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Research Article

The nutritional role of free sialic acid, a human milk monosaccharide, and its application as a functional food ingredient

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Guirong Liu, Mengzhen Hao, Binghui Zeng, Manman Liu, Junjuan Wang, Shanfeng Sun, Changqi Liu & Che Huilian. (2022) Sialic acid and food allergies: The link between nutrition and immunology. Critical Reviews in Food Science and Nutrition 0:0, pages 1-27.
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Tawfik Abou Assale, Thomas Kuenzel, Tamara Schink, Anahita Shahraz, Harald Neumann & Christine Klaus. (2023) 6’-sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotic neomycin in susceptible mice. Frontiers in Immunology 14.
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Fan Liu, Jan van der Molen, Folkert Kuipers & Sander S. van Leeuwen. (2023) Quantitation of bioactive components in infant formulas: Milk oligosaccharides, sialic acids and corticosteroids. Food Research International 174, pages 113589.
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Mingli Zhao, Yingying Zhu, Hao Wang, Wenli Zhang & Wanmeng Mu. (2023) Recent advances on N-acetylneuraminic acid: Physiological roles, applications, and biosynthesis. Synthetic and Systems Biotechnology 8:3, pages 509-519.
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Chenglong Liu, Peicong Ge, Chaofan Zeng, Xiaofan Yu, Yuanren Zhai, Wei Liu, Qiheng He, Junsheng Li, Xingju Liu, Jia Wang, Xun Ye, Qian Zhang, Rong Wang, Yan Zhang, Jizong Zhao & Dong Zhang. (2023) Correlation of Serum N-Acetylneuraminic Acid with the Risk of Moyamoya Disease. Brain Sciences 13:6, pages 913.
Crossref
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Paolo Colombo, Estefanía Noriega Fernández & Helle Katrine Knutsen. (2023) Safety of 6′‐sialyllactose (6′‐SL) sodium salt produced by a derivative strain (Escherichia coli NEO6) of E. coli W (ATCC 9637) as a Novel Food pursuant to Regulation (EU) 2015/2283. EFSA Journal 21:6.
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Xiaoqin Wang, Zhenhua Li, Wenqing Li, Cheng Li, Jing Liu, Yu Lu, Jiangbo Fan, Haiyan Ren, Linjuan Huang & Zhongfu Wang. (2023) Gestational diabetes mellitus affects the fucosylation and sialylation levels of N/O-glycans in human milk glycoproteins. Carbohydrate Polymers 301, pages 120312.
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Marefa Jahan, Peter C. Thomson, Peter C. Wynn & Bing Wang. (2023) Red Meat Derived Glycan, N-acetylneuraminic Acid (Neu5Ac) Is a Major Sialic Acid in Different Skeletal Muscles and Organs of Nine Animal Species—A Guideline for Human Consumers. Foods 12:2, pages 337.
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Dan Bi Park, Lila Kim, Jeong Ho Hwang, Kyung-Tai Kim, Ji Eun Park, Jong-Soon Choi & Hyun Joo An. (2023) Temporal quantitative profiling of sialyllactoses and sialic acids after oral administration of sialyllactose to mini-pigs with osteoarthritis. RSC Advances 13:2, pages 1115-1124.
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Julia Hinterseher, Juliane Günther, Kristina Zlatina, Lisa Isernhagen, Torsten Viergutz, Elisa Wirthgen, Andreas Hoeflich, Andreas Vernunft & Sebastian Peter Galuska. (2022) Milk Polysialic Acid Levels Rapidly Decrease in Line with the N-Acetylneuraminic Acid Concentrations during Early Lactation in Dairy Cows. Biology 12:1, pages 5.
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Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Henk van Loveren, Paolo Colombo, Estefanía Noriega Fernández & Helle Katrine Knutsen. (2022) Safety of 6′‐sialyllactose (6’‐SL) sodium salt produced by derivative strains of Escherichia coli BL21 (DE3) as a novel food pursuant to Regulation (EU) 2015/2283. EFSA Journal 20:12.
