334
Views
63
CrossRef citations to date
0
Altmetric
Research Article

Carcinogenicity and Genotoxicity of Ethylene Oxide: New Aspects and Recent Advances

Pages 595-608 | Published online: 29 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

CR Kirman, AA Li, PJ Sheehan, JS Bus, RC Lewis & SM Hays. (2021) Ethylene oxide review: characterization of total exposure via endogenous and exogenous pathways and their implications to risk assessment and risk management. Journal of Toxicology and Environmental Health, Part B 24:1, pages 1-29.
Read now
Berthold Moser & Josef Rieder. (2012) High-Speed Ambient Air Monitoring of Ethylene Oxide in Sterilization Units. Journal of Occupational and Environmental Hygiene 9:8, pages D143-D145.
Read now
Gary Ginsberg, Susan Smolenski, Dale Hattis, Kathryn Z. Guyton, Douglas O. Johns & Babasaheb Sonawane. (2009) Genetic Polymorphism in Glutathione Transferases (GST): Population Distribution of GSTM1, T1, and P1 Conjugating Activity. Journal of Toxicology and Environmental Health, Part B 12:5-6, pages 389-439.
Read now
Richard J. Albertini & Lisa M. Sweeney. (2007) Propylene Oxide: Genotoxicity Profile of a Rodent Nasal Carcinogen. Critical Reviews in Toxicology 37:6, pages 489-520.
Read now
Hermann M. Bolt. (2005) Vinyl Chloride—A Classical Industrial Toxicant of New Interest. Critical Reviews in Toxicology 35:4, pages 307-323.
Read now

Articles from other publishers (58)

Catherine J. Shelp. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 489 496 .
Jiayi Feng, Jun Qi, Su Fu & Jie Luan. (2023) Effect of radiation sterilization on the ability to induce adipose regeneration in vivo in decellularized adipose‐derived matrix. Biotechnology Journal 18:11.
Crossref
Emma Mongkhoun, Philippe Guégan & Nicolas Illy. (2023) γ-Thiobutyrolactone – ethylene carbonate decarboxylative copolymerization, an original pathway to prepare aliphatic oxidizable poly(γ-thioether ester). Polymer Chemistry 14:32, pages 3729-3738.
Crossref
Qiong Huang, Siqi Li, Jinfa Wan, Wenbin Nan & Baimei He. (2023) Association between ethylene oxide exposure and prevalence of COPD: Evidence from NHANES 2013–2016. Science of The Total Environment 885, pages 163871.
Crossref
Sonia Lanzalaco, Christine Weis, Kamelia A. Traeger, Pau Turon, Carlos Alemán & Elaine Armelin. (2023) Mechanical Properties of Smart Polypropylene Meshes: Effects of Mesh Architecture, Plasma Treatment, Thermosensitive Coating, and Sterilization Process. ACS Biomaterials Science & Engineering 9:6, pages 3699-3711.
Crossref
Hua Jiang, Keyi Wang, Heng Zhang, Bin Yang, Weipu Mao, Ming Chen & Shuigen Zhou. (2023) Physical activity can influence the relationship between ethylene oxide and risk of kidney stones: A cross-sectional study from the NHANES 2013–2016. Environmental Science and Pollution Research 30:23, pages 64673-64681.
Crossref
Zeeshan Afzal & Emmanuel Laurent Huguet. (2023) Bioengineering liver tissue by repopulation of decellularised scaffolds. World Journal of Hepatology 15:2, pages 151-179.
Crossref
Dandan Wang, Aijing Zhang, Wenxu Guo, Bingqi Zhu, Hui Yu & Yue Chen. (2022) Identification of residues in ethylene oxide sterilized hard gelatin capsule shells by gas chromatography-mass spectrometry and development of a simple gas chromatography-flame ionization detector method for the determination of residues. Journal of Chromatography Open 2, pages 100061.
Crossref
Tetyana Kobets, Benjamin P. C. Smith & Gary M. Williams. (2022) Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk. Foods 11:18, pages 2828.
Crossref
Xu Zhu, Xiangying Kong, Mengli Chen, Shi Shi, Iokfai Cheang, Qingqing Zhu, Xinyi Lu, Xin Yue, Yuan Tang, Shengen Liao, Yanli Zhou, Haifeng Zhang, Wenming Yao & Xinli Li. (2022) Blood ethylene oxide, systemic inflammation, and serum lipid profiles: Results from NHANES 2013–2016. Chemosphere 299, pages 134336.
