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Research Article

Protein Hydroperoxides are a Major Product of Low Density Lipoprotein Oxidation During Copper, Peroxyl Radical and Macrophage-mediated Oxidation

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Pages 983-991 | Published online: 07 Jul 2009

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Read on this site (10)

Nooshin Ghodsian, Anthony Yeandle, Barry D. Hock & Steven P. Gieseg. (2022) CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin through modulation of PPAR-γ activity. Free Radical Research 56:5-6, pages 366-377.
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Linyi Zhou, Yao Zhang, Chengbin Zhao, Haijing Lin, Zhongjiang Wang & Fei Wu. (2017) Structural and functional properties of rice bran protein oxidized by peroxyl radicals. International Journal of Food Properties 20:sup2, pages 1456-1467.
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Enkhtsetseg Sukhbold, Shogo Sekimoto, Emiko Watanabe, Akane Yamazaki, Lifeng Yang, Mikako Takasugi, Koji Yamada, Ryota Hosomi, Kenji Fukunaga & Hirofumi Arai. (2017) Effects of oolonghomobisflavan A on oxidation of low-density lipoprotein. Bioscience, Biotechnology, and Biochemistry 81:8, pages 1569-1575.
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An Chen, Gonghui Li & Yingfeng Liu. (2015) Association between copper levels and myocardial infarction: a meta-analysis. Inhalation Toxicology 27:5, pages 237-246.
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Andreia Tache, Serafina Cotrone, Simona-Carmen Litescu, Nicola Cioffi, Luisa Torsi, Luigia Sabbatini & Gabriel-Lucian Radu. (2011) Spectrochemical Characterization of Thin Layers of Lipoprotein Self-Assembled Films on Solid Supports Under Oxidation Process. Analytical Letters 44:5, pages 747-760.
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Carole A. Firth & Steven P. Gieseg. (2007) Redistribution of metal ions to control low density lipoprotein oxidation in Ham's F10 medium. Free Radical Research 41:10, pages 1109-1115.
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Carole A. Firth, Ya-Ting Yang & Steven P. Gieseg. (2007) Lipid oxidation predominates over protein hydroperoxide formation in human monocyte-derived macrophages exposed to aqueous peroxyl radicals. Free Radical Research 41:7, pages 839-848.
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Vitality Starosta & Matthias Griese. (2006) Oxidative damage to surfactant protein D in pulmonary diseases. Free Radical Research 40:4, pages 419-425.
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Stylianos Kapiotis, Marcela Hermann, Markus Exner, Brigitte N. Sturm, Barbara Scheiber-Mojdehkar, Hans Goldenberg, Stefan Kopp, Peter Chiba & Bernhard M.K. Gmeiner. (2005) Aluminum ions stimulate the oxidizability of low density lipoprotein by Fe2+: Implication in hemodialysis mediated atherogenic LDL modification. Free Radical Research 39:11, pages 1225-1231.
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Articles from other publishers (29)

