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More than sugar in the milk: human milk oligosaccharides as essential bioactive molecules in breast milk and current insight in beneficial effects

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Fan Liu, Anna Bella Simpson, Esmée D’Costa, Fanny Sophia Bunn & Sander S. van Leeuwen. (2023) Sialic acid, the secret gift for the brain. Critical Reviews in Food Science and Nutrition 63:29, pages 9875-9894.
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Zhipeng Gu, Shiqi Xu, Yuxing Zheng, Jonathan A. Lane, Sushil Dhital, Qiang Huang, Ruibiao Hu, Feitong Liu & Bin Zhang. (2023) In vitro faecal fermentation metabolites of 2'-fucosyllactose protect against intestinal epithelial injury: Infant enterotype effects. International Dairy Journal, pages 105860.
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Mingguang Yu, Qinggang Xie, Huanlu Song, Lijin Wang, Han Sun, Shilong Jiang, Yongjiu Zhang & Chengdong Zheng. (2023) Characterization of the odor compounds in human milk by DHS/GC × GC-O-MS: A feasible and efficient method. Food Research International 174, pages 113597.
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Yue Clare Lou, Benjamin E. Rubin, Marie C. Schoelmerich, Kaden S. DiMarco, Adair L. Borges, Rachel Rovinsky, Leo Song, Jennifer A. Doudna & Jillian F. Banfield. (2023) Infant microbiome cultivation and metagenomic analysis reveal Bifidobacterium 2’-fucosyllactose utilization can be facilitated by coexisting species. Nature Communications 14:1.
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Ivana Hyrslova, Vladimir Drab, Jaromir Cihlar, Gabriela Krausova, Iva Mrvikova, Antonin Kana, Jiri Stetina & Sarka Musilova. (2023) Functional and Probiotic Characterization of Newly Isolated Strains from Infant Feces and Breast Milk. Fermentation 9:11, pages 960.
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Na-Hyung Kim, Juhae Kim, Joo-Yeon Lee, Hyeon-A Bae & Choon Young Kim. (2023) Application of Milk Exosomes for Musculoskeletal Health: Talking Points in Recent Outcomes. Nutrients 15:21, pages 4645.
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Liuying Zhu, Hongyan Li, Ting Luo, Zeyuan Deng, Jing Li, Liufeng Zheng & Bing Zhang. (2023) Human Milk Oligosaccharides: A Critical Review on Structure, Preparation, Their Potential as a Food Bioactive Component, and Future Perspectives. Journal of Agricultural and Food Chemistry 71:43, pages 15908-15925.
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Chunsheng Jin, Jon Lundstrøm, Emma Korhonen, Ana S. Luis & Daniel Bojar. (2023) Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc. Molecular & Cellular Proteomics 22:9, pages 100635.
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Marshall J. Smith, Emma L. Gates, Göran Widmalm, Ralph W. Adams, Gareth A. Morris & Mathias Nilsson. (2023) Resolving the complexity in human milk oligosaccharides using pure shift NMR methods and CASPER. Organic & Biomolecular Chemistry 21:19, pages 3984-3990.
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Chao Zhang, Houyu Chi, Xueting Han, Jie Zheng, Sijia Yang, Ai li Li & Wei Yu. (2023) Advances in the protection of intestinal mucosal barrier function by milk-derived miRNAs. Food & Function 14:9, pages 3909-3928.
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Alena Golubkova & Catherine J. Hunter. (2023) Development of the Neonatal Intestinal Barrier, Microbiome, and Susceptibility to NEC. Microorganisms 11:5, pages 1247.
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Gozde Okburan & Serap Kızıler. (2023) Human milk oligosaccharides as prebiotics. Pediatrics & Neonatology 64:3, pages 231-238.
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Çağla AYER, Pakize Eylem ŞEKER ARI & Gulcin SAGDİCOGLU CELEP. (2023) A Brief Overview: Breast Milk Colostrum Bioactives. Journal of Gazi University Health Sciences Institute 5:1, pages 49-58.
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Carlos Jiménez-Pérez, Francisco Guzmán-Rodríguez, Alma E. Cruz-Guerrero & Sergio Alatorre-Santamaría. (2023) The dual role of fucosidases: tool or target. Biologia 78:7, pages 1773-1788.