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Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Henk van Loveren, Paolo Colombo, Estefanía Noriega Fernández & Helle Katrine Knutsen. (2022) Safety of 3’‐sialyllactose (3’‐SL) sodium salt produced by derivative strains of Escherichia coli BL21 (DE3) as a Novel Food pursuant to Regulation (EU) 2015/2283. EFSA Journal 20:5.
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Zekun Chen, Yanmei Chang, Hui Liu, Yanxia You, Yanpin Liu, Xue Yu, Yuqi Dou, Defu Ma, Lijun Chen, Xiaomei Tong & Yan Xing. (2022) Distribution and Influencing Factors of the Sialic Acid Content in the Breast Milk of Preterm Mothers at Different Stages. Frontiers in Nutrition 9.
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Min Pang, Donglei Zheng, Pengpeng Jia & Lili Cao. (2022) Novel Water-in-Oil Emulsions for Co-Loading Sialic Acid and Chitosan: Formulation, Characterization, and Stability Evaluation. Foods 11:6, pages 873.
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Lee-Hoon Ho, Thuan-Chew Tan & Li-Choo Chong. 2022. Future Foods. Future Foods 469 497 .
Hao Yue, Peng Wang, Lei Zhang, Ding Ning, Weizhen Cai, Yanchao Wang & Jingfeng Wang. (2021) Sialoglycoproteins isolated from the eggs of Carassius auratus alleviates CCL4‐induced liver injury via downregulation of the IRE‐α/NF‐κB signaling pathway . Journal of Food Biochemistry 45:12.
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DongSheng Bian, Xinyue Wang, Jiale Huang, Xiaoxuan Chen & Hongwei Li. (2021) Maternal Neu5Ac Supplementation During Pregnancy Improves Offspring Learning and Memory Ability in Rats. Frontiers in Nutrition 8.
Crossref
Christel Tran, Licia Turolla, Diana Ballhausen, Sandrine Cornaz Buros, Tony Teav, Hector Gallart-Ayala, Julijana Ivanisevic, Mohamed Faouzi, Dirk J. Lefeber, Ivan Ivanovski, Sara Giangiobbe, Stefano Giuseppe Caraffi, Livia Garavelli & Andrea Superti-Furga. (2021) The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects. Molecular Genetics and Metabolism Reports 28, pages 100777.
Crossref
Tan Hui Yan, Abdul Salam Babji, Seng Joe Lim & Shahrul Razid Sarbini. (2021) A Systematic Review of Edible Swiftlet's Nest (ESN): Nutritional bioactive compounds, health benefits as functional food, and recent development as bioactive ESN glycopeptide hydrolysate. Trends in Food Science & Technology 115, pages 117-132.
Crossref
Xue-Ning Wang, Li-Li Hong & Jian-Qiang Kong. (2021) Diacerein as a Promising Acyl Donor in Biosynthetic Acetyl-CoA and Glycosyl Esters Mediated by a Multifunctional Maltose O -Acetyltransferase from Escherichia coli . Journal of Agricultural and Food Chemistry 69:23, pages 6623-6635.
Crossref
Bibiche den Hollander, Anne Rasing, Merel A. Post, Willemijn M. Klein, Machteld M. Oud, Marion M. Brands, Lonneke de Boer, Udo F. H. Engelke, Peter van Essen, Sabine A. Fuchs, Charlotte A. Haaxma, Brynjar O. Jensson, Leo A. J. Kluijtmans, Anna Lengyel, Klaske D. Lichtenbelt, Elsebet Østergaard, Gera Peters, Ramona Salvarinova, Marleen E. H. Simon, Kari Stefansson, Ólafur Thorarensen, Ulrike Ulmen, Karlien L. M. Coene, Michèl A. Willemsen, Dirk J. Lefeber & Clara D. M. van Karnebeek. (2021) NANS-CDG: Delineation of the Genetic, Biochemical, and Clinical Spectrum. Frontiers in Neurology 12.
