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Original Articles

Hepatotoxic Cyanobacteria: A Review of the Biological Importance of Microcystins in Freshwater Environments

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Pages 1-37 | Published online: 14 Mar 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (49)

Simone Maria Teixeira de Sabóia-Morais, João Marcos de Lima Faria, Jéssica Custódio da Silva Rabelo, Alex Lucas Hanusch, Lorena Alves Mesquita, Raquel de Andrade Silva, Jerusa Maria de Oliveira & Lázaro Wender Oliveira de Jesus. (2024) Cylindrospermopsin exposure promotes redox unbalance and tissue damage in the liver of Poecilia reticulata, a neotropical fish species. Journal of Toxicology and Environmental Health, Part A 87:3, pages 120-132.
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Lorgio G. Valdiviezo Gonzales, Fausto F. García Ávila, Rita J. Cabello Torres, Carlos A. Castañeda Olivera & Emigdio A. Alfaro Paredes. (2021) Scientometric study of drinking water treatments technologies: Present and future challenges. Cogent Engineering 8:1.
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Jiannan Ding, Hang Jiang, Xuyue Wu, Shanshan Zhang, Roger Mamitiana Razanajatovo & Hua Zou. (2020) Investigation and assessment of environmental pollution in Gonghu Bay, Taihu Lake, China: A year-long study. Human and Ecological Risk Assessment: An International Journal 26:4, pages 906-920.
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Yue Yang, Cong Wen, Shuilin Zheng, Wenya Liu, Jihua Chen, Xiangling Feng, Xiaoyan Wang, Fei Yang & Zhen Ding. (2019) Influence of microcystins-LR (MC-LR) on autophagy in human neuroblastoma SK-N-SH cells. Journal of Toxicology and Environmental Health, Part A 82:21, pages 1129-1136.
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Feiyu Huang, Hai Feng, Xiaoyu Li, Xiping Yi, Jian Guo, Tezi Clara & Fei Yang. (2019) Anaerobic degradation of microcystin-LR by an indigenous bacterial Enterobacter sp. YF3. Journal of Toxicology and Environmental Health, Part A 82:21, pages 1120-1128.
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Cong Wen, Shuilin Zheng, Yue Yang, Xiaoyu Li, Jihua Chen, Xiaoyan Wang, Xiangling Feng & Fei Yang. (2019) Effects of microcystins-LR on genotoxic responses in human intestinal epithelial cells (NCM460). Journal of Toxicology and Environmental Health, Part A 82:21, pages 1113-1119.
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Shuilin Zheng, Cong Wen, Shu Yang, Yue Yang & Fei Yang. (2019) Circular RNA expression profiles following MC-LR treatment in human normal liver cell line (HL7702) cells using high-throughput sequencing analysis. Journal of Toxicology and Environmental Health, Part A 82:21, pages 1103-1112.
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Chengcheng Zhang, Isaac Yaw Massey, Yan Liu, Feiyu Huang, Ruihuan Gao, Ming Ding, Lin Xiang, Chuning He, Jia Wei, Yunhui Li, Yuliang Ge & Fei Yang. (2019) Identification and characterization of a novel indigenous algicidal bacterium Chryseobacterium species against Microcystis aeruginosa. Journal of Toxicology and Environmental Health, Part A 82:15, pages 845-853.
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Cong Wen, Shu Yang, Shuilin Zheng, Xiangling Feng, Jihua Chen & Fei Yang. (2018) Analysis of long non-coding RNA profiled following MC-LR-induced hepatotoxicity using high-throughput sequencing. Journal of Toxicology and Environmental Health, Part A 81:22, pages 1165-1172.
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Isaac Yaw Massey, Xian Zhang & Fei Yang. (2018) Importance of bacterial biodegradation and detoxification processes of microcystins for environmental health. Journal of Toxicology and Environmental Health, Part B 21:6-8, pages 357-369.
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Pin Liu, Jia Wei, Kun Yang, Isaac Yaw Massey, Jian Guo, Chengcheng Zhang & Fei Yang. (2018) Isolation, molecular identification, and characterization of a unique toxic cyanobacterium Microcystis sp. found in Hunan Province, China. Journal of Toxicology and Environmental Health, Part A 81:21, pages 1142-1149.
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Fei Yang, Cong Wen, Shuilin Zheng, Shu Yang, Jihua Chen & Xiangling Feng. (2018) Involvement of MAPK/ERK1/2 pathway in microcystin-induced microfilament reorganization in HL7702 hepatocytes. Journal of Toxicology and Environmental Health, Part A 81:21, pages 1135-1141.
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Rodrigo de Cássio da Silva, Sonia Regina Grötzner, Daniele Dietrich Moura Costa, Juan Ramón Esquivel Garcia, Juan Muelbert, Valéria Freitas de Magalhães, Francisco Filipak Neto & Ciro Alberto de Oliveira Ribeiro. (2018) Comparative bioaccumulation and effects of purified and cellular extract of cylindrospermopsin to freshwater fish Hoplias malabaricus. Journal of Toxicology and Environmental Health, Part A 81:14, pages 620-632.