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Miaomiao Hu, Mengli Li, Chenchen Li, Ming Miao & Tao Zhang. (2023) Effects of Human Milk Oligosaccharides in Infant Health Based on Gut Microbiota Alteration. Journal of Agricultural and Food Chemistry 71:2, pages 994-1001.
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Jitendra Kumar, Priya Sharma, Murli Dhar Mitra, Sonia Sangwan & Haribrahma Singh. 2022. Immunology of the GI Tract - Recent Advances. Immunology of the GI Tract - Recent Advances.
Mauricio E. Pavón-Chimal, Carlos Jiménez-Pérez, Francisco Guzmán-Rodriguez, Sergio Alatorre-Santamaría, Luis G. González-Olivares, Mariano García-Garibay, Lorena Gómez-Ruiz, Gabriela Rodríguez-Serrano & Alma E. Cruz-Guerrero. (2022) Mechanistic insight into the synthesis of fucooligosaccharides by α-L-fucosidase from Thermotoga maritima belonging to the GH29 family: in silico study. Biologia 78:7, pages 1825-1832.
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Christoph Bührer, Regina Ensenauer, Frank Jochum, Hermann Kalhoff, Berthold Koletzko, Burkhard Lawrenz, Walter Mihatsch, Carsten Posovszky & Silvia Rudloff. (2022) Infant formulas with synthetic oligosaccharides and respective marketing practices: Position Statement of the German Society for Child and Adolescent Medicine e.V. (DGKJ), Commission for Nutrition. Molecular and Cellular Pediatrics 9:1.
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Swati Shukla, Ramesh C. Dubey & Jyoti Choudhary. 2022. Microbial Biotechnology. Microbial Biotechnology 43 58 .
Pan Zhang, Yingying Zhu, Zeyu Li, Wenli Zhang, Cuie Guang & Wanmeng Mu. (2022) Designing a Highly Efficient Biosynthetic Route for Lacto- N -Neotetraose Production in Escherichia coli . Journal of Agricultural and Food Chemistry 70:32, pages 9961-9968.
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Jaclyn B. Wiggins, Rachael Trotman, Patti H. Perks & Jonathan R. Swanson. (2022) Enteral Nutrition. Clinics in Perinatology 49:2, pages 427-445.
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Kai-Eng Ooi, Xiu-Wen Zhang, Cheng-Yu Kuo, Ying-Jia Liu & Ching-Ching Yu. (2022) Chemoenzymatic Synthesis of Asymmetrically Branched Human Milk Oligosaccharide Lacto-N-Hexaose. Frontiers in Chemistry 10.
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Pan Zhang, Yingying Zhu, Zeyu Li, Wenli Zhang & Wanmeng Mu. (2022) Recent Advances on Lacto- N -neotetraose, a Commercially Added Human Milk Oligosaccharide in Infant Formula . Journal of Agricultural and Food Chemistry 70:15, pages 4534-4547.
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Irene Cuxart, Joan Coines, Oriol Esquivias, Magda Faijes, Antoni Planas, Xevi Biarnés & Carme Rovira. (2022) Enzymatic Hydrolysis of Human Milk Oligosaccharides. The Molecular Mechanism of Bifidobacterium Bifidum Lacto- N -biosidase . ACS Catalysis 12:8, pages 4737-4743.
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Meral Kilic-Akyilmaz, Barbaros Ozer, Tugba Bulat & Ali Topcu. (2022) Effect of heat treatment on micronutrients, fatty acids and some bioactive components of milk. International Dairy Journal 126, pages 105231.
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Chunli Kong, Anne de Jong, Bart J. de Haan, Jan Kok & Paul de Vos. (2022) Human milk oligosaccharides and non-digestible carbohydrates reduce pathogen adhesion to intestinal epithelial cells by decoy effects or by attenuating bacterial virulence. Food Research International 151, pages 110867.
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Lucie Marousez, Norbert Sprenger, Marie De Lamballerie, Sarahi Jaramillo-Ortiz, Léa Tran, Edwina Micours, Frédéric Gottrand, Michael Howsam, Frederic J. Tessier, Delphine Ley & Jean Lesage. (2022) High hydrostatic pressure processing of human milk preserves milk oligosaccharides and avoids formation of Maillard reaction products. Clinical Nutrition 41:1, pages 1-8.
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Bin Zhang, Long-Qing Li, Feitong Liu & Jian-Yong Wu. (2022) Human milk oligosaccharides and infant gut microbiota: Molecular structures, utilization strategies and immune function. Carbohydrate Polymers 276, pages 118738.
