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Critical Reviews in Food Science and Nutrition Volume 62, 2022 - Issue 2
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Betanin as a multipath oxidative stress and inflammation modulator: a beetroot pigment with protective effects on cardiovascular disease pathogenesis

Davi Vieira Teixeira da Silvaa Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BrasilORCID Iconhttps://orcid.org/0000-0003-2839-9984View further author information
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Diego dos Santos Baiãoa Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BrasilORCID Iconhttps://orcid.org/0000-0002-8278-7067View further author information
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Vitor Francisco Ferreirab Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, BrasilORCID Iconhttps://orcid.org/0000-0002-2166-766XView further author information
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Vania Margaret Flosi Paschoalina Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BrasilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6093-134XView further author information
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Pages 539-554 | Published online: 30 Sep 2020

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Peter Jan D. de Vera, Janeth C. Tayone & Ma. Cristina S. De Las Llagas. (2022) Cyperus iria linn. Roots ethanol extract: its phytochemicals, cytotoxicity, and anti-inflammatory activity. Journal of Taibah University for Science 16:1, pages 854-862.
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Susmita Ghosh, Tanmay Sarkar, Runu Chakraborty, Mohammad Ali Shariati & Jesus Simal-Gandara. (2022) Nature’s palette: An emerging frontier for coloring dairy products. Critical Reviews in Food Science and Nutrition 0:0, pages 1-45.
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Muthu Thiruvengadam, Ill-Min Chung, Ramkumar Samynathan, S. R. Harish Chandar, Baskar Venkidasamy, Tanmay Sarkar, Maksim Rebezov, Olga Gorelik, Mohammad Ali Shariati & Jesus Simal-Gandara. (2022) A comprehensive review of beetroot (Beta vulgaris L.) bioactive components in the food and pharmaceutical industries. Critical Reviews in Food Science and Nutrition 0:0, pages 1-33.
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Articles from other publishers (25)

