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EPA uncertainty factor workshop

Interspecies extrapolation based on mechanistic determinants of chemical disposition

Pages 641-662 | Published online: 02 Dec 2008

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Read on this site (12)

Eileen D. Kuempel, Lisa M. Sweeney, John B. Morris & Annie M. Jarabek. (2015) Advances in Inhalation Dosimetry Models and Methods for Occupational Risk Assessment and Exposure Limit Derivation. Journal of Occupational and Environmental Hygiene 12:sup1, pages S18-S40.
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Michael Dourson, Richard A. Becker, Lynne T. Haber, Lynn H. Pottenger, Tiffany Bredfeldt & Penelope A. Fenner-Crisp. (2013) Advancing human health risk assessment: Integrating recent advisory committee recommendations. Critical Reviews in Toxicology 43:6, pages 467-492.
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ChadM. Thompson, Babasaheb Sonawane, HughA. Barton, RobertS. DeWoskin, JohnC. Lipscomb, Paul Schlosser, WeihsuehA. Chiu & Kannan Krishnan. (2008) Approaches for Applications of Physiologically Based Pharmacokinetic Models in Risk Assessment. Journal of Toxicology and Environmental Health, Part B 11:7, pages 519-547.
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GaryL. Ginsberg, Bahman Asgharian, JuliaS. Kimbell, JamesS. Ultman & AnnieM. Jarabek. (2007) Modeling Approaches for Estimating the Dosimetry of Inhaled Toxicants in Children. Journal of Toxicology and Environmental Health, Part A 71:3, pages 166-195.
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Brenda Foos, Melanie Marty, Joel Schwartz, William Bennett, Jacqueline Moya, AnnieM. Jarabek & AndrewG. Salmon. (2007) Focusing on Children's Inhalation Dosimetry and Health Effects for Risk Assessment: An Introduction. Journal of Toxicology and Environmental Health, Part A 71:3, pages 149-165.
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MichaelL. Dourson & AnnL. Parker. (2007) Past and Future Use of Default Assumptions and Uncertainty Factors: Default Assumptions, Misunderstandings, and New Concepts. Human and Ecological Risk Assessment: An International Journal 13:1, pages 82-87.
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LorenzR. Rhomberg & ThomasA. Lewandowski. (2006) Methods for Identifying a Default Cross-Species Scaling Factor. Human and Ecological Risk Assessment: An International Journal 12:6, pages 1094-1127.
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James S. Brown, William E. Wilson & Lester D. Grant. (2005) Dosimetric Comparisons of Particle Deposition and Retention in Rats and Humans. Inhalation Toxicology 17:7-8, pages 355-385.
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Annie M. Jarabek, Bahman Asgharian & Frederick J. Miller. (2005) Dosimetric Adjustments for Interspecies Extrapolation of Inhaled Poorly Soluble Particles (PSP). Inhalation Toxicology 17:7-8, pages 317-334.
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RobertaL. Grant, RositaJ. Rodriguez, ChrisS. Hofelt & LaurieC. Haws. (2002) Shortcomings in USEPA's Approach for Predicting Risk Due to Consumption of Animal Food Products Impacted by Air Emissions from Hazardous Waste Combustion Facilities: A Case Study Involving Phthalates. Human and Ecological Risk Assessment: An International Journal 8:5, pages 1137-1154.
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GloriaA. Skowronski & MohamedS. Abdel‐Rahman. (1997) Interspecies comparison of kinetic data of chlorinated chemicals of potential relevance to risk assessment. Human and Ecological Risk Assessment: An International Journal 3:4, pages 635-653.
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EdwardV. Ohanian. (1997) Improving noncancer risk assessment in regulatory decisions. Human and Ecological Risk Assessment: An International Journal 3:4, pages 591-597.
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G.D. Nielsen & I.K Koponen. (2018) Insulation fiber deposition in the airways of men and rats. A review of experimental and computational studies. Regulatory Toxicology and Pharmacology 94, pages 252-270.
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Michael L. Dourson, Bernard K. Gadagbui, Rod B. Thompson, Edward J. Pfau & John Lowe. (2016) Managing risks of noncancer health effects at hazardous waste sites: A case study using the Reference Concentration (RfC) of trichloroethylene (TCE). Regulatory Toxicology and Pharmacology 80, pages 125-133.
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John C. Lipscomb, Sami Haddad, Torka Poet & Kannan Krishnan. 2012. New Technologies for Toxicity Testing. New Technologies for Toxicity Testing 76 95 .
William Farland, William Wood & Kerry Dearfield. 2006. Toxicological Testing Handbook. Toxicological Testing Handbook 439 464 .
Michael Dourson. 2005. Encyclopedia of Toxicology. Encyclopedia of Toxicology 401 406 .
John C. Lipscomb, Linda K. Teuschler, Jeff Swartout, Doug Popken, Tony Cox & Gregory L. Kedderis. (2003) The Impact of Cytochrome P450 2E1‐Dependent Metabolic Variance on a Risk‐Relevant Pharmacokinetic Outcome in Humans. Risk Analysis 23:6, pages 1221-1238.
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Justin E. Aldridge, Jennifer A. Gibbons, Meghan M. Flaherty, Marisa L. Kreider, Jocelyn A. Romano & Edward D. Levin. (2003) Heterogeneity of Toxicant Response: Sources of Human Variability. Toxicological Sciences 76:1, pages 3-20.
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William D. Bennett, Kirby L. Zeman & Annie M. Jarabek. (2003) Nasal contribution to breathing with exercise: effect of race and gender. Journal of Applied Physiology 95:2, pages 497-503.
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Chris S. Hofelt, Michael Honeycutt, J.Torin McCoy & Laurie C. Haws. (2001) Development of a Metabolism Factor for Polycyclic Aromatic Hydrocarbons for Use in Multipathway Risk Assessments of Hazardous Waste Combustion Facilities. Regulatory Toxicology and Pharmacology 33:1, pages 60-65.
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R R Dietert, R A Etzel, D Chen, M Halonen, S D Holladay, A M Jarabek, K Landreth, D B Peden, K Pinkerton, R J Smialowicz & T Zoetis. (2000) Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary.. Environmental Health Perspectives 108:suppl 3, pages 483-490.
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Matthew S. Bogdanffy & Annie M. Jarabek. (1995) Understanding mechanisms of inhaled toxicants: implications for replacing default factors with chemical-specific data. Toxicology Letters 82-83, pages 919-932.
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