Crossref
Kathrin Cohen Kadosh, Leilani Muhardi, Panam Parikh, Melissa Basso, Hamid Jan Jan Mohamed, Titis Prawitasari, Folake Samuel, Guansheng Ma & Jan M. W. Geurts. (2021) Nutritional Support of Neurodevelopment and Cognitive Function in Infants and Young Children—An Update and Novel Insights. Nutrients 13:1, pages 199.
Crossref
Haiquan Yang, Liping Lu & Xianzhong Chen. (2021) An overview and future prospects of sialic acids. Biotechnology Advances 46, pages 107678.
Crossref
Wakako Yoshioka, Naoyuki Miyasaka, Ryo Okubo, Reiko Shimizu, Yuji Takahashi, Yuriko Oda, Ichizo Nishino, Harumasa Nakamura & Madoka Mori-Yoshimura. (2020) Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan. Orphanet Journal of Rare Diseases 15:1.
Crossref
Miao-Nan Li, Shao-Huan Qian, Zhuo-Ya Yao, Sheng-Ping Ming, Xiao-Jun Shi, Ping-Fang Kang, Ning-Ru Zhang, Xiao-Jing Wang, Da-Sheng Gao, Qing Gao, Heng Zhang & Hong-Ju Wang. (2020) Correlation of serum N-Acetylneuraminic acid with the risk and prognosis of acute coronary syndrome: a prospective cohort study. BMC Cardiovascular Disorders 20:1.
Crossref
Weiwei Zhu, Xiangsong Chen, Lixia Yuan, Jinyong Wu & Jianming Yao. (2020) Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values. Molecules 25:21, pages 5141.
Crossref
Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Karl Heinz Engel, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Morten Poulsen, Josef Rudolf Schlatter, Henk van Loveren, Paolo Colombo & Helle Katrine Knutsen. (2020) Safety of 3’‐Sialyllactose (3’‐SL) sodium salt as a novel food pursuant to Regulation (EU) 2015/2283. EFSA Journal 18:5.
Crossref
Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Karl Heinz Engel, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Morten Poulsen, Josef Rudolf Schlatter, Henk van Loveren, Paolo Colombo & Helle Katrine Knutsen. (2020) Safety of 6′‐Sialyllactose (6′‐SL) sodium salt as a novel food pursuant to Regulation (EU) 2015/2283. EFSA Journal 18:5.
Crossref
Linyang Ye, Li Mu, Gang Li & Yi Bao. (2020) Assessing sialic acid content in food by hydrophilic chromatography-high performance liquid chromatography. Journal of Food Composition and Analysis 87, pages 103393.
Crossref
Candice Quin, Sara D. Vicaretti, Nina A Mohtarudin, Alexander M. Garner, Deanna M. Vollman, Deanna L. Gibson & Wesley F. Zandberg. (2020) Influence of sulfonated and diet-derived human milk oligosaccharides on the infant microbiome and immune markers. Journal of Biological Chemistry 295:12, pages 4035-4048.
Crossref
Shyamasree Ghosh. 2020. Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease. Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease 109 125 .
Chao Zhang, Jingyuan Chen, Yuhao Liu & Danyan Xu. (2019) Sialic acid metabolism as a potential therapeutic target of atherosclerosis. Lipids in Health and Disease 18:1.
Crossref
Mengdi Song, Jie Zeng, Tian Jia, Haiyan Gao, Ruiyao Zhang, Jikai Jiang, Guanglei Li & Tongchao Su. (2019) Effects of sialylated lactulose on the mouse intestinal microbiome using Illumina high-throughput sequencing. Applied Microbiology and Biotechnology 103:21-22, pages 9067-9076.
Crossref
Jolanta Lis-Kuberka, Barbara Królak-Olejnik, Marta Berghausen-Mazur & Magdalena Orczyk-Pawiłowicz. (2019) Lectin-Based Method for Deciphering Human Milk IgG Sialylation. Molecules 24:20, pages 3797.