Agnieszka Kumorkiewicz-Jamro, Renata Górska, Małgorzata Krok-Borkowicz, Katarzyna Reczyńska-Kolman, Przemysław Mielczarek, Łukasz Popenda, Aneta Spórna-Kucab, Anna Tekieli, Elżbieta Pamuła & Sławomir Wybraniec. (2023) Betalains isolated from underexploited wild plant Atriplex hortensis var. rubra L. exert antioxidant and cardioprotective activity against H9c2 cells. Food Chemistry 414, pages 135641.
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Zhuo Wu, Le Chen, Qinyu Wang, Chandramohan Govindasamy, Allur Subramaniyan Sivakumar & Xinjun Chen. (2023) Betanin ameliorates Lipopolysaccharide-induced acute lung injury in mice via inhibition of inflammatory response and oxidative stress. Arabian Journal of Chemistry 16:6, pages 104763.
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Banashree Chetia Phukan, Rubina Roy, Rajib Paul, Muhammed Khairujjaman Mazumder, Joyobrato Nath, Pallab Bhattacharya & Anupom Borah. (2023) Traversing through the cell signaling pathways of neuroprotection by betanin: therapeutic relevance to Alzheimer’s Disease and Parkinson’s Disease. Metabolic Brain Disease 38:3, pages 805-817.
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Gloria Stephanie Villa-Jaimes, Han Moshage, Francisco Javier Avelar-González, Herson Antonio González-Ponce, Manon Buist-Homan, Fidel Guevara-Lara, Esperanza Sánchez-Alemán, Sandra Luz Martínez-Hernández, Javier Ventura-Juárez, Martín Humberto Muñoz-Ortega & Ma. Consolación Martínez-Saldaña. (2023) Molecular and Antioxidant Characterization of Opuntia robusta Fruit Extract and Its Protective Effect against Diclofenac-Induced Acute Liver Injury in an In Vivo Rat Model. Antioxidants 12:1, pages 113.
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Sandra Machado LIRA, Marcelo Oliveira HOLANDA, José Ytalo Gomes da SILVA, Chayane Gomes MARQUES, Lia Corrêa COELHO, Carla Laíne Silva LIMA, Joana Talita Galdino COSTA, Juliana Barbosa DANTAS, Gladstone Lima MACIEL, Gisele Silvestre da SILVA, Glauber Batista Moreira SANTOS, Guilherme Julião ZOCOLO, Ana Paula DIONÍSIO & Maria Izabel Florindo GUEDES. (2023) Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice. Food Science and Technology 43.
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D. V. Sokolova. (2022) Genetic diversity of the table beet (<I>Beta</I> L.) collection at VIR as a potential source for breeding (a review). Proceedings on applied botany, genetics and breeding 183:4, pages 239-250.
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Xiaoyu Wu, Jiajia Wei, Yang Yi, Qihai Gong & Jianmei Gao. (2022) Activation of Nrf2 signaling: A key molecular mechanism of protection against cardiovascular diseases by natural products. Frontiers in Pharmacology 13.
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Urszula Trych, Magdalena Buniowska-Olejnik & Krystian Marszałek. (2022) Bioaccessibility of Betalains in Beetroot (Beta vulgaris L.) Juice under Different High-Pressure Techniques. Molecules 27:20, pages 7093.
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Min Qiu, Jimei Chen, Xiaohong Li & Jian Zhuang. (2022) Intersection of the Ubiquitin–Proteasome System with Oxidative Stress in Cardiovascular Disease. International Journal of Molecular Sciences 23:20, pages 12197.
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Maryam Mousavi, Nasim Abedimanesh, Kosar Mohammadnejad, Elham Sharini, Maryam Nikkhah, Mohammad Reza Eskandari, Behrooz Motlagh, Javad Mohammadnejad, Hadi Khodabandehloo, Mojtaba Fathi & Moosa Talebi. (2022) Betanin alleviates oxidative stress through the Nrf2 signaling pathway in the liver of STZ-induced diabetic rats. Molecular Biology Reports 49:10, pages 9345-9354.
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Cristiana Caliceti, Marco Malaguti, Luisa Marracino, Maria Cristina Barbalace, Paola Rizzo & Silvana Hrelia. (2022) Agri-Food Waste from Apple, Pear, and Sugar Beet as a Source of Protective Bioactive Molecules for Endothelial Dysfunction and Its Major Complications. Antioxidants 11:9, pages 1786.
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Jing Wang, Li Zeng, Ying Zhang, Wenxiu Qi, Ziyuan Wang, Lin Tian, Daqing Zhao, Qibiao Wu, Xiangyan Li & Tan Wang. (2022) Pharmacological properties, molecular mechanisms and therapeutic potential of ginsenoside Rg3 as an antioxidant and anti-inflammatory agent. Frontiers in Pharmacology 13.
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Matteo Tosato, Francesca Ciciarello, Maria Beatrice Zazzara, Cristina Pais, Giulia Savera, Anna Picca, Vincenzo Galluzzo, Hélio José Coelho-Júnior, Riccardo Calvani, Emanuele Marzetti & Francesco Landi. (2022) Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19. Clinics in Geriatric Medicine 38:3, pages 565-591.
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Jesús Herrera-Bravo, Jorge F. Beltrán, Nolberto Huard, Kathleen Saavedra, Nicolás Saavedra, Marysol Alvear, Fernando Lanas & Luis A. Salazar. (2022) Anthocyanins Found in Pinot Noir Waste Induce Target Genes Related to the Nrf2 Signalling in Endothelial Cells. Antioxidants 11:7, pages 1239.
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Diana V. Sokolova, Natalia A. Shvachko, Aleksandra S. Mikhailova & Vitaliy S. Popov. (2022) Betalain Content and Morphological Characteristics of Table Beet Accessions: Their Interplay with Abiotic Factors. Agronomy 12:5, pages 1033.
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Erick L. Bastos & Willibald Schliemann. 2022. Plant Antioxidants and Health. Plant Antioxidants and Health 51 93 .
AA Hafez, Z Jamali, S Samiei, S Khezri & A Salimi. (2021) Reduction of doxorubicin-induced cytotoxicity and mitochondrial damage by betanin in rat isolated cardiomyocytes and mitochondria. Human & Experimental Toxicology 40:12, pages 2123-2134.
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Laila Naif Al-Harbi, Subash-Babu Pandurangan, Alhanouf Mohammed Al-Dossari, Ghalia Shamlan, Ahmad Mohammad Salamatullah, Ali A Alshatwi & Amna Abdullah Alotiby. (2021) Beta vulgaris rubra L. (Beetroot) Peel Methanol Extract Reduces Oxidative Stress and Stimulates Cell Proliferation via Increasing VEGF Expression in H2O2 Induced Oxidative Stressed Human Umbilical Vein Endothelial Cells. Genes 12:9, pages 1380.
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Violetta Krajka-Kuźniak & Wanda Baer-Dubowska. (2021) Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?. International Journal of Molecular Sciences 22:15, pages 8223.
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Iñaki Milton-Laskibar, J. Alfredo Martínez & María P. Portillo. (2021) Current Knowledge on Beetroot Bioactive Compounds: Role of Nitrate and Betalains in Health and Disease. Foods 10:6, pages 1314.
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Hamid Arazi & Ehsan Eghbali. (2021) Possible Effects of Beetroot Supplementation on Physical Performance Through Metabolic, Neuroendocrine, and Antioxidant Mechanisms: A Narrative Review of the Literature. Frontiers in Nutrition 8.
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Izabela Sadowska-Bartosz & Grzegorz Bartosz. (2021) Biological Properties and Applications of Betalains. Molecules 26:9, pages 2520.
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Thanh T. H. Le & Ngoc Lieu Le. (2021) Antioxidant capacities and betacyanin lc‐ms profile of red‐fleshed dragon fruit juice ( hylocereus polyrhizus ) extracted by ultrasound‐assisted enzymatic treatment and optimized by response surface methodology . Journal of Food Processing and Preservation 45:3.
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Erick L. Bastos & Willibald Schliemann. 2020. Plant Antioxidants and Health. Plant Antioxidants and Health 1 44 .
Erick L. Bastos & Willibald Schliemann. 2020. Plant Antioxidants and Health. Plant Antioxidants and Health 1 44 .

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