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Research Article

Synthetic Vitreous Fibers: A Review Toxicology, Epidemiology and Regulations

Pages 839-886 | Published online: 10 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

M. Solvang, D. V. Okhrimenko & C. Koch. (2023) Investigation of the occurrence of binder material on airborne respirable mineral wool fibers. Journal of Occupational and Environmental Hygiene 20:5-6, pages 240-253.
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Joseph D. T. Ndika, Jukka Sund, Harri Alenius & Anne Puustinen. (2018) Elucidating differential nano-bio interactions of multi-walled andsingle-walled carbon nanotubes using subcellular proteomics. Nanotoxicology 12:6, pages 554-570.
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L. Daniel Maxim & Mark J. Utell. (2018) Review of refractory ceramic fiber (RCF) toxicity, epidemiology and occupational exposure. Inhalation Toxicology 30:2, pages 49-71.
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Helmut Greim, Mark J. Utell, L. Daniel Maxim & Ron Niebo. (2014) Perspectives on refractory ceramic fiber (RCF) carcinogenicity: comparisons with other fibers. Inhalation Toxicology 26:13, pages 789-810.
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Paolo Boffetta, Ken Donaldson, Suresh Moolgavkar & Jack S. Mandel. (2014) A systematic review of occupational exposure to synthetic vitreous fibers and mesothelioma. Critical Reviews in Toxicology 44:5, pages 436-449.
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Peter Møller, Pernille Høgh Danielsen, Kim Jantzen, Martin Roursgaard & Steffen Loft. (2013) Oxidatively damaged DNA in animals exposed to particles. Critical Reviews in Toxicology 43:2, pages 96-118.
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David Bernstein, Jacques Dunnigan, Thomas Hesterberg, Robert Brown, Juan Antonio Legaspi Velasco, Raúl Barrera, John Hoskins & Allen Gibbs. (2013) Health risk of chrysotile revisited. Critical Reviews in Toxicology 43:2, pages 154-183.
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V. Courtney Broaddus, Jeffrey I. Everitt, Brad Black & Agnes B. Kane. (2011) Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure. Journal of Toxicology and Environmental Health, Part B 14:1-4, pages 153-178.
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Brooke T. Mossman$suffix/text()$suffix/text(), Morton Lippmann, Thomas W. Hesterberg, Karl T. Kelsey, Aaron Barchowsky & James C. Bonner. (2011) Pulmonary Endpoints (Lung Carcinomas and Asbestosis) Following Inhalation Exposure to Asbestos. Journal of Toxicology and Environmental Health, Part B 14:1-4, pages 76-121.
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BrianR. Strohmeier, J. Craig Huntington, KristinL. Bunker, MatthewS. Sanchez, Kimberly Allison & RichardJ. Lee. (2010) What is asbestos and why is it important? Challenges of defining and characterizing asbestos. International Geology Review 52:7-8, pages 801-872.
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Hermine Nguea, Aymon de Reydellet, Alain Le Faou, Mohamed Zaiou & Bertrand Rihn. (2008) Macrophage Culture as a Suitable Paradigm for Evaluation of Synthetic Vitreous Fibers. Critical Reviews in Toxicology 38:8, pages 675-695.
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Articles from other publishers (39)

Samantha Bilske, Larry Glass, Kelly Scribner & Paul Nony. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 865 873 .
Andrew J. Ghio, Matthew Stewart, Rahul G. Sangani, Elizabeth N. Pavlisko & Victor L. Roggli. (2023) Asbestos and Iron. International Journal of Molecular Sciences 24:15, pages 12390.
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Christophe Paris, Isabelle Thaon, François Laurent, Anastasia Saade, Pascal Andujar, Patrick Brochard, Julia Benoist, Bénédicte Clin, Gilbert Ferretti, Antoine Gislard, Cecile Gramond, Pascal Wild, Aude Lacourt, Fleur Delva & Jean-Claude Pairon. (2023) Pleural Plaques and the Role of Exposure to Mineral Particles in the Asbestos Post-exposure Survey. CHEST 164:1, pages 149-158.
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Paul T.C. Harrison. 2003. Patty's Toxicology. Patty's Toxicology 1 20 .
