2,451
Views
58
CrossRef citations to date
0
Altmetric
Research Article

Sustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic evaluation in rabbits

, , & ORCID Icon
Pages 1340-1349 | Received 30 Mar 2018, Accepted 14 May 2018, Published online: 05 Jun 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (18)

Eman Abdelhakeem, Mohamed El-nabarawi & Rehab Shamma. (2021) Effective Ocular Delivery of Eplerenone Using Nanoengineered Lipid Carriers in Rabbit Model. International Journal of Nanomedicine 16, pages 4985-5002.
Read now
Rofida Albash, Menna M Abdellatif, Mariam Hassan & Noha M Badawi. (2021) Tailoring Terpesomes and Leciplex for the Effective Ocular Conveyance of Moxifloxacin Hydrochloride (Comparative Assessment): In-vitro, Ex-vivo, and In-vivo Evaluation. International Journal of Nanomedicine 16, pages 5247-5263.
Read now
Axel Kattar, Angel Concheiro & Carmen Alvarez-Lorenzo. (2021) Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment. Expert Opinion on Drug Delivery 18:11, pages 1589-1607.
Read now
Ameeduzzafar Zafar, Nabil K. Alruwaili, Syed Sarim Imam, Omar Awad Alsaidan, Khalid Saad Alharbi, Mohd Yasir, Mohammed Elmowafy, Mohammad Javed Ansari, Mohammed Salahuddin & Sultan Alshehri. (2021) Formulation of carteolol chitosomes for ocular delivery: formulation optimization, ex-vivo permeation, and ocular toxicity examination. Cutaneous and Ocular Toxicology 40:4, pages 338-349.
Read now
Asmaa Ashraf Nemr, Galal Mohamed El-mahrouk & Hany Abdo Badie. (2021) Development and evaluation of proniosomes to enhance the transdermal delivery of cilostazole and to ensure the safety of its application. Drug Development and Industrial Pharmacy 47:3, pages 403-415.
Read now
Amit Verma, Ankita Tiwari, Shivani Saraf, Pritish Kumar Panda, Ankit Jain & Sanjay K. Jain. (2021) Emerging potential of niosomes in ocular delivery. Expert Opinion on Drug Delivery 18:1, pages 55-71.
Read now
Basant A. Habib, Amina S. Abd El-Samiae, Boushra M. El-Houssieny & Randa Tag. (2021) Formulation, characterization, optimization, and in-vivo performance of febuxostat self-nano-emulsifying system loaded sublingual films. Drug Delivery 28:1, pages 1321-1333.
Read now
Sinar Sayed, Mostafa Abdel-Moteleb, Maha Mohamed Amin & Omnia Mohamed Khowessah. (2021) Cubogel as potential platform for glaucoma management. Drug Delivery 28:1, pages 293-305.
Read now
Abdurrahman Muhammad Fahmy, Mariam Hassan, Doaa Ahmed El-Setouhy, Saadia Ahmed Tayel & Abdulaziz Mohsen Al-Mahallawi. (2021) Statistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization and in vivo evaluation. Drug Delivery 28:1, pages 77-86.
Read now
Ghada Ahmed El-Emam, Germeen N S Girgis, Mohamed M Adel El-Sokkary, Osama Abd El-Azeem Soliman & Abd El Gawad H Abd El Gawad. (2020) Ocular Inserts of Voriconazole-Loaded Proniosomal Gels: Formulation, Evaluation and Microbiological Studies. International Journal of Nanomedicine 15, pages 7825-7840.
Read now
Dongyan Guo, Ji Liu, Yu Fan, Jiangxue Cheng, Yajun Shi, Junbo Zou & Xiaofei Zhang. (2020) Optimization, characterization and evaluation of liposomes from Malus hupehensis (Pamp.) Rehd. extracts. Journal of Liposome Research 30:4, pages 366-376.
Read now
Claudiu T. Supuran, Abdulmalik Saleh Alfawaz Altamimi & Fabrizio Carta. (2019) Carbonic anhydrase inhibition and the management of glaucoma: a literature and patent review 2013-2019. Expert Opinion on Therapeutic Patents 29:10, pages 781-792.
