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Original Articles

Minimizing the Maximum Expected Sample Size in Two-Stage Phase II Clinical Trials with Continuous Outcomes

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Pages 836-852 | Received 06 Apr 2010, Accepted 10 Sep 2010, Published online: 31 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Yen Chang, Tianhao Song, Jane Monaco & Anastasia Ivanova. (2020) Futility stopping in clinical trials, optimality and practical considerations. Journal of Biopharmaceutical Statistics 30:6, pages 1050-1059.
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Hayet Merabet, Ahlam Labdaoui & Pierre Druilhet. (2017) Bayesian prediction for two-stage sequential analysis in clinical trials. Communications in Statistics - Theory and Methods 46:19, pages 9807-9816.
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Pierpaolo Brutti, Fulvio De Santis, Stefania Gubbiotti & Valeria Sambucini. (2016) Continuous endpoints in Bayesian two-stage designs. Journal of Biopharmaceutical Statistics 26:5, pages 966-977.
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John A. Kairalla, Christopher S. Coffey, Mitchell A. Thomann, Ronald I. Shorr & Keith E. Muller. (2015) Adaptive designs for comparative effectiveness research trials. Clinical Research and Regulatory Affairs 32:1, pages 36-44.
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James M. S. Wason. (2013) Reducing the average number of patients needed in a phase II trial through novel design. Clinical Research and Regulatory Affairs 30:4, pages 47-54.
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Articles from other publishers (11)

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Michael J. Grayling & Adrian P. Mander. (2021) Accounting for variation in the required sample size in the design of group-sequential trials. Contemporary Clinical Trials 107, pages 106459.
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Maximilian Pilz, Kevin Kunzmann, Carolin Herrmann, Geraldine Rauch & Meinhard Kieser. (2021) Optimal planning of adaptive two‐stage designs. Statistics in Medicine 40:13, pages 3196-3213.
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Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A. Julious, Adrian P. Mander, Christopher J. Weir, Franz Koenig, Marc K. Walton, Jon P. Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A. Proschan, John A. Scott, Yuki Ando, Daniel Hind, Douglas G. Altman, Munyaradzi Dimairo, Toshimitsu Hamasaki, Susan Todd, Christopher J. Weir, Adrian P. Mander, James Wason, Franz Koenig, Steven A. Julious, Daniel Hind, Jon Nicholl, Douglas G. Altman, William J. Meurer, Christopher Cates, Matthew Sydes, Yannis Jemiai, Deborah Ashby, Christina Yap, Frank Waldron-Lynch, James Roger, Joan Marsh, Olivier Collignon, David J. Lawrence, Catey Bunce, Tom Parke, Gus Gazzard, Elizabeth Coates, Marc K. Walton, Sally Hopewell, Philip Pallmann, Thomas Jaki, Katie Biggs, Michael A. Proschan, John A. Scott & Yuki Ando. (2020) The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials 21:1.
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Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind & Douglas G Altman. (2020) The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ, pages m115.
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Kim May Lee, James Wason & Nigel Stallard. (2019) To add or not to add a new treatment arm to a multiarm study: A decision‐theoretic framework. Statistics in Medicine.
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Tim Pickles, Robin Christensen, Lai-Shan Tam, Lee S Simon & Ernest H Choy. (2018) Early phase and adaptive design clinical trials in rheumatoid arthritis: a systematic review of early phase trials. Rheumatology Advances in Practice 2:2.
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Wei Jiang, Jonathan D. Mahnken, Jianghua He & Matthew S. Mayo. (2016) Generalized optimal design for two-arm, randomized phase II clinical trials with endpoints from the exponential dispersion family. Pharmaceutical Statistics 15:6, pages 459-470.
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Deli Wang, Lu Cui, Lanju Zhang & Bo Yang. 2016. New Developments in Statistical Modeling, Inference and Application. New Developments in Statistical Modeling, Inference and Application 121 147 .
James M. S. Wason. 2014. Developments in Statistical Evaluation of Clinical Trials. Developments in Statistical Evaluation of Clinical Trials 97 118 .
James M. S. WasonThomas Jaki. (2012) Optimal design of multi-arm multi-stage trials. Statistics in Medicine 31:30, pages 4269-4279.
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