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Research Article

Determination of process variables affecting drug particle attrition within multi-component blends during powder feed transmission

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Pages 904-909 | Received 18 Mar 2016, Accepted 12 May 2016, Published online: 27 Jun 2016

References

  • Leane M, Pitt K, Reynolds G, et al. A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms. Pharm Dev Technol 2015;20:12–21.
  • Ghadiri M, Ning Z, Kenter SJ, Puik E. Attrition of granular solids in a shear cell. Chem Eng Sci 2000;55:5445–5456.
  • Ghadiri M, Zhang Z. Impact attrition of particulate solids. Part 1: a theoretical model of chipping. Chem Eng Sci 2002;57:3659–3669.
  • Zhang Z, Ghadiri M. Impact attrition of particulate solids. Part 2: experimental work. Chem Eng Sci 2002;57:3671–3686.
  • Bridgwater J, Utsumi R, Zhang Z, Tuladhar T. Particle attrition due to shearing-the effects of stress, strain and particle shape. Chem Eng Sci 2003;58:4649–4665.
  • Ghadiri M, Yuregir KR, Pollock HM, et al. Influence of processing conditions on attrition of NaCl crystals. Powder Technol 1991;65:311–320.
  • Neil AU, Bridgwater J. Attrition of particulate solids under shear. Powder Technol 1994;80:207–219.
  • Paramanathan BK, Bridgwater J. Attrition of solids-II. Material behaviour and kinetics of attrition. Chem Eng Sci 1983;38:207–224.
  • Bridgwater J. Attrition of bulk particulate solids. In: Briscoe BJ, Adams MJ, eds. Tribology in particulate technology. Bristol: Adam Hilger; 1987:364.
  • Bemrose CR, Bridgwater J. A review of attrition and attrition test methods. Powder Technol 1987;49:97–126.
  • Kwan CC, Chen YQ, Ding YL, et al. Development of a novel approach towards predicting the milling behaviour of pharmaceutical powders. Eur J Pharm Sci 2004;23:327–336.
  • Lamberto DJ, Cohen B, Marencic J, et al. Laboratory methods for assessing API sensitivity to mechanical stress during agitated drying. Chem Eng Sci 2011;66:3868–3875.
  • Hamilton P, Littlejohn D, Nordon A, et al. Investigation of factors affecting isolation of needle-shaped particles in a vacuum-agitated filter drier through non-invasive measurements by Raman spectrometry. Chem Eng Sci 2013;101:878–885.
  • Lekhal A, Girard KP, Brown MA, et al. The effect of agitated drying on the morphology of L-threonine (needle-like) crystals. Int J Pharm 2004;270:263–277.
  • MacLeod CS, Muller FL. On the fracture of pharmaceutical needle-shaped crystals during pressure filtration: case studies and mechanistic understanding. Org Process Res Dev 2012;16:425–434.
  • Gamble JF, Ferreira AP, Tobyn M, et al. Application of imaging based tools for the characterisation of hollow spray dried amorphous dispersion particles. Int J Pharm 2014;465:210–217.
  • Am Ende D, Birch M, Brenek SJ, Maloney MT. Development and application of laboratory tools to predict particle properties upon scale-up in agitated filter-dryers. Org Process Res Dev 2013;17:1345–1358.
  • Hare CL, Ghadiri M, Dennehy R, Collier A. Particle breakage in agitated dryers. 6th International Conference on Micromechanics of Granular Media, Powders and Grains; Golden, CO, USA; 2009.
  • Kom PK, Cook W, Kougoulos E. Impact of laboratory vacuum contact drying on material drying rates and physical properties. Org Process Res Dev 2011;15:360–366.
  • Kougoulos E, Chadwick CE, Ticehurst MD. Impact of agitated drying on the powder properties of an active pharmaceutical ingredient. Powder Technol 2011;210:308–314.
  • Lekhal A, Girard KP, Brown MA, et al. Impact of agitated drying on crystal morphology: KCl-water system. Powder Technol 2003;132:119–130.
  • Remy B, Kightlinger W, Saurer EM, et al. Scale-up of agitated drying: effect of shear stress and hydrostatic pressure on active pharmaceutical ingredient powder properties. AIChE J 2015;61:407–418.
  • Mendez R, Velazquez C, Muzzio FJ. Effect of feed frame design and operating parameters on powder attrition, particle breakage, and powder properties. Powder Technol 2012;229:253–260.
  • Gamble JF, Hoffmann M, Hughes H, et al. Monitoring process induced attrition of drug substance particles within formulated blends. Int J Pharm 2014;470:77–87.
  • Hoffmann M, Wray PS, Gamble JF, Tobyn M. Investigation into process-induced de-aggregation of cohesive micronised API particles. Int J f Pharm 2015;493:341–346.
  • Dawes J, Gamble JF, Greenwood R, et al. An investigation into the impact of magnesium stearate on powder feeding during roller compaction. Drug Dev Ind Pharm 2012;38:111–122.
  • Gamble JF, Tobyn M, Hamey R. Application of image-based particle size and shape characterization systems in the development of small molecule pharmaceuticals. J Pharm Sci 2015;104:1563–1574.
  • Gamble JF, Chiu WS, Tobyn M. Investigation into the impact of sub-populations of agglomerates on the particle size distribution and flow properties of conventional microcrystalline cellulose grades. Pharm Dev Technol 2011;16:542–548.
  • Kendall K. The impossibility of comminuting small particles by compression. Nature 1978;272:710–711.

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