Read now

Articles from other publishers (40)

Mayada Said, Ibrahim Elsayed, Ahmed A. Aboelwafa, Ahmed H. Elshafeey & Mariam Hassan. (2023) Ocular Mucoadhesive and Biodegradable Sponge-Like Inserts for the Sustained and Controlled Delivery of Voriconazole; Preparation, D-optimal Factorial Optimization and in-vivo Evaluation. Journal of Pharmaceutical Sciences.
Crossref
Changying Huang, Liyang Peng, Xinqi Xu, Yunshu Lu, Xueting Wang, Zhongming Lan, Jingdi Chen & Yanxia Zhou. (2023) Preparation and characteristics of a thermosensitive in situ gel loaded with chitosan nanoparticles for optimal ocular delivery of chloramphenicol. Journal of Drug Delivery Science and Technology 89, pages 104962.
Crossref
Anamika Saxena, Pragya Apurvi & Ramsha Aslam. (2023) A Review on Proniosomes: A Propitious Outlook to the Provesicular Drug Delivery System. Current Drug Delivery 20:8, pages 1115-1126.
Crossref
Sagar R. Pardeshi, Mahesh P. More, Chandrakantsing V. Pardeshi, Prashant J. Chaudhari, Amol D. Gholap, Ankit Patil, Pritam B. Patil & Jitendra B. Naik. (2023) Novel crosslinked nanoparticles of chitosan oligosaccharide and dextran sulfate for ocular administration of dorzolamide against glaucoma. Journal of Drug Delivery Science and Technology 86, pages 104719.
Crossref
Mahmoud Mostafa, Adel Al Fatease, Raid G. Alany & Hamdy Abdelkader. (2023) Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases. Pharmaceutics 15:6, pages 1746.
Crossref
Hemangi Ramesh Trivedi & Prashant Keshao Puranik. (2023) Chlorogenic acid loaded niosomes and proniosomes: in vitro antioxidant and antibacterial activities with efficacy in wound healing. Digital Chinese Medicine 6:2, pages 170-188.
Crossref
Kevin Y. Wu, Said Ashkar, Shrieda Jain, Michael Marchand & Simon D. Tran. (2023) Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma. Polymers 15:6, pages 1373.
Crossref
Udesh Kaushal, Malkiet Kaur, Manju Nagpal, Madhusmita Bhuyan & Kailasam Periyana Gounder. (2023) Nanocarriers Based Ocular Therapeutics: Updates, Challenges and Future Prospectives. Current Drug Research Reviews 15:1, pages 15-28.
Crossref
Jasjeet Kaur Narang, Kiranjeet Kaur, Gurpreet Kaur, Anmol Dogra & Deepti Pandita. 2023. Nanotechnology in Ophthalmology. Nanotechnology in Ophthalmology 151 179 .
Kariman M AbouElhassan, Hatem A Sarhan, Amal K Hussein, Ashraf Taye, Yasmin M Ahmed & Mohamed A Safwat. (2022) Brain Targeting of Citicoline Sodium via Hyaluronic Acid-Decorated Novel Nano-Transbilosomes for Mitigation of Alzheimer’s Disease in a Rat Model: Formulation, Optimization, in vitro and in vivo Assessment. International Journal of Nanomedicine Volume 17, pages 6347-6376.
Crossref
Mohamed M. Badran, Abdullah H. Alomrani, Aliyah Almomen, Yousef A. Bin Jardan & Amal El Sayeh Abou El Ela. (2022) Novel Metoprolol-Loaded Chitosan-Coated Deformable Liposomes in Thermosensitive In Situ Gels for the Management of Glaucoma: A Repurposing Approach. Gels 8:10, pages 635.
Crossref
DEEPIKA YADAV, PANKAJ AGGARWAL, MAMTA YADAV & ANAND SINGH. (2022) PREPARATION AND EVALUATION OF TMC LOADED VORICONAZOLE NANOPARTICLES. Asian Journal of Pharmaceutical and Clinical Research, pages 155-161.
Crossref
Marzina AJRIN & Fahmida ANJUM. (2022) Proniosome: A Promising Approach for Vesicular Drug Delivery. Turkish Journal of Pharmaceutical Sciences 19:4, pages 462-475.
Crossref
Manuela-Ramona (Blanaru) Ozturk, Marcel Popa, Delia Mihaela Rata, Anca Niculina Cadinoiu, Frederique Parfait, Christelle Delaite, Leonard Ionut Atanase, Carmen Solcan & Oana Maria Daraba. (2022) Drug-Loaded Polymeric Micelles Based on Smart Biocompatible Graft Copolymers with Potential Applications for the Treatment of Glaucoma. International Journal of Molecular Sciences 23:16, pages 9382.