Crossref
Ivonne M. C. M. Rietjens, Arand Michael, Hermann M. Bolt, Bourdoux Siméon, Hartwig Andrea, Hinrichsen Nils, Kalisch Christine, Mally Angela, Pellegrino Gloria, Ribera Daniel, Thatcher Natalie & Eisenbrand Gerhard. (2022) The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment. Archives of Toxicology 96:5, pages 1297-1352.
Crossref
Tirukalikundram S. Kumaravel, Tiruvathipuram N. Sathya, Ramalingam Balaje, Pitchaipillai Pradeepa, Desikan Yogaraj, Malliga R. Murali, K.R. Navaneethakrishnan, Sivasubramanian Murugan & Awadhesh N. Jha. (2022) Genotoxicity evaluation of medical devices: A regulatory perspective. Mutation Research/Reviews in Mutation Research 789, pages 108407.
Crossref
Meihan Tao, Tianrang Ao, Xiaoyan Mao, Xinzhu Yan, Rabia Javed, Weijian Hou, Yang Wang, Cong Sun, Shuang Lin, Tianhao Yu & Qiang AoProf.Prof.. (2021) Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal. Bioactive Materials 6:9, pages 2927-2945.
Crossref
William C. Drewe, Krista L. Dobo, Zhanna Sobol, Joel P. Bercu, Patricia Parris & John Nicolette. (2021) Deriving Compound-Specific Exposure Limits for Chemicals Used in Pharmaceutical Synthesis: Challenges in Expert Decision-Making Exemplified Through a Case Study-Based Workshop. International Journal of Toxicology 40:3, pages 285-298.
Crossref
Mi Suk Noh, Suk Hee Jung, Ohryun Kwon, Sang-Il Lee, Sung-Jin Yang, Eunil Hahm & Bong-Hyun Jun. (2020) Evaluation of Sterilization Performance for Vaporized-Hydrogen-Peroxide-Based Sterilizer with Diverse Controlled Parameters. ACS Omega 5:45, pages 29382-29387.
Crossref
Dorota Rybitwa, Anna Wawrzyk, Sławomir Wilczyński & Michał Łobacz. (2020) Irradiation with medical diode laser as a new method of spot-elimination of microorganisms to preserve historical cellulosic objects and human health. International Biodeterioration & Biodegradation 154, pages 105055.
Crossref
Amandine Moretton & Joanna I. Loizou. (2020) Interplay between Cellular Metabolism and the DNA Damage Response in Cancer. Cancers 12:8, pages 2051.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1392 1424 .
Anne D. Lucas, Christopher Forrey, David M. Saylor & Katherine Vorvolakos. (2018) Solvent or thermal extraction of ethylene oxide from polymeric materials: Medical device considerations. Journal of Biomedical Materials Research Part B: Applied Biomaterials 106:6, pages 2455-2463.
Crossref
V. Sharma, P.B. Upton, J.A. Swenberg & D. La. 2018. Comprehensive Toxicology. Comprehensive Toxicology 68 86 .
Mugimane G. Manjanatha, Sharon D. Shelton, Ying Chen, Barbara L. Parsons, Meagan B. Myers, Karen L. McKim, B. Bhaskar Gollapudi, Nigel P. Moore, Lynne T. Haber, Bruce Allen & Martha M. Moore. (2017) Dose and temporal evaluation of ethylene oxide-induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations. Environmental and Molecular Mutagenesis 58:3, pages 122-134.
Crossref
L. Wilson-Wilde, D. Yakovchyts, S. Neville, P. Maynard & P. Gunn. (2017) Investigation into ethylene oxide treatment and residuals on DNA and downstream DNA analysis. Science & Justice 57:1, pages 13-20.
Crossref
Jing Zhang, Chenchen Wang, Li Ji & Weiping Liu. (2016) Modeling of Toxicity-Relevant Electrophilic Reactivity for Guanine with Epoxides: Estimating the Hard and Soft Acids and Bases (HSAB) Parameter as a Predictor. Chemical Research in Toxicology 29:5, pages 841-850.
Crossref
Johannes Georg Filser, Anna Artati, Qiang Li, Christian Pütz, Brigitte Semder, Dominik Klein & Winfried Kessler. (2015) Novel and existing data for a future physiological toxicokinetic model of ethylene and its metabolite ethylene oxide in mouse, rat, and human. Chemico-Biological Interactions 241, pages 76-86.
Crossref
Damien Breheny, Fiona Cunningham, Joanne Kilford, Rebecca Payne, Deborah Dillon & Clive Meredith. (2014) Application of a modified gaseous exposure system to the in vitro toxicological assessment of tobacco smoke toxicants . Environmental and Molecular Mutagenesis 55:8, pages 662-672.