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Konstantinos C. Mountzouris. 2022. Encyclopedia of Dairy Sciences. Encyclopedia of Dairy Sciences 352 358 .
Chunli Kong, Renate Akkerman, Cynthia E. Klostermann, Martin Beukema, Marjolein M. P. Oerlemans, Henk A. Schols & Paul de Vos. (2021) Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells . Food & Function 12:24, pages 12513-12525.
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Diao Zhou, Ying Zhao, Jing Li, Vinothkannan Ravichandran, Leli Wang, Qiuyun Huang, Cang Chen, Hengjia Ni & Jia Yin. (2021) Effects of Phytic Acid-Degrading Bacteria on Mineral Element Content in Mice. Frontiers in Microbiology 12.
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Seoyoon Cho, Ziliang Zhu, Tengfei Li, Kristine Baluyot, Brittany R Howell, Heather C Hazlett, Jed T Elison, Jonas Hauser, Norbert Sprenger, Di Wu & Weili Lin. (2021) Human milk 3’-Sialyllactose is positively associated with language development during infancy. The American Journal of Clinical Nutrition 114:2, pages 588-597.
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Stella A. Verkhnyatskaya, Chunli Kong, Cynthia E. Klostermann, Henk A. Schols, Paul de Vos & Marthe T. C. Walvoort. (2021) Digestion, fermentation, and pathogen anti-adhesive properties of the hMO-mimic di-fucosyl-β-cyclodextrin. Food & Function 12:11, pages 5018-5026.
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Guocong Luo, Yingying Zhu, Jiawei Meng, Li Wan, Wenli Zhang & Wanmeng Mu. (2021) A Novel β-1,4-Galactosyltransferase from Histophilus somni Enables Efficient Biosynthesis of Lacto- N -Neotetraose via Both Enzymatic and Cell Factory Approaches . Journal of Agricultural and Food Chemistry 69:20, pages 5683-5690.
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Lianghui Cheng, Chunli Kong, Wenjia Wang, Andre Groeneveld, Arjen Nauta, Matthew R. Groves, Mensiena B. G. Kiewiet & Paul de Vos. (2021) The Human Milk Oligosaccharides 3‐FL, Lacto‐N‐Neotetraose, and LDFT Attenuate Tumor Necrosis Factor‐α Induced Inflammation in Fetal Intestinal Epithelial Cells In Vitro through Shedding or Interacting with Tumor Necrosis Factor Receptor 1. Molecular Nutrition & Food Research 65:7.
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Carole Ayoub Moubareck. (2021) Human Milk Microbiota and Oligosaccharides: A Glimpse into Benefits, Diversity, and Correlations. Nutrients 13:4, pages 1123.
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Pieter Van den Abbeele, Norbert Sprenger, Jonas Ghyselinck, Benoît Marsaux, Massimo Marzorati & Florence Rochat. (2021) A Comparison of the In Vitro Effects of 2’Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers. Nutrients 13:3, pages 726.
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Laura E. Carr, Misty D. Virmani, Fernanda Rosa, Daniel Munblit, Katelin S. Matazel, Ahmed A. Elolimy & Laxmi Yeruva. (2021) Role of Human Milk Bioactives on Infants' Gut and Immune Health. Frontiers in Immunology 12.
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Aristea Binia, Luca Lavalle, Cheng Chen, Sean Austin, Massimo Agosti, Isam Al-Jashi, Almerinda Barroso Pereira, Maria Jose Costeira, Maria Gorett Silva, Giovanna Marchini, Cecilia Martínez -Costa, Tom Stiris, Sylvia-Maria Stoicescu, Mireille Vanpée, Thameur Rakza, Claude Billeaud, Jean-Charles Picaud, Magnus Domellöf, Rachel Adams, Euridice Castaneda-Gutierrez & Norbert Sprenger. (2021) Human milk oligosaccharides, infant growth, and adiposity over the first 4 months of lactation. Pediatric Research.
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Won-Ho Hahn, Soon Young Shin, Jun Hwan Song & Nam Mi Kang. (2021) Effect of human breast milk on innate immune response: Up-regulation of bacterial pattern recognition receptors and innate cytokines in THP-1 monocytic cells. European Journal of Inflammation 19, pages 205873922110261.
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