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Original

In Vitro Comparison of Dodecafluoropentane (DDFP), Perfluorodecalin (PFD), and Perfluoroctylbromide (PFOB) in the Facilitation of Oxygen Exchange

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Pages 156-162 | Published online: 13 Aug 2009

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Thunnalin Winuprasith, Pankaj Koirala, David J McClements & Piyachai Khomein. (2023) Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents. International Journal of Nanomedicine 18, pages 4449-4470.
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Nannan Li, Jennifer Noro, Jing Su, Hongbo Wang, Carla Silva & Artur Cavaco-Paulo. (2022) Enhancing laccase-assisted polymerization reactions with perfluorinated compounds. Biochemical Engineering Journal 189, pages 108736.
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Sheng Liu, Jian Xu, Yu Lu, Yong Huang, Zhi-Wen Fang, Mei Lv & Li-Tao Wang. (2021) Trace Analysis of Anions in Perfluorodecalin by Green Liquid–Liquid Extraction Combined with Ion Chromatography. Journal of Analysis and Testing 6:3, pages 346-351.
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A. V. Moshnyaga, A. V. Khoroshilov, M. P. Semyashkin & V. V. Mel’nikov. (2018) Density of N2O Solutions in Perfluorodecalin As a Function of Concentration. Russian Journal of Physical Chemistry A 92:4, pages 719-723.
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Fengqiao Li, Hao Mei, Yu Gao, Xiaodong Xie, Huifang Nie, Tao Li, Huijuan Zhang & Lee Jia. (2017) Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer. Biomaterials 145, pages 56-71.
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M. Christine Arthur, Aliza Brown, Kristen Carlson, John Lowery, Robert D. Skinner & William C. Culp. (2016) Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke. Molecular Neurobiology 54:6, pages 4764-4770.
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Christine Arthur, Lin Song, William Culp, Aliza Brown, Michael Borrelli, Robert Skinner & Howard Hendrickson. (2016) Tissue Concentration of Dodecafluoropentane (DDFP) Following Repeated IV Administration in the New Zealand White Rabbit. The AAPS Journal 19:2, pages 520-526.
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Jennifer L. H. Johnson. 2017. Neuroprotective Therapy for Stroke and Ischemic Disease. Neuroprotective Therapy for Stroke and Ischemic Disease 621 640 .
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Kirthi Radhakrishnan, Christy K. Holland & Kevin J. Haworth. (2016) Scavenging dissolved oxygen via acoustic droplet vaporization. Ultrasonics Sonochemistry 31, pages 394-403.
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Alexander Moncion, Keith J. Arlotta, Oliver D. Kripfgans, J. Brian Fowlkes, Paul L. Carson, Andrew J. Putnam, Renny T. Franceschi & Mario L. Fabiilli. (2016) Design and Characterization of Fibrin-Based Acoustically Responsive Scaffolds for Tissue Engineering Applications. Ultrasound in Medicine & Biology 42:1, pages 257-271.
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W. C. Culp, A. T. Brown, J. D. Lowery, M. C. Arthur, P. K. Roberson & R. D. Skinner. (2015) Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model. Molecular Neurobiology 52:2, pages 979-984.
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R.T. Fitzgerald, X. Ou, J.S. Nix, M.C. Arthur, A.T. Brown, R.D. Skinner, M.J. Borrelli & W.C. Culp. (2015) Dodecafluoropentane emulsion delays and reduces MRI markers of infarction in a rat stroke model: a preliminary report. Magnetic Resonance Imaging 33:2, pages 236-239.
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A.T Brown, M.C Arthur, J.S Nix, J.A Montgomery, R.D Skinner, P.K Roberson, Michael Borrelli & W.C Culp. (2014) Dodecafluoropentane Emulsion (DDFPe) Decreases Stroke Size and Improves Neurological Scores in a Permanent Occlusion Rat Stroke Model. The Open Neurology Journal 8:1, pages 27-33.
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Joshua Strom, Trevor Swyers, David Wilson, Evan Unger, Qin M. Chen & Douglas F. Larson. (2014) Dodecafluoropentane Emulsion Elicits Cardiac Protection Against Myocardial Infarction Through an ATP-Sensitive K+ Channel Dependent Mechanism. Cardiovascular Drugs and Therapy 28:6, pages 541-547.
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TW Swyer, J Strom & DF Larson. (2014) Nanoparticle oxygen delivery to the ischemic heart. Perfusion 29:6, pages 539-543.
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Evan Unger, Thomas Porter, Jonathan Lindner & Paul Grayburn. (2014) Cardiovascular drug delivery with ultrasound and microbubbles. Advanced Drug Delivery Reviews 72, pages 110-126.
Crossref
S. D. Woods, R. D. Skinner, A. M. Ricca, A. T. Brown, J. D. Lowery, M. J. Borrelli, J. O. Lay & W. C. Culp. (2013) Progress in Dodecafluoropentane Emulsion as a Neuroprotective Agent in a Rabbit Stroke Model. Molecular Neurobiology 48:2, pages 363-367.
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Mario L. Fabiilli, Christopher G. Wilson, Frédéric Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes & Renny T. Franceschi. (2013) Acoustic droplet–hydrogel composites for spatial and temporal control of growth factor delivery and scaffold stiffness. Acta Biomaterialia 9:7, pages 7399-7409.
Crossref
Sarah A. Hosgood, Harriet F. L. Nicholson & Michael L. Nicholson. (2012) Oxygenated Kidney Preservation Techniques. Transplantation 93:5, pages 455-459.
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William C. Culp, Sean D. Woods, Robert D. Skinner, Aliza T. Brown, John D. Lowery, Jennifer L.H. Johnson, Evan C. Unger, Leah J. Hennings, Michael J. Borrelli & Paula K. Roberson. (2012) Dodecafluoropentane Emulsion Decreases Infarct Volume in a Rabbit Ischemic Stroke Model. Journal of Vascular and Interventional Radiology 23:1, pages 116-121.
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W.C. Culp, P.K. Roberson, S.D. Woods, R. Flores, J.D. Lowery, R.D. Skinner, A. Brown & M.J. Borrelli. (2011) Abstract No. 53: Dodecafluoropentane emulsion decreases infarct volume in a rabbit ischemic stroke model. Journal of Vascular and Interventional Radiology 22:3, pages S26.
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Mario L. Fabiilli, Kevin J. Haworth, Ian E. Sebastian, Oliver D. Kripfgans, Paul L. Carson & J. Brian Fowlkes. (2010) Delivery of Chlorambucil Using an Acoustically-Triggered Perfluoropentane Emulsion. Ultrasound in Medicine & Biology 36:8, pages 1364-1375.
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