Crossref
Wolfgang Urfer. 2001. Encyclopedia of Environmetrics. Encyclopedia of Environmetrics.
H.M. Bolt. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 170 173 .
H. M. Bolt. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 9 13 .
Sun-Yeong Lee, Yang-Jee Kim, Young-Joo Choi, Joong-Won Lee, Young-Hyun Lee, Mi-Yeon Shin, Won Kim, Chung-Sik Yoon, Sung-Kyoon Kim & Hai-Won Chung. (2011) Analysis of Micronuclei and Its Association with Genetic Polymorphisms in Hospital Workers Exposed to Ethylene Oxide. Korean Journal of Environmental Health Sciences 37:6, pages 429-439.
Crossref
Kuen-Yuh Wu, Su-Yin Chiang, Wei-Chung Shih, Chih-Chun Jean Huang, Ming-Feng Chen & James A. Swenberg. (2011) The application of mass spectrometry in molecular dosimetry: Ethylene oxide as an example. Mass Spectrometry Reviews 30:5, pages 733-756.
Crossref
Wieslawa Kosinska, Michael Khmelnitsky, Jung Hyun Kim, Zhong-Lin Zhao & Joseph B. Guttenplan. (2011) Effects of potential dietary inhibitors of endogenous DNA damage on mutagenesis and lipid peroxidation in lacZ mice. Environmental and Molecular Mutagenesis 52:6, pages 502-509.
Crossref
Sibel Kiran, Pierluigi Cocco, Andreat Mannetje, Giannina Satta, Ileana D'Andrea, Nikolaus Becker, Silvia de Sanjosé, Lenka Foretova, Anthony Staines, Silke Kleefeld, Marc Maynadié, Alexandra Nieters, Paul Brennan & Paolo Boffetta. (2010) Occupational Exposure to Ethylene Oxide and Risk of Lymphoma. Epidemiology 21:6, pages 905-910.
Crossref
E. M. Donner, B. A. Wong, R. A. James & R. J. Preston. (2009) Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment. Mutagenesis 25:1, pages 49-55.
Crossref
D.K. La, P.B. Upton & J.A. Swenberg. 2010. Comprehensive Toxicology. Comprehensive Toxicology 63 83 .
Yeh‐Chung Chien, Po‐Chi Su, Lien‐Hsiung Lee & Chang‐Yuh Chen. (2009) Emission characteristics of plastic syringes sterilized with ethylene oxide—A controlled study. Journal of Biomedical Materials Research Part B: Applied Biomaterials 91B:2, pages 579-586.
Crossref
Debbie A. Marsden, Donald J.L. Jones, Robert G. Britton, Ted Ognibene, Esther Ubick, George E. Johnson, Peter B. Farmer & Karen Brown. (2009) Dose-Response Relationships for N 7-(2-Hydroxyethyl)Guanine Induced by Low-Dose [14C]Ethylene Oxide: Evidence for a Novel Mechanism of Endogenous Adduct Formation . Cancer Research 69:7, pages 3052-3059.
Crossref
Anne D. Lucas & Melvin E. Stratmeyer. (2008) Extraction and Stability of Ethylene Oxide Residue in Medical Devices. Biomedical Instrumentation & Technology 42:1, pages 76-79.
Crossref
Yeh-Chung Chien, Hung-Hsin Liu, Yi-Chang Lin, Po-Chi Su, Lien-Hsiung Li, Cheng-Ping Chang, Da-Toung Tang & Chang-Yuh Chen. (2007) Ethylene oxide sterilization in the medical-supply manufacturing industry: Assessment and control of worker exposure. Journal of Biomedical Materials Research Part B: Applied Biomaterials 83B:2, pages 527-537.
Crossref
Vincent Haufroid, Brigitte Merz, Annette Hofmann, Alois Tschopp, Dominique Lison & Philippe Hotz. (2007) Exposure to Ethylene Oxide in Hospitals: Biological Monitoring and Influence of Glutathione S -Transferase and Epoxide Hydrolase Polymorphisms . Cancer Epidemiology, Biomarkers & Prevention 16:4, pages 796-802.
Crossref
Jiune-Shyoung Lin, Karl T. Chuang, Mao-Sun Huang & Kuo-Ming Wei. (2007) Emission of ethylene oxide during frying of foods in soybean oil. Food and Chemical Toxicology 45:4, pages 568-574.
Crossref
Alvaro A.A. de Queiroz, Gustavo A. Abraham & Olga Zazuco Higa. (2006) Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films. Acta Biomaterialia 2:6, pages 641-650.