Crossref
Nihal Farid Younes & Basant Ahmed Habib. (2022) Augmented local skin accumulation efficiency of sertaconazole nitrate via glycerosomal hydrogel: Formulation, statistical optimization, ex vivo performance and in vivo penetration. Journal of Drug Delivery Science and Technology 72, pages 103364.
Crossref
Kurls E. Anwer, Nour E. A. Abd El-Sattar, Marium M. Shamaa, Mohamed Y. Zakaria & Botros Y. Beshay. (2022) Design, Green Synthesis and Tailoring of Vitamin E TPGS Augmented Niosomal Nano-Carrier of Pyrazolopyrimidines as Potential Anti-Liver and Breast Cancer Agents with Accentuated Oral Bioavailability. Pharmaceuticals 15:3, pages 330.
Crossref
Ameeduzzafar Zafar, Syed Sarim Imam, Mohd Yasir, Nabil K. Alruwaili, Omar Awad Alsaidan, Musarrat Husain Warsi, Shehla Nasar Mir Najib Ullah, Sultan Alshehri & Mohammed M. Ghoneim. (2022) Preparation of NLCs-Based Topical Erythromycin Gel: In Vitro Characterization and Antibacterial Assessment. Gels 8:2, pages 116.
Crossref
Ahmed Alaa Kassem, Abeer Salama & Amira Mohamed Mohsen. (2022) Formulation and optimization of cationic nanoemulsions for enhanced ocular delivery of dorzolamide hydrochloride using Box-Behnken design: In vitro and in vivo assessments. Journal of Drug Delivery Science and Technology 68, pages 103047.
Crossref
Bharti Sapra, Dhriti Mahajan, Sagar Chaudhary & Ashok Kumar Tiwary. 2022. Drug Delivery Systems for Metabolic Disorders. Drug Delivery Systems for Metabolic Disorders 371 409 .
Sophia G. Antimisiaris & Evangelos Natsaridis. 2022. Applications of Nanovesicular Drug Delivery. Applications of Nanovesicular Drug Delivery 53 80 .
Nabil A. Alhakamy, Shaimaa M. Badr-Eldin, Waleed S. Alharbi, Mohamed A. Alfaleh, Omar D. Al-hejaili, Hibah M. Aldawsari, Basma G. Eid, Rana Bakhaidar, Filippo Drago, Filippo Caraci & Giuseppe Caruso. (2021) Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells. Pharmaceuticals 14:12, pages 1309.
Crossref
Mai M. El Taweel, Mona H. Aboul-Einien, Mohammed A. Kassem & Nermeen A. Elkasabgy. (2021) Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery. Pharmaceutics 13:11, pages 1828.
Crossref
Yasmin A. El-Feky, Ahmed Roshdy Fares, Gamal Zayed, Rania Farag A. El-Telbany, Kawkab A. Ahmed & Dalia Farag A. El-Telbany. (2021) Repurposing of nifedipine loaded in situ ophthalmic gel as a novel approach for glaucoma treatment. Biomedicine & Pharmacotherapy 142, pages 112008.
Crossref
Phatsawee Jansook, Hay Marn Hnin, Thorsteinn Loftsson & Einar Stefánsson. (2021) Cyclodextrin-based formulation of carbonic anhydrase inhibitors for ocular delivery – A review. International Journal of Pharmaceutics 606, pages 120955.
Crossref
Melitini Koutsoviti, Angeliki Siamidi, Panagoula Pavlou & Marilena Vlachou. (2021) Recent Advances in the Excipients Used for Modified Ocular Drug Delivery. Materials 14:15, pages 4290.
Crossref
Abdurrahman Muhammad Fahmy, Mariam Hassan, Doaa Ahmed El-Setouhy, Saadia Ahmed Tayel & Abdulaziz Mohsen Al-mahallawi. (2021) Voriconazole Ternary Micellar Systems for the Treatment of Ocular Mycosis: Statistical Optimization and In Vivo Evaluation. Journal of Pharmaceutical Sciences 110:5, pages 2130-2138.
Crossref
Ayat Allam, Mahmoud Elsabahy, Mahmoud El Badry & Nermin E. Eleraky. (2021) Betaxolol‐loaded niosomes integrated within pH‐sensitive in situ forming gel for management of glaucoma. International Journal of Pharmaceutics 598, pages 120380.