Ondrej Heneberk, Eliska Wurfelova & Vladimira Radochova. (2023) Neopterin, the Cell-Mediated Immune Response Biomarker, in Inflammatory Periodontal Diseases: A Narrative Review of a More than Fifty Years Old Biomarker. Biomedicines 11:5, pages 1294.
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Nooshin Ghodsian, Anthony Yeandle & Steven P. Gieseg. (2021) Foam cell formation but not oxLDL cytotoxicity is inhibited by CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin. The International Journal of Biochemistry & Cell Biology 133, pages 105918.
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Camilo López-Alarcón, Eduardo Fuentes-Lemus, Juan David Figueroa, Eva Dorta, Christian Schöneich & Michael J. Davies. (2020) Azocompounds as generators of defined radical species: Contributions and challenges for free radical research. Free Radical Biology and Medicine 160, pages 78-91.
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Nazim Husain & Riaz Mahmood. (2019) Copper(II) generates ROS and RNS, impairs antioxidant system and damages membrane and DNA in human blood cells. Environmental Science and Pollution Research 26:20, pages 20654-20668.
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Steven Gieseg, Gregory Baxter-Parker & Angus Lindsay. (2018) Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?. Antioxidants 7:7, pages 80.
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Ana Teresa Romero-Calderón, Hortensia Moreno-Macías, Joel David Manrique-Moreno, Horacio Riojas-Rodríguez, Yessica Dorín Torres-Ramos, Araceli Montoya-Estrada, Juan José Hicks-Gómez, Benigno Linares-Segovia, Beatriz Cárdenas-González, Claudia Bárcenas & Albino Barraza-Villarreal. (2017) Estrés oxidativo, función pulmonar y exposición a contaminantes atmosféricos en escolares mexicanos con y sin asma. Salud Pública de México 59:6, nov-dic, pages 630.
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Anastasia A. Shchepetkina, Barry D. Hock, Allison Miller, Martin A. Kennedy & Steven P. Gieseg. (2017) Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages. The International Journal of Biochemistry & Cell Biology 87, pages 27-33.
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Yesim Oztas & Ahmet Yalcinkaya. (2017) Oxidative alterations in sickle cell disease: Possible involvement in disease pathogenesis. World Journal of Hematology 6:3, pages 55.
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Leonardo Oliveira Bittencourt, Bruna Puty, Senda Charone, Walessa Alana Bragança Aragão, Paulo Mecenas Farias-Junior, Marcia Cristina Freitas Silva, Maria Elena Crespo-Lopez, Aline de Lima Leite, Marilia Afonso Rabelo Buzalaf & Rafael Rodrigues Lima. (2017) Oxidative Biochemistry Disbalance and Changes on Proteomic Profile in Salivary Glands of Rats Induced by Chronic Exposure to Methylmercury. Oxidative Medicine and Cellular Longevity 2017, pages 1-15.
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Janusz M. Gebicki. (2016) Oxidative stress, free radicals and protein peroxides. Archives of Biochemistry and Biophysics 595, pages 33-39.
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Hanadi Katouah, Alpha Chen, Izani Othman & Steven P. Gieseg. (2015) Oxidised low density lipoprotein causes human macrophage cell death through oxidant generation and inhibition of key catabolic enzymes. The International Journal of Biochemistry & Cell Biology 67, pages 34-42.
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H Tomšíková, P Tomšík, P Solich & L Nováková. (2013) Determination of pteridines in biological samples with an emphasis on their stability. Bioanalysis 5:18, pages 2307-2326.
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Frederick A. Villamena. 2013. Molecular Basis of Oxidative Stress. Molecular Basis of Oxidative Stress 1 48 .
Lucy D. Rutherford & Steven P. Gieseg. (2011) 7-Ketocholesterol is Not Cytotoxic to U937 Cells When Incorporated into Acetylated Low Density Lipoprotein. Lipids 47:3, pages 239-247.
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Steven P. GiesegZunika AmitYa-Ting YangAnastasia ShchepetkinaHanadi Katouah. (2010) Oxidant Production, oxLDL Uptake, and CD36 Levels in Human Monocyte–Derived Macrophages Are Downregulated by the Macrophage-Generated Antioxidant 7,8-Dihydroneopterin. Antioxidants & Redox Signaling 13:10, pages 1525-1534.
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Jie Shao, Nicholas E. Geacintov & Vladimir Shafirovich. (2010) Oxidative Modification of Guanine Bases Initiated by Oxyl Radicals Derived from Photolysis of Azo Compounds. The Journal of Physical Chemistry B 114:19, pages 6685-6692.
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Jie Shao, Nicholas E. Geacintov & Vladimir Shafirovich. (2010) Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine by Oxyl Radicals Produced by Photolysis of Azo Compounds. Chemical Research in Toxicology 23:5, pages 933-938.
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Zvi RappoportJean Cadet & Paolo Di Mascio. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Steven P. Gieseg, Elizabeth Crone & Zunika Amit. 2009. Endogenous Toxins. Endogenous Toxins 619 645 .
Wei Wu, Caimeng Zhang, Xiangzhen Kong & Yufei Hua. (2009) Oxidative modification of soy protein by peroxyl radicals. Food Chemistry 116:1, pages 295-301.
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Nicholas P.L. Tuckey, Malcolm E. Forster & Steven P. Gieseg. (2009) Lipid Oxidation Is Inhibited by Isoeugenol Exposure in Chinook Salmon ( Oncorhynchus Tshawytscha ) Fillets during Storage at 15 °C . Journal of Food Science 74:4, pages C333-C338.
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Carole A. Firth, Andrew D. Laing, Sarah K. Baird, Joseph Pearson & Steven P. Gieseg. (2008) Inflammatory sites as a source of plasma neopterin: Measurement of high levels of neopterin and markers of oxidative stress in pus drained from human abscesses. Clinical Biochemistry 41:13, pages 1078-1083.
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Carole A. Firth, Elizabeth M. Crone, Elizabeth A. Flavall, Justin A. Roake & Steven P. Gieseg. (2008) Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:6, pages 1095-1101.
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Andrew B. Gerry, Leanne Satchell & David S. Leake. (2008) A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein. Atherosclerosis 197:2, pages 579-587.
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S P Gieseg, E M Crone, E A Flavall & Z Amit. (2008) Potential to inhibit growth of atherosclerotic plaque development through modulation of macrophage neopterin/7,8-dihydroneopterin synthesis. British Journal of Pharmacology 153:4, pages 627-635.
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Elizabeth A. Flavall, Elizabeth M. Crone, Grant A. Moore & Steven P. Gieseg. (2008) Dissociation of neopterin and 7,8-dihydroneopterin from plasma components before HPLC analysis. Journal of Chromatography B 863:1, pages 167-171.
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Yoshiko Fukuchi, Yoko Miura, Yuka Nabeno, Yoji Kato, Toshihiko Osawa & Michitaka Naito. (2008) Immunohistochemical Detection of Oxidative Stress Biomarkers, Dityrosine and N&sup.EPSILON.;-(hexanoyl)lysine, and C-Reactive Protein in Rabbit Atherosclerotic Lesions. Journal of Atherosclerosis and Thrombosis 15:4, pages 185-192.
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Joshua S. Sharp & Kenneth B. Tomer. (2006) Effects of Anion Proximity in Peptide Primary Sequence on the Rate and Mechanism of Leucine Oxidation. Analytical Chemistry 78:14, pages 4885-4893.
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Sarah K. Baird, Linzi Reid, Mark B. Hampton & Steven P. Gieseg. (2005) OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1745:3, pages 361-369.
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