Alexandra Friesen, Susanne Fritsch-Decker, Sonja Mülhopt, Caroline Quarz, Jonathan Mahl, Werner Baumann, Manuela Hauser, Manuela Wexler, Christoph Schlager, Bastian Gutmann, Tobias Krebs, Ann-Kathrin Goßmann, Frederik Weis, Matthias Hufnagel, Dieter Stapf, Andrea Hartwig & Carsten Weiss. (2023) Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers. International Journal of Molecular Sciences 24:3, pages 1927.
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Fabio Santanelli di Pompeo, Guido Paolini, Guido Firmani & Michail Sorotos. (2022) History of breast implants: Back to the future. JPRAS Open 32, pages 166-177.
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D.V. Okhrimenko, J.A. Bøtner, H.K. Riis, M. Ceccato, M. Foss & M. Solvang. (2022) The dissolution of stone wool fibers with sugar-based binder and oil in different synthetic lung fluids. Toxicology in Vitro 78, pages 105270.
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David M. Bernstein, Balazs Toth, Rick A. Rogers, Peter Kunzendorf, James I. Phillips & Dirk Schaudien. (2021) Final results from a 90-day quantitative inhalation toxicology study evaluating the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, crocidolite or amosite asbestos: Histopathological examination, confocal microscopy and collagen quantification of the lung and pleural cavity. Toxicology and Applied Pharmacology 424, pages 115598.
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Yishuo Gu, Wei He, Yanhua Wang, Juan Chen, Hongfei Wang, Panjun Gao, Siwen Yang, Xiaojun Zhu, Wenjun Ma & Tao Li. (2020) Respiratory effects induced by occupational exposure to refractory ceramic fibers. Journal of Applied Toxicology 41:3, pages 421-441.
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Qun Zu, Mette Solvang & Hong Li. 2021. Fiberglass Science and Technology. Fiberglass Science and Technology 1 87 .
Susanne H. Q. Barly, Denis V. Okhrimenko, Mette Solvang, Yuanzheng Yue & Susan L. S. Stipp. (2019) Dissolution of Stone Wool Fibers with Phenol-urea-formaldehyde Binder in a Synthetic Lung Fluid. Chemical Research in Toxicology 32:12, pages 2398-2410.
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Naoya Takahashi, Shinobu Hashimoto, Yusuke Daiko, Sawao Honda & Yuji Iwamoto. (2019) Fabrication and characterization of a novel lightweight adiabatic refractory composite consisting of alkaline earth silicate fibers and SiC particles. Ceramics International 45:17, pages 23248-23255.
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A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 2054 2107 .
Cinzia L. Ursini, Antonella Campopiano, Anna M. Fresegna, Aureliano Ciervo, Annapaola Cannizzaro, Federica Angelosanto, Raffaele Maiello, Sergio Iavicoli & Delia Cavallo. (2019) Alkaline earth silicate (AES) wools: Evaluation of potential cyto-genotoxic and inflammatory effects on human respiratory cells. Toxicology in Vitro 59, pages 228-237.
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. 2018. Toxicology and Risk Assessment. Toxicology and Risk Assessment 221 387 .
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1360 1416 .
Shabnam Abtahi, Mahyar Malekzadeh, Ghafour Nikravan & Abbas Ghaderi. (2018) Measurement of Lung Cancer Tumor Markers in a Glass Wool Company Workers Exposed to Respirable Synthetic Vitreous Fiber and Dust. The International Journal of Occupational and Environmental Medicine 9:1, pages 23-31.
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Xiaojun Zhu, Yishuo Gu, Wenjun Ma, Panjun Gao, Mengxuan Liu, Pei Xiao, Hongfei Wang, Juan Chen & Tao Li. (2017) Biomarkers for Pulmonary Inflammation and Fibrosis and Lung Ventilation Function in Chinese Occupational Refractory Ceramic Fibers-Exposed Workers. International Journal of Environmental Research and Public Health 15:1, pages 42.
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F. Schulz. 2017. Das Toxikologiebuch. Das Toxikologiebuch 275 296 .
C. Endes, S. Camarero-Espinosa, S. Mueller, E. J. Foster, A. Petri-Fink, B. Rothen-Rutishauser, C. Weder & M. J. D. Clift. (2016) A critical review of the current knowledge regarding the biological impact of nanocellulose. Journal of Nanobiotechnology 14:1.
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Paul Harrison, Philip Holmes, Ruth Bevan, Klaus Kamps, Leonard Levy & Helmut Greim. (2015) Regulatory risk assessment approaches for synthetic mineral fibres. Regulatory Toxicology and Pharmacology 73:1, pages 425-441.