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Lisa Chedik, Arnaud Bruyere, Astrid Bacle, Sophie Potin, Marc Le Vée & Olivier Fardel. (2018) Interactions of pesticides with membrane drug transporters: implications for toxicokinetics and toxicity. Expert Opinion on Drug Metabolism & Toxicology 14:7, pages 739-752.
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N. Chernoff, D.J. Hill, I. Chorus, D.L. Diggs, H. Huang, D. King, J.R. Lang, T.-T. Le, J.E. Schmid, G.S. Travlos, E.M. Whitley, R.E. Wilson & C.R. Wood. (2018) Cylindrospermopsin toxicity in mice following a 90-d oral exposure. Journal of Toxicology and Environmental Health, Part A 81:13, pages 549-566.
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Azam Omidi, Maranda Esterhuizen-Londt & Stephan Pflugmacher. (2018) Still challenging: the ecological function of the cyanobacterial toxin microcystin – What we know so far. Toxin Reviews 37:2, pages 87-105.
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Fei Yang, Isaac Yaw Massey, Jian Guo, Shu Yang, Yuepu Pu, Weiming Zeng & Hongzhuan Tan. (2018) Microcystin-LR degradation utilizing a novel effective indigenous bacterial community YFMCD1 from Lake Taihu. Journal of Toxicology and Environmental Health, Part A 81:7, pages 184-193.
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Shu Yang, Lv Chen, Cong Wen, Xian Zhang, Xiangling Feng & Fei Yang. (2018) MicroRNA expression profiling involved in MC-LR-induced hepatotoxicity using high-throughput sequencing analysis. Journal of Toxicology and Environmental Health, Part A 81:5, pages 89-97.
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N. Chernoff, D. J. Hill, D. L. Diggs, B. D. Faison, B. M. Francis, J. R Lang, M. M. Larue, T.-T. Le, K. A. Loftin, J. N. Lugo, J. E. Schmid & W. M. Winnik. (2017) A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans. Journal of Toxicology and Environmental Health, Part B 20:4, pages 183-229.
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Damjana Drobac, Nada Tokodi, Biljana Kiprovski, Djordje Malenčić, Tamara Važić, Sonja Nybom, Jussi Meriluoto & Zorica Svirčev. (2017) Microcystin accumulation and potential effects on antioxidant capacity of leaves and fruits of Capsicum annuum. Journal of Toxicology and Environmental Health, Part A 80:3, pages 145-154.
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Leonardo Cerasino, Shiva Shams, Adriano Boscaini & Nico Salmaso. (2016) Multiannual trend of microcystin production in the toxic cyanobacterium Planktothrix rubescens in Lake Garda (Italy). Chemistry and Ecology 32:5, pages 492-506.
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Dongwoo Yang, Sungjin Nam, Soon-Jin Hwang, Kwang-Guk An, Young-Seuk Park, Kyung-Hoon Shin & Sangkyu Park. (2016) Fatty acid biomarkers to verify cyanobacteria feeding abilities of herbivorous consumers. Journal of Freshwater Ecology 31:1, pages 77-91.
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Silvia P. Melegari, Cátia R. S. de Carvalho Pinto, Serge Moukha, Edmond E. Creppy & William G. Matias. (2015) Evaluation of Cytotoxicity and Cell Death Induced In Vitro by Saxitoxin in Mammalian Cells. Journal of Toxicology and Environmental Health, Part A 78:19, pages 1189-1200.
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Maria Sofia Costa, Margarida Costa, Vítor Ramos, Pedro N. Leão, Aldo Barreiro, Vítor Vasconcelos & Rosário Martins. (2015) Picocyanobacteria From a Clade of Marine Cyanobium Revealed Bioactive Potential Against Microalgae, Bacteria, and Marine Invertebrates. Journal of Toxicology and Environmental Health, Part A 78:7, pages 432-442.
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Caroline Ajonina, Christopher Buzie, Rafi Herfini Rubiandini & Ralf Otterpohl. (2015) Microbial Pathogens in Wastewater Treatment Plants (WWTP) in Hamburg. Journal of Toxicology and Environmental Health, Part A 78:6, pages 381-387.
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A. Zastepa, F. R. Pick & J. M. Blais. (2014) Fate and Persistence of Particulate and Dissolved Microcystin-LA from Microcystis Blooms. Human and Ecological Risk Assessment: An International Journal 20:6, pages 1670-1686.
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N. Chernoff, E. H. Rogers, R. D. Zehr, M. I. Gage, G. S. Travlos, D. E. Malarkey, A. Brix, J. E. Schmid & D. Hill. (2014) The Course of Toxicity in the Pregnant Mouse After Exposure to the Cyanobacterial Toxin Cylindrospermopsin: Clinical Effects, Serum Chemistries, Hematology, and Histopathology. Journal of Toxicology and Environmental Health, Part A 77:17, pages 1040-1060.
