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Pharmaceutical Development and Technology Volume 22, 2017 - Issue 7: Issue Theme: Pharmaceutical QbD, statistical analysis and experimental design optimization
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Research Article

Determination of process variables affecting drug particle attrition within multi-component blends during powder feed transmission

John F. GambleDrug Product Science & Technology, Bristol-Myers Squibb, Moreton, Wirral, UK; Correspondence[email protected]
,
Andrew B. DennisDrug Product Science & Technology, Bristol-Myers Squibb, Moreton, Wirral, UK;
,
Paul HutchinsDrug Product Science & Technology, Bristol-Myers Squibb, Moreton, Wirral, UK;
,
John W. JonesDrug Product Science & Technology, Bristol-Myers Squibb, Moreton, Wirral, UK;
,
Pauline MusembiSchool of Chemistry, Cardiff University, Park Place, Cardiff, UK
&
Mike TobynDrug Product Science & Technology, Bristol-Myers Squibb, Moreton, Wirral, UK;
Pages 904-909 | Received 18 Mar 2016, Accepted 12 May 2016, Published online: 27 Jun 2016

Citations (9)

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Read on this site (1)

Simon Grote & Peter Kleinebudde. (2019) A comparative study of the influence of alpha-lactose monohydrate particle morphology on granule and tablet properties after roll compaction/dry granulation. Pharmaceutical Development and Technology 24:3, pages 314-322.
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Articles from other publishers (8)

Sri Sharath Kulkarni, Pauline H.M. Janssen & Bastiaan H.J. Dickhoff. (2023) The impact of material chemistry and morphology on attrition behavior of excipients during high shear blending. Powder Technology 427, pages 118694.
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John F. Gamble, Ilgaz Akseli, Ana P. Ferreira, Michael Leane, Stephen Thomas, Mike Tobyn & Robert C. Wadams. (2023) Morphological distribution mapping: Utilisation of modelling to integrate particle size and shape distributions. International Journal of Pharmaceutics 635, pages 122743.
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Brandon J. Thomas, Mohammad Absar, Renishkumar Delvadia, Denise S. Conti, Kimberly Witzmann & Changning Guo. (2021) Analytical method development for characterizing ingredient-specific particle size distributions of nasal spray suspension products. Journal of Pharmaceutical Sciences 110:7, pages 2778-2788.
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Hervé Barjat, Stephen Checkley, Toma Chitu, Neil Dawson, Amin Farshchi, Ana Ferreira, John Gamble, Michael Leane, Andy Mitchell, Chris Morris, Kendal Pitt, Richard Storey, Furqan Tahir & Mike Tobyn. (2020) Demonstration of the Feasibility of Predicting the Flow of Pharmaceutically Relevant Powders from Particle and Bulk Physical Properties. Journal of Pharmaceutical Innovation 16:1, pages 181-196.
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James Clarke, John F. Gamble, John W. Jones, Mike Tobyn, Neil Dawson, Conrad Davies, Andrew Ingram & Richard Greenwood. (2020) Determining the Impact of Roller Compaction Processing Conditions on Granule and API Properties. AAPS PharmSciTech 21:6.
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John F. Gamble, Neil Dawson, Dean Murphy, Andrew Theophilus & Paul Kippax. (2019) A Proposal for an Alternative Approach to Particle Size Method Development During Early-Stage Small Molecule Pharmaceutical Development. Journal of Pharmaceutical Sciences 108:11, pages 3515-3520.
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James Clarke, John F. Gamble, John W. Jones, Mike Tobyn, Richard Greenwood & Andy Ingram. (2019) Alternative approach for defining the particle population requirements for static image analysis based particle characterization methods. Advanced Powder Technology 30:5, pages 920-929.
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Ana Patricia Ferreira, John F. Gamble, Michael M. Leane, Hyunsoo Park, Dolapo Olusanmi & Mike Tobyn. (2018) Enhanced Understanding of Pharmaceutical Materials Through Advanced Characterisation and Analysis. AAPS PharmSciTech 19:8, pages 3462-3480.
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