Crossref
Zimeng Zhai, Yiyun Cheng & Jiaxu Hong. (2021) Nanomedicines for the treatment of glaucoma: Current status and future perspectives. Acta Biomaterialia 125, pages 41-56.
Crossref
Nada M. El Hoffy, Engy A. Abdel Azim, Rania M. Hathout, Marwa A. Fouly & Seham A. Elkheshen. (2021) Glaucoma: Management and Future Perspectives for Nanotechnology-Based Treatment Modalities. European Journal of Pharmaceutical Sciences 158, pages 105648.
Crossref
Mayada Said, Ahmed A. Aboelwafa, Ahmed H. Elshafeey & Ibrahim Elsayed. (2021) Central composite optimization of ocular mucoadhesive cubosomes for enhanced bioavailability and controlled delivery of voriconazole. Journal of Drug Delivery Science and Technology 61, pages 102075.
Crossref
Joel Hardwick, Jack Taylor, Meenu Mehta, Saurabh Satija, Keshav R. Paudel, Philip M. Hansbro, Dinesh K. Chellappan, Mary Bebawy & Kamal Dua. (2021) Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems. Current Pharmaceutical Design 27:1, pages 2-14.
Crossref
Subramanian Natesan, Ravichandiran Vellayutham, Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Saranya Thekkilaveedu, Dhilin Pathayappurakkal Mohanan & Ruckmani Kandasamy. 2021. Chitosan for Biomaterials IV. Chitosan for Biomaterials IV 381 409 .
Fatma A. Aboali, Doaa A. Habib, Heba M. Elbedaiwy & Ragwa M. Farid. (2020) Curcumin-loaded proniosomal gel as a biofreindly alternative for treatment of ocular inflammation: In-vitro and in-vivo assessment. International Journal of Pharmaceutics 589, pages 119835.
Crossref
Alexandra Zamboulis, Stavroula Nanaki, Georgia Michailidou, Ioanna Koumentakou, Maria Lazaridou, Nina Maria Ainali, Eleftheria Xanthopoulou & Dimitrios N. Bikiaris. (2020) Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments. Polymers 12:7, pages 1519.
Crossref
Ameeduzzafar, Nabil K Alruwaili, Syed Sarim Imam, Nasser Hadal Alotaibi, Nabil A. Alhakamy, Khalid Saad Alharbi, Sultan Alshehri, Muhammad Afzal, Sattam Khulaif Alenezi & Syed Nasir Abbas Bukhari. (2020) Formulation of Chitosan Polymeric Vesicles of Ciprofloxacin for Ocular Delivery: Box-Behnken Optimization, In Vitro Characterization, HET-CAM Irritation, and Antimicrobial Assessment. AAPS PharmSciTech 21:5.
Crossref
Eman A. Hakeem, Galal M. El-Mahrouk, Ghada Abdelbary & Mahmoud H. Teaima. (2020) Freeze-Dried Clopidogrel Loaded Lyotropic Liquid Crystal: Box-Behnken Optimization, In-Vitro and In-Vivo Evaluation. Current Drug Delivery 17:3, pages 207-217.
Crossref
Sinar Sayed, Mostafa Abdelmoteleb, Maha M. Amin & Omnia M. Khowessah. (2020) Effect of Formulation Variables and Gamma Sterilization on Transcorneal Permeation and Stability of Proniosomal Gels as Ocular Platforms for Antiglaucomal Drug. AAPS PharmSciTech 21:3.
Crossref
Sanjeev Kumar Paikra, Janmejaya Bag & Monalisa Mishra. 2020. Nanoformulations in Human Health. Nanoformulations in Human Health 259 283 .
Alaa Emad Eldeeb, Salwa Salah & Mahmoud Ghorab. (2019) Formulation and evaluation of cubosomes drug delivery system for treatment of glaucoma: Ex-vivo permeation and in-vivo pharmacodynamic study. Journal of Drug Delivery Science and Technology 52, pages 236-247.
Crossref
Nihal Farid Younes, Sally Adel Abdel-Halim & Abdelhalim I. Elassasy. (2018) Corneal targeted Sertaconazole nitrate loaded cubosomes: Preparation, statistical optimization, in vitro characterization, ex vivo permeation and in vivo studies. International Journal of Pharmaceutics 553:1-2, pages 386-397.
Crossref