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Original Article

Safety and effectiveness of 24-week treatment with iguratimod, a new oral disease-modifying antirheumatic drug, for patients with rheumatoid arthritis: interim analysis of a post-marketing surveillance study of 2679 patients in Japan

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Pages 755-765 | Received 20 Oct 2016, Accepted 14 Nov 2016, Published online: 21 Dec 2016

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Naoki Ishiguro, Kai Shibata, Akiko Yoshimura, Satoshi Ikeuchi & Mika Ishii. (2020) Investigation of the predictors of the response to Iguratimod therapy: A post-hoc analysis of post-marketing surveillance study. Modern Rheumatology 30:4, pages 626-632.
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Tsuneyo Mimori, Masayoshi Harigai, Tatsuya Atsumi, Takao Fujii, Masataka Kuwana, Hiroaki Matsuno, Shigeki Momohara, Syuji Takei, Naoto Tamura, Yoshinari Takasaki, Kazuhiko Yamamoto, Satoshi Ikeuchi, Satoru Kushimoto & Takao Koike. (2019) Safety and effectiveness of iguratimod in patients with rheumatoid arthritis: Final report of a 52-week, multicenter postmarketing surveillance study. Modern Rheumatology 29:2, pages 314-323.
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Y Luo, N Zheng & R Wu. (2018) Is iguratimod effective in refractory axial spondyloarthritis?. Scandinavian Journal of Rheumatology 47:6, pages 518-520.
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Ryosuke Kamei, Masanori Kono, Yukiko Iwasaki, Hirofumi Shoda, Kanae Kubo, Keishi Fujio & Kazuhiko Yamamoto. (2017) Iguratimod-induced acute interstitial pneumonia with hypogammaglobulinemia in a rheumatoid arthritis patient. Modern Rheumatology Case Reports 1:2, pages 54-59.
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Qingran Yan, Bei Liu, Jieying Wang, Hanlin Yin, Qianqian Li & Liangjing Lu. (2023) Iguratimod as an alternative therapy for systemic sclerosis and prevention of the occurrence of ischemic digital ulcer. Frontiers in Medicine 10.
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Hiroshi Takei, Satoshi Takanashi, Kotaro Otomo, Hironari Hanaoka, Jun Kikuchi, Kunihiro Yamaoka, Keiko Yoshimoto, Takayuki Abe, Tsutomu Takeuchi & Yuko Kaneko. (2022) Clinical and immunological effects of hydroxychloroquine in patients with active rheumatoid arthritis despite antirheumatic treatment. Modern Rheumatology.
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Kaue Franco Malange, Juliana M. Navia-Pelaez, Elayne Vieira Dias, Julia Borges Paes Lemes, Soo-Ho Choi, Gilson Goncalves Dos Santos, Tony L. Yaksh & Maripat Corr. (2022) Macrophages and glial cells: Innate immune drivers of inflammatory arthritic pain perception from peripheral joints to the central nervous system. Frontiers in Pain Research 3.
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Dan Ouyang, Yuan Zhi Ma, Jie Zou, Yong Long Wang, Zheng Chen, Yu Ying Yang, Bin Zou, Xin Li & Jian Zhong Cao. (2022) Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology 13.
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Wentian Lu, Zhichun Liu & Leixi Xue. (2022) Allergic Skin Rash Caused by Iguratimod: A Report of Two Cases. Cureus.
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Kai Shibata, Akiko Yoshimura, Satoshi Ikeuchi & Mika Ishii. (2021) Effectiveness of drug safety measures for reducing the incidence of adverse drug reactions: Post-hoc analysis of data from all-case surveillance of iguratimod using generalized estimating equations. PLOS ONE 16:7, pages e0253513.
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L.-J. Chen, Y.-J. Zhou, Z.-H. Wen, F. Tian & J.-Y. Li. (2020) Efficacy and safety of iguratimod combined with methotrexate vs. methotrexate alone in rheumatoid arthritisWirksamkeit und Sicherheit von Iguratimod in Kombination mit Methotrexat vs. Methotrexat allein bei rheumatoider Arthritis. Zeitschrift für Rheumatologie 80:5, pages 432-446.
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Yuji Nozaki. (2021) Iguratimod: Novel Molecular Insights and a New csDMARD for Rheumatoid Arthritis, from Japan to the World. Life 11:5, pages 457.
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Rong Mu, Chun Li, Xiaomei Li, Yao Ke, Ling Zhao, Lin Chen, Rui Wu, Zhenbiao Wu, Xiaoxia Zuo, Yanli Xie, Jinwei Chen, Wei Wei, Yi Liu, Zhijun Li, Lie Dai, Lingyun Sun, Xiangyuan Liu & Zhanguo Li. (2021) Effectiveness and safety of iguratimod treatment in patients with active rheumatoid arthritis in Chinese: A nationwide, prospective real-world study. The Lancet Regional Health - Western Pacific 10, pages 100128.
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Satoshi Mizutani, Hitoshi Kodera, Yoshiko Sato, Toshihiro Nanki, Shunji Yoshida & Hidekata Yasuoka. (2020) Clinical effectiveness of iguratimod based on real-world data of patients with rheumatoid arthritis. Clinical Rheumatology 40:1, pages 123-132.
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Asuka Inoue, Yuji Nozaki, Yasuaki Hirooka, Koji Kinoshita, Yasutaka Chiba, Masanori Funauchi & Itaru Matsumura. (2020) The Effectiveness and Retention Rate of Iguratimod in Japanese Rheumatoid Arthritis Patients with/without Methotrexate in Daily Medical Care. Life 10:11, pages 261.
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Sisi Xie, Shu Li, Jing Tian & Fen Li. (2020) Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape. Frontiers in Pharmacology 11.
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Huihui Jiang, Hongyan Gao, Qin Wang, Miao Wang & Bin Wu. (2020) Molecular mechanisms and clinical application of Iguratimod: A review. Biomedicine & Pharmacotherapy 122, pages 109704.
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Yan Ye, Mei Liu, Longhai Tang, Fang Du, Yuanhua Liu, Pei Hao, Qiong Fu, Qiang Guo, Qingran Yan, Xiaoming Zhang & Chunde Bao. (2019) Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis. Arthritis Research & Therapy 21:1.
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Jie Li, Jun Bao, Jian Zeng, Aizhu Yan, Chunqiu Zhao & Qiang Shu. (2019) Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology. Bone Research 7:1.
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Xiao-li Li, Xiao-Chang Liu, Yu-Lin Song, Ru-Tao Hong & Hai Shi. (2018) Suspected drug-induced liver injury associated with iguratimod: a case report and review of the literature. BMC Gastroenterology 18:1.
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Guangrui Li, Ryo Yamasaki, Mei Fang, Katsuhisa Masaki, Hirofumi Ochi, Takuya Matsushita & Jun-ichi Kira. (2018) Novel disease-modifying anti-rheumatic drug iguratimod suppresses chronic experimental autoimmune encephalomyelitis by down-regulating activation of macrophages/microglia through an NF-κB pathway. Scientific Reports 8:1.
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Atsushi Hashimoto, Shiori Suto, Kouichiro Horie, Hidefumi Fukuda, Shinichi Nogi, Kanako Iwata, Hirotaka Tsuno, Hideki Ogihara, Misato Kawakami, Akiko Komiya, Hiroshi Furukawa, Toshihiro Matsui & Shigeto Tohma. (2017) Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis. International Journal of Rheumatology 2017, pages 1-8.
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