 54:3, pages 277-291.
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Montserrat Pinent, Lidia Cedó, Gemma Montagut, Mayte Blay & Anna Ardévol. (2012) Procyanidins Improve some Disrupted Glucose Homoeostatic Situations: An Analysis of Doses and Treatments According to Different Animal Models. Critical Reviews in Food Science and Nutrition 52:7, pages 569-584.
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Articles from other publishers (48)

Jessica Maiuolo, Rosa Maria Bulotta, Francesca Oppedisano, Francesca Bosco, Federica Scarano, Saverio Nucera, Lorenza Guarnieri, Stefano Ruga, Roberta Macri, Rosamaria Caminiti, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Antonio Cardamone, Annarita Coppoletta, Martina Nicita, Adriano Carnevali, Vincenzo Scorcia & Vincenzo Mollace. (2022) Potential Properties of Natural Nutraceuticals and Antioxidants in Age-Related Eye Disorders. Life 13:1, pages 77.
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Jiawen Liu, Jinrong Tong, Qian Wu, Jing Liu, Mengqi Yuan, Cuifang Tian, Huan Xu, Pradeep K. Malakar, Yingjie Pan, Yong Zhao & Zhaohuan Zhang. (2022) Natural Inhibitors Targeting the Localization of Lipoprotein System in Vibrio parahaemolyticus. International Journal of Molecular Sciences 23:22, pages 14352.
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Marta Sierra-Cruz, Alba Miguéns-Gómez, Carme Grau-Bové, Esther Rodríguez-Gallego, Mayte Blay, Montserrat Pinent, Anna Ardévol, Ximena Terra & Raúl Beltrán-Debón. (2021) Grape-Seed Proanthocyanidin Extract Reverts Obesity-Related Metabolic Derangements in Aged Female Rats. Nutrients 13:6, pages 2059.
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Tianli Yue, Qinglin Sheng, Yane Luo, Zhengcao Xiao, Yuan Wang, Wei Song, Min Yan, Haili Niu, Ting Zhang & Na Li. 2021. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 155 203 .
Baishakhi De, Koushik Bhandari, Rajeev K. Singla, Gargi Saha & Tridib Kumar Goswami. (2020) In silico molecular GRIP docking of some secondary metabolites combating diabesity. Bulletin of the National Research Centre 44:1.
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Alix Barbe, Namya Mellouk, Christelle Ramé, Jérémy Grandhaye, Christophe Staub, Eric Venturi, Marine Cirot, Angélique Petit, Karine Anger, Marine Chahnamian, Patrice Ganier, Olivier Callut, Estelle Cailleau-Audouin, Sonia Metayer-Coustard, Antonella Riva, Pascal Froment & Joëlle Dupont. (2020) A grape seed extract maternal dietary supplementation in reproductive hens reduces oxidative stress associated to modulation of plasma and tissue adipokines expression and improves viability of offsprings. PLOS ONE 15:4, pages e0231131.
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Miao Liu, Peng Yun, Ying Hu, Jiao Yang, Rim Bahadur Khadka & Xiaochun Peng. (2020) Effects of Grape Seed Proanthocyanidin Extract on Obesity. Obesity Facts 13:2, pages 279-291.
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Tianli Yue, Qinglin Sheng, Yane Luo, Zhengcao Xiao, Yuan Wang, Wei Song, Min Yan, Haili Niu, Ting Zhang & Na Li. 2020. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 1 49 .
Alpna Tyagi, Sushil Kumar, Komal Raina, Michael F. Wempe, Paul D. Maroni, Rajesh Agarwal & Chapla Agarwal. (2019) Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di- O -gallate against prostate cancer stem cells . Molecular Carcinogenesis 58:7, pages 1105-1117.
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Jasmin & Vikas Jaitak. (2019) A Review on Molecular Mechanism of Flavonoids as Antidiabetic Agents. Mini-Reviews in Medicinal Chemistry 19:9, pages 762-786.
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Ana Paula Simões da CUNHA, Luana BALDISSERA, Débora Linsbinski PEREIRA, Lucineia Reuse ALBIERO, Lindsey CASTOLDI, Adilson Paulo SINHORIN & Valéria Dornelles Gindri SINHORIN. (2019) Evaluation of the antioxidant potential of Copaifera multijuga in Ehrlich tumor-bearing mice. Acta Amazonica 49:1, pages 41-47.
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Cinta Bladé, Anna Arola-Arnal, Anna Crescenti, Manuel Suárez, Francisca I. Bravo, Gerard Aragonès, Begoña Muguerza & Lluís Arola. 2019. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1933 1956 .
Iris Ginés, Katherine Gil-Cardoso, Joan Serrano, Àngela Casanova-Martí, MTeresa Blay, Montserrat Pinent, Anna Ardévol & Ximena Terra. (2018) Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats. Nutrients 10:3, pages 315.
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Anuradha S. Majumdar & Sahil J. Somani. 2018. Natural Products and Drug Discovery. Natural Products and Drug Discovery 327 347 .