Crossref
Agata Kranjc & Janez Mavri. (2006) Guanine Alkylation by Ethylene Oxide:  Calculation of Chemical Reactivity. The Journal of Physical Chemistry A 110:17, pages 5740-5744.
Crossref
Urban Bren, Mateja Zupan, F. Peter Guengerich & Janez Mavri. (2006) Chemical Reactivity as a Tool to Study Carcinogenicity:  Reaction between Chloroethylene Oxide and Guanine. The Journal of Organic Chemistry 71:11, pages 4078-4084.
Crossref
Bobby R. Scott, Dale M. Walker & Vernon E. Walker. (2004) Low-Dose Radiation and Genotoxic Chemicals Can Protect against Stochastic Biological Effects. Nonlinearity in Biology, Toxicology, Medicine 2:3, pages 154014204905076.
Crossref
Hermann M Bolt, Heidi Foth, Jan G Hengstler & Gisela H Degen. (2004) Carcinogenicity categorization of chemicals—new aspects to be considered in a European perspective. Toxicology Letters 151:1, pages 29-41.
Crossref
Leslie Recio, Maria Donner, Diane Abernethy, Linda Pluta, Ann‐Marie Steen, Brian A. Wong, Arden James & R.Julian Preston. (2004) In vivo mutagenicity and mutation spectrum in the bone marrow and testes of B6C3F1 lacI transgenic mice following inhalation exposure to ethylene oxide. Mutagenesis 19:3, pages 215-222.
Crossref
David Kirkland & David Snodin. (2004) Setting Limits for Genotoxic Impurities in Drug Substances. International Journal of Pharmaceutical Medicine 18:4, pages 197-207.
Crossref
Christian Streffer, H. Bolt, D. Føllesdal, P. Hall, J. G. Hengstler, P. Jakob, D. Oughton, K. Prieß, E. Rehbinder & E. SwatonChristian Streffer, H. Bolt, D. Føllesdal, P. Hall, J. G. Hengstler, P. Jakob, D. Oughton, K. Prieß, E. Rehbinder & E. Swaton. 2004. Low Dose Exposures in the Environment. Low Dose Exposures in the Environment 83 180 .
Nicholas V. Coleman & Jim C. Spain. (2003) Epoxyalkane:Coenzyme M Transferase in the Ethene and Vinyl Chloride Biodegradation Pathways of Mycobacterium Strain JS60 . Journal of Bacteriology 185:18, pages 5536-5545.
Crossref
Anne D. Lucas, Katharine Merritt, Victoria M. Hitchins, Terry O. Woods, Scott G. McNamee, Dan B. Lyle & Stanley A. Brown. (2003) Residual ethylene oxide in medical devices and device material. Journal of Biomedical Materials Research 66B:2, pages 548-552.
Crossref
Daniela Vecchio, Annie J. Sasco & Cristina I. Cann. (2003) Occupational risk in health care and research. American Journal of Industrial Medicine 43:4, pages 369-397.
Crossref
Ada Kolman, Miroslav Chovanec & Siv Osterman-Golkar. (2002) Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990–2001). Mutation Research/Reviews in Mutation Research 512:2-3, pages 173-194.
Crossref
M. Plessi, D. Bertelli & F. Miglietta. (2002) Effect of Microwaves on Volatile Compounds in White and Black Pepper. LWT - Food Science and Technology 35:3, pages 260-264.
Crossref
A.Hamid Boulares, Francisco J. Contreras, Luis A. Espinoza & Mark E. Smulson. (2002) Roles of Oxidative Stress and Glutathione Depletion in JP-8 Jet Fuel-Induced Apoptosis in Rat Lung Epithelial Cells. Toxicology and Applied Pharmacology 180:2, pages 92-99.
Crossref
James V. Rogers, Palur G. Gunasekar, Carol M. Garrett, Mahendra B. Kabbur & James N. McDougal. (2001) Detection of oxidative species and low‐molecular‐weight DNA in skin following dermal exposure with JP‐8 jet fuel. Journal of Applied Toxicology 21:6, pages 521-525.
Crossref
Ricarda Thier, Heiko Balkenhol, Jürgen Lewalter, Silvia Selinski, Anja Dommermuth & Hermann M Bolt. (2001) Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 482:1-2, pages 41-46.
Crossref
R. Thier & H.M. Bolt. (2001) European Aspects of Standard Setting in Occupational Hygiene and Medicine. Reviews on Environmental Health 16:2.
Crossref
Harri Vainio. (2001) Review Use of biomarkers in risk assessment. International Journal of Hygiene and Environmental Health 204:2-3, pages 91-102.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.