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Peter Møller, Daniel Vest Christophersen, Ditte Marie Jensen, Ali Kermanizadeh, Martin Roursgaard, Nicklas Raun Jacobsen, Jette Gjerke Hemmingsen, Pernille Høgh Danielsen, Yi Cao, Kim Jantzen, Henrik Klingberg, Lars-Georg Hersoug & Steffen Loft. (2014) Role of oxidative stress in carbon nanotube-generated health effects. Archives of Toxicology 88:11, pages 1939-1964.
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Antonella Campopiano, Annapaola Cannizzaro, Federica Angelosanto, Maria Luisa Astolfi, Deborah Ramires, Angelo Olori, Silvia Canepari & Sergio Iavicoli. (2014) Dissolution of glass wool, rock wool and alkaline earth silicate wool: Morphological and chemical changes in fibers. Regulatory Toxicology and Pharmacology 70:1, pages 393-406.
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David M. Bernstein. (2014) The health risk of chrysotile asbestos. Current Opinion in Pulmonary Medicine 20:4, pages 366-370.
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Lennart Lundgren, Cecilia Moberg & Carola Lidén. (2014) Do insulation products of man‐made vitreous fibres still cause skin discomfort?. Contact Dermatitis 70:6, pages 351-360.
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Olli Väntsi & Timo Kärki. (2013) Mineral wool waste in Europe: a review of mineral wool waste quantity, quality, and current recycling methods. Journal of Material Cycles and Waste Management 16:1, pages 62-72.
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P. Nony, K. Scribner & T. Hesterberg. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 448 453 .
L.D. Maxim & M.J. Utell. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 156 160 .
Roser Costa & Ramon Orriols. (2012) Fibras minerales artificiales y aparato respiratorio. Archivos de Bronconeumología 48:12, pages 460-468.
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Roser Costa & Ramon Orriols. (2012) Man-Made Mineral Fibers and the Respiratory Tract. Archivos de Bronconeumología (English Edition) 48:12, pages 460-468.
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Robert C. Brown & Paul T.C. Harrison. (2012) Alkaline earth silicate wools – A new generation of high temperature insulation. Regulatory Toxicology and Pharmacology 64:2, pages 296-304.
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Roger O. McClellan, Thomas W. Hesterberg & John C. Wall. (2012) Evaluation of carcinogenic hazard of diesel engine exhaust needs to consider revolutionary changes in diesel technology. Regulatory Toxicology and Pharmacology 63:2, pages 225-258.
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Thomas W. Hesterberg, Robert Anderson, David M. Bernstein, William B. Bunn, Gerald A. Chase, Angela Libby Jankousky, Gary M. Marsh & Roger O. McClellan. (2012) Product stewardship and science: Safe manufacture and use of fiber glass. Regulatory Toxicology and Pharmacology 62:2, pages 257-277.
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Roger O. McClellan. 2012. Veterinary Toxicology. Veterinary Toxicology 8 36 .
François Devreux, Céline Cailleteau & Philippe Barboux. (2009) Evidence for a threshold in the biosolubility of aluminosilicate vitreous fibers. Journal of Materials Science 45:5, pages 1154-1159.
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Angela S. Ferreira, Valéria B. Moreira, Marcos César S. Castro, Porfírio J. Soares, Eduardo Algranti & Leonardo R. Andrade. (2010) Case Report: Analytical Electron Microscopy of Lung Granulomas Associated with Exposure to Coating Materials Carried by Glass Wool Fibers. Environmental Health Perspectives 118:2, pages 249-252.
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Eve Galimany, Montserrat Ramón & Maximino Delgado. (2009) First evidence of fiberglass ingestion by a marine invertebrate (Mytilus galloprovincialis L.) in a N.W. Mediterranean estuary. Marine Pollution Bulletin 58:9, pages 1334-1338.
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Henri Pezerat. (2009) Chrysotile Biopersistence: The Misuse of Biased Studies. International Journal of Occupational and Environmental Health 15:1, pages 102-106.
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Hermine Dika Nguea, Aymon de Reydellet, Patrice Lehuédé, Alain De Meringo, Alain Le Faou, Lucia Marcocci & Bertrand H. Rihn. (2007) Gene expression profile in monocyte during in vitro mineral fiber degradation. Archives of Toxicology 82:6, pages 355-362.
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