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Jafar Shahraki, Abbasali Motallebi, Iman Barekati, Enayatollah Seydi & Jalal Pourahmad. (2014) Comparison of cellular and molecular cytotoxic mechanisms of Cochlodinium polykrikoides in isolated trout and rat hepatocytes. Toxicological & Environmental Chemistry 96:6, pages 917-930.
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Fernando Bellém, Susana Nunes & Manuela Morais. (2013) Cyanobacteria Toxicity: Potential Public Health Impact in South Portugal Populations. Journal of Toxicology and Environmental Health, Part A 76:4-5, pages 263-271.
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Neetu Shahi, Monalisa Sahoo, Sumanta Kumar Mallik, Debajit Sarma & Partha Das. (2012) The microcystins-induced DNA damage in the liver and the heart of zebrafish, Danio rerio . Toxicological & Environmental Chemistry 94:2, pages 340-349.
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DI Weller. (2011) Detection, identification and toxigenicity of cyanobacteria in New Zealand lakes using PCR-based methods. New Zealand Journal of Marine and Freshwater Research 45:4, pages 651-664.
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Am Jang, Hye-Weon Yu & In S. Kim. (2011) Potential integration of cadmium lab chip with immunoassay using quantum dot/antibody probe for detection of microcystin-LR. Desalination and Water Treatment 33:1-3, pages 382-388.
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AngelineR. Tillmanns & FrancesR. Pick. (2011) The effect of sampling scales on the interpretation of environmental drivers of the cyanotoxin microcystin. Lake and Reservoir Management 27:3, pages 183-193.
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Susana R. Pereira, Vítor M. Vasconcelos & Agostinho Antunes. (2011) The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins. Critical Reviews in Toxicology 41:2, pages 83-110.
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David R. Ruebhart, Wasantha Wickramasinghe & Ian E. Cock. (2009) Protective Efficacy of the Antioxidants Vitamin E and Trolox Against Microcystis aeruginosa and Microcystin-LR in Artemia franciscana Nauplii. Journal of Toxicology and Environmental Health, Part A 72:24, pages 1567-1575.
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Christoph Schmidtkunz, Hans Bernd Stich & Thomas Welsch. (2009) Improving the Selectivity and Confidence in the HPLC Analysis of Microcystins in Lake Sediments. Journal of Liquid Chromatography & Related Technologies 32:6, pages 801-821.
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SuzanneM. Froscio, Stella Fanok & AndrewR. Humpage. (2009) Cytotoxicity Screening for the Cyanobacterial Toxin Cylindrospermopsin. Journal of Toxicology and Environmental Health, Part A 72:5, pages 345-349.
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JoséC. Martins & VítorM. Vasconcelos. (2009) Microcystin Dynamics in Aquatic Organisms. Journal of Toxicology and Environmental Health, Part B 12:1, pages 65-82.
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Enzo Funari & Emanuela Testai. (2008) Human Health Risk Assessment Related to Cyanotoxins Exposure. Critical Reviews in Toxicology 38:2, pages 97-125.
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Anthony Fristachi, Glenn Rice, Jeffery Steevens & Igor Linkov. (2007) A preliminary exposure assessment of microcystins from consumption of drinking water in the United States. Lake and Reservoir Management 23:2, pages 203-210.
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BrantW. Touchette, JoAnnM. Burkholder, ElleH. Allen, JessicaL. Alexander, CarolA. Kinder, Cavell Brownie, Jennifer James & ClayH. Britton. (2007) Eutrophication and cyanobacteria blooms in run-of-river impoundments in North Carolina, U.S.A.. Lake and Reservoir Management 23:2, pages 179-192.
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Huirong Chen, JaniceM. Burke, W. Paul Dinsmore, EllieE. Prepas & PhillipM. Fedorak. (2007) First assessment of cyanobacterial blooms and microcystin-LR in the Canadian portion of Lake of the Woods. Lake and Reservoir Management 23:2, pages 169-178.
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B.G. Kotak & R.W. Zurawell. (2007) Cyanobacterial toxins in Canadian freshwaters: A review. Lake and Reservoir Management 23:2, pages 109-122.
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Pavel Babica, Klára Hilscherová, Kateřina Bártová, Luděk Bláha & Blahoslav Maršálek. (2007) Effects of dissolved microcystins on growth of planktonic photoautotrophs. Phycologia 46:2, pages 137-142.
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S.A. Wood, P.T. Holland, D. J. Stirling, L. R. Briggs, J. Sprosen, J. G. Ruck & R. G. Wear. (2006) Survey of cyanotoxins in New Zealand water bodies between 2001 and 2004. New Zealand Journal of Marine and Freshwater Research 40:4, pages 585-597.
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Ronald W. Zurawell, Charles F. B. Holmes & Ellie E. Prepas. (2006) Elimination of the Cyanobacterial Hepatotoxin Microcystin from the freshwater Pulmonate Snail Lymnaea stagnalis jugularis (SAY). Journal of Toxicology and Environmental Health, Part A 69:4, pages 303-318.
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