Erika N. Bentz, Alicia B. Pomilio & Rosana M. Lobayan. (2017) Donor-acceptor interactions as descriptors of the free radical scavenging ability of flavans and catechin. Computational and Theoretical Chemistry 1110, pages 14-24.
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Maria Margalef, Zara Pons, Lisard Iglesias-Carres, Mar Quiñones, Francisca Isabel Bravo, Anna Arola-Arnal & Begoña Muguerza. (2017) Rat health status affects bioavailability, target tissue levels, and bioactivity of grape seed flavanols. Molecular Nutrition & Food Research 61:2, pages 1600342.
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M Ibars, A Ardid-Ruiz, M Suárez, B Muguerza, C Bladé & G Aragonès. (2016) Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity. International Journal of Obesity 41:1, pages 129-136.
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Cinta Bladé, Anna Arola-Arnal, Anna Crescenti, Manuel Suárez, Francisca I. Bravo, Gerard Aragonès, Begoña Muguerza & Lluís Arola. 2017. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1 24 .
Mingxia Li, Shuangjia Xue, Si Tan, Xiaoxiao Qin, Ming Gu, Dongshan Wang, Yu Zhang, Lu Guo, Feisi Huang, Yunchong Yao, Zhiqin Zhou, Shengjie Fan & Cheng Huang. (2016) Crabapple fruit extracts lower hypercholesterolaemia in high-fat diet-induced obese mice. Journal of Functional Foods 27, pages 416-428.
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Joan Serrano, Àngela Casanova-Martí, Mayte Blay, Ximena Terra, Anna Ardévol & Montserrat Pinent. (2016) Defining Conditions for Optimal Inhibition of Food Intake in Rats by a Grape-Seed Derived Proanthocyanidin Extract. Nutrients 8:10, pages 652.
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Gerard Aragonès, Manuel Suárez, Andrea Ardid-Ruiz, Maria Vinaixa, Miguel A. Rodríguez, Xavier Correig, Lluís Arola & Cinta Bladé. (2016) Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats. Scientific Reports 6:1.
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Joan Serrano, Àngela Casanova-Martí, Katherine Gil-Cardoso, M. Teresa Blay, Ximena Terra, Montserrat Pinent & Anna Ardévol. (2016) Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent. Food & Function 7:1, pages 483-490.
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Wenbin Yin, Baoying Li, Xiaoli Li, Fei Yu, Qian Cai, Zhen Zhang, Mei Cheng & Haiqing Gao. (2015) Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas. Food & Function 6:9, pages 3065-3071.
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M. Josepa Salvadó, Ester Casanova, Anabel Fernández-Iglesias, Lluis Arola & Cinta Bladé. (2015) Roles of proanthocyanidin rich extracts in obesity. Food & Function 6:4, pages 1053-1071.
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J M del Bas, A Crescenti, A Arola-Arnal, G Oms-Oliu, L Arola & A Caimari. (2014) Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth. International Journal of Obesity 39:1, pages 7-15.
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Antoni Caimari, Anna Crescenti, Francesc Puiggròs, Noemí Boqué, Lluís Arola & Josep Maria del Bas. (2014) The intake of a high-fat diet and grape seed procyanidins induces gene expression changes in peripheral blood mononuclear cells of hamsters: capturing alterations in lipid and cholesterol metabolisms. Genes & Nutrition 10:1.
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Sushil Kumar, Dileep Kumar, Komal Raina, Rajesh Agarwal & Chapla Agarwal. (2014) Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells. Oncotarget 5:20, pages 10151-10169.
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Anna-Marja Aura. 2014. A Systems Biology Approach to Study Metabolic Syndrome. A Systems Biology Approach to Study Metabolic Syndrome 251 278 .
A. Ardévol, M.J. Motilva, A. Serra, M. Blay & M. Pinent. (2013) Procyanidins target mesenteric adipose tissue in Wistar lean rats and subcutaneous adipose tissue in Zucker obese rat. Food Chemistry 141:1, pages 160-166.
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So-Youn Jeon, Sejong Oh, Eungseok Kim & Jee-Young Imm. (2013) α-Glucosidase Inhibiton and Antiglycation Activity of Laccase-Catalyzed Catechin Polymers. Journal of Agricultural and Food Chemistry 61:19, pages 4577-4584.
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A Caimari, J M del Bas, A Crescenti & L Arola. (2012) Low doses of grape seed procyanidins reduce adiposity and improve the plasma lipid profile in hamsters. International Journal of Obesity 37:4, pages 576-583.
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Anna-Marja Aura, Ismo Mattila, Tuulia Hyötyläinen, Peddinti Gopalacharyulu, Veronique Cheynier, Jean-Marc Souquet, Magali Bes, Carine Le Bourvellec, Sylvain Guyot & Matej Orešič. (2012) Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches. European Journal of Nutrition 52:2, pages 833-846.
