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Research Article

Formulation, Characterization, and In Vitro Evaluation of Silymarin-Loaded Lipid Microspheres

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Pages 185-191 | Published online: 19 Oct 2008

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Behrouz Khaleghipour, Heshmatollah Khosravinia, Majid Toghiyani & Arash Azarfar. (2020) Efficacy of silymarin-nanohydrogle complex in attenuation of aflatoxins toxicity in Japanese quails. Italian Journal of Animal Science 19:1, pages 351-359.
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Amira Mohamed Mohsen, Marwa Hasanein Asfour & Abeer A. A. Salama. (2017) Improved hepatoprotective activity of silymarin via encapsulation in the novel vesicular nanosystem bilosomes. Drug Development and Industrial Pharmacy 43:12, pages 2043-2054.
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Vikas Jhawat, Sumeet Gupta & Vipin Saini. (2016) Formulation and evaluation of novel controlled release of topical pluronic lecithin organogel of mefenamic acid. Drug Delivery 23:9, pages 3573-3581.
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Shubham Misra, Kanwaljit Chopra, V. R. Sinha & Bikash Medhi. (2016) Galantamine-loaded solid–lipid nanoparticles for enhanced brain delivery: preparation, characterization, in vitro and in vivo evaluations. Drug Delivery 23:4, pages 1434-1443.
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J. Q. Zhang, J. Liu, X. L. Li & B. R. Jasti. (2007) Preparation and Characterization of Solid Lipid Nanoparticles Containing Silibinin. Drug Delivery 14:6, pages 381-387.
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Shahla Ranjbar, Abbasali Emamjomeh, Fatemeh Sharifi, Atefeh Zarepour, Kian Aghaabbasi, Ali Dehshahri, Azadeh Mohammadi Sepahvand, Ali Zarrabi, Hamid Beyzaei, Mohammad Mehdi Zahedi & Reza Mohammadinejad. (2023) Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles. Pharmaceutics 15:7, pages 1944.
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Im-Sook Song, So-Jeong Nam, Ji-Hyeon Jeon, Soo-Jin Park & Min-Koo Choi. (2021) Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity. Pharmaceutics 13:5, pages 628.
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Yu. I. Poltavets, S. L. Kuznetsov, I. A. Tubasheva, A. I. Murav’eva & N. V. Gukasova. (2021) Nano- and Microsized Forms of Silymarin and Silybin. Nanobiotechnology Reports 16:2, pages 115-137.
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M. R. Bahman, N. B. Feldman, S. N. Orekhov, N. E. Sedyakina, T. I. Gromovykh & S. V. Lutsenko. (2021) Saturation of Bacterial Cellulose with Silymarin Flavolignans in the Composition of Lipid Nanoparticles. Nanobiotechnology Reports 16:2, pages 239-245.
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Mina Shafiee, Samira Sadat Abolmaali, Ali Mohammad Tamaddon, Mozhgan Abedanzadeh & Mehdi Abedi. (2020) One-pot synthesis of poly(alkyl methacrylate)-functionalized mesoporous silica hybrid nanocomposites for microencapsulation of poorly soluble phytochemicals. Colloid and Interface Science Communications 37, pages 100298.
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Fatemeh Rezaee-Tazangi, Negar Varaa, Layasadat Khorsandi & Mohammadreza Abbaspour. (2020) Effects of Silymarin-Loaded Polylactic-co-Glycolic Acid Nanoparticles on Osteoarthritis in Rats. Iranian Journal of Science and Technology, Transactions A: Science 44:3, pages 605-614.
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Shesan John Owonubi, Emmanuel Mukwevho & Neerish Revaprasadu. 2019. The Therapeutic Properties of Medicinal Plants. The Therapeutic Properties of Medicinal Plants 285 316 .
Alfonso Di Costanzo & Ruggero Angelico. (2019) Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art. Molecules 24:11, pages 2155.
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Ahmed H. Ibrahim, Emil Rosqvist, Jan-Henrik Smått, Hany M. Ibrahim, Hatem R. Ismael, Mohsen I. Afouna, Ahmed M. Samy & Jessica M. Rosenholm. (2019) Formulation and optimization of lyophilized nanosuspension tablets to improve the physicochemical properties and provide immediate release of silymarin. International Journal of Pharmaceutics 563, pages 217-227.
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Ji-Soo Lee, Da Young Hong, Eun Suh Kim & Hyeon Gyu Lee. (2017) Improving the water solubility and antimicrobial activity of silymarin by nanoencapsulation. Colloids and Surfaces B: Biointerfaces 154, pages 171-177.
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S. C. B Penjuri, R. Nagaraju, S. Shaik, S. Damineni & S. R. Poreddy. (2017) GASTRORETENTIVE MICROBALLOONS OF RIBOFLAVIN: FORMULATION AND EVALUATION. INDIAN DRUGS 54:04, pages 47-52.
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Ankitkumar S. Jain, Vivek V. Dhawan, Bruno Sarmento & Mangal S. Nagarsenker. (2016) In Vitro and Ex Vivo Evaluations of Lipid Anti-Cancer Nanoformulations: Insights and Assessment of Bioavailability Enhancement. AAPS PharmSciTech 17:3, pages 553-571.
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Usama Ahmad, Md Faiyazuddin, Md Talib Hussain, Sarfaraz Ahmad, Thamir M Alshammari & Faiyaz Shakeel. (2015) Silymarin: an insight to its formulation and analytical prospects. Acta Physiologiae Plantarum 37:11.
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Li-Wen Chang, Mei-Ling Hou & Tung-Hu Tsai. (2014) Silymarin in Liposomes and Ethosomes: Pharmacokinetics and Tissue Distribution in Free-Moving Rats by High-Performance Liquid Chromatography–Tandem Mass Spectrometry. Journal of Agricultural and Food Chemistry 62:48, pages 11657-11665.
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Yosra S.R. Elnaggar, Wessam M. El-Refaie, Magda A. El-Massik & Ossama Y. Abdallah. (2014) Lecithin-based nanostructured gels for skin delivery: An update on state of art and recent applications. Journal of Controlled Release 180, pages 10-24.
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D. Voinovich, B. Perissutti, M. Grassi, N. Passerini & A. Bigotto. (2009) Solid State Mechanochemical Activation of Silybum marianum Dry Extract With Betacyclodextrins: Characterization and Bioavailability of the Coground Systems. Journal of Pharmaceutical Sciences 98:11, pages 4119-4129.
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Jonathan P. Fast & Sandro Mecozzi. 2009. Nanotechnology in Drug Delivery. Nanotechnology in Drug Delivery 461 489 .
S Leung, A Gironella, C Trigo, A Bhushan, C K Daniels & J C K Lai. (2007) Cationic surfactants and other factors that affect enzymatic activities and transport. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 221:2, pages 153-160.
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Bill Gurley, Martha A. Hubbard, D. Keith Williams, John Thaden, Yudong Tong, W. Brooks Gentry, Philip Breen, Danielle J. Carrier & Shreekar Cheboyina. (2006) Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin. The Journal of Clinical Pharmacology 46:2, pages 201-213.
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Rajiv Kumar & Om Prakash Katare. (2005) Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review. AAPS PharmSciTech 6:2, pages E298-E310.
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S. Palakurthi, S.P. Vyas & P.V. Diwan. (2005) Biodisposition of PEG-coated lipid microspheres of indomethacin in arthritic rats. International Journal of Pharmaceutics 290:1-2, pages 55-62.
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