Crossref
Kirt R. Phipps, Nigel J. Baldwin, Barry Lynch, Diane R. Stannard, Alica Šoltésová, Ben Gilby, Marta H. Mikš & Christoph H. Röhrig. (2019) Toxicological safety evaluation of the human‐identical milk oligosaccharide 6′‐sialyllactose sodium salt. Journal of Applied Toxicology 39:10, pages 1444-1461.
Crossref
Kirt R. Phipps, Nigel J. Baldwin, Barry Lynch, Diane R. Stannard, Alica Šoltésová, Ben Gilby, Marta H. Mikš & Christoph H. Röhrig. (2019) Toxicological safety assessment of the human‐identical milk oligosaccharide 3′‐sialyllactose sodium salt. Journal of Applied Toxicology 39:10, pages 1378-1393.
Crossref
Maria Gloria Dominguez-Bello, Filipa Godoy-Vitorino, Rob Knight & Martin J Blaser. (2019) Role of the microbiome in human development. Gut 68:6, pages 1108-1114.
Crossref
Susana Figueroa‐Lozano & Paul de Vos. (2018) Relationship Between Oligosaccharides and Glycoconjugates Content in Human Milk and the Development of the Gut Barrier. Comprehensive Reviews in Food Science and Food Safety 18:1, pages 121-139.
Crossref
Aaron D. Wylie & Wesley F. Zandberg. (2018) Quantitation of Sialic Acids in Infant Formulas by Liquid Chromatography–Mass Spectrometry: An Assessment of Different Protein Sources and Discovery of New Analogues. Journal of Agricultural and Food Chemistry 66:30, pages 8114-8123.
Crossref
Stephen Fleming, Maciej Chichlowski, Brian Berg, Sharon Donovan & Ryan Dilger. (2018) Dietary Sialyllactose Does Not Influence Measures of Recognition Memory or Diurnal Activity in the Young Pig. Nutrients 10:4, pages 395.
Crossref
Dominique Turck, Jean‐Louis Bresson, Barbara Burlingame, Tara Dean, Susan Fairweather‐Tait, Marina Heinonen, Karen Ildico Hirsch‐Ernst, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Monika Neuhäuser‐Berthold, Grażyna Nowicka, Kristina Pentieva, Yolanda Sanz, Alfonso Siani, Anders Sjödin, Martin Stern, Daniel Tomé, Marco Vinceti, Peter Willatts, Karl‐Heinz Engel, Rosangela Marchelli, Annette Pöting, Morten Poulsen, Josef Rudolf Schlatter, Emanuela Turla & Henk van Loveren. (2017) Safety of synthetic N‐acetyl‐d‐neuraminic acid as a novel food pursuant to Regulation (EC) No 258/97. EFSA Journal 15:7.
Crossref
Clara D M van Karnebeek, Luisa Bonafé, Xiao-Yan Wen, Maja Tarailo-Graovac, Sara Balzano, Beryl Royer-Bertrand, Angel Ashikov, Livia Garavelli, Isabella Mammi, Licia Turolla, Catherine Breen, Dian Donnai, Valérie Cormier-Daire, Delphine Heron, Gen Nishimura, Shinichi Uchikawa, Belinda Campos-Xavier, Antonio Rossi, Thierry Hennet, Koroboshka Brand-Arzamendi, Jacob Rozmus, Keith Harshman, Brian J Stevenson, Enrico Girardi, Giulio Superti-Furga, Tammie Dewan, Alissa Collingridge, Jessie Halparin, Colin J Ross, Margot I Van Allen, Andrea Rossi, Udo F Engelke, Leo A J Kluijtmans, Ed van der Heeft, Herma Renkema, Arjan de Brouwer, Karin Huijben, Fokje Zijlstra, Torben Heise, Thomas Boltje, Wyeth W Wasserman, Carlo Rivolta, Sheila Unger, Dirk J Lefeber, Ron A Wevers & Andrea Superti-Furga. (2016) NANS-mediated synthesis of sialic acid is required for brain and skeletal development. Nature Genetics 48:7, pages 777-784.
Crossref

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