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Rosana M. Lobayan, Erika N. Bentz, Alicia H. Jubert & Alicia B. Pomilio. (2013) Charge delocalization in Z-isomers of (4α→6″, 2α→O→1″)-phenylflavans with R=H, OH and OCH3. Effects on bond dissociation enthalpies and ionization potentials. Computational and Theoretical Chemistry 1006, pages 37-46.
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Anna Castell-Auví, Lídia Cedó, Victor Pallarès, M. Teresa Blay, Montserrat Pinent, M. José Motilva, Santiago Garcia-Vallvé, Gerard Pujadas, Pierre Maechler & Anna Ardévol. (2012) Procyanidins modify insulinemia by affecting insulin production and degradation. The Journal of Nutritional Biochemistry 23:12, pages 1565-1572.
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Stephan W. Barth, Tatiana C. L. Koch, Bernhard Watzl, Helmut Dietrich, Frank Will & Achim Bub. (2011) Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content. European Journal of Nutrition 51:7, pages 841-850.
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Rosana Maria Lobayan, Erika N. Bentz, Alicia H. Jubert & Alicia B. Pomilio. (2011) Structural and electronic properties of Z isomers of (4α→6´´,2α→O→1´´)-phenylflavans substituted with R = H, OH and OCH3 calculated in aqueous solution with PCM solvation model. Journal of Molecular Modeling 18:4, pages 1667-1676.
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Shu-Dong Wei, Hai-Chao Zhou & Yi-Ming Lin. (2011) Antioxidant Activities of Fractions of Polymeric Procyanidins from Stem Bark of Acacia confusa. International Journal of Molecular Sciences 12:2, pages 1146-1160.
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Alfred Zoechling, Falk Liebner & Alois Jungbauer. (2011) Red wine: A source of potent ligands for peroxisome proliferator-activated receptor γ. Food Funct. 2:1, pages 28-38.
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Hideto Kimura, Satoshi Ogawa, Akihiko Sugiyama, Mitsuo Jisaka, Takashi Takeuchi & Kazushige Yokota. (2011) Anti-obesity effects of highly polymeric proanthocyanidins from seed shells of Japanese horse chestnut (Aesculus turbinata Blume). Food Research International 44:1, pages 121-126.
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Erika N. Bentz, Alicia H. Jubert, Alicia B. Pomilio & Rosana M. Lobayan. (2010) Theoretical study of Z isomers of A-type dimeric proanthocyanidins substituted with R=H, OH and OCH3: stability and reactivity properties. Journal of Molecular Modeling 16:12, pages 1895-1909.
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Yuqing Duan, Haihui Zhang, Feifei Xu, Bijun Xie, Xianwen Yang, Yong Wang & Yongsheng Yan. (2010) Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro. Food Chemistry 122:1, pages 84-91.
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Isabel Baiges, Johan Palmfeldt, Cinta Bladé, Niels Gregersen & Lluís Arola. (2010) Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet. Molecular & Cellular Proteomics 9:7, pages 1499-1513.
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Chi-Hua Chen, Mei-Yui Chang, Yu-Shen Lin, Da-Gin Lin, Shiow-Wen Chen & Pei-Min Chao. (2009) A herbal extract with acetyl–coenzyme A carboxylase inhibitory activity and its potential for treating metabolic syndrome. Metabolism 58:9, pages 1297-1305.
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Matilde R. Chacón, Victòria Ceperuelo-Mallafré, Elsa Maymó-Masip, Josep Maria Mateo-Sanz, Lluis Arola, Cristina Guitiérrez, José Manuel Fernandez-Real, Ana Ardèvol, Imma Simón & Joan Vendrell. (2009) Grape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitro. Cytokine 47:2, pages 137-142.
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Rosana M. Lobayan, Alicia H. Jubert, Martín G. Vitale & Alicia B. Pomilio. (2008) Conformational and electronic (AIM/NBO) study of unsubstituted A-type dimeric proanthocyanidin. Journal of Molecular Modeling 15:5, pages 537-550.
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Vanda Mendes, Rosário Monteiro, Diogo Pestana, Diana Teixeira, Conceição Calhau & Isabel Azevedo. (2008) Xanthohumol Influences Preadipocyte Differentiation: Implication of Antiproliferative and Apoptotic Effects. Journal of Agricultural and Food Chemistry 56:24, pages 11631-11637.
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Sarah Bazzocco, Ismo Mattila, Sylvain Guyot, Catherine M. G. C. Renard & Anna-Marja Aura. (2008) Factors affecting the conversion of apple polyphenols to phenolic acids and fruit matrix to short-chain fatty acids by human faecal microbiota in vitro. European Journal of Nutrition 47:8, pages 442-452.
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Montserrat Pinent, Anna Castell, Isabel Baiges, Gemma Montagut, Lluís Arola & Anna Ardévol. (2008) Bioactivity of Flavonoids on Insulin-Secreting Cells. Comprehensive Reviews in Food Science and Food Safety 7:4